Motif ID: NKX2-2,8.p2

Z-value: 1.702


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8



Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_40454188 7.191 ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_-_122862391 5.490 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_122862447 5.085 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr4_+_95595419 3.656 PDLIM5
PDZ and LIM domain 5
chr9_+_122923864 3.502 CEP110
centrosomal protein 110kDa
chr1_+_239762179 3.385 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr3_-_15814678 3.005 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr21_-_14840506 2.928 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr9_+_115303527 2.900 NM_130795
RGS3
regulator of G-protein signaling 3
chr2_+_102320148 2.860 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr11_+_65027721 2.689


chr6_+_88021644 2.676 ZNF292
zinc finger protein 292
chr13_-_40454360 2.563 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_+_183290912 2.328 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr10_+_97505398 2.303 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chrX_-_154216929 2.225 NM_001289
CLIC2
chloride intracellular channel 2
chr18_+_54039730 2.178 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_+_11687655 2.084 NM_006800
MSL3
male-specific lethal 3 homolog (Drosophila)
chr11_+_65023218 2.073


chr18_+_54039779 2.071 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_65023038 2.053 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr18_+_54039818 1.992 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr7_-_92686773 1.984 NM_198151
HEPACAM2
HEPACAM family member 2
chr12_-_101115677 1.980 NM_002674
PMCH
pro-melanin-concentrating hormone
chr12_-_9913199 1.877 CLEC2B
C-type lectin domain family 2, member B
chr4_-_83566045 1.873


chr5_+_40877053 1.807 NM_032587
CARD6
caspase recruitment domain family, member 6
chr12_+_61645361 1.795 RPL14
ribosomal protein L14
chr5_-_78316832 1.794 ARSB
arylsulfatase B
chr4_-_24590867 1.747 NM_173463
CCDC149
coiled-coil domain containing 149
chr5_-_78316891 1.677 ARSB
arylsulfatase B
chr13_+_110653407 1.672 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_+_165564904 1.659 NM_001198783
POU2F1
POU class 2 homeobox 1
chr1_+_242281175 1.600 NM_205768
ZNF238
zinc finger protein 238
chr15_-_58477407 1.567 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr17_-_26665144 1.552 EVI2B
ecotropic viral integration site 2B
chr7_+_113853790 1.528 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr19_+_54530458 1.520 CD37
CD37 molecule
chr3_-_153541468 1.510 NM_001123228
TMEM14E
transmembrane protein 14E
chr1_+_53253204 1.508 SCP2
sterol carrier protein 2
chr5_-_78316888 1.505 ARSB
arylsulfatase B
chr1_-_143708467 1.492 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_165565006 1.470 POU2F1
POU class 2 homeobox 1
chr1_+_242281199 1.455 ZNF238
zinc finger protein 238
chr5_-_98290117 1.450 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr19_+_54530485 1.441 NM_001040031
NM_001774
CD37

CD37 molecule

chr3_+_188197029 1.437


chr1_-_41398126 1.432 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr10_+_50177192 1.421 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr8_+_26206648 1.419 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr12_-_120725210 1.398 LOC338799
hypothetical LOC338799
chr17_-_35975227 1.384 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr5_+_162862808 1.380 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr12_-_52975777 1.364 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_+_196874867 1.362 PTPRC
protein tyrosine phosphatase, receptor type, C
chr13_-_48873735 1.360 NM_030925
CAB39L
calcium binding protein 39-like
chr19_+_54530497 1.359 CD37
CD37 molecule
chr10_-_98326435 1.359 TM9SF3
transmembrane 9 superfamily member 3
chr12_-_52975823 1.344 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr17_-_64462976 1.296 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr8_-_66863841 1.292 NM_002603
PDE7A
phosphodiesterase 7A
chr19_+_54530512 1.289 CD37
CD37 molecule
chr10_-_64698831 1.274 NM_004241
JMJD1C
jumonji domain containing 1C
chrX_+_134482212 1.272 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr1_-_20374273 1.264 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr1_+_53253161 1.262 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr12_+_25096755 1.259 LRMP
lymphoid-restricted membrane protein
chr1_-_205161821 1.251 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chrX_-_70391771 1.247 NM_001171162
ZMYM3
zinc finger, MYM-type 3
chr11_+_65023556 1.223


