Motif ID: PAX4.p2

Z-value: 1.797


Transcription factors associated with PAX4.p2:

Gene SymbolEntrez IDGene Name
PAX4 5078 paired box 4



Activity profile for motif PAX4.p2.

activity profile for motif PAX4.p2


Sorted Z-values histogram for motif PAX4.p2

Sorted Z-values for motif PAX4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_39874921 3.051 NM_004310
RHOH
ras homolog gene family, member H
chr8_-_21827057 2.580 NM_003974
DOK2
docking protein 2, 56kDa
chr1_+_12046020 2.574 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr1_+_101475149 2.545 S1PR1
sphingosine-1-phosphate receptor 1
chr6_+_32515596 2.328 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr11_+_1830763 2.268 NM_002339
LSP1
lymphocyte-specific protein 1
chr2_-_136590210 2.229 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr1_-_158948176 2.030 NM_001778
CD48
CD48 molecule
chr6_+_32713160 1.992 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr3_+_123779122 1.976 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr15_+_64481270 1.871 MAP2K1
mitogen-activated protein kinase kinase 1
chr3_+_190831909 1.845 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr1_+_101474892 1.804 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr11_-_58736897 1.776 NM_001039396
MPEG1
macrophage expressed 1
chr19_+_14405216 1.731 PKN1
protein kinase N1
chr20_+_42644633 1.694 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr19_-_55008172 1.542 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr14_+_66901237 1.506 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr22_-_16080265 1.498 CECR1
cat eye syndrome chromosome region, candidate 1
chr11_+_20341806 1.495 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr18_-_51406841 1.473 NM_001083962
NM_003199
TCF4

transcription factor 4

chr7_+_68702516 1.473 AUTS2
autism susceptibility candidate 2
chr11_+_65027721 1.443


chr11_+_20341900 1.430 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr8_+_145718702 1.425


chr4_-_84250019 1.376 NM_001130716
PLAC8
placenta-specific 8
chr8_-_102029997 1.374 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr6_-_32227645 1.371 PRRT1
proline-rich transmembrane protein 1
chrX_-_102829595 1.367 MORF4L2
mortality factor 4 like 2
chr3_+_120781212 1.278 NM_001125
ADPRH
ADP-ribosylarginine hydrolase
chr6_-_32227695 1.269 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr15_-_58477407 1.246 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr12_+_74160779 1.245 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr4_+_82171142 1.218 NM_001201
BMP3
bone morphogenetic protein 3
chr1_-_25164061 1.207 NM_001031680
RUNX3
runt-related transcription factor 3
chr5_+_42792676 1.205 NM_001134848
CCDC152
coiled-coil domain containing 152
chr5_+_162862808 1.198 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr6_-_32665409 1.150 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr1_-_208024491 1.146 NM_152485
C1orf74
chromosome 1 open reading frame 74
chr2_-_198248828 1.141 NM_144629
RFTN2
raftlin family member 2
chr22_-_41447214 1.126 A4GALT
alpha 1,4-galactosyltransferase
chr3_+_51870684 1.099 NM_203424
IQCF2
IQ motif containing F2
chr13_-_28190961 1.093 NM_001135919
NM_181785
SLC46A3

solute carrier family 46, member 3

chr7_-_33047042 1.080 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr6_-_137536412 1.053 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr11_+_20341835 1.047 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr19_-_4867814 1.040


chr19_-_50688310 1.023 NM_206901
RTN2
reticulon 2
chr17_+_22823151 1.009 NM_014238
KSR1
kinase suppressor of ras 1
chr7_+_68702252 1.006 AUTS2
autism susceptibility candidate 2
chr19_+_14405100 0.950 NM_002741
PKN1
protein kinase N1
chr1_-_148936123 0.950 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr4_-_109308893 0.945 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr1_-_39910296 0.942 NM_032526
NT5C1A
5'-nucleotidase, cytosolic IA
chr19_-_46504831 0.935


chr2_+_185171337 0.930 NM_194250
ZNF804A
zinc finger protein 804A
chr6_-_161614962 0.925 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr3_-_17757402 0.923 NM_014744
TBC1D5
TBC1 domain family, member 5
chrX_-_102829621 0.907 NM_001142419
NM_001142420
NM_001142421
NM_001142422
NM_001142427
NM_001142428
NM_001142431
NM_001142432
MORF4L2







mortality factor 4 like 2







chr18_-_51406359 0.870 TCF4
transcription factor 4
chr17_-_44154878 0.867 NM_032391
PRAC
prostate cancer susceptibility candidate
chrX_-_134257624 0.862 NM_001185063
NM_007131
ZNF75D

