Motif ID: KLF4.p3

Z-value: 4.260


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)



Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_32992131 8.038


chr8_-_145609737 7.430 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr19_-_6718417 6.566 NM_005490
SH2D3A
SH2 domain containing 3A
chr7_-_150305933 6.080 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr19_-_51829778 5.487 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr6_-_6632197 4.400


chr1_+_30964199 4.323 LOC100129196
hypothetical LOC100129196
chr8_-_99906944 4.059 NM_006281
STK3
serine/threonine kinase 3
chr17_+_77582774 4.019 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr9_+_129962292 3.997 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr19_-_43438818 3.771 PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr8_-_144887876 3.601 NM_198488
FAM83H
family with sequence similarity 83, member H
chr1_-_164402575 3.508 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr8_+_144870482 3.493 NM_139021
MAPK15
mitogen-activated protein kinase 15
chrX_+_15666312 3.457 NM_007220
CA5B
carbonic anhydrase VB, mitochondrial
chr18_-_26935883 3.408 NM_004949
NM_024422
DSC2

desmocollin 2

chr11_+_384238 3.404 PKP3
plakophilin 3
chr11_+_384199 3.209 NM_007183
PKP3
plakophilin 3
chr22_-_17489718 3.192 DGCR2
DiGeorge syndrome critical region gene 2
chr1_-_203985780 3.191 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr16_-_47873183 3.175 NM_004352
CBLN1
cerebellin 1 precursor
chr11_-_2248757 3.160 NM_005170
ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr6_-_33393696 3.152 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr11_-_64268841 3.139 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr17_-_17667580 3.122 SREBF1
sterol regulatory element binding transcription factor 1
chr6_-_33393471 3.105 NM_005453
ZBTB22
zinc finger and BTB domain containing 22
chr6_+_37245860 3.073 NM_002648
PIM1
pim-1 oncogene
chr1_-_27582368 3.068 NM_207397
CD164L2
CD164 sialomucin-like 2
chr19_-_43439011 3.045 NM_033256
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr18_+_586997 3.004 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr1_+_26728827 2.990 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_26728846 2.977 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_26728839 2.892 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr22_-_37296012 2.847 NM_007068
DMC1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
chr4_-_174687104 2.785 HAND2
heart and neural crest derivatives expressed 2
chr7_+_73136085 2.762 NM_002314
LIMK1
LIM domain kinase 1
chr16_+_87047159 2.748 ZFPM1
zinc finger protein, multitype 1
chr1_-_203985752 2.730 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chrX_-_151688850 2.723 NM_005362
MAGEA3
melanoma antigen family A, 3
chr15_-_26017994 2.722 NM_000275
OCA2
oculocutaneous albinism II
chr22_+_38183480 2.721 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr11_+_133706977 2.689 NM_138342
GLB1L2
galactosidase, beta 1-like 2
chr22_-_17546296 2.685 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr12_+_55896844 2.670 NM_007224
NXPH4
neurexophilin 4
chr15_+_78232160 2.638 FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr1_+_41022066 2.638 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr1_-_1840564 2.631 NM_178545
TMEM52
transmembrane protein 52
chr6_-_29708647 2.628 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr19_+_50535837 2.614 NM_177417
KLC3
kinesin light chain 3
chr16_+_29725311 2.564 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr19_-_7896974 2.547 NM_206833
CTXN1
cortexin 1
chr22_-_17489912 2.540 NM_001173533
NM_001173534
NM_001184781
NM_005137
DGCR2



DiGeorge syndrome critical region gene 2



chr15_-_81146188 2.507 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr12_+_56435042 2.504 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr19_+_1033797 2.504 HMHA1
histocompatibility (minor) HA-1
chr11_-_65070625 2.498 LTBP3
latent transforming growth factor beta binding protein 3
chr22_-_17546276 2.488 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr12_-_53071285 2.485 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A

