Motif ID: PAX6.p2

Z-value: 0.622


Transcription factors associated with PAX6.p2:

Gene SymbolEntrez IDGene Name
PAX6 5080 paired box 6



Activity profile for motif PAX6.p2.

activity profile for motif PAX6.p2


Sorted Z-values histogram for motif PAX6.p2

Sorted Z-values for motif PAX6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_49760841 1.228 NM_001165257
NM_013243
SCG3

secretogranin III

chr1_+_165564904 1.131 NM_001198783
POU2F1
POU class 2 homeobox 1
chr1_+_165565006 1.076 POU2F1
POU class 2 homeobox 1
chr6_+_147568795 0.774 STXBP5
syntaxin binding protein 5 (tomosyn)
chr6_-_42270671 0.607 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr19_-_56825400 0.448 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr12_-_68379331 0.405 NM_032735
BEST3
bestrophin 3
chr2_+_214984705 0.387 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr1_-_6502655 0.367 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chrX_-_13745134 0.363 GPM6B
glycoprotein M6B
chr6_-_131333173 0.352 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr4_-_174557191 0.340 NM_007281
SCRG1
stimulator of chondrogenesis 1
chrX_-_123925343 0.338 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr5_-_135259403 0.312 NM_000590
IL9
interleukin 9
chrX_-_106336199 0.309 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chrX_+_48127911 0.301 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr16_+_70646008 0.294 NM_001126102
NM_005143
HP

haptoglobin

chr7_+_154943466 0.288 NM_001427
EN2
engrailed homeobox 2
chrX_+_52797004 0.281 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr22_+_24468168 0.277 MYO18B
myosin XVIIIB
chr10_-_82039158 0.265 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr4_+_130236731 0.263 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr8_+_21972804 0.261 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr8_-_62764839 0.229 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr2_+_170074457 0.218 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr5_-_98290117 0.213 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr8_-_21827057 0.202 NM_003974
DOK2
docking protein 2, 56kDa
chr19_+_56990222 0.181 NM_002030
FPR3
formyl peptide receptor 3
chr10_+_35934343 0.177 NM_153368
GJD4
gap junction protein, delta 4, 40.1kDa
chr8_+_124264054 0.177 FAM83A
family with sequence similarity 83, member A
chr1_-_31117948 0.174 SDC3
syndecan 3
chrX_-_130251068 0.173 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr7_-_26198673 0.170 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr5_-_169657312 0.168 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr16_-_11282595 0.157 NM_002761
PRM1
protamine 1
chr17_-_36276987 0.156 NM_000223
KRT12
keratin 12
chr2_-_171631728 0.149 NM_001136555
TLK1
tousled-like kinase 1
chrX_-_135783496 0.147


chr11_+_123600553 0.147 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr15_-_48192804 0.146 ATP8B4
ATPase, class I, type 8B, member 4
chr12_-_131725848 0.145 POLE
polymerase (DNA directed), epsilon
chr1_+_61697209 0.139 NFIA
nuclear factor I/A
chr1_+_97033103 0.138


chr17_-_1195096 0.138 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr5_+_180399871 0.137 BTNL9
butyrophilin-like 9
chr5_+_180399830 0.135 NM_152547
BTNL9
butyrophilin-like 9
chr11_-_58099884 0.134 NM_004811
LPXN
leupaxin
chr2_+_108571177 0.132 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_209732881 0.130 NM_001164688
NM_183059
RD3

retinal degeneration 3

chr2_-_157890400 0.130 NM_020711
ERMN
ermin, ERM-like protein
chr9_+_102380156 0.129 NM_001018116
MURC
muscle-related coiled-coil protein
chr3_-_196792059 0.129 APOD
apolipoprotein D
chr19_+_15920817 0.125 NM_001004465
OR10H4
olfactory receptor, family 10, subfamily H, member 4
chr5_-_79982584 0.125 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chrX_-_13745234 0.125 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr6_+_155579788 0.124 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chrX_-_130250880 0.122 IGSF1
immunoglobulin superfamily, member 1
chr12_+_97513644 0.121 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr22_+_38652555 0.115 GRAP2
GRB2-related adaptor protein 2
chr11_+_28086373 0.114 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr11_+_4859624 0.112 NM_001004759
OR51T1
olfactory receptor, family 51, subfamily T, member 1
chr6_-_64087806 0.110 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr17_-_36294962 0.108 NM_019010
KRT20
keratin 20
chr3_+_134978615 0.107 TF
transferrin
chr2_+_178893216 0.107 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr6_+_25760352 0.106 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr20_+_31713750 0.106 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr1_+_35623688 0.105 ZMYM4
zinc finger, MYM-type 4
chr12_+_108035424 0.105


