Motif ID: TGIF1.p2

Z-value: 1.401


Transcription factors associated with TGIF1.p2:

Gene SymbolEntrez IDGene Name
TGIF1 7050 TGFB-induced factor homeobox 1



Activity profile for motif TGIF1.p2.

activity profile for motif TGIF1.p2


Sorted Z-values histogram for motif TGIF1.p2

Sorted Z-values for motif TGIF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TGIF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_179623030 2.708 NM_173648
CCDC141
coiled-coil domain containing 141
chr16_+_27320983 2.551 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr10_-_11614279 2.308 NM_001080491
USP6NL
USP6 N-terminal like
chr20_+_54420574 2.175 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr8_+_121892719 1.989


chr18_+_13601664 1.902 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr2_+_223625105 1.899 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr13_+_96726415 1.815 MBNL2
muscleblind-like 2 (Drosophila)
chr3_+_142587973 1.775


chr5_+_43228083 1.752 NM_153361
MGC42105
serine/threonine-protein kinase NIM1
chr22_-_37480898 1.558 SUN2
Sad1 and UNC84 domain containing 2
chr12_+_51728999 1.505 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_+_78858675 1.505 NM_006820
IFI44L
interferon-induced protein 44-like
chr4_+_114433551 1.481 ANK2
ankyrin 2, neuronal
chr11_-_110755112 1.468 POU2AF1
POU class 2 associating factor 1
chr2_-_225519974 1.428 DOCK10
dedicator of cytokinesis 10
chr13_+_96726197 1.369 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_38185312 1.346 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr2_+_33213111 1.326 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr3_+_179736917 1.285 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr13_-_59223074 1.284


chr19_-_44518516 1.283 NM_004877
GMFG
glia maturation factor, gamma
chr17_-_60439764 1.270 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr15_-_46725087 1.267 NM_000138
FBN1
fibrillin 1
chr12_+_51729239 1.256 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr18_+_64616296 1.250 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr19_-_44518465 1.249 GMFG
glia maturation factor, gamma
chr6_-_41781655 1.239 TFEB
transcription factor EB
chr15_+_42815851 1.220 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr1_-_158948176 1.197 NM_001778
CD48
CD48 molecule
chr1_-_38185307 1.197 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr3_-_129023850 1.137 NM_007283
MGLL
monoglyceride lipase
chr3_-_124821868 1.135 MYLK
myosin light chain kinase
chr17_+_56832255 1.126 TBX2
T-box 2
chr1_-_38185291 1.105 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr2_-_188021117 1.101 NM_005795
CALCRL
calcitonin receptor-like
chr17_+_56831951 1.082 NM_005994
TBX2
T-box 2
chr1_-_38185254 1.080 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr7_+_119700924 1.075 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr6_+_32515596 1.071 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr3_-_145049853 1.065 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr15_+_63124760 1.055 NM_178859
OSTBETA
organic solute transporter beta
chr4_+_120168002 1.041 SYNPO2
synaptopodin 2
chr22_+_34374421 1.034 APOL6
apolipoprotein L, 6
chr13_-_37070862 1.029 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr2_+_185171682 1.025 ZNF804A
zinc finger protein 804A
chr16_+_10878539 1.024 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr7_+_136203938 1.018 NM_001006627
NM_001006630
CHRM2

cholinergic receptor, muscarinic 2

chr3_+_52803823 1.016 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr1_-_197173159 1.014 LOC100131234
familial acute myelogenous leukemia related factor
chr9_+_124836666 1.008 NM_005294
GPR21
G protein-coupled receptor 21
chr9_-_35640852 0.999 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr3_-_129024665 0.997 NM_001003794
MGLL
monoglyceride lipase
chr19_-_51856129 0.995 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr22_+_34374358 0.983 NM_030641
APOL6
apolipoprotein L, 6
chr8_+_134272463 0.981 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr4_+_54790190 0.981 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr8_-_41641881 0.972 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr4_+_113958652 0.969 NM_001127493
ANK2
ankyrin 2, neuronal
chr5_-_44424423 0.960 NM_004465
FGF10
fibroblast growth factor 10
chr4_-_122357104 0.957 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr12_+_6768934 0.955 NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4