chr1_-_203985701 2.472 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr8_+_144888275 2.449 LOC100128338
hypothetical LOC100128338
chr9_+_132961723 2.434 AIF1L
allograft inflammatory factor 1-like
chr19_-_55763091 2.410 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr7_+_73136254 2.393 LIMK1
LIM domain kinase 1
chr1_+_3679168 2.356 NM_001163724
LOC388588
hypothetical protein LOC388588
chr20_-_55533544 2.338 NM_080618
CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr19_+_18069596 2.338 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr7_+_150390566 2.335 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr19_+_54558798 2.334 NM_001197302
NM_001197301
NM_014419
DKKL1


dickkopf-like 1


chr20_-_538909 2.325 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr15_+_78232232 2.315 FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr19_-_60587414 2.307 NM_001190764
LOC388564
hypothetical protein LOC388564
chr17_+_7495140 2.305 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr15_+_78232184 2.277 FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr16_+_29725665 2.276


chr1_+_158603480 2.270 NM_005598
NHLH1
nescient helix loop helix 1
chr16_+_29725597 2.258


chr16_+_65756179 2.253 HSF4
heat shock transcription factor 4
chr22_+_18081968 2.243 NM_002688
SEPT5
septin 5
chr11_+_63758550 2.239 NM_003377
VEGFB
vascular endothelial growth factor B
chr1_-_203985896 2.234 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr17_-_7106987 2.229 NM_001185023
NM_001307
CLDN7

claudin 7

chr19_+_60283571 2.208 NM_017729
EPS8L1
EPS8-like 1
chr10_+_45189673 2.194 ALOX5
arachidonate 5-lipoxygenase
chr15_+_78232194 2.163 FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr19_+_1033816 2.160 HMHA1
histocompatibility (minor) HA-1
chr2_+_10101822 2.152 NM_001177718
KLF11
Kruppel-like factor 11
chr1_-_208046011 2.143 NM_006147
IRF6
interferon regulatory factor 6
chr17_-_23928048 2.130 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr7_-_4889772 2.129 NM_018059
RADIL
Ras association and DIL domains
chr3_-_47595190 2.122 NM_006574
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)
chr1_+_103841155 2.120 NM_017619
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr7_-_150283794 2.105 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr19_+_60487345 2.098 NM_032430
BRSK1
BR serine/threonine kinase 1
chr19_-_50975121 2.094


chr1_+_224317030 2.088 H3F3A
H3 histone, family 3A
chr19_-_45888259 2.085 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr7_-_150306169 2.077 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr1_-_33588085 2.074 NM_004427
PHC2
polyhomeotic homolog 2 (Drosophila)
chr19_+_10392128 2.061 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr11_+_133707107 2.052 GLB1L2
galactosidase, beta 1-like 2
chr1_-_164402700 2.048 FAM78B
family with sequence similarity 78, member B
chr7_+_128257698 2.045 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr14_-_104705753 2.042 JAG2
jagged 2
chr17_-_23928041 2.040 ALDOC
aldolase C, fructose-bisphosphate
chr7_+_73136042 2.010 LIMK1
LIM domain kinase 1
chr22_+_18085990 2.007 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr15_-_70399301 1.999 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr1_+_38046404 1.985 C1orf122
chromosome 1 open reading frame 122
chr22_-_18635614 1.982 NM_023004
RTN4R
reticulon 4 receptor
chr3_-_14964620 1.979


chr19_-_60827746 1.978 NM_203374
ZNF784
zinc finger protein 784
chr17_-_23927973 1.971 ALDOC
aldolase C, fructose-bisphosphate
chrX_+_148671394 1.964 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr1_+_224317056 1.961 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr6_+_44346457 1.960 NM_001137560
TMEM151B
transmembrane protein 151B
chr1_+_42920946 1.960 YBX1
Y box binding protein 1
chr6_+_34312906 1.959 HMGA1
high mobility group AT-hook 1
chr14_-_20562962 1.959 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr1_-_203985932 1.955


chr22_-_17545872 1.945 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_-_48976852 1.944 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr22_-_17546234 1.944 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr11_-_2248374 1.943 ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr1_-_221383212 1.939 NM_003268
TLR5
toll-like receptor 5
chr16_-_47872973 1.930 CBLN1
cerebellin 1 precursor
chr19_+_12805747 1.917 MAST1
microtubule associated serine/threonine kinase 1
chr4_-_174686918 1.905 HAND2
heart and neural crest derivatives expressed 2
chrX_-_153016173 1.904 MECP2
LOC728653
methyl CpG binding protein 2 (Rett syndrome)
hypothetical protein LOC728653
chr22_+_18085891 1.902 SEPT5
septin 5
chr1_-_203985963 1.890 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr14_-_91372365 1.885 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chr15_-_73818013 1.881