zinc finger protein 75D

chr19_+_59796858 0.845 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr7_+_18296569 0.843 HDAC9
histone deacetylase 9
chr16_+_29739215 0.840 NM_005115
NM_017458
MVP

major vault protein

chr6_+_134800533 0.837 LOC154092
hypothetical LOC154092
chr2_-_64944214 0.829


chr6_-_31805932 0.822 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr18_-_59137488 0.819 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr3_+_188222337 0.812 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr6_-_31806012 0.805 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr17_-_30414789 0.804 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr10_-_85921703 0.802 LOC642934
hypothetical LOC642934
chrX_-_101297417 0.779 NM_001159560
NM_001012978
BEX5

brain expressed, X-linked 5

chr2_-_222145240 0.777 NM_004438
EPHA4
EPH receptor A4
chr7_+_133884388 0.768 NM_001080538
AKR1B15
aldo-keto reductase family 1, member B15
chr5_+_68703036 0.764 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr11_+_10439253 0.761 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr20_-_23010786 0.758 CD93
CD93 molecule
chr4_+_2783764 0.752 SH3BP2
SH3-domain binding protein 2
chr1_-_158759606 0.748 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr17_+_69833945 0.733 NM_153209
KIF19
kinesin family member 19
chr2_-_232087293 0.723 C2orf52
chromosome 2 open reading frame 52
chr12_+_32003553 0.712 NM_018169
C12orf35
chromosome 12 open reading frame 35
chr2_-_213723298 0.705 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr20_+_61654816 0.704 NM_024059
C20orf195
chromosome 20 open reading frame 195
chr10_+_35524835 0.699 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr8_+_39890484 0.697 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr16_+_28850760 0.696 NM_001178098
NM_001770
CD19

CD19 molecule

chr7_-_112545847 0.689 LOC401397
hypothetical LOC401397
chr7_-_112545840 0.687 LOC401397
hypothetical LOC401397
chr6_-_90119329 0.685 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr17_-_8004671 0.682 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr10_-_49483002 0.679 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr19_+_59833719 0.675 NM_001081638
NM_001081639
NM_001081637
LILRB1


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1


chr16_-_87297525 0.670 NM_001171816
RNF166
ring finger protein 166
chrX_-_47815426 0.669 NM_001037735
ZNF630
zinc finger protein 630
chr5_-_95184121 0.668 GLRX
glutaredoxin (thioltransferase)
chr1_+_84540921 0.660 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr9_-_98580148 0.657 NM_014930
ZNF510
zinc finger protein 510
chr12_+_103375116 0.656 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr19_+_40849554 0.644 NM_007000
UPK1A
uroplakin 1A
chr5_+_147775652 0.632 FBXO38
F-box protein 38
chr15_-_32289480 0.628 C15orf29
chromosome 15 open reading frame 29
chr11_+_5573906 0.626 NM_058166
TRIM6
tripartite motif containing 6
chr12_+_32003648 0.625 C12orf35
chromosome 12 open reading frame 35
chr7_+_134567270 0.624 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr8_+_75066117 0.613 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr17_+_69781980 0.611 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr1_+_149299504 0.608 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr4_-_46086150 0.607 NM_001114175
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr11_-_87548199 0.605 NM_022337
RAB38
RAB38, member RAS oncogene family
chr7_-_124192265 0.600 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_+_45789111 0.598 AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr6_+_31661934 0.597 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr3_+_191588354 0.593 NM_006580
CLDN16
claudin 16
chr1_+_149299530 0.592 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_-_90119169 0.581 UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr7_+_26158257 0.580 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr15_-_32289561 0.574 NM_024713
C15orf29
chromosome 15 open reading frame 29
chr2_+_104837004 0.569


chr1_+_157246305 0.569 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr3_+_195887903 0.569 NM_153690
FAM43A
family with sequence similarity 43, member A
chrX_-_154216929 0.568 NM_001289
CLIC2
chloride intracellular channel 2
chr7_+_93388951 0.567 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr5_+_68702617 0.566 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr7_-_149960218 0.563 GIMAP6
GTPase, IMAP family member 6
chr11_+_113671744 0.558 NM_006169
NNMT
nicotinamide N-methyltransferase
chr12_+_15955549 0.553 DERA
deoxyribose-phosphate aldolase (putative)
chr6_+_158990982 0.553 NM_001009991
SYTL3
synaptotagmin-like 3
chr4_+_113958652 0.551 NM_001127493
ANK2
ankyrin 2, neuronal
chr17_-_44037332 0.547 NM_018952
HOXB6
homeobox B6
chr11_+_85763425 0.545 NM_001156474
NM_021827
CCDC81

