Motif ID: EWSR1-FLI1.p2

Z-value: 1.231


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1



Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_42807901 2.570 NM_022358
KCNK15
potassium channel, subfamily K, member 15
chr1_-_93030538 2.264 NM_005665
EVI5
ecotropic viral integration site 5
chr3_-_50353209 1.761 NM_007182
NM_170714
RASSF1

Ras association (RalGDS/AF-6) domain family member 1

chr1_+_185064654 1.457 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr1_+_165865953 1.370 NM_052862
RCSD1
RCSD domain containing 1
chr17_+_45706786 1.043 NM_153229
TMEM92
transmembrane protein 92
chr1_-_31003181 0.876 LAPTM5
lysosomal protein transmembrane 5
chr1_+_246087230 0.867 TRIM58
tripartite motif containing 58
chr20_-_48741481 0.823


chr2_-_99284070 0.809 NM_174898
LYG1
lysozyme G-like 1
chr3_-_193609531 0.799 NM_021032
FGF12
fibroblast growth factor 12
chr1_+_246087104 0.785 NM_015431
TRIM58
tripartite motif containing 58
chr1_+_165866127 0.770 RCSD1
RCSD domain containing 1
chrX_-_78509662 0.753 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr1_-_31003260 0.731 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr12_+_84198015 0.731 NM_006982
ALX1
ALX homeobox 1
chr7_+_143043871 0.717 NM_001130026
FAM115C
family with sequence similarity 115, member C
chrX_+_48529905 0.692 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr5_-_71838875 0.681 NM_152625
ZNF366
zinc finger protein 366
chr1_+_221955876 0.679 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr11_+_10434056 0.674 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chrX_-_78509367 0.663 ITM2A
integral membrane protein 2A
chrX_+_1361570 0.612 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr12_-_48017223 0.603 NM_001008223
C1QL4
complement component 1, q subcomponent-like 4
chr8_-_38127489 0.596 NM_000349
STAR
steroidogenic acute regulatory protein
chr12_+_44409762 0.581 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chrX_+_138060 0.578 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr1_+_12627152 0.568 NM_001013630
AADACL4
arylacetamide deacetylase-like 4
chr3_+_77171938 0.550 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr19_-_1966628 0.547 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr12_-_92489652 0.527 LOC144481
hypothetical protein LOC144481
chr11_+_10433241 0.515 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr6_+_31698447 0.513


chr4_+_120029426 0.502 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr10_+_83627422 0.497 NM_001165973
NRG3
neuregulin 3
chr4_-_57216816 0.494 HOPX
HOP homeobox
chr5_+_156819782 0.487 NIPAL4
NIPA-like domain containing 4
chr1_-_224993498 0.478 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr5_+_156819604 0.477 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr5_-_81082699 0.468 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr10_+_88708267 0.465 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr9_+_134843918 0.461 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr18_-_5620629 0.457 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr1_-_6468600 0.454 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr8_-_145671947 0.445 FOXH1
forkhead box H1
chr1_-_202730135 0.435 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr1_-_231498081 0.420 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr8_-_93176819 0.416 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_-_16509354 0.414 LDB2
LIM domain binding 2
chr1_+_242691295 0.401 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chr4_-_16509126 0.398 LDB2
LIM domain binding 2
chr8_-_111056099 0.381 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr8_-_145672525 0.380 NM_003923
FOXH1
forkhead box H1
chr8_-_93177057 0.380 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr19_-_44518465 0.379 GMFG
glia maturation factor, gamma
chr15_-_77085056 0.375 NM_153815
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr19_+_17972923 0.374 NM_001025604
ARRDC2
arrestin domain containing 2
chr11_+_58668827 0.364 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr4_-_16509446 0.359 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr10_+_23424383 0.355 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr11_-_76800525 0.355 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr10_+_119292699 0.351


chr11_+_63730766 0.344 FERMT3
fermitin family member 3
chr1_-_171442937 0.343 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr19_-_4867814 0.338


chr1_+_26895108 0.335 NM_006015
NM_139135
ARID1A

AT rich interactive domain 1A (SWI-like)

chr1_-_68071635 0.333 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr7_+_16759845 0.329 NM_014399
TSPAN13
tetraspanin 13
chr6_+_117044334 0.329 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chr12_-_107238568 0.316 NM_001142345
CMKLR1
chemokine-like receptor 1
chr4_-_57217226 0.309 NM_001145459
NM_139211
HOPX

