Motif ID: IRF1,2,7.p3

Z-value: 3.463


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7



Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_78858675 23.131 NM_006820
IFI44L
interferon-induced protein 44-like
chr12_+_111900650 15.979 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr21_+_41655786 14.124 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr10_+_91082218 11.563 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_78888064 9.634 NM_006417
IFI44
interferon-induced protein 44
chr3_+_188568861 9.549 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr22_-_34886727 9.420 NM_145640
APOL3
apolipoprotein L, 3
chr16_-_88358946 9.347 FANCA
Fanconi anemia, complementation group A
chr1_+_157246305 8.747 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr7_+_150013716 8.290 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr10_+_91142301 7.841 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr1_-_25164061 7.387 NM_001031680
RUNX3
runt-related transcription factor 3
chr7_+_134483305 7.273 NM_018295
TMEM140
transmembrane protein 140
chr9_+_5500544 7.246 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr11_-_104421240 7.179 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr10_+_91077581 6.892 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr17_-_37518213 6.636 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr7_+_73826244 6.629 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr7_+_128367961 6.437 NM_001098627
IRF5
interferon regulatory factor 5
chr12_+_93066370 6.374 NM_005761
PLXNC1
plexin C1
chr16_+_10878539 6.152 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr17_+_75851984 6.135


chr6_+_37081387 6.135 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr19_-_7672978 6.133 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr4_-_138673078 6.099 NM_019035
PCDH18
protocadherin 18
chr1_-_9052170 6.083 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr2_+_6935246 6.043 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr3_-_173723754 5.987 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr22_-_16080265 5.976 CECR1
cat eye syndrome chromosome region, candidate 1
chr17_+_6600080 5.954 XAF1
XIAP associated factor 1
chr17_+_44643067 5.931 ABI3
ABI family, member 3
chr11_+_1830763 5.874 NM_002339
LSP1
lymphocyte-specific protein 1
chr9_-_21375258 5.846 NM_000605
IFNA2
interferon, alpha 2
chr1_-_9052207 5.804 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr17_-_44642934 5.737 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr6_+_31648071 5.658 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr17_+_38719371 5.600 NM_145041
TMEM106A
FLJ77644
transmembrane protein 106A
hypothetical LOC728772
chr12_+_25096755 5.561 LRMP
lymphoid-restricted membrane protein
chr6_-_133126278 5.559 NM_078488
VNN2
vanin 2
chr6_+_6533932 5.394 NM_004271
LY86
lymphocyte antigen 86
chr2_-_88946767 5.323


chr11_-_104274606 5.321 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr17_-_40695216 5.262 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr1_+_157067729 5.255 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr20_-_55628852 5.162 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr17_+_6599879 5.134 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr10_+_63478974 5.117 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr7_-_92615593 5.115 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr8_-_27997306 5.099 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr7_-_149960218 5.064 GIMAP6
GTPase, IMAP family member 6
chr7_-_76667045 5.060 NM_006682
FGL2
fibrinogen-like 2
chr11_-_60475558 5.050 NM_016582
SLC15A3
solute carrier family 15, member 3
chr1_-_89303478 5.027 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr4_+_89597257 5.025 NM_016323
HERC5
hect domain and RLD 5
chr1_-_89261021 4.984 NM_018284
GBP3
guanylate binding protein 3
chr6_-_31432543 4.928 HLA-B
major histocompatibility complex, class I, B
chr11_-_63087430 4.899 NM_017878
HRASLS2
HRAS-like suppressor 2
chr5_+_156628929 4.835 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr12_+_111829121 4.814 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr19_-_55091942 4.777 NM_152899
IL4I1
interleukin 4 induced 1
chr16_-_49272617 4.776 SNX20
sorting nexin 20
chr10_+_22765996 4.657 LOC100289455
hypothetical LOC100289455
chr13_-_42464301 4.624 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr4_+_142777172 4.620 NM_000585
NM_172174
IL15