chr19_-_48977247 1.876 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_224317036 1.873 NM_002107
H3F3A
H3 histone, family 3A
chr9_+_100609754 1.873 NM_024642
GALNT12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
chr21_+_46473494 1.871 MCM3AP-AS1
MCM3AP antisense RNA 1 (non-protein coding)
chr1_-_21821597 1.867 RAP1GAP
RAP1 GTPase activating protein
chr19_-_3737382 1.865 NM_139354
NM_139355
MATK

megakaryocyte-associated tyrosine kinase

chr1_+_224317062 1.864 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr1_-_117011824 1.861 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr5_+_177473071 1.860 NM_015111
N4BP3
NEDD4 binding protein 3
chr11_-_2863536 1.857 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr16_+_65756084 1.856 HSF4
heat shock transcription factor 4
chr15_+_78232395 1.846 NM_000137
FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr12_+_115455579 1.844 NCRNA00173
non-protein coding RNA 173
chr17_+_75849221 1.841 NM_020914
NM_020954
RNF213

ring finger protein 213

chr11_-_64368616 1.839 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr22_+_21742727 1.832 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr18_-_50004770 1.821 MBD2
methyl-CpG binding domain protein 2
chr1_-_33587998 1.811 PHC2
polyhomeotic homolog 2 (Drosophila)
chrX_-_153016337 1.810 MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr16_+_23754822 1.807 PRKCB
protein kinase C, beta
chr16_+_23754772 1.805 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr19_-_55524445 1.802 NM_004977
KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr1_+_231530136 1.800 NM_032435
KIAA1804
mixed lineage kinase 4
chr7_-_97868101 1.800 BAIAP2L1
BAI1-associated protein 2-like 1
chr19_-_1993022 1.792 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr1_-_199259133 1.792 KIF21B
kinesin family member 21B
chr19_-_60827732 1.789 ZNF784
zinc finger protein 784
chr16_+_1143241 1.775 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr16_+_29582069 1.773 NM_003123
SPN
sialophorin
chr17_+_38430773 1.773 NM_005440
RND2
Rho family GTPase 2
chrX_-_152804731 1.772 L1CAM
L1 cell adhesion molecule
chr15_-_70399523 1.769 CELF6
CUGBP, Elav-like family member 6
chr22_-_20419975 1.762 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chrX_-_153016368 1.757 NM_001110792
NM_004992
MECP2

methyl CpG binding protein 2 (Rett syndrome)

chr7_-_105712646 1.752 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr7_-_44152232 1.749 GCK
glucokinase (hexokinase 4)
chr9_-_129573330 1.740 NM_005489
SH2D3C
SH2 domain containing 3C
chrX_-_148476903 1.737 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr14_-_20636568 1.736 NM_016423
ZNF219
zinc finger protein 219
chr16_+_65756138 1.735 HSF4
heat shock transcription factor 4
chr9_+_138680064 1.728 EGFL7
EGF-like-domain, multiple 7
chr22_+_21817512 1.709 NM_004914
RAB36
RAB36, member RAS oncogene family
chr22_+_20316968 1.708 NM_152612
CCDC116
coiled-coil domain containing 116
chr8_+_22513043 1.701 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr6_+_44203335 1.697 NM_018426
TMEM63B
transmembrane protein 63B
chrX_-_100527799 1.695 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr11_+_46256161 1.693 CREB3L1
cAMP responsive element binding protein 3-like 1
chr22_-_20551937 1.690 MAPK1
mitogen-activated protein kinase 1
chr22_+_21742364 1.685 NM_002073
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr12_+_56202874 1.683 NM_052897
MBD6
methyl-CpG binding domain protein 6
chr1_+_224317044 1.683 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr19_+_7608010 1.672 STXBP2
syntaxin binding protein 2
chr16_+_88305743 1.663 LOC100128881
hypothetical LOC100128881
chr8_-_144722141 1.663 C8orf73
chromosome 8 open reading frame 73
chr7_+_154720547 1.649 INSIG1
insulin induced gene 1
chr9_-_138701644 1.647 AGPAT2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr8_-_145671947 1.638 FOXH1
forkhead box H1
chr16_+_23754860 1.637 PRKCB
protein kinase C, beta
chr22_-_20551953 1.633 NM_002745
NM_138957
MAPK1