coiled-coil domain containing 81

chr13_-_40491491 0.542 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_+_31662454 0.540 NM_205837
LST1
leukocyte specific transcript 1
chr1_-_89364273 0.537 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr18_-_21184824 0.537


chr12_-_119172339 0.535 NM_025157
PXN
paxillin
chr7_-_129868059 0.535 NM_018718
TSGA14
testis specific, 14
chr7_+_106292975 0.534 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_+_52126131 0.532 PRR13
proline rich 13
chr21_+_37713076 0.530 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr18_+_59726183 0.521 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_+_65024889 0.519 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr14_+_20319049 0.518 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr11_-_67174684 0.518 NM_080658
ACY3
aspartoacylase (aminocyclase) 3
chr1_-_72520735 0.518 NM_173808
NEGR1
neuronal growth regulator 1
chr3_-_79899748 0.516 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_-_89437098 0.511 NM_052941
GBP4
guanylate binding protein 4
chr2_+_45022540 0.510 NM_005413
SIX3
SIX homeobox 3
chr11_+_44742551 0.505 NM_130783
TSPAN18
tetraspanin 18
chr10_-_61570665 0.502 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_149299490 0.502 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr5_-_95184221 0.497 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr14_+_61653827 0.495 FLJ43390
hypothetical LOC646113
chr22_-_22426551 0.489 NM_013378
VPREB3
pre-B lymphocyte 3
chr13_+_36146048 0.487 NM_203451
C13orf36
chromosome 13 open reading frame 36
chr20_-_33783409 0.486 RBM39
RNA binding motif protein 39
chr1_+_26516967 0.483 NM_001803
CD52
CD52 molecule
chr1_+_45789048 0.479 NM_006066
NM_153326
AKR1A1

aldo-keto reductase family 1, member A1 (aldehyde reductase)

chr1_-_90955365 0.477 NM_020063
BARHL2
BarH-like homeobox 2
chr1_-_26517342 0.469 NM_145345
UBXN11
UBX domain protein 11
chr1_-_152845399 0.469 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr1_-_158815850 0.468 CD84
CD84 molecule
chr16_+_49288550 0.465 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr12_+_15955372 0.465 NM_015954
DERA
deoxyribose-phosphate aldolase (putative)
chr4_+_47181987 0.465 NM_020453
ATP10D
ATPase, class V, type 10D
chr7_+_150013716 0.459 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr6_+_33151703 0.458 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr8_-_82557956 0.458 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr2_-_96351345 0.453


chr22_+_35290271 0.450


chr14_+_87541220 0.448 NM_003608
GPR65
G protein-coupled receptor 65
chr19_+_17239264 0.448 BABAM1
BRISC and BRCA1 A complex member 1
chr10_+_91142301 0.448 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr9_+_91409746 0.445 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr10_+_102285690 0.440 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr2_-_217267742 0.430 IGFBP5
insulin-like growth factor binding protein 5
chr4_+_75242671 0.428 NM_001144978
MTHFD2L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
chr7_+_72486044 0.426 NM_003508
FZD9
frizzled homolog 9 (Drosophila)
chr11_+_57285809 0.421 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr3_+_29297806 0.419 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr16_+_31273969 0.418 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_+_149299307 0.409 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151897817 0.409 SNAPIN
SNAP-associated protein
chr13_-_113916115 0.407 RASA3
RAS p21 protein activator 3
chr10_-_69661860 0.403 NM_145178
ATOH7
atonal homolog 7 (Drosophila)
chr6_+_26071255 0.400 TRIM38
tripartite motif containing 38
chr15_+_78232160 0.397 FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr1_-_31003181 0.393 LAPTM5
lysosomal protein transmembrane 5
chr7_-_135263737 0.392 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr2_+_157000225 0.391 GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr4_+_40953698 0.391 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr5_+_150137700 0.391 NM_032947
C5orf62
chromosome 5 open reading frame 62
chr4_-_170915602 0.387 NM_017867
C4orf27
chromosome 4 open reading frame 27
chr1_+_191357680 0.387 NM_024529
CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr1_+_51208499 0.386 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr4_+_109308126 0.384 LOC641518
hypothetical LOC641518
chr9_-_108416 0.381 NM_207305
FOXD4
forkhead box D4
chr5_-_43550891 0.380 NM_198566
C5orf34
chromosome 5 open reading frame 34

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.12 4.33e-03 GO:0009987 cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
20.37 4.06e-02 GO:0031235 intrinsic to internal side of plasma membrane

Nothing significant found in function category.