interleukin 15

chr3_-_49826221 4.609 UBA7
ubiquitin-like modifier activating enzyme 7
chr4_-_169476391 4.574 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr12_+_12115668 4.566 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr1_+_159334774 4.539 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr3_+_120904555 4.519 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr3_-_49826360 4.513 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr4_+_37569093 4.493 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr5_-_149772469 4.455 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr21_-_42219849 4.429 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr10_+_91051685 4.379 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr16_+_55580910 4.366 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr17_-_30783631 4.355 NM_018042
SLFN12
schlafen family member 12
chrX_+_110252960 4.329 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr5_-_149772528 4.303


chr6_-_27948065 4.287 NM_003533
HIST1H3I
histone cluster 1, H3i
chr6_+_26548678 4.233 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr16_-_49272741 4.208 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr18_-_6404900 4.144 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr17_+_22982383 4.136 LGALS9
lectin, galactoside-binding, soluble, 9
chr22_+_34979118 4.127 APOL1
apolipoprotein L, 1
chr12_+_25096472 4.091 NM_006152
LRMP
lymphoid-restricted membrane protein
chr22_+_17012841 4.061 USP18
ubiquitin specific peptidase 18
chr16_-_11783908 4.060 NM_014153
ZC3H7A
zinc finger CCCH-type containing 7A
chr10_+_97505398 4.039 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr19_-_18058632 3.968 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr13_+_30207668 3.944 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr2_-_55090759 3.935 NM_007008
RTN4
reticulon 4
chr11_+_5667392 3.920 TRIM22
tripartite motif containing 22
chr1_-_159306369 3.798 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr9_+_5440455 3.784 NM_014143
CD274
CD274 molecule
chr1_-_159306327 3.758 ARHGAP30
Rho GTPase activating protein 30
chr3_+_114733907 3.732 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr2_-_142605739 3.720 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr2_+_85665041 3.677 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr11_-_605649 3.666 NM_004031
IRF7
interferon regulatory factor 7
chr12_+_12115139 3.655 NM_138723
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr11_+_5602782 3.643 NM_021616
TRIM34
tripartite motif containing 34
chr17_+_22982344 3.595 LGALS9
lectin, galactoside-binding, soluble, 9
chr17_+_22982372 3.570 LGALS9
lectin, galactoside-binding, soluble, 9
chr11_-_104344473 3.564 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr2_-_231697999 3.518 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr2_+_218641982 3.449 NM_198483
RUFY4
RUN and FYVE domain containing 4
chr17_+_69974361 3.437 CD300A
CD300a molecule
chr12_+_38905053 3.435 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr17_+_22982278 3.425 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr17_+_22982319 3.397 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_9052253 3.348 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr22_+_34374358 3.272 NM_030641
APOL6
apolipoprotein L, 6
chr17_+_44642587 3.263 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr15_+_86983038 3.256 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr22_+_34979062 3.245 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr6_-_32919751 3.235 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr5_-_95184121 3.228 GLRX
glutaredoxin (thioltransferase)
chr9_+_139758336 3.207 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr11_-_605920 3.204 IRF7
interferon regulatory factor 7
chr22_+_17012704 3.202 NM_017414
USP18
ubiquitin specific peptidase 18
chr6_+_32713160 3.193 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr17_-_74244539 3.193


