Motif ID: NFATC1..3.p2

Z-value: 2.450


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3



Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_13240983 9.820 EMP1
epithelial membrane protein 1
chr12_+_13240987 9.616 EMP1
epithelial membrane protein 1
chr12_+_13240868 8.266 NM_001423
EMP1
epithelial membrane protein 1
chr18_-_51219880 6.854 TCF4
transcription factor 4
chr22_-_34566210 6.143 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr8_-_13416554 5.603 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr1_+_160868932 5.258 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_+_161305558 5.100 NM_001113381
RGS4
regulator of G-protein signaling 4
chr22_-_34566367 5.045 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr22_-_34566276 5.008 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr18_+_64616296 4.809 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr1_+_160868822 4.642 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr1_+_157246305 4.507 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr21_-_27261276 4.378 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr12_-_90097384 4.279 NM_133503
DCN
decorin
chr8_-_93144039 4.065


chr2_-_237987545 3.955 COL6A3
collagen, type VI, alpha 3
chr2_-_237987553 3.790 COL6A3
collagen, type VI, alpha 3
chr2_+_66519949 3.654 MEIS1
Meis homeobox 1
chr20_+_42644633 3.649 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr8_-_93144366 3.515 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_-_36266930 3.372 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr4_-_152366970 3.341 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr11_-_85115105 3.333 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr13_-_32822759 3.292 STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_+_189547377 3.276 COL3A1
collagen, type III, alpha 1
chr6_+_39868770 3.260 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr9_+_35528890 3.209 RUSC2
RUN and SH3 domain containing 2
chr2_-_237987509 3.181 COL6A3
collagen, type VI, alpha 3
chr8_-_6407882 3.094 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr2_-_237987554 3.048 COL6A3
collagen, type VI, alpha 3
chr1_-_68470585 3.032 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr1_+_66772393 2.998 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr2_-_237987579 2.943 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr4_-_115120251 2.930 NM_024590
ARSJ
arylsulfatase family, member J
chr9_+_74956494 2.916 NM_000700
ANXA1
annexin A1
chr5_-_54317102 2.881 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr14_+_62740878 2.880 NM_020663
RHOJ
ras homolog gene family, member J
chr4_-_153493133 2.872 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr2_+_189547323 2.794 NM_000090
COL3A1
collagen, type III, alpha 1
chr12_+_118100977 2.788 NM_014365
HSPB8
heat shock 22kDa protein 8
chr17_+_44643067 2.788 ABI3
ABI family, member 3
chr1_-_79244948 2.775 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr12_+_32578513 2.751 FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_-_149047329 2.746 NM_000396
CTSK
cathepsin K
chr3_+_158637273 2.704 NM_002852
PTX3
pentraxin 3, long
chr2_+_189547358 2.689 COL3A1
collagen, type III, alpha 1
chrX_+_56772391 2.597 LOC550643
hypothetical LOC550643
chr3_-_113841448 2.573 CCDC80
coiled-coil domain containing 80
chr7_+_120416680 2.559 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr3_-_150533948 2.553 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr19_+_46417117 2.539 AXL
AXL receptor tyrosine kinase
chr2_-_188021117 2.538 NM_005795
CALCRL
calcitonin receptor-like
chr16_-_63713382 2.522 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr16_+_1524162 2.505 NM_024600
TMEM204
transmembrane protein 204
chr9_+_35528628 2.432 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr2_-_134042500 2.380 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr4_-_55686503 2.367 NM_002253
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr16_-_63713485 2.363 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr10_-_31328426 2.343 NM_001143769
ZNF438
zinc finger protein 438
chr6_+_116939500 2.325 NM_153711
FAM26E
family with sequence similarity 26, member E
chr16_-_63713466 2.308 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_-_189752575 2.303 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_-_134680888 2.302 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr21_-_26867138 2.293 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr13_-_22905822 2.289 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr15_-_40537002 2.260 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr4_-_159312973 2.252 FAM198B
family with sequence similarity 198, member B
chr17_+_29606408 2.245 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr13_-_79810972 2.244 SPRY2
sprouty homolog 2 (Drosophila)
chr12_-_14929991 2.230 NM_000900
NM_001190839
MGP

