Motif ID: CEBPA,B_DDIT3.p2

Z-value: 2.567


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
CEBPA 1050 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB 1051 CCAAT/enhancer binding protein (C/EBP), beta
DDIT3 1649 DNA-damage-inducible transcript 3



Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_149221122 7.709 NM_003568
ANXA9
annexin A9
chr9_+_116125123 6.077 NM_000607
ORM1
orosomucoid 1
chr17_-_36346240 5.067 KRT23
keratin 23 (histone deacetylase inducible)
chr6_+_32003380 4.136 C2
complement component 2
chr20_+_54420574 3.722 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr3_+_187813553 3.649 AHSG
alpha-2-HS-glycoprotein
chrX_+_9391314 3.610 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr11_-_33870411 3.466 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr3_+_187813538 3.455 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr6_+_32003180 3.378 NM_000063
NM_001145903
C2

complement component 2

chr12_-_53153639 3.087 NM_144594
GTSF1
gametocyte specific factor 1
chr11_+_67534364 3.076 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr11_+_47236072 3.071 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr3_+_187813405 2.979 AHSG
alpha-2-HS-glycoprotein
chr19_-_53950458 2.846 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr11_+_67534371 2.782 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr10_+_85994788 2.642 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr6_+_167624792 2.533 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr12_-_120781002 2.526 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr1_-_149611768 2.325 NM_003944
SELENBP1
selenium binding protein 1
chr6_-_11219932 2.310 NM_207582
ERVFRDE1
HERV-FRD provirus ancestral Env polyprotein
chr9_-_129752687 2.151 NM_203305
FAM102A
family with sequence similarity 102, member A
chr9_-_122852356 1.984 NM_001735
C5
complement component 5
chr1_-_159543847 1.910 MPZ
myelin protein zero
chr11_+_59580630 1.880 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr1_-_1701313 1.850 NM_001198994
NADK
NAD kinase
chr11_+_59580705 1.826 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr14_+_31868229 1.813 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr12_+_52105131 1.798 AMHR2
anti-Mullerian hormone receptor, type II
chr17_+_1612056 1.697 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr12_+_99391870 1.691 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr1_+_116744992 1.660 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_-_143708467 1.627 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr17_-_36232366 1.619 NM_000421
KRT10
keratin 10
chr6_+_132000134 1.585 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr4_-_9632192 1.547 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr1_+_99884018 1.542 NM_017734
PALMD
palmdelphin
chr1_-_20122638 1.472 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr8_+_124263932 1.471 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr3_-_42818221 1.452


chr8_+_124264054 1.411 FAM83A
family with sequence similarity 83, member A
chr17_-_53847937 1.372 RNF43
ring finger protein 43
chr22_+_21393107 1.371 IGLJ3
immunoglobulin lambda joining 3
chr6_-_11887265 1.367 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_+_26220895 1.363 EXTL1
exostoses (multiple)-like 1
chr17_+_1612031 1.343 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr13_+_51496679 1.343 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr11_+_20000938 1.341 NAV2
neuron navigator 2
chr22_+_43451351 1.338 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr17_+_1612092 1.335 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_62893836 1.326 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr17_-_61655915 1.322 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_-_55103938 1.320 DHCR24
24-dehydrocholesterol reductase
chr5_-_16791346 1.317 MYO10
myosin X
chr16_-_28457728 1.313 NUPR1
nuclear protein, transcriptional regulator, 1
chr3_-_150422474 1.305 NM_000096
CP
ceruloplasmin (ferroxidase)
chr17_-_45280377 1.289 NM_001077503
NM_001077504
NM_001077505
NM_001077506
NM_170685
TAC4




tachykinin 4 (hemokinin)




chr20_+_309272 1.276 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr20_+_32926452 1.241 ACSS2
acyl-CoA synthetase short-chain family member 2
chr21_-_10120690 1.221 NM_001187
NM_182484
NM_181704
NM_182481
NM_182482
BAGE
BAGE5
BAGE4
BAGE3
BAGE2
B melanoma antigen
B melanoma antigen family, member 5
B melanoma antigen family, member 4
B melanoma antigen family, member 3
B melanoma antigen family, member 2
chr3_-_9570412 1.209 NM_198560
LHFPL4
lipoma HMGIC fusion partner-like 4
chr6_+_28601767 1.199 NM_001509
NM_003996
GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr17_+_71508581 1.187 NM_001258
CDK3
cyclin-dependent kinase 3
chr14_-_22515725 1.183 JUB
jub, ajuba homolog (Xenopus laevis)
chr1_+_64442077 1.172 NM_152489
UBE2U
ubiquitin-conjugating enzyme E2U (putative)
chr9_-_76692082 1.119 NM_001177311
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chrX_-_13745108 1.082 GPM6B
glycoprotein M6B
chr3_+_138159396 1.079 NM_144717
IL20RB
interleukin 20 receptor beta
chr8_-_110730183 1.063 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr19_+_11211282 1.046 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr1_+_111571803 1.046 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr14_-_23752875 1.045 NM_014169
CHMP4A
chromatin modifying protein 4A
chr11_+_2279932 1.038 TSPAN32
tetraspanin 32
chrX_-_24241352 1.034 NM_001136233
FAM48B2
family with sequence similarity 48, member B2
chr20_+_309938 1.024 TRIB3
tribbles homolog 3 (Drosophila)
chr14_+_20493467 1.010 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr16_+_3345889 1.003 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr1_+_559129 1.003