CD4 molecule



chr4_+_120167950 0.946 SYNPO2
synaptopodin 2
chr3_+_45042754 0.938 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr11_+_89507465 0.937 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr12_+_6768960 0.925 CD4
CD4 molecule
chr11_-_110755366 0.923 NM_006235
POU2AF1
POU class 2 associating factor 1
chr9_+_133154896 0.922 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chrX_+_129133234 0.909 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr12_+_6768966 0.908 CD4
CD4 molecule
chr4_+_120167770 0.898 SYNPO2
synaptopodin 2
chr5_-_179040580 0.888 NM_001164444
CBY3
chibby homolog 3 (Drosophila)
chr14_-_22974707 0.886 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chrX_-_48818585 0.886 NM_007213
PRAF2
PRA1 domain family, member 2
chr8_-_93099040 0.877 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_+_19947314 0.871 TTC39C
tetratricopeptide repeat domain 39C
chr2_+_66519949 0.870 MEIS1
Meis homeobox 1
chr6_-_25044156 0.864 FAM65B
family with sequence similarity 65, member B
chr4_-_114901672 0.861 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr12_+_6768866 0.858 NM_000616
CD4
CD4 molecule
chr2_+_190916863 0.852 INPP1
inositol polyphosphate-1-phosphatase
chr9_-_129580732 0.834 NM_170600
SH2D3C
SH2 domain containing 3C
chr8_+_67201684 0.827 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr6_-_46401363 0.819 NM_005822
RCAN2
regulator of calcineurin 2
chr4_-_39199527 0.809 UGDH
UDP-glucose 6-dehydrogenase
chr13_+_107720561 0.806 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr14_+_92049396 0.805 NM_024832
RIN3
Ras and Rab interactor 3
chr1_-_143643064 0.800 PDE4DIP
phosphodiesterase 4D interacting protein
chr4_+_54790020 0.787 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr5_+_140848905 0.782 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr2_-_162638174 0.765 DPP4
dipeptidyl-peptidase 4
chr14_+_23527866 0.763 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr4_-_114901789 0.758 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr13_-_32757835 0.756 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_+_125786975 0.756 GRAMD3
GRAM domain containing 3
chr6_+_136214495 0.753 NM_018945
PDE7B
phosphodiesterase 7B
chr10_+_69539255 0.752 NM_032578
MYPN
myopalladin
chr5_-_36337756 0.749 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr2_-_202271598 0.739 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr3_-_69120188 0.730 C3orf64
chromosome 3 open reading frame 64
chr7_-_94123308 0.724 SGCE
sarcoglycan, epsilon
chr10_+_90629880 0.720 NM_020799
STAMBPL1
STAM binding protein-like 1
chr17_+_19255083 0.712 NM_007148
RNF112
ring finger protein 112
chr5_+_149867866 0.709 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr5_+_110587546 0.681 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr2_+_185171537 0.678 ZNF804A
zinc finger protein 804A
chr1_-_143750988 0.678 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr9_+_126094067 0.675 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr8_-_93181091 0.670 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_+_52469559 0.666 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr7_-_116750278 0.665 NM_003391
WNT2
wingless-type MMTV integration site family member 2
chr4_+_151722526 0.660 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr4_+_120167721 0.658 SYNPO2
synaptopodin 2
chr3_-_48573556 0.646 PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr5_+_148766632 0.644 LOC728264
hypothetical LOC728264
chr7_-_94123362 0.642 SGCE
sarcoglycan, epsilon
chr7_-_94123413 0.640 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr15_+_79376295 0.640 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr7_-_5533621 0.636 ACTB
actin, beta
chr1_-_239865724 0.635 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr9_+_131123115 0.635 NM_001012715
C9orf106
chromosome 9 open reading frame 106
chr11_-_76058542 0.635 NM_005512
LRRC32
leucine rich repeat containing 32
chr12_-_9159780 0.623 A2M
alpha-2-macroglobulin
chr1_-_89364273 0.610 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr17_-_15109315 0.609 NM_000304
PMP22
peripheral myelin protein 22
chr11_-_76059435 0.607 NM_001128922
LRRC32
leucine rich repeat containing 32
chr11_-_118799452 0.607 NM_006288
THY1
Thy-1 cell surface antigen
chr6_-_56824672 0.600 DST
dystonin
chr2_-_191580567 0.598 STAT1
signal transducer and activator of transcription 1, 91kDa
chr2_-_74460933 0.589 NM_001135040
NM_001190837
NM_004082
DCTN1


dynactin 1


chr7_+_94123556 0.587 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr3_-_124822113 0.585 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr2_-_40593074 0.582 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr19_-_20011013 0.581 NM_001077349
ZNF682
zinc finger protein 682
chr13_-_33148899 0.578 STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_-_7672978 0.577 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr11_+_111353218 0.575 NM_033425
DIXDC1
DIX domain containing 1
chr17_+_70540265 0.564 KCTD2
potassium channel tetramerisation domain containing 2
chr5_+_125786717 0.563 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr12_-_9159742 0.562 A2M
alpha-2-macroglobulin
chr3_+_51550635 0.561 NM_015106
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr8_-_121892877 0.557 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr4_-_114902043 0.552 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr8_+_42671718 0.545 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr1_-_46853380 0.543 NM_145279
MOBKL2C
MOB1, Mps One Binder kinase activator-like 2C (yeast)
chr12_+_118100977 0.540 NM_014365
HSPB8
heat shock 22kDa protein 8
chr10_-_73203202 0.539 NM_022153
C10orf54
chromosome 10 open reading frame 54
chr14_-_105862080 0.536 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr7_-_104696678 0.534 NM_182691
SRPK2
SRSF protein kinase 2
chr9_-_16717887 0.534 BNC2
basonuclin 2
chrX_-_11593741 0.532 NM_006125
NM_013427
ARHGAP6