chr1_-_87152372 0.105 SEP15
15 kDa selenoprotein
chr1_+_113038202 0.103 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr5_+_121493113 0.103 NM_207317
ZNF474
zinc finger protein 474
chr7_+_80113570 0.101 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chrX_-_13745108 0.101 GPM6B
glycoprotein M6B
chr16_-_46823682 0.094 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr3_+_153499883 0.091 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr12_+_9925354 0.089 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chrX_-_48156287 0.088 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chrX_-_13744933 0.088 GPM6B
glycoprotein M6B
chr11_+_76561471 0.087 MYO7A
myosin VIIA
chr11_+_111294868 0.085 C11orf52
chromosome 11 open reading frame 52
chr4_+_100714995 0.084 MTTP
microsomal triglyceride transfer protein
chr2_+_108571209 0.081 LIMS1
LIM and senescent cell antigen-like domains 1
chr19_+_59941785 0.081 NM_015868
KIR2DS2
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr1_+_93830106 0.081 LOC100129046
hypothetical LOC100129046
chr5_+_147672181 0.080 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr8_-_59575249 0.079 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr20_-_32877029 0.078 NM_014071
NCOA6
nuclear receptor coactivator 6
chr1_-_87152396 0.074 SEP15
15 kDa selenoprotein
chr8_+_7340777 0.074 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr16_+_70654625 0.074 NM_020995
HPR
haptoglobin-related protein
chr9_+_123088217 0.074 GSN
gelsolin
chr3_+_16949585 0.073 NM_015184
PLCL2
phospholipase C-like 2
chr17_-_33602374 0.071 NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr19_-_59019240 0.069 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr5_+_79651545 0.069 NM_032567
SPZ1
spermatogenic leucine zipper 1
chrX_-_52700674 0.067 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr1_+_202033273 0.067 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr11_-_5178505 0.066 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr8_-_7710547 0.066 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr1_-_161105174 0.065 NM_178550
C1orf110
chromosome 1 open reading frame 110
chr17_-_8602601 0.064 NM_001128076
SPDYE4
speedy homolog E4 (Xenopus laevis)
chr8_-_102029997 0.063 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr11_+_111294810 0.062 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr6_-_28591542 0.061 NM_182701
GPX6
glutathione peroxidase 6 (olfactory)
chr12_-_43556220 0.060 NELL2
NEL-like 2 (chicken)
chr5_+_42792676 0.058 NM_001134848
CCDC152
coiled-coil domain containing 152
chr15_+_27001131 0.058 NM_001130414
NM_005503
APBA2

amyloid beta (A4) precursor protein-binding, family A, member 2

chr10_-_45350804 0.058 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr1_+_108794426 0.058 NM_001143987
NM_001143988
NBPF4
NBPF6

neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6

chr14_-_30927931 0.058 NM_015473
HEATR5A
HEAT repeat containing 5A
chr1_-_108588186 0.057 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chrX_+_36163971 0.056 NM_001098843
CXorf30
chromosome X open reading frame 30
chr15_+_43331719 0.056 NM_004212
SLC28A2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
chr1_-_89230844 0.055 RBMXL1
CCBL2
RNA binding motif protein, X-linked-like 1
cysteine conjugate-beta lyase 2
chrX_-_65176564 0.052 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr6_-_74284522 0.050 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr14_+_28311740 0.050 C14orf23
chromosome 14 open reading frame 23
chr14_-_20694023 0.049 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr2_+_119416214 0.048 NM_006770
MARCO
macrophage receptor with collagenous structure
chr2_-_133256097 0.047 NCKAP5
NCK-associated protein 5
chr1_-_12830728 0.046 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chrX_-_84250629 0.044 NM_001012980
SATL1
spermidine/spermine N1-acetyl transferase-like 1
chr1_+_148747208 0.044 ECM1
extracellular matrix protein 1
chr7_-_107930170 0.043 PNPLA8
patatin-like phospholipase domain containing 8
chr1_+_145841569 0.042 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr11_+_117680504 0.041 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr10_-_79298876 0.041 DLG5
discs, large homolog 5 (Drosophila)
chr1_+_84539876 0.040 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr10_-_7699192 0.040 ITIH5
inter-alpha (globulin) inhibitor H5
chrX_-_15242589 0.039 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr6_-_134415311 0.039 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr5_+_40945244 0.038 C7
complement component 7
chr11_-_123130435 0.037 NM_001005188
OR6X1
olfactory receptor, family 6, subfamily X, member 1
chr22_-_48865907 0.037 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr3_-_109730858 0.036 NM_014981
MYH15
myosin, heavy chain 15
chr3_-_195670256 0.035 NM_024524
ATP13A3
ATPase type 13A3
chr21_-_30855478 0.034 NM_181614
KRTAP19-7
keratin associated protein 19-7
chr8_+_39911630 0.032 NM_194294
IDO2
indoleamine 2,3-dioxygenase 2
chr12_+_119224506 0.032 NM_012240
SIRT4
sirtuin 4
chr6_+_167624792 0.031 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr5_-_58918031 0.031 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_+_15713200 0.031 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr1_+_51855133 0.029 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chr21_+_38550739 0.029 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_+_77575276 0.029 NM_020859
SHROOM3
shroom family member 3
chr6_-_155818728 0.027 NM_015718
NOX3
NADPH oxidase 3
chr11_-_28086277 0.027 NM_031217
KIF18A
kinesin family member 18A
chr11_-_95715976 0.025 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr3_+_122769467 0.025 NM_001012659
ARGFX
arginine-fifty homeobox
chr4_-_170314382 0.025 SH3RF1
SH3 domain containing ring finger 1
chr2_+_38746742 0.024 GALM
galactose mutarotase (aldose 1-epimerase)
chr1_-_54861656 0.024 NM_176782
FAM151A
family with sequence similarity 151, member A
chr15_-_23204887 0.023 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr2_-_200033445 0.023 SATB2
SATB homeobox 2
chr10_+_18280773 0.023 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr1_-_87152596 0.022 NM_004261
NM_203341
SEP15