mitogen-activated protein kinase 1

chr1_-_173428455 1.633 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr20_-_31737731 1.631 E2F1
E2F transcription factor 1
chr1_+_945331 1.624 NM_198576
AGRN
agrin
chr22_+_38183262 1.622 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr10_-_80875097 1.616 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr19_-_14177980 1.612 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr5_+_176726918 1.612 RGS14
regulator of G-protein signaling 14
chrX_-_152642716 1.611 NM_001139457
NM_001139441
BCAP31

B-cell receptor-associated protein 31

chr10_-_134940315 1.604 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 1.76e-16 GO:0009987 cellular process
1.11 6.84e-15 GO:0044237 cellular metabolic process
1.15 4.69e-12 GO:0031323 regulation of cellular metabolic process
1.09 5.27e-12 GO:0050789 regulation of biological process
1.09 1.81e-11 GO:0050794 regulation of cellular process
1.14 5.85e-11 GO:0019222 regulation of metabolic process
1.08 1.02e-10 GO:0065007 biological regulation
1.15 1.16e-10 GO:0080090 regulation of primary metabolic process
1.10 2.34e-10 GO:0044238 primary metabolic process
1.12 4.77e-10 GO:0044260 cellular macromolecule metabolic process
1.09 6.38e-10 GO:0008152 metabolic process
1.20 1.91e-07 GO:0023051 regulation of signaling
1.18 2.42e-07 GO:0006464 protein modification process
1.13 2.47e-07 GO:0060255 regulation of macromolecule metabolic process
1.10 2.66e-07 GO:0043170 macromolecule metabolic process
1.14 5.06e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.14 7.26e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.16 7.78e-07 GO:0048523 negative regulation of cellular process
1.15 1.42e-06 GO:0048519 negative regulation of biological process
1.13 1.11e-05 GO:0048518 positive regulation of biological process
1.19 1.72e-05 GO:0009966 regulation of signal transduction
1.16 2.58e-05 GO:0043412 macromolecule modification
1.14 2.96e-05 GO:0048522 positive regulation of cellular process
1.14 3.91e-05 GO:0051252 regulation of RNA metabolic process
1.22 7.60e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.13 8.42e-05 GO:0044267 cellular protein metabolic process
1.17 9.98e-05 GO:0006996 organelle organization
1.30 1.37e-04 GO:0051338 regulation of transferase activity
1.13 1.43e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.12 1.53e-04 GO:0031326 regulation of cellular biosynthetic process
1.14 1.95e-04 GO:0006355 regulation of transcription, DNA-dependent
1.11 2.15e-04 GO:0016043 cellular component organization
1.13 2.52e-04 GO:0010468 regulation of gene expression
1.17 2.65e-04 GO:0009056 catabolic process
1.12 4.06e-04 GO:0009889 regulation of biosynthetic process
1.17 4.25e-04 GO:0007399 nervous system development
1.29 4.49e-04 GO:0043549 regulation of kinase activity
1.23 6.25e-04 GO:0031399 regulation of protein modification process
1.24 6.76e-04 GO:0019220 regulation of phosphate metabolic process
1.24 6.76e-04 GO:0051174 regulation of phosphorus metabolic process
1.25 8.00e-04 GO:0045595 regulation of cell differentiation
1.21 8.57e-04 GO:0048468 cell development
1.18 1.02e-03 GO:0050790 regulation of catalytic activity
1.19 1.23e-03 GO:0051246 regulation of protein metabolic process
1.25 1.34e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 1.38e-03 GO:0051726 regulation of cell cycle
1.09 1.48e-03 GO:0032502 developmental process
1.29 1.48e-03 GO:0045859 regulation of protein kinase activity
1.25 1.55e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.12 1.65e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.10 1.88e-03 GO:0006807 nitrogen compound metabolic process
1.16 2.00e-03 GO:0065009 regulation of molecular function
1.20 2.01e-03 GO:0050793 regulation of developmental process
1.45 2.33e-03 GO:0016569 covalent chromatin modification
1.26 2.58e-03 GO:0051253 negative regulation of RNA metabolic process
1.10 2.78e-03 GO:0071840 cellular component organization or biogenesis
1.25 2.86e-03 GO:0010629 negative regulation of gene expression
1.16 2.87e-03 GO:0035556 intracellular signal transduction
1.32 3.03e-03 GO:0016568 chromatin modification
1.23 3.04e-03 GO:0042325 regulation of phosphorylation
1.44 3.32e-03 GO:0016570 histone modification
1.19 3.82e-03 GO:0032268 regulation of cellular protein metabolic process
1.11 3.86e-03 GO:0071842 cellular component organization at cellular level