chr7_-_107667728 1.194 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr3_-_33675484 1.181 CLASP2
cytoplasmic linker associated protein 2
chr22_+_38627031 1.174 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr14_-_99911409 1.170 WARS
tryptophanyl-tRNA synthetase
chr14_+_66901237 1.162 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_-_158759606 1.159 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr19_+_54530546 1.156 CD37
CD37 molecule
chr6_-_33393696 1.138 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr7_+_139175420 1.137 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr22_+_38627129 1.136 GRAP2
GRB2-related adaptor protein 2
chr12_-_69317441 1.132 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr5_-_78316923 1.123 ARSB
arylsulfatase B
chr3_-_71262426 1.121 FOXP1
forkhead box P1
chr5_-_39306465 1.115 FYB
FYN binding protein
chr14_-_99911528 1.114 WARS
tryptophanyl-tRNA synthetase
chr15_+_70193652 1.112 NM_001166340
SENP8
SUMO/sentrin specific peptidase family member 8
chr18_-_65766068 1.101 CD226
CD226 molecule
chrX_+_47999740 1.080 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr13_-_45654327 1.075 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_+_108665665 1.067 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr12_+_25096472 1.063 NM_006152
LRMP
lymphoid-restricted membrane protein
chr17_-_1195096 1.059 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr11_+_93916653 1.047 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr18_-_3835295 1.044 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr5_-_43550891 1.034 NM_198566
C5orf34
chromosome 5 open reading frame 34
chr1_+_185064654 1.033 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr9_+_263025 1.021 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr4_+_109763119 1.016 RPL34
ribosomal protein L34
chr2_-_144991556 1.015 ZEB2
zinc finger E-box binding homeobox 2
chr7_+_115650240 1.008 NM_152829
TES
testis derived transcript (3 LIM domains)
chr7_+_838663 1.006 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr1_+_23994914 1.004


chr7_-_87180499 1.001 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr1_-_180622083 0.997 GLUL
glutamate-ammonia ligase
chr5_+_42792676 0.995 NM_001134848
CCDC152
coiled-coil domain containing 152
chr2_+_170742900 0.990 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr7_+_37689903 0.987


