Motif ID: EVI1.p2

Z-value: 2.508


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1



Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_50025115 6.211 NM_001166478
DEFB133
defensin, beta 133
chrX_-_119095544 4.296 NM_001099685
NM_032498
RHOXF2B
RHOXF2
Rhox homeobox family, member 2B
Rhox homeobox family, member 2
chr15_+_64661560 4.238


chr8_-_38127489 3.364 NM_000349
STAR
steroidogenic acute regulatory protein
chr6_+_105511615 3.109 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr22_+_43451351 2.984 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr1_+_58899 2.812 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr12_-_9804682 2.783 NM_001781
CD69
CD69 molecule
chr6_-_41276901 2.669 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr4_-_40212670 2.656 NM_019027
RBM47
RNA binding motif protein 47
chr17_-_64462976 2.545 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr11_+_93940121 2.479 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr12_-_8110268 2.443 C3AR1
complement component 3a receptor 1
chrX_-_101581504 2.419 NM_022053
NXF2
nuclear RNA export factor 2
chr7_+_106292975 2.270 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_-_8110196 2.209 NM_004054
C3AR1
complement component 3a receptor 1
chr11_-_5247948 2.171 NM_005330
HBE1
hemoglobin, epsilon 1
chr15_-_100280784 2.160 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr7_+_106292932 2.127 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr11_-_33848013 2.056 LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_+_111053488 2.018 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr8_-_17812151 1.952


chr11_+_64694200 1.950 NM_001008778
SPDYC
speedy homolog C (Xenopus laevis)
chr11_-_33848061 1.949 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr14_+_54291255 1.921 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chrX_-_11194015 1.909 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr11_-_33847937 1.907 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_-_32054164 1.852 NM_144569
SPOCD1
SPOC domain containing 1
chr7_+_106293112 1.836 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr6_-_11887265 1.792 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr6_+_38798529 1.777 NM_001371
DNAH8
dynein, axonemal, heavy chain 8
chr2_+_157822355 1.765 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr1_-_28376041 1.753 NM_000952
PTAFR
platelet-activating factor receptor
chr5_+_171553780 1.733 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr1_+_152560179 1.732 NM_080429
AQP10
aquaporin 10
chr20_-_45418818 1.706 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr17_+_53769562 1.678 LOC100506779
hypothetical LOC100506779
chr11_+_59580630 1.627 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr14_-_62638336 1.625 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr1_+_181028016 1.591 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr17_-_39822366 1.589 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr8_-_91164100 1.557 NM_004929
CALB1
calbindin 1, 28kDa
chr11_-_118405288 1.550 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr11_+_59580705 1.530 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chrX_+_30169977 1.529 NM_002367
MAGEB4
melanoma antigen family B, 4
chr8_-_110724594 1.509 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr3_-_180467483 1.508 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr2_-_175207521 1.493 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr9_-_99746923 1.456 NM_018437
HEMGN
hemogen
chr21_+_29322100 1.455 USP16
ubiquitin specific peptidase 16
chr1_-_180822686 1.373 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr1_+_111217244 1.361 NM_000560
CD53
CD53 molecule
chr11_-_123816190 1.353 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr7_-_75794919 1.333 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chrX_+_101388810 1.331 NM_022053
NXF2
nuclear RNA export factor 2
chr19_+_61624 1.323 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr7_+_129634935 1.323 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr11_-_64520964 1.310 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr9_+_33230165 1.285 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr11_+_60765219 1.280 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr1_+_203503214 1.272 TMCC2
transmembrane and coiled-coil domain family 2
chr7_-_130069399 1.261 NM_138693
KLF14
Kruppel-like factor 14
chr1_+_202033273 1.256 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr11_+_46339691 1.249 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr18_-_65775139 1.226 NM_006566
CD226
CD226 molecule
chr6_-_49712483 1.215 NM_000324
RHAG
Rh-associated glycoprotein
chr2_-_144994349 1.212 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr1_+_179269183 1.204 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr11_+_64950074 1.193 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr11_-_64484184 1.193 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr13_+_49487390 1.190 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr1_-_153537810 1.187 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr2_-_135498716 1.187 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr17_-_59437782 1.184 NM_000873
ICAM2
intercellular adhesion molecule 2
chr1_-_47468029 1.172 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr1_+_15675182 1.169 NM_015849
CELA2B
chymotrypsin-like elastase family, member 2B
chr8_-_101384633 1.151 NM_015435
RNF19A
ring finger protein 19A
chr1_+_50342168 1.143 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr17_+_53769659 1.134 LOC100506779
hypothetical LOC100506779
chr16_+_2807228 1.132 PRSS21
protease, serine, 21 (testisin)
chr2_+_169637255 1.115 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_+_123625632 1.111 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr6_+_135558744 1.100 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr7_-_112513379 1.097 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr11_-_10487212 1.096 NM_001190702
MTRNR2L8
MT-RNR2-like 8
chr21_+_37714470 1.091 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr7_-_16471817 1.091 NM_015464
SOSTDC1
sclerostin domain containing 1
chr21_-_14840506 1.079 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr12_+_56802 1.078 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr1_-_178100204 1.072