1.26 4.59e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.10 4.71e-03 GO:0034641 cellular nitrogen compound metabolic process
1.20 5.05e-03 GO:0022008 neurogenesis
1.17 5.05e-03 GO:0009893 positive regulation of metabolic process
1.33 5.12e-03 GO:0051347 positive regulation of transferase activity
1.22 6.21e-03 GO:0006468 protein phosphorylation
1.18 6.22e-03 GO:0010646 regulation of cell communication
1.20 6.94e-03 GO:0008219 cell death
1.11 7.20e-03 GO:0009058 biosynthetic process
1.18 7.83e-03 GO:0007049 cell cycle
1.34 8.16e-03 GO:0071900 regulation of protein serine/threonine kinase activity
1.20 9.40e-03 GO:0016265 death
1.27 9.76e-03 GO:0008283 cell proliferation
1.28 9.81e-03 GO:0008285 negative regulation of cell proliferation
1.11 9.94e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 9.99e-03 GO:0006793 phosphorus metabolic process
1.18 9.99e-03 GO:0006796 phosphate metabolic process
1.17 1.02e-02 GO:0031325 positive regulation of cellular metabolic process
1.23 1.12e-02 GO:0001932 regulation of protein phosphorylation
1.11 1.12e-02 GO:0044249 cellular biosynthetic process
1.19 1.23e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.20 1.37e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.18 1.52e-02 GO:0042127 regulation of cell proliferation
1.22 1.54e-02 GO:0010628 positive regulation of gene expression
1.19 1.61e-02 GO:0048699 generation of neurons
1.19 1.75e-02 GO:0016310 phosphorylation
1.30 1.89e-02 GO:0003006 developmental process involved in reproduction
1.19 1.98e-02 GO:0031324 negative regulation of cellular metabolic process
1.10 2.00e-02 GO:0019538 protein metabolic process
1.15 2.22e-02 GO:0051239 regulation of multicellular organismal process
1.18 2.23e-02 GO:0009892 negative regulation of metabolic process
1.31 2.23e-02 GO:0033674 positive regulation of kinase activity
1.09 2.46e-02 GO:0007275 multicellular organismal development
1.17 2.62e-02 GO:0042981 regulation of apoptosis
1.16 2.73e-02 GO:0044248 cellular catabolic process
1.17 3.21e-02 GO:0043067 regulation of programmed cell death
1.21 3.22e-02 GO:0009790 embryo development
1.16 3.29e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.24 3.30e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.19 3.51e-02 GO:0051128 regulation of cellular component organization
1.53 3.63e-02 GO:0021700 developmental maturation
1.17 3.85e-02 GO:0032879 regulation of localization
1.09 3.91e-02 GO:0048856 anatomical structure development
1.16 4.15e-02 GO:0010941 regulation of cell death
1.31 4.15e-02 GO:0045860 positive regulation of protein kinase activity
1.12 4.87e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 1.53e-48 GO:0044424 intracellular part
1.10 9.77e-47 GO:0005622 intracellular
1.13 4.97e-40 GO:0043231 intracellular membrane-bounded organelle
1.13 7.06e-40 GO:0043227 membrane-bounded organelle
1.11 5.58e-38 GO:0043229 intracellular organelle
1.11 7.49e-38 GO:0043226 organelle
1.12 4.08e-30 GO:0005737 cytoplasm
1.15 3.79e-24 GO:0005634 nucleus
1.14 2.02e-22 GO:0044444 cytoplasmic part
1.13 1.83e-17 GO:0044446 intracellular organelle part
1.12 1.51e-16 GO:0044422 organelle part
1.03 2.00e-10 GO:0044464 cell part
1.03 2.29e-10 GO:0005623 cell
1.19 2.82e-10 GO:0005829 cytosol
1.18 1.30e-09 GO:0044428 nuclear part
1.16 1.33e-07 GO:0070013 intracellular organelle lumen
1.15 2.22e-07 GO:0031974 membrane-enclosed lumen
1.15 3.19e-07 GO:0043233 organelle lumen
1.17 5.58e-07 GO:0031981 nuclear lumen
1.18 7.46e-07 GO:0012505 endomembrane system
1.19 3.62e-06 GO:0005654 nucleoplasm
1.14 7.02e-06 GO:0031090 organelle membrane
1.36 9.13e-06 GO:0048471 perinuclear region of cytoplasm
1.21 1.06e-05 GO:0005794 Golgi apparatus
1.21 4.16e-04 GO:0031982 vesicle
1.21 5.71e-04 GO:0031410 cytoplasmic vesicle
1.21 1.24e-03 GO:0031988 membrane-bounded vesicle
1.21 1.77e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.10 2.00e-03 GO:0043234 protein complex
1.18 2.92e-03 GO:0042995 cell projection
1.21 4.36e-03 GO:0015630 microtubule cytoskeleton
1.20 4.62e-03 GO:0044451 nucleoplasm part
1.26 6.30e-03 GO:0043005 neuron projection
1.24 8.25e-03 GO:0000139 Golgi membrane
1.21 1.16e-02 GO:0044431 Golgi apparatus part
1.21 1.44e-02 GO:0030054 cell junction
1.09 2.97e-02 GO:0043228 non-membrane-bounded organelle
1.09 2.97e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.50 3.99e-02 GO:0016585 chromatin remodeling complex
1.14 4.60e-02 GO:0005783 endoplasmic reticulum