chr1_+_17779528 1.002 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr16_+_65552600 0.995 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr5_-_24680841 0.991 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr16_-_28457825 0.990 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr22_+_21079355 0.979


chr19_+_50144267 0.974 APOC2
apolipoprotein C-II
chr16_-_30694799 0.968


chr8_-_13018123 0.966 NM_001164271
DLC1
deleted in liver cancer 1
chr3_+_142525744 0.946 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr2_+_108360798 0.946 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr8_+_82807218 0.942 NM_152284
CHMP4C
chromatin modifying protein 4C
chr14_-_22516271 0.940 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr12_-_61615124 0.923 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr10_+_70650064 0.921 NM_025130
HKDC1
hexokinase domain containing 1
chr19_+_52504914 0.909 NM_001736
C5AR1
complement component 5a receptor 1
chr8_-_38127489 0.888 NM_000349
STAR
steroidogenic acute regulatory protein
chr20_-_5982617 0.887 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr6_+_135558572 0.884


chr17_+_1611983 0.883 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_-_12858956 0.876 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr12_+_54910086 0.871 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr21_-_46428788 0.866 NM_001142854
NM_032261
C21orf56

chromosome 21 open reading frame 56

chr6_-_24597717 0.853 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr9_-_76692829 0.852 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr10_+_135010833 0.846 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr11_-_116168316 0.845 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr9_-_14076901 0.845 NFIB
nuclear factor I/B
chr2_-_158439868 0.842 NM_001105
ACVR1
activin A receptor, type I
chr2_+_169465995 0.842 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr10_-_15237351 0.841 LOC100192204
peptidylprolyl isomerase A pseudogene
chr7_-_111216180 0.841 DOCK4
dedicator of cytokinesis 4
chr20_+_16312 0.839 NM_153325
DEFB125
defensin, beta 125
chr3_-_49701085 0.836 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr9_+_124526089 0.824 NM_001005235
OR1L4
olfactory receptor, family 1, subfamily L, member 4
chr3_+_1109619 0.822 NM_014461
CNTN6
contactin 6
chr20_-_31055892 0.821 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chrX_-_13745134 0.812 GPM6B
glycoprotein M6B
chr17_+_53670785 0.805 NM_001160102
NM_006151
LPO

lactoperoxidase

chr7_-_92686773 0.804 NM_198151
HEPACAM2
HEPACAM family member 2
chr1_-_16006779 0.800 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chr1_-_228916486 0.781 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_80397690 0.777 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr15_+_80741876 0.754 LOC80154
hypothetical LOC80154
chr4_+_187424336 0.733 F11
coagulation factor XI
chr1_+_40612891 0.732 NM_001198978
SMAP2
small ArfGAP2
chr12_+_105519049 0.731 NM_002920
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr12_-_61832856 0.727 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr6_+_7524691 0.714 DSP
desmoplakin
chr1_-_31117948 0.710 SDC3
syndecan 3
chr2_-_39310176 0.708 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr7_+_129634935 0.707 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr2_-_21084911 0.706 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_172153024 0.704 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr7_+_99263571 0.704 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr22_+_21384862 0.701 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr6_+_12824873 0.700 PHACTR1
phosphatase and actin regulator 1
chr1_-_180822686 0.697 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr15_+_80741827 0.696 LOC80154
hypothetical LOC80154
chr20_+_5935897 0.693 NM_001127458
CRLS1
cardiolipin synthase 1
chr11_+_73339011 0.691 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr2_-_74395657 0.681 NM_021196
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr6_-_49862858 0.666 NM_138733
PGK2
phosphoglycerate kinase 2
chr20_+_309675 0.664 TRIB3
tribbles homolog 3 (Drosophila)
chr19_-_4253389 0.663 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr1_-_176205672 0.662 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr6_+_135558744 0.659 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_-_51660328 0.656 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr4_+_110991934 0.655 NM_198506
LRIT3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
chr1_-_57057956 0.654 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr3_+_171022403 0.653 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr6_+_32021899 0.649 CFB
complement factor B
chr1_-_228916470 0.623 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr22_+_19248810 0.621 MED15
mediator complex subunit 15
chr12_+_27740694 0.620 NM_001029874
REP15
RAB15 effector protein
chrX_+_44588192 0.618 NM_022076
DUSP21
dual specificity phosphatase 21
chr17_+_4621924 0.614 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr1_-_92144146 0.612 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr6_+_131936057 0.604 NM_000045
ARG1
arginase, liver
chr20_+_61842880 0.602 SLC2A4RG
SLC2A4 regulator
chr7_-_36991189 0.593 NM_001039459
ELMO1
engulfment and cell motility 1
chr15_+_80434362 0.592 UBE2Q2P2
ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 2
chr15_-_70385709 0.589 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr5_-_150264622 0.588 ZNF300
zinc finger protein 300
chr7_-_112515035 0.577 GPR85
G protein-coupled receptor 85
chrX_-_15198509 0.571 NM_001168531
ASB9
ankyrin repeat and SOCS box containing 9
chr16_+_142853 0.570 NM_005332
HBZ
hemoglobin, zeta
chr1_+_557269 0.566