chrX_-_24600661 1.070 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr1_+_242582559 1.068 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr22_-_37214480 1.066 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr3_+_66527586 1.057


chr4_+_123311207 1.055 NM_015312
KIAA1109
KIAA1109
chr22_+_21340757 1.028


chr20_+_36365965 1.026 NM_001725
BPI
bactericidal/permeability-increasing protein
chr1_+_111217314 1.022 CD53
CD53 molecule
chr19_+_56452775 1.017 NM_173635
C19orf75
chromosome 19 open reading frame 75
chr3_-_143230124 1.016 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr6_+_112775224 1.010 NM_001013734
RFPL4B
ret finger protein-like 4B
chr6_-_76027286 1.005 TMEM30A
transmembrane protein 30A
chr1_-_180624380 1.001 GLUL
glutamate-ammonia ligase
chr11_-_47467094 0.998 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr6_-_49862858 0.994 NM_138733
PGK2
phosphoglycerate kinase 2
chr1_+_47674275 0.985 NM_004474
FOXD2
forkhead box D2
chr12_-_69434598 0.981 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr5_+_121493113 0.981 NM_207317
ZNF474
zinc finger protein 474
chr11_+_113671744 0.977 NM_006169
NNMT
nicotinamide N-methyltransferase
chr16_-_4795160 0.974 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr11_+_55554470 0.966 NM_001001921
OR5AS1
olfactory receptor, family 5, subfamily AS, member 1
chr2_+_102401580 0.965 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_+_179269766 0.955 MR1
major histocompatibility complex, class I-related
chr19_-_56825400 0.948 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr9_+_134843918 0.943 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr12_-_101036407 0.939 NM_024057
NUP37
nucleoporin 37kDa
chr5_+_118993152 0.938 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr5_-_96175560 0.931 NM_001198541
ERAP1
endoplasmic reticulum aminopeptidase 1
chr16_-_4794749 0.929 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr12_-_69434650 0.926 PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_-_101396459 0.919 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr7_+_18296569 0.915 HDAC9
histone deacetylase 9
chr1_+_179269761 0.912 MR1
major histocompatibility complex, class I-related
chr20_+_35445350 0.912 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr7_+_123036312 0.910 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr10_-_48036698 0.908 NM_016204
GDF2
growth differentiation factor 2
chr1_+_208067986 0.907 DIEXF
digestive organ expansion factor homolog (zebrafish)
chr11_-_8921155 0.907 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr16_+_31446703 0.906 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr1_-_180624494 0.906 GLUL
glutamate-ammonia ligase
chr12_-_94469357 0.902 NM_032147
USP44
ubiquitin specific peptidase 44
chr11_-_123772456 0.899 NM_001005467
OR8B3
olfactory receptor, family 8, subfamily B, member 3
chr19_-_45022993 0.898 FBL
fibrillarin
chr4_-_77042599 0.892 NM_006239
PPEF2
protein phosphatase, EF-hand calcium binding domain 2
chr15_-_35178888 0.888 NM_172316
MEIS2
Meis homeobox 2
chr2_-_39310176 0.873 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr11_-_117589283 0.862 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_-_165754325 0.862 NM_000734
NM_198053
CD247