HOP homeobox

chr16_+_67697622 0.308 NM_138612
HAS3
hyaluronan synthase 3
chr17_-_31146660 0.307 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr19_-_44060729 0.304 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr12_+_64869271 0.304 IRAK3
interleukin-1 receptor-associated kinase 3
chr6_+_31746706 0.303 NM_021221
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr19_-_44518516 0.303 NM_004877
GMFG
glia maturation factor, gamma
chr20_+_10147455 0.302 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr7_-_99604127 0.300 GAL3ST4
galactose-3-O-sulfotransferase 4
chr10_+_104211148 0.300 NM_024789
TMEM180
transmembrane protein 180
chr8_-_22606653 0.300 NM_004430
EGR3
early growth response 3
chr8_-_145530639 0.293 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr3_-_120878910 0.290 NM_005694
COX17
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr1_+_109036431 0.288 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr12_+_14409875 0.286 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr10_+_104211134 0.284 TMEM180
transmembrane protein 180
chr12_+_64869296 0.279 IRAK3
interleukin-1 receptor-associated kinase 3
chr7_-_127458231 0.278 NM_022143
LRRC4
leucine rich repeat containing 4
chr8_-_37943143 0.277 NM_000025
ADRB3
adrenergic, beta-3-, receptor
chr12_+_10222823 0.276 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr6_-_10520592 0.274 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chrX_+_107569671 0.274 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr6_-_10520264 0.274 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr19_-_242168 0.274 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr7_-_99604171 0.273 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr10_-_103869923 0.267 NM_001113407
LDB1
LIM domain binding 1
chr1_-_21478571 0.267 NM_001113347
ECE1
endothelin converting enzyme 1
chr5_-_148422799 0.266 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr1_-_167947301 0.244 NM_000655
SELL
selectin L
chr19_+_13066956 0.237 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr4_-_44145580 0.236 NM_198353
KCTD8
potassium channel tetramerisation domain containing 8
chr6_-_24827265 0.234 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr17_-_8004671 0.230 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr7_+_128218685 0.229 CCDC136
coiled-coil domain containing 136
chr12_+_64869181 0.227 NM_001142523
NM_007199
IRAK3

interleukin-1 receptor-associated kinase 3

chr9_+_124836666 0.226 NM_005294
GPR21
G protein-coupled receptor 21
chr11_+_9736408 0.226 LOC283104
hypothetical LOC283104
chr12_+_2774550 0.225 FKBP4
FK506 binding protein 4, 59kDa
chr9_-_138701721 0.224 NM_001012727
NM_006412
AGPAT2

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)

chr12_-_47651812 0.218 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chrX_-_109447954 0.218 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr3_-_109292444 0.217 NM_001777
NM_198793
CD47

CD47 molecule

chr1_+_44185005 0.217 NM_014652
IPO13
importin 13
chr17_+_2443652 0.217 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr15_+_81906983 0.213 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr7_+_21434818 0.212


chr21_+_39099624 0.212 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr19_-_18220009 0.211 NM_000923
PDE4C
phosphodiesterase 4C, cAMP-specific
chr19_-_9098625 0.211 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chr15_+_89248423 0.211 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr1_-_68470585 0.209 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr6_+_26491302 0.206 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
BTN2A2





butyrophilin, subfamily 2, member A2





chr9_+_35528890 0.204 RUSC2
RUN and SH3 domain containing 2
chr8_+_104222052 0.200 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr19_+_54621499 0.199 NM_001195256
LOC645971
hypothetical protein LOC645971
chr19_-_242335 0.197 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr12_+_44409743 0.197 ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr19_-_52243721 0.196 NM_017854
TMEM160
transmembrane protein 160
chr19_-_51820133 0.195 NM_000960
PTGIR
prostaglandin I2 (prostacyclin) receptor (IP)
chr15_+_81907176 0.194 SH3GL3
SH3-domain GRB2-like 3
chr11_+_63730720 0.194 NM_031471
NM_178443
FERMT3