chr22_+_37747063 3.190 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr5_-_149772563 3.163 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_+_12149637 3.140 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr5_+_131774478 3.134 NM_001013717
C5orf56
chromosome 5 open reading frame 56
chr20_-_24986501 3.115 ACSS1
acyl-CoA synthetase short-chain family member 1
chr3_+_48482625 3.100 TREX1
three prime repair exonuclease 1
chr22_-_48604455 3.063 NM_014577
BRD1
bromodomain containing 1
chr13_+_30207690 3.035 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr14_-_22358752 3.028 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr18_+_59726183 3.028 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr17_-_15526917 3.003 NM_006470
TRIM16
tripartite motif containing 16
chr1_+_173111306 2.997 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr6_+_126282078 2.988 NCOA7
nuclear receptor coactivator 7
chr21_+_41719847 2.961 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr19_-_47724365 2.933 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr15_+_73278285 2.900 C15orf39
chromosome 15 open reading frame 39
chr12_+_6431437 2.879 NM_018009
TAPBPL
TAP binding protein-like
chr19_+_59866217 2.858 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr2_-_6923215 2.835 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr2_+_68445821 2.831 NM_002664
PLEK
pleckstrin
chr19_-_17377383 2.825 NM_004335
BST2
bone marrow stromal cell antigen 2
chr5_-_95184221 2.822 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr1_-_2486313 2.803 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr11_+_63060848 2.800 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr19_+_59866237 2.792 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr12_+_8167494 2.780 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr2_-_242205556 2.775 NM_001164356
THAP4
THAP domain containing 4
chr11_-_60880799 2.757 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr2_-_227737009 2.755 COL4A4
collagen, type IV, alpha 4
chr4_-_38460983 2.751 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr22_+_36008465 2.748 CYTH4
cytohesin 4
chr11_-_605998 2.738 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr12_+_9713472 2.733 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr8_-_145132551 2.728 PARP10
poly (ADP-ribose) polymerase family, member 10
chr7_-_76883642 2.724 NM_017439
PION
pigeon homolog (Drosophila)
chr16_+_29739256 2.712 MVP
major vault protein
chr13_+_42046182 2.662 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr9_-_94338072 2.655 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr17_+_18320822 2.624 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr2_-_225519974 2.621 DOCK10
dedicator of cytokinesis 10
chrX_-_1291526 2.603 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chrX_+_37524250 2.595 CYBB
cytochrome b-245, beta polypeptide
chr14_+_90650466 2.585 C14orf159
chromosome 14 open reading frame 159
chr1_+_154390939 2.581 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_+_40511909 2.559 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr8_-_145132582 2.550 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr12_-_9913199 2.544 CLEC2B
C-type lectin domain family 2, member B
chr2_+_230798687 2.524 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chrX_+_37524190 2.522 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr17_-_44022595 2.497 HOXB3
homeobox B3
chr2_-_230792844 2.484 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr14_+_90650720 2.482 NM_001102367
C14orf159
chromosome 14 open reading frame 159
chr3_+_161189322 2.473 NM_000882
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr11_+_124438217 2.446 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr2_-_242449662 2.442 NM_005018
PDCD1
programmed cell death 1
chr6_-_30289092 2.437 NM_003449
TRIM26
tripartite motif containing 26
chr4_+_160408447 2.424 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr20_-_45410033 2.378 ZMYND8
zinc finger, MYND-type containing 8
chr12_-_57600336 2.356 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr16_+_29739215 2.355 NM_005115
NM_017458
MVP

