Motif ID: PRRX1,2.p2

Z-value: 1.354


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2



Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_143230124 8.853 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr7_-_26202626 8.167 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr8_+_107807415 7.766 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr7_-_104696678 7.759 NM_182691
SRPK2
SRSF protein kinase 2
chr7_-_92615593 6.171 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr5_+_67622242 5.867 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_+_115650240 5.865 NM_152829
TES
testis derived transcript (3 LIM domains)
chr8_-_17599438 5.597 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr7_-_13992351 5.530 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chrX_+_114734074 5.357 NM_001136025
NM_001172335
PLS3

plastin 3

chr4_-_153493133 5.143 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr12_-_15005761 4.980 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_-_55090759 4.962 NM_007008
RTN4
reticulon 4
chr5_-_169340321 4.809 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr8_-_102029997 4.701 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr21_-_34820916 4.692 NM_203418
RCAN1
regulator of calcineurin 1
chr4_-_74307637 4.668 ANKRD17
ankyrin repeat domain 17
chr5_-_94442941 4.653 MCTP1
multiple C2 domains, transmembrane 1
chr1_-_197173159 4.608 LOC100131234
familial acute myelogenous leukemia related factor
chr3_+_69895310 4.558 NM_001184967
MITF
microphthalmia-associated transcription factor
chr14_+_69306019 4.495 SRSF5
serine/arginine-rich splicing factor 5
chr18_+_19826734 4.450 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr5_+_36642213 4.425 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr5_+_36642424 4.415 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_95231933 4.409 NM_013451
NM_133337
MYOF

myoferlin

chr11_+_5667494 4.349 NM_006074
TRIM22
tripartite motif containing 22
chr13_-_40491405 4.343 ELF1
E74-like factor 1 (ets domain transcription factor)
chr15_+_91244563 4.340 CHD2
chromodomain helicase DNA binding protein 2
chr3_-_152517204 4.224 NM_023915
GPR87
G protein-coupled receptor 87
chr15_+_91244422 4.222 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr13_-_40491491 4.193 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr4_-_83566246 4.185 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr22_+_27998367 4.082 EWSR1
Ewing sarcoma breakpoint region 1
chr11_+_128067598 4.076 NM_001167681
FLI1
Friend leukemia virus integration 1
chr1_-_89261021 4.007 NM_018284
GBP3
guanylate binding protein 3
chr10_-_32707549 3.938 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr5_-_88155360 3.893 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr12_-_101036407 3.889 NM_024057
NUP37
nucleoporin 37kDa
chr12_-_48902692 3.888 NM_001113547
LIMA1
LIM domain and actin binding 1
chr1_-_114215768 3.832 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr11_+_5667392 3.799 TRIM22
tripartite motif containing 22
chr11_-_104421240 3.688 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr4_+_160408447 3.665 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr7_+_18501876 3.629 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr4_-_38710376 3.620 NM_024943
TMEM156
transmembrane protein 156
chr2_-_175170674 3.593 WIPF1
WAS/WASL interacting protein family, member 1
chr11_-_104411065 3.515 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr12_+_14429499 3.507 ATF7IP
activating transcription factor 7 interacting protein
chr4_-_90197140 3.473 NM_014883
FAM13A
family with sequence similarity 13, member A
chr7_-_30032649 3.421 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr13_-_34948758 3.364 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr22_-_34566210 3.359 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_-_188021117 3.357 NM_005795
CALCRL
calcitonin receptor-like
chr8_-_120720200 3.357 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr22_-_34566367 3.338 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr8_-_108579270 3.330 NM_001146
ANGPT1
angiopoietin 1
chr3_-_152585226 3.288 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr4_+_86918870 3.286 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr11_-_83071084 3.281 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr1_+_81544432 3.273 LPHN2
latrophilin 2
chr12_+_9871343 3.259 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr10_-_64698831 3.238 NM_004241
JMJD1C
jumonji domain containing 1C
chr12_-_9804682 3.228 NM_001781
CD69
CD69 molecule
chr22_-_34566276 3.186 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr16_+_11966464 3.173 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr5_+_162862808 3.169 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr1_+_165564904 3.127 NM_001198783
POU2F1
POU class 2 homeobox 1
chr6_-_33016561 3.078 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr13_-_40454188 3.069 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_214663360 3.050 NM_007123
NM_206933
USH2A

Usher syndrome 2A (autosomal recessive, mild)