chr3_-_71262405 0.987 FOXP1
forkhead box P1
chr1_+_116727514 0.986 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr8_+_107807415 0.981 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_-_180840016 0.959 NM_002928
RGS16
regulator of G-protein signaling 16
chr3_-_113701073 0.955 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr1_+_61642287 0.954 NFIA
nuclear factor I/A
chr21_-_35343065 0.948 RUNX1
runt-related transcription factor 1
chr1_-_115060956 0.947 NM_002524
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr2_+_143603368 0.933 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr5_-_88155360 0.933 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_+_196874839 0.930 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_-_30505804 0.917 NM_025159
CXorf21
chromosome X open reading frame 21
chr12_-_53664722 0.911 NM_001136030
KIAA0748
KIAA0748
chr17_-_26665220 0.897 NM_006495
EVI2B
ecotropic viral integration site 2B
chr4_-_38534802 0.893 NM_006068
TLR6
toll-like receptor 6
chr15_-_91078307 0.892 FAM174B
family with sequence similarity 174, member B
chr9_+_124172644 0.884 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr17_-_26665194 0.857 EVI2B
ecotropic viral integration site 2B
chr10_+_94584449 0.848 NM_001013848
EXOC6
exocyst complex component 6
chr4_-_145046109 0.835 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chr2_+_102401580 0.833 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr17_-_26648375 0.833 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr1_-_242073094 0.830 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr1_-_115060857 0.825 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr9_-_113561613 0.824 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr5_-_95044415 0.819 NM_031952
SPATA9
spermatogenesis associated 9
chr1_+_196874759 0.818 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr11_+_117680504 0.811 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr10_-_93992982 0.808 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr6_-_11490487 0.806 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr21_-_30796278 0.800 NM_181611
KRTAP19-5
keratin associated protein 19-5
chr4_+_88147107 0.797 NM_005935
AFF1
AF4/FMR2 family, member 1
chrX_-_70248022 0.792 NM_000206
IL2RG
interleukin 2 receptor, gamma
chrX_+_122923279 0.786 STAG2
stromal antigen 2
chr1_+_111818111 0.784 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr7_-_92693716 0.780 NM_001039372
HEPACAM2
HEPACAM family member 2
chr4_-_100070808 0.775 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr21_+_34112456 0.773 ITSN1
intersectin 1 (SH3 domain protein)
chr3_+_63928459 0.772 NM_001128149
ATXN7
ataxin 7
chr12_-_48902692 0.767 NM_001113547
LIMA1
LIM domain and actin binding 1
chr8_+_124264054 0.766 FAM83A
family with sequence similarity 83, member A
chr1_+_173111306 0.759 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr7_+_69869099 0.759 AUTS2
autism susceptibility candidate 2
chr11_-_72111027 0.754 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr10_+_35524060 0.754 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr1_-_115060904 0.754 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr21_+_37714470 0.746 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr1_+_111217244 0.744 NM_000560
CD53
CD53 molecule
chr1_+_103840900 0.744 RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr16_+_28413421 0.743 NM_018690
APOBR
apolipoprotein B receptor
chr1_+_100099353 0.730 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr10_-_61570665 0.729 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_-_13992351 0.723 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr5_-_139662864 0.714 NM_002622
PFDN1
prefoldin subunit 1
chr12_+_115455579 0.712 NCRNA00173
non-protein coding RNA 173
chr5_+_159781454 0.710 PTTG1
pituitary tumor-transforming 1
chr4_+_86918870 0.707 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr4_-_153493133 0.703 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr11_-_128217550 0.703 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr5_-_139662858 0.697 PFDN1
prefoldin subunit 1
chr4_-_170770111 0.696 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr1_-_74971679 0.696 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr4_-_110942783 0.694 NM_000204
CFI
complement factor I
chr12_+_63510481 0.688


chr5_-_96544694 0.687 RIOK2
RIO kinase 2 (yeast)
chr2_+_201464884 0.687 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr17_-_31281843 0.685 NM_001034836
NM_001163120
NM_001163121
NM_145654
RDM1



RAD52 motif 1



chr3_+_38010081 0.682 NM_015873
VILL
villin-like
chr2_-_158008763 0.681 NM_004288
CYTIP
cytohesin 1 interacting protein
chr3_-_187744808 0.681 NM_017541
CRYGS
crystallin, gamma S
chr1_-_31311140 0.679 NM_001020658
NM_014676
PUM1

pumilio homolog 1 (Drosophila)

chr5_+_71538456 0.675 MAP1B
microtubule-associated protein 1B
chr10_+_88975184 0.674 NM_001099338
FAM22A
FAM22D
family with sequence similarity 22, member A
family with sequence similarity 22, member D
chr4_-_74307637 0.672 ANKRD17
ankyrin repeat domain 17
chr10_+_5126613 0.671 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_-_96544639 0.667 RIOK2
RIO kinase 2 (yeast)
chr11_-_110755112 0.662 POU2AF1
POU class 2 associating factor 1
chr15_-_32398220 0.662 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr17_-_26665213 0.660 EVI2B
ecotropic viral integration site 2B
chr2_-_191580567 0.657 STAT1
signal transducer and activator of transcription 1, 91kDa
chr10_-_50066386 0.653 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr14_+_20319049 0.650 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr6_+_143971009 0.650 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr1_+_117345894 0.648 NM_004258
CD101
CD101 molecule
chr14_-_99911679 0.646 NM_004184
NM_213646
WARS

tryptophanyl-tRNA synthetase

chr2_-_144994349 0.644 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr22_+_38903825 0.643 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr5_+_147423727 0.641 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr6_-_88095714 0.640 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr2_+_33514896 0.637 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr10_+_57028755 0.634 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chrX_-_153016368 0.631 NM_001110792
NM_004992
MECP2

methyl CpG binding protein 2 (Rett syndrome)

chr22_-_39189369 0.631 MKL1
megakaryoblastic leukemia (translocation) 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.