matrix Gla protein

chr1_+_169421011 2.205 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr15_+_37330176 2.201 NM_207445
C15orf54
chromosome 15 open reading frame 54
chrX_+_100692071 2.199 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr6_-_112682401 2.181 LAMA4
laminin, alpha 4
chr7_-_41709191 2.167 NM_002192
INHBA
inhibin, beta A
chr4_-_141293572 2.159 MAML3
mastermind-like 3 (Drosophila)
chr8_+_70567634 2.103 SULF1
sulfatase 1
chr6_-_169395847 2.101 THBS2
thrombospondin 2
chr5_+_140742585 2.088 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr8_+_70567581 2.086 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr12_-_48902692 2.072 NM_001113547
LIMA1
LIM domain and actin binding 1
chr11_+_65027721 2.053


chr11_+_113672407 2.053 NNMT
nicotinamide N-methyltransferase
chr6_-_112682459 2.032 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr1_+_98899734 2.023 NM_015976
NM_152238
SNX7

sorting nexin 7

chr11_-_68537243 2.020 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr5_-_58607673 1.975 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_201862845 1.940 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr9_+_22437353 1.937 DMRTA1
DMRT-like family A1
chr6_-_112186977 1.927 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chr4_+_71806538 1.924 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr6_-_112682573 1.885 LAMA4
laminin, alpha 4
chr9_-_35679902 1.878 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr6_-_76259976 1.854 NM_015687
FILIP1
filamin A interacting protein 1
chr7_+_93388951 1.840 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr1_+_78243181 1.837 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_+_25444753 1.834 NM_016152
RARB
retinoic acid receptor, beta
chr13_+_96672541 1.828 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr2_-_198248828 1.828 NM_144629
RFTN2
raftlin family member 2
chr3_+_25445071 1.828 RARB
retinoic acid receptor, beta
chr11_-_35503720 1.808 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr9_-_90983195 1.808 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr6_-_169395972 1.804 NM_003247
THBS2
thrombospondin 2
chr7_+_22733626 1.789 IL6
interleukin 6 (interferon, beta 2)
chr2_-_202271598 1.782 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr9_-_35679799 1.780 TPM2
tropomyosin 2 (beta)
chr3_+_45042754 1.771 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr22_+_29808845 1.762 SMTN
smoothelin
chr4_-_152368492 1.756 SH3D19
SH3 domain containing 19
chr5_-_59100091 1.751 PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_44642934 1.750 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr17_-_44022595 1.736 HOXB3
homeobox B3
chr19_-_48401532 1.732 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr10_-_116434364 1.725 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr4_-_149582948 1.720 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr12_-_21985433 1.709 ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr1_+_78888064 1.703 NM_006417
IFI44
interferon-induced protein 44
chr12_+_12829807 1.703 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr2_-_231697999 1.698 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr2_+_33514896 1.689 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_-_113842553 1.672 CCDC80
coiled-coil domain containing 80
chr3_+_158743852 1.661 NM_001099777
NM_001130001
NM_001130002
C3orf55


chromosome 3 open reading frame 55


chr6_+_10663934 1.648 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr12_+_2032964 1.638 CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr4_+_134289893 1.637 NM_020815
NM_032961
PCDH10

protocadherin 10

chr3_-_113842652 1.627 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr11_+_48303047 1.622 NM_001004702
OR4C3
olfactory receptor, family 4, subfamily C, member 3
chr9_-_128924819 1.614 NM_012098
ANGPTL2
angiopoietin-like 2
chr1_+_183970093 1.612 NM_031935
HMCN1
hemicentin 1
chr2_-_227952249 1.612 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr6_-_152744022 1.611 SYNE1
spectrin repeat containing, nuclear envelope 1
chr5_-_59100194 1.606 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_192419896 1.603 SDPR
serum deprivation response
chr17_-_64649608 1.574 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr11_-_71458739 1.573 NUMA1
nuclear mitotic apparatus protein 1
chr5_+_38481392 1.567 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr5_+_140187746 1.551 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr4_+_95595419 1.545 PDLIM5
PDZ and LIM domain 5
chr14_+_85066265 1.540 FLRT2
fibronectin leucine rich transmembrane protein 2
chr9_+_12764988 1.540 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr6_-_56824371 1.540 DST
dystonin
chr18_+_7936885 1.540 PTPRM
protein tyrosine phosphatase, receptor type, M
chr2_-_224974954 1.540 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr3_-_143230124 1.534 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr19_+_42689881 1.519 ZNF793
zinc finger protein 793
chr6_+_106640903 1.519 PRDM1
PR domain containing 1, with ZNF domain
chr11_+_65023556 1.519