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 1.47e-29 GO:0005515 protein binding
1.06 6.98e-20 GO:0005488 binding
1.15 2.99e-07 GO:0000166 nucleotide binding
1.25 2.46e-05 GO:0019899 enzyme binding
1.20 1.72e-04 GO:0030528 transcription regulator activity
1.15 2.38e-04 GO:0016740 transferase activity
1.20 2.95e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.34 6.16e-04 GO:0016564 transcription repressor activity
1.12 6.36e-04 GO:0003677 DNA binding
1.21 6.67e-04 GO:0016301 kinase activity
1.23 8.26e-04 GO:0043565 sequence-specific DNA binding
1.13 1.14e-03 GO:0032553 ribonucleotide binding
1.13 1.14e-03 GO:0032555 purine ribonucleotide binding
1.14 1.62e-03 GO:0032559 adenyl ribonucleotide binding
1.13 1.66e-03 GO:0017076 purine nucleotide binding
1.13 1.90e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.14 1.91e-03 GO:0030554 adenyl nucleotide binding
1.14 2.17e-03 GO:0005524 ATP binding
1.18 2.43e-03 GO:0001071 nucleic acid binding transcription factor activity
1.18 2.43e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.29 2.69e-03 GO:0000988 protein binding transcription factor activity
1.29 2.69e-03 GO:0000989 transcription factor binding transcription factor activity
1.29 3.51e-03 GO:0003712 transcription cofactor activity
1.23 3.74e-03 GO:0004672 protein kinase activity
1.20 8.56e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.09 1.35e-02 GO:0003676 nucleic acid binding
1.19 2.08e-02 GO:0042802 identical protein binding
1.25 2.18e-02 GO:0004674 protein serine/threonine kinase activity
1.24 2.49e-02 GO:0019904 protein domain specific binding
1.06 2.89e-02 GO:0003824 catalytic activity
1.32 3.88e-02 GO:0019900 kinase binding