major vault protein

chr16_-_28425632 2.341 NM_145659
IL27
interleukin 27
chr13_+_48968528 2.328 NM_001040444
PHF11
PHD finger protein 11
chr6_-_32920167 2.324 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr2_+_68445936 2.282 PLEK
pleckstrin
chr8_+_144711619 2.253 NM_024736
GSDMD
gasdermin D
chr17_+_69974375 2.234 CD300A
CD300a molecule
chr14_-_94677807 2.233 NM_030621
DICER1
dicer 1, ribonuclease type III
chr2_+_230900121 2.233 NM_138402
SP140L
SP140 nuclear body protein-like
chr19_+_17377502 2.226 LOC100507535
hypothetical LOC100507535
chr4_-_138673014 2.226 PCDH18
protocadherin 18
chr11_+_10439253 2.223 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr12_-_57600564 2.203 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr11_+_71388310 2.195 NM_001145057
IL18BP
interleukin 18 binding protein
chr2_+_143351695 2.182 KYNU
kynureninase
chr16_+_56134077 2.170 NM_153837
GPR114
G protein-coupled receptor 114
chr12_+_8499788 2.167 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr1_+_208568811 2.165 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr12_-_9913724 2.151 NM_005127
CLEC2B
C-type lectin domain family 2, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
9.39 8.65e-22 GO:0060337 type I interferon-mediated signaling pathway
9.39 8.65e-22 GO:0071357 cellular response to type I interferon
9.24 1.72e-21 GO:0034340 response to type I interferon
2.72 4.02e-18 GO:0006955 immune response
2.27 4.24e-18 GO:0002376 immune system process
5.16 3.36e-17 GO:0009615 response to virus
3.52 4.70e-17 GO:0045087 innate immune response
4.41 1.85e-16 GO:0071345 cellular response to cytokine stimulus
4.60 3.38e-16 GO:0019221 cytokine-mediated signaling pathway
2.38 7.76e-13 GO:0006952 defense response
3.43 1.25e-12 GO:0034097 response to cytokine stimulus
2.79 1.02e-09 GO:0051707 response to other organism
9.41 1.63e-09 GO:0060338 regulation of type I interferon-mediated signaling pathway
3.76 9.04e-09 GO:0045088 regulation of innate immune response
2.92 1.60e-08 GO:0031347 regulation of defense response
2.07 1.91e-08 GO:0051704 multi-organism process
2.47 2.70e-08 GO:0009607 response to biotic stimulus
2.12 9.15e-07 GO:0002682 regulation of immune system process
2.44 9.22e-07 GO:0050776 regulation of immune response
5.41 1.72e-06 GO:0001959 regulation of cytokine-mediated signaling pathway
5.32 2.33e-06 GO:0060759 regulation of response to cytokine stimulus
1.51 7.64e-06 GO:0006950 response to stress
2.21 2.06e-05 GO:0080134 regulation of response to stress
2.06 2.43e-05 GO:0071310 cellular response to organic substance
1.24 2.06e-04 GO:0050896 response to stimulus
15.12 5.10e-04 GO:0019883 antigen processing and presentation of endogenous antigen
3.26 6.16e-04 GO:0001819 positive regulation of cytokine production
2.12 1.28e-03 GO:0002684 positive regulation of immune system process
2.76 2.27e-03 GO:0050867 positive regulation of cell activation
2.21 2.69e-03 GO:0044419 interspecies interaction between organisms
1.71 2.69e-03 GO:0070887 cellular response to chemical stimulus
2.40 3.13e-03 GO:0001817 regulation of cytokine production
4.78 4.08e-03 GO:0032479 regulation of type I interferon production
3.75 4.53e-03 GO:0034341 response to interferon-gamma
1.65 5.27e-03 GO:0043067 regulation of programmed cell death
1.28 6.45e-03 GO:0051716 cellular response to stimulus
1.64 6.79e-03 GO:0042981 regulation of apoptosis
1.62 9.98e-03 GO:0010941 regulation of cell death
1.77 1.04e-02 GO:0012501 programmed cell death
3.89 1.11e-02 GO:0071346 cellular response to interferon-gamma
1.31 1.18e-02 GO:0007165 signal transduction
1.77 1.23e-02 GO:0006915 apoptosis
1.69 1.32e-02 GO:0008219 cell death
2.69 1.37e-02 GO:0051251 positive regulation of lymphocyte activation
2.90 1.45e-02 GO:0050870 positive regulation of T cell activation
1.68 1.58e-02 GO:0016265 death
2.61 1.61e-02 GO:0002696 positive regulation of leukocyte activation
3.57 1.74e-02 GO:0043900 regulation of multi-organism process
1.43 1.89e-02 GO:0048583 regulation of response to stimulus
2.81 2.37e-02 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
3.18 2.73e-02 GO:0050670 regulation of lymphocyte proliferation
2.31 2.85e-02 GO:0050865 regulation of cell activation
3.15 3.14e-02 GO:0032944 regulation of mononuclear cell proliferation
3.26 3.31e-02 GO:0051222 positive regulation of protein transport
2.39 3.98e-02 GO:0051249 regulation of lymphocyte activation
1.16 4.15e-02 GO:0050789 regulation of biological process
1.27 4.50e-02 GO:0023052 signaling
3.05 4.76e-02 GO:0070663 regulation of leukocyte proliferation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.56 3.20e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.15 2.00e-06 GO:0005126 cytokine receptor binding
15.44 7.21e-06 GO:0005132 interferon-alpha/beta receptor binding
6.26 2.80e-04 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
14.12 2.52e-02 GO:0005143 interleukin-12 receptor binding
2.31 3.13e-02 GO:0005125 cytokine activity