fermitin family member 3

chrX_+_24077649 0.191 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr1_-_224563461 0.190 LIN9
lin-9 homolog (C. elegans)
chr1_+_28936030 0.189 NM_001172828
YTHDF2
YTH domain family, member 2
chr1_-_150276064 0.187 S100A11
S100 calcium binding protein A11
chr8_+_133948384 0.187 NM_003235
TG
thyroglobulin
chr13_-_32678142 0.175 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_-_166397142 0.174 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chrX_-_109447970 0.169 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr19_-_11355882 0.169 NM_000121
EPOR
erythropoietin receptor
chr5_+_110587546 0.169 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr1_-_150276114 0.168 NM_005620
S100A11
S100 calcium binding protein A11
chr9_+_35528628 0.167 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chrX_-_108611940 0.165 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr1_-_150276091 0.164 S100A11
S100 calcium binding protein A11
chr1_+_109969571 0.164 NM_203404
AMPD2
adenosine monophosphate deaminase 2
chr11_-_2279642 0.161 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr12_+_2774362 0.160 NM_002014
FKBP4
FK506 binding protein 4, 59kDa
chr10_+_75211810 0.159 NM_203298
CHCHD1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr14_-_93665678 0.157 NM_032036
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr3_-_48516486 0.156 NM_016479
SHISA5
shisa homolog 5 (Xenopus laevis)
chr8_-_95556460 0.154 NM_012415
RAD54B
RAD54 homolog B (S. cerevisiae)
chrX_-_152844880 0.154 ARHGAP4
Rho GTPase activating protein 4
chr12_+_52060191 0.154 NM_138473
SP1
Sp1 transcription factor
chr11_-_62231358 0.154 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr21_+_38550533 0.154 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_53946899 0.153 MTMR4
myotubularin related protein 4
chr3_+_33130563 0.152 CRTAP
cartilage associated protein
chr5_-_38631263 0.151 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr11_+_2279812 0.150 NM_139022
TSPAN32
tetraspanin 32
chr21_+_38550739 0.148 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr8_-_93176618 0.148 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr11_-_65244718 0.146 NM_032193
RNASEH2C
ribonuclease H2, subunit C
chr19_-_53515143 0.145 NM_144577
CCDC114
coiled-coil domain containing 114
chrX_+_154650590 0.143 NM_005840
SPRY3
sprouty homolog 3 (Drosophila)
chr11_+_2279932 0.143 TSPAN32
tetraspanin 32
chr7_+_128142661 0.143 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr15_+_88345612 0.141 NM_198526
ZNF710
zinc finger protein 710
chr11_+_71605466 0.140 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr3_+_188131209 0.138 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr12_-_120502483 0.138 NM_001005366
KDM2B
lysine (K)-specific demethylase 2B
chr11_-_65244486 0.135 RNASEH2C
ribonuclease H2, subunit C
chrX_-_148394570 0.135 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr18_+_41659542 0.134 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr12_+_29193399 0.134 FAR2
fatty acyl CoA reductase 2
chr11_-_66897584 0.133 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr12_+_105692466 0.133 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr11_+_73034870 0.131 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_+_157441133 0.130 NM_002036
DARC
Duffy blood group, chemokine receptor
chr12_-_1573591 0.127 NM_152441
FBXL14
F-box and leucine-rich repeat protein 14
chr14_-_93665668 0.126 IFI27L2
interferon, alpha-inducible protein 27-like 2
chr4_+_151218862 0.126 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr16_-_79811475 0.126 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr12_+_54838408 0.125 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr5_-_158459006 0.124 EBF1
early B-cell factor 1
chr2_+_113533155 0.123 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr20_-_44370537 0.123 CDH22
cadherin 22, type 2
chr18_+_54682261 0.122 ZNF532
zinc finger protein 532
chr12_+_52060689 0.122 NM_003109
SP1
Sp1 transcription factor
chr15_-_38185578 0.120 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr1_+_177827647 0.119 NM_173533
TDRD5
tudor domain containing 5
chr9_-_125732005 0.118 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr21_+_39099717 0.118 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr1_-_224563820 0.114 NM_173083
LIN9
lin-9 homolog (C. elegans)
chr16_+_29728932 0.113 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr16_+_87397715 0.113 CDT1
chromatin licensing and DNA replication factor 1
chr17_+_24598000 0.113 NM_005208
CRYBA1
crystallin, beta A1
chr11_-_117628211 0.112 NM_198275
MPZL3
myelin protein zero-like 3
chr12_-_54869511 0.110 SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr16_+_87397686 0.107 NM_030928
CDT1
chromatin licensing and DNA replication factor 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.