chr17_-_30783631 1.508 NM_018042
SLFN12
schlafen family member 12
chr7_+_136204371 1.499 NM_000739
NM_001006631
NM_001006632
NM_001006626
NM_001006629
NM_001006628
CHRM2





cholinergic receptor, muscarinic 2





chr2_-_133144950 1.490 NM_144586
LYPD1
LY6/PLAUR domain containing 1
chr5_-_146813343 1.485 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr1_+_168898898 1.475 PRRX1
paired related homeobox 1
chr4_+_169654742 1.475 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr13_-_37070862 1.458 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr5_+_155686750 1.458 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr15_-_50316996 1.456 MYO5C
myosin VC
chr15_+_22652790 1.451 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr3_-_113841200 1.443 CCDC80
coiled-coil domain containing 80
chr1_-_94475504 1.429 ARHGAP29
Rho GTPase activating protein 29
chr7_+_91762227 1.428


chr5_-_124108672 1.412 NM_020747
ZNF608
zinc finger protein 608
chr5_+_140733664 1.405 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr6_+_106653429 1.400 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr19_+_46417099 1.394 AXL
AXL receptor tyrosine kinase
chr8_-_116750427 1.394 TRPS1
trichorhinophalangeal syndrome I
chr5_-_150306298 1.393 ZNF300P1
zinc finger protein 300 pseudogene 1
chr8_-_6680429 1.391 NM_207411
XKR5
XK, Kell blood group complex subunit-related family, member 5
chr2_-_192420168 1.391 NM_004657
SDPR
serum deprivation response
chr21_+_25856311 1.387 MIR155HG
MIR155 host gene (non-protein coding)
chrX_-_43717864 1.384 NM_000266
NDP
Norrie disease (pseudoglioma)
chr1_+_19807168 1.373


chr4_-_90978469 1.369 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr7_-_15692551 1.367 MEOX2
mesenchyme homeobox 2
chr4_+_156899575 1.366 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr5_+_140154627 1.364 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr6_-_128883125 1.355 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr8_+_107807415 1.354 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr9_-_116920232 1.347 NM_002160
TNC
tenascin C
chr22_-_43986896 1.347 KIAA0930
KIAA0930
chr20_-_10148137 1.342 LOC100131208
similar to hCG2045825
chr16_-_54466709 1.341 NM_001143685
NM_145024
CES5A

carboxylesterase 5A

chr8_+_144802972 1.338 NM_014789
ZNF623
zinc finger protein 623
chr13_+_100902942 1.334 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr21_-_38792173 1.330 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr9_+_74956601 1.327 ANXA1
annexin A1
chr4_-_87593306 1.325 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr3_+_69895651 1.320 NM_006722
MITF
microphthalmia-associated transcription factor
chr13_-_101852028 1.318 NM_175929
FGF14
fibroblast growth factor 14
chr5_+_140714951 1.315 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr4_-_90197140 1.312 NM_014883
FAM13A
family with sequence similarity 13, member A
chr1_-_89261021 1.310 NM_018284
GBP3
guanylate binding protein 3
chr12_+_77782925 1.309 SYT1
synaptotagmin I
chr12_-_50871953 1.309 NM_001081492
NM_182507
KRT80

keratin 80

chr17_+_44642587 1.299 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr10_-_116434102 1.297 ABLIM1
actin binding LIM protein 1
chr6_-_56824672 1.287 DST
dystonin
chr7_-_13992351 1.284 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_-_109201228 1.284 NM_152763
AKNAD1
AKNA domain containing 1
chr11_+_101488380 1.282 NM_001195045
YAP1
Yes-associated protein 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 6.92e-05 GO:0005576 extracellular region
1.41 1.00e-04 GO:0044421 extracellular region part
1.64 7.46e-03 GO:0005578 proteinaceous extracellular matrix
1.38 1.42e-02 GO:0005615 extracellular space
2.98 2.23e-02 GO:0005581 collagen
1.53 4.16e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.93 1.88e-02 GO:0005539 glycosaminoglycan binding
1.61 2.35e-02 GO:0003779 actin binding