CD247 molecule

chr1_+_179269689 0.859 MR1
major histocompatibility complex, class I-related
chr12_+_112344529 0.854 NM_138432
SDSL
serine dehydratase-like
chr9_+_95886558 0.847 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr1_+_200698493 0.838 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr16_+_33111656 0.829 NM_001099687
TP53TG3B
TP53 target 3B
chr1_-_171838802 0.827 NM_178527
SLC9A11
solute carrier family 9, member 11
chr16_+_33168191 0.824 NM_001099687
TP53TG3B
TP53 target 3B
chr8_-_110411283 0.823 NM_001128211
NUDCD1
NudC domain containing 1
chrX_+_154880439 0.823 NM_002186
IL9R
interleukin 9 receptor
chr22_+_21464980 0.819


chr15_+_39839866 0.818 MGA
MAX gene associated
chr22_-_25343959 0.817 NM_001887
CRYBB1
crystallin, beta B1
chr4_-_77163609 0.816 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr16_+_20682812 0.808 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr1_-_148854503 0.804


chr7_+_63410620 0.804 NM_001170905
ZNF736
zinc finger protein 736
chr1_+_108904493 0.803 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr2_+_175292771 0.792 H3F3A
H3 histone, family 3A
chr1_+_208067890 0.779 NM_014388
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr16_-_79811475 0.777 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr7_-_13992351 0.770 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_+_144152864 0.769 TXNIP
thioredoxin interacting protein
chrX_-_153716130 0.766 NM_001162936
LOC100132963
hypothetical protein LOC100132963
chr5_+_140719773 0.765 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr6_-_29081015 0.760 NM_001010877
ZNF311
zinc finger protein 311
chr20_-_55368284 0.759 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chrX_+_86659370 0.756 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr16_+_2807164 0.753 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr2_-_144991386 0.752 ZEB2
zinc finger E-box binding homeobox 2
chr11_-_113935789 0.748 NM_152315
FAM55A
family with sequence similarity 55, member A
chr20_-_604443 0.746


chr22_+_38652555 0.745 GRAP2
GRB2-related adaptor protein 2
chr19_-_46080496 0.741 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr18_-_27594696 0.735 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr9_+_124072947 0.734 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr7_-_112514990 0.733 GPR85
G protein-coupled receptor 85
chr12_+_94200306 0.724 VEZT
vezatin, adherens junctions transmembrane protein
chr7_-_137271191 0.722 CREB3L2
cAMP responsive element binding protein 3-like 2
chr3_-_153541468 0.720 NM_001123228
TMEM14E
transmembrane protein 14E
chr12_+_25096755 0.720 LRMP
lymphoid-restricted membrane protein
chr16_-_45562840 0.719 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr4_-_100070808 0.718 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr12_+_91654395 0.717 NM_001004330
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr17_-_53849929 0.714 NM_017763
RNF43
ring finger protein 43
chr12_+_55018925 0.713 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr2_-_26395420 0.712 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr7_+_137411717 0.710 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr3_-_161584137 0.708 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr15_-_91078307 0.706 FAM174B
family with sequence similarity 174, member B
chr17_-_53849888 0.705 RNF43
ring finger protein 43
chr9_+_95886625 0.702 PTPDC1
protein tyrosine phosphatase domain containing 1
chr5_+_125723686 0.700 NM_001146319
GRAMD3
GRAM domain containing 3
chr19_+_39402167 0.699 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr6_-_6632197 0.698


chr1_+_208068022 0.697 DIEXF
digestive organ expansion factor homolog (zebrafish)
chr17_-_53976681 0.696 NM_001038704
C17orf47
chromosome 17 open reading frame 47
chr1_+_1374931 0.693 NM_001039211
ATAD3C
ATPase family, AAA domain containing 3C
chr5_-_79982584 0.693 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chr1_-_28375722 0.690 NM_001164723
PTAFR
platelet-activating factor receptor
chr8_+_77928372 0.688 ZFHX4
zinc finger homeobox 4
chr7_-_112515068 0.687 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr11_+_65023218 0.685



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.27 1.97e-06 GO:0007608 sensory perception of smell
2.06 6.33e-05 GO:0007606 sensory perception of chemical stimulus
9.52 1.78e-02 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 1.35e-06 GO:0071944 cell periphery
1.30 1.80e-06 GO:0005886 plasma membrane
1.16 6.16e-03 GO:0044425 membrane part
1.18 6.29e-03 GO:0031224 intrinsic to membrane
1.18 1.05e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.34 2.04e-07 GO:0004984 olfactory receptor activity
1.80 3.39e-06 GO:0004930 G-protein coupled receptor activity
1.56 9.01e-05 GO:0004888 transmembrane receptor activity
1.44 4.60e-04 GO:0004872 receptor activity
1.36 3.45e-03 GO:0004871 signal transducer activity
1.36 3.45e-03 GO:0060089 molecular transducer activity