chr12_-_120220493 0.553 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chr19_-_18058632 0.551 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr8_+_110443881 0.547 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr11_-_10487212 0.545 NM_001190702
MTRNR2L8
MT-RNR2-like 8
chr1_-_150463292 0.544 NM_001009931
HRNR
hornerin
chr4_+_159350850 0.541 NM_018342
TMEM144
transmembrane protein 144
chr11_-_59237893 0.537 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr8_-_66863841 0.536 NM_002603
PDE7A
phosphodiesterase 7A
chr7_-_156494741 0.533 NM_001165255
MNX1
motor neuron and pancreas homeobox 1
chr5_-_150264583 0.529 ZNF300
zinc finger protein 300
chr7_+_74962234 0.527 NM_001099435
SPDYE5
speedy homolog E5 (Xenopus laevis)
chr6_+_32021831 0.526 CFB
complement factor B
chr20_+_31613800 0.522 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr9_-_94226380 0.519 NM_005014
OMD
osteomodulin
chr17_-_37599953 0.519 NM_001142622
NM_001142623
NM_032484
GHDC


GH3 domain containing


chr9_-_76692455 0.509 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr11_+_61732715 0.505 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr9_-_94095807 0.505 IARS
isoleucyl-tRNA synthetase
chr9_-_94095787 0.499 NM_013417
IARS
isoleucyl-tRNA synthetase
chr3_+_187917791 0.498 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr1_+_234748187 0.497 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr11_-_16953135 0.493 RPL36A
ribosomal protein L36a
chr19_-_57924946 0.490 NM_030972
ZNF611
zinc finger protein 611
chr5_-_150264486 0.482 ZNF300
zinc finger protein 300
chr8_-_110726921 0.477 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr17_-_77488258 0.475 NM_006907
NM_153824
PYCR1

pyrroline-5-carboxylate reductase 1

chr1_+_26376611 0.474 CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr11_+_2279812 0.472 NM_139022
TSPAN32
tetraspanin 32
chr11_+_75106512 0.462 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr6_+_26195426 0.461 NM_000410
NM_139003
NM_139004
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011
HFE








hemochromatosis








chr10_-_29963847 0.460


chr4_+_74499651 0.459 ALB
albumin
chrX_+_24290798 0.454 NM_001136234
FAM48B1
family with sequence similarity 48, member B1
chr17_-_31231421 0.454 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr22_-_41685827 0.449 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.51 8.62e-03 GO:0071702 organic substance transport
5.06 1.45e-02 GO:0006638 neutral lipid metabolic process
5.06 1.45e-02 GO:0006639 acylglycerol metabolic process
5.58 1.51e-02 GO:0072376 protein activation cascade
14.19 2.09e-02 GO:0045723 positive regulation of fatty acid biosynthetic process
4.94 4.60e-02 GO:0006641 triglyceride metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.61 7.64e-04 GO:0005576 extracellular region
6.81 1.48e-02 GO:0032994 protein-lipid complex
6.81 1.48e-02 GO:0034358 plasma lipoprotein particle
1.86 2.78e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
34.05 1.01e-02 GO:0060230 lipoprotein lipase activator activity
3.79 3.14e-02 GO:0019955 cytokine binding