Rho GTPase activating protein 6

chr1_-_111018798 0.532 KCNA3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr7_+_94953148 0.532 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr13_+_107720206 0.530 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr14_+_23575460 0.528 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr10_-_49483002 0.526 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr3_-_189354510 0.525 LOC339929
hypothetical LOC339929
chr2_+_238200922 0.521 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr17_-_8711701 0.517 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr2_-_197883739 0.513 NM_001195144
NM_153697
ANKRD44

ankyrin repeat domain 44

chr13_+_107720475 0.512 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr5_+_143171918 0.512 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr14_-_106352471 0.506


chr2_-_231498184 0.505 NM_005683
GPR55
G protein-coupled receptor 55
chr4_+_8935987 0.505 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr3_-_52694554 0.504 NM_018313
PBRM1
polybromo 1
chr7_+_94123672 0.503 PEG10
paternally expressed 10
chr1_+_161305188 0.503 NM_005613
RGS4
regulator of G-protein signaling 4
chr18_-_54447168 0.503 NM_052947
ALPK2
alpha-kinase 2
chr14_+_37746937 0.502 NM_001049
SSTR1
somatostatin receptor 1
chr7_+_33911636 0.499 NM_133468
BMPER
BMP binding endothelial regulator
chr6_-_133120587 0.497 NM_004665
VNN2
vanin 2
chr13_+_107719977 0.497 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr7_+_94123612 0.497 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr6_-_46091238 0.494 NM_016929
CLIC5
chloride intracellular channel 5
chr15_-_68781662 0.490 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_-_218516950 0.490 NM_022648
TNS1
tensin 1
chr10_+_105243724 0.490 NM_004210
NEURL
neuralized homolog (Drosophila)
chr6_-_119137923 0.489 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr7_-_81237162 0.489 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr15_+_29406335 0.485 NM_015995
KLF13
Kruppel-like factor 13
chr11_-_83071084 0.484 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr12_-_8656705 0.481 NM_020661
AICDA
activation-induced cytidine deaminase
chr4_+_42094612 0.480 NM_001080505
SHISA3
shisa homolog 3 (Xenopus laevis)
chr3_-_52844274 0.476 NM_205853
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr3_+_186563529 0.476 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr6_-_33822659 0.476 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr6_-_130224108 0.475 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr17_-_36409632 0.468 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr7_+_99654806 0.468 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr20_-_62071584 0.467 NM_020713
ZNF512B
zinc finger protein 512B
chr12_+_38905053 0.458 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr5_+_125723686 0.457 NM_001146319
GRAMD3
GRAM domain containing 3
chr19_-_41335610 0.454 NM_001864
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr14_+_23907065 0.453 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr12_-_47604930 0.451 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr12_-_9159789 0.448 NM_000014
A2M
alpha-2-macroglobulin
chr20_+_42777419 0.447 WISP2
WNT1 inducible signaling pathway protein 2
chr20_+_32762976 0.444 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr2_-_215951161 0.443 FN1
fibronectin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 2.61e-05 GO:0007165 signal transduction
1.31 3.52e-05 GO:0023052 signaling
1.17 1.05e-04 GO:0065007 biological regulation
1.18 4.10e-04 GO:0050789 regulation of biological process
1.18 4.17e-04 GO:0050794 regulation of cellular process
1.19 1.19e-03 GO:0050896 response to stimulus
1.26 1.47e-03 GO:0051716 cellular response to stimulus
1.38 2.29e-03 GO:0048523 negative regulation of cellular process
1.33 1.08e-02 GO:0048519 negative regulation of biological process
1.68 3.13e-02 GO:0042060 wound healing
2.95 4.47e-02 GO:0045637 regulation of myeloid cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.11 4.04e-03 GO:0016323 basolateral plasma membrane
2.70 1.02e-02 GO:0005925 focal adhesion
2.59 1.28e-02 GO:0030055 cell-substrate junction
2.57 2.20e-02 GO:0005924 cell-substrate adherens junction
1.87 2.86e-02 GO:0015629 actin cytoskeleton
1.35 2.99e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 4.08e-04 GO:0005515 protein binding
1.85 2.86e-02 GO:0003779 actin binding