15 kDa selenoprotein

chrX_-_138742050 0.020 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr3_-_121117647 0.020 GSK3B
glycogen synthase kinase 3 beta
chr11_-_4827013 0.017 NM_001004758
OR51S1
olfactory receptor, family 51, subfamily S, member 1
chr12_-_10433852 0.017 NM_007360
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr17_-_33552166 0.016 NM_001123391
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr19_-_62659665 0.016 NM_020633
VN1R1
vomeronasal 1 receptor 1
chr7_+_72913424 0.016 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr2_+_62787534 0.015 NM_001142614
EHBP1
EH domain binding protein 1
chrX_-_53478016 0.015 NM_001037811
NM_004493
HSD17B10

hydroxysteroid (17-beta) dehydrogenase 10

chr8_+_18123456 0.014 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr11_+_117452995 0.014 TMPRSS4
transmembrane protease, serine 4
chr1_+_148747110 0.013 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr11_-_57054756 0.013 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr6_-_10520264 0.013 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr3_+_134601479 0.012 NM_003571
BFSP2
beaded filament structural protein 2, phakinin
chr4_+_114190233 0.012 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr1_+_51855343 0.012 OSBPL9
oxysterol binding protein-like 9
chr20_-_45360903 0.011 ZMYND8
zinc finger, MYND-type containing 8
chr5_-_94250357 0.011 MCTP1
multiple C2 domains, transmembrane 1
chr2_-_18634257 0.010 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr3_-_15538164 0.010 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr17_-_31528027 0.009 NM_001001417
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr6_-_152681171 0.009 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_+_19328846 0.009 NM_001111018
NAV2
neuron navigator 2
chr5_-_142795269 0.009 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr4_+_71261066 0.008 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chr12_-_78853365 0.008 NM_001143885
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr1_+_93830169 0.008 LOC100129046
hypothetical LOC100129046
chrX_-_76823813 0.006


chr12_+_67366989 0.006 NM_020401
NUP107
nucleoporin 107kDa
chr17_-_31831093 0.004 NM_001123392
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3H
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3H
TBC1 domain family, member 3F
chr16_+_68705029 0.003 NM_017990
PDPR
pyruvate dehydrogenase phosphatase regulatory subunit
chr20_+_18070867 0.003 NM_020536
CSRP2BP
CSRP2 binding protein
chr11_+_119862014 0.003 ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr11_+_55617328 0.002 NM_001003750
OR8I2
olfactory receptor, family 8, subfamily I, member 2
chr5_-_141318810 0.002 NM_016580
PCDH12
protocadherin 12
chr16_-_29514140 0.002



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
12.24 5.32e-03 GO:0032313 regulation of Rab GTPase activity
12.24 5.32e-03 GO:0032483 regulation of Rab protein signal transduction
4.84 1.00e-02 GO:0046578 regulation of Ras protein signal transduction
6.48 1.94e-02 GO:0032318 regulation of Ras GTPase activity

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
12.00 1.50e-03 GO:0005097 Rab GTPase activator activity