chr2_-_144994038 3.028 ZEB2
zinc finger E-box binding homeobox 2
chr1_+_84540921 3.027 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr3_-_11598829 3.018 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr7_+_90177082 3.014 CDK14
cyclin-dependent kinase 14
chr2_-_158008763 2.998 NM_004288
CYTIP
cytohesin 1 interacting protein
chr4_-_152366970 2.967 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr8_-_28403652 2.961 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr9_-_116920232 2.950 NM_002160
TNC
tenascin C
chr6_-_56824672 2.948 DST
dystonin
chr3_+_2528272 2.946 CNTN4
contactin 4
chr3_-_71262426 2.896 FOXP1
forkhead box P1
chr14_+_51025604 2.889 NM_001042481
FRMD6
FERM domain containing 6
chr16_+_10878539 2.871 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr11_-_58099884 2.858 NM_004811
LPXN
leupaxin
chr4_+_86918882 2.852 ARHGAP24
Rho GTPase activating protein 24
chr3_+_29297806 2.839 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr3_+_190831909 2.839 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr5_-_75954807 2.826 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr4_+_75393053 2.822 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr5_+_147775652 2.817 FBXO38
F-box protein 38
chr6_-_139654807 2.801 NM_153235
TXLNB
taxilin beta
chr9_-_19368815 2.774 RPS6
ribosomal protein S6
chr1_+_13903936 2.771 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr1_+_202033273 2.764 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr3_-_71262405 2.760 FOXP1
forkhead box P1
chr2_-_162808123 2.756 NM_004460
FAP
fibroblast activation protein, alpha
chr12_-_52939584 2.750 NM_001127322
CBX5
chromobox homolog 5
chr5_-_88215034 2.743 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr5_+_40877053 2.715 NM_032587
CARD6
caspase recruitment domain family, member 6
chr1_-_205012348 2.694 NM_000572
IL10
interleukin 10
chr17_-_43977273 2.657 NM_002145
HOXB2
homeobox B2
chr3_-_115585178 2.656 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr4_-_153820535 2.655 NM_152680
TMEM154
transmembrane protein 154
chr12_-_52939636 2.647 NM_001127321
CBX5
chromobox homolog 5
chr6_+_34314545 2.624 NM_145905
HMGA1
high mobility group AT-hook 1
chr5_-_94443300 2.605 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr7_-_81237162 2.593 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr10_+_63478974 2.576 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_-_52281050 2.567 NM_001130059
ATF7
activating transcription factor 7
chr1_-_21373816 2.557 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr3_+_179736917 2.546 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr6_+_83129641 2.544 NM_006670
TPBG
trophoblast glycoprotein
chr6_+_121798443 2.542 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr6_+_32515596 2.535 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr11_+_57285809 2.496 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr4_-_138673014 2.478 PCDH18
protocadherin 18
chr1_+_198263352 2.469 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr4_-_152368492 2.438 SH3D19
SH3 domain containing 19
chr13_+_23042722 2.424 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr6_-_33862690 2.415 NM_001143944
LEMD2
LEM domain containing 2
chrX_+_28515479 2.400 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr1_+_78243181 2.398 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr12_+_9713472 2.397 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chrX_-_30505804 2.382 NM_025159
CXorf21
chromosome X open reading frame 21
chr7_-_26198673 2.379 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr3_+_153468518 2.372 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr7_-_76667045 2.365 NM_006682
FGL2
fibrinogen-like 2
chr5_-_98290117 2.362 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr14_+_66901237 2.349 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr7_-_112545840 2.346 LOC401397
hypothetical LOC401397
chr14_+_101346032 2.327 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr7_+_113853790 2.324 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr3_+_179759181 2.324 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr3_+_142587973 2.315


chr3_+_123256902 2.312 NM_175862
CD86
CD86 molecule
chr11_+_65026382 2.292


chr1_-_89303478 2.276 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr3_-_145049853 2.244 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr7_-_41709191 2.235 NM_002192
INHBA
inhibin, beta A
chr3_+_157877146 2.224 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr4_-_83566045 2.192


chr20_+_56912146 2.180 GNAS
GNAS complex locus
chr11_+_65023556 2.178


chr7_-_137271191 2.172 CREB3L2
cAMP responsive element binding protein 3-like 2
chr5_-_124108672 2.164 NM_020747
ZNF608
zinc finger protein 608
chr10_+_118177371 2.160 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr2_-_213723298 2.158 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr21_-_41140908 2.156 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr1_+_169421011 2.148 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr6_-_56824371 2.146 DST
dystonin
chr4_+_109763119 2.125 RPL34
ribosomal protein L34
chr11_+_59979857 2.109 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr4_+_106851415 2.106 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr3_+_138132006 2.104 NM_001190796
NCK1
NCK adaptor protein 1
chr5_+_68703036 2.102 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr7_-_83662152 2.101 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr13_-_74799898 2.090 TBC1D4
TBC1 domain family, member 4
chr13_+_96672705 2.089 MBNL2
muscleblind-like 2 (Drosophila)
chr12_+_97513644 2.082 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr1_+_86662356 2.069 NM_006536
CLCA2
chloride channel accessory 2
chr3_-_15814678 2.067 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr2_-_44440358 2.066 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr2_-_191580567 2.060 STAT1
signal transducer and activator of transcription 1, 91kDa
chr4_+_77575276 2.056 NM_020859
SHROOM3
shroom family member 3
chr7_-_107667728 2.049 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr17_-_44026042 2.049 NM_002147
HOXB5
homeobox B5
chr1_+_165565006 2.043 POU2F1
POU class 2 homeobox 1
chr7_-_83116414 2.043 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr7_-_28186867 2.039 NM_175061
JAZF1
JAZF zinc finger 1
chr7_-_87180499 2.036 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr17_-_60439764 2.034 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr7_+_18515488 2.031 HDAC9
histone deacetylase 9
chr16_-_21221872 2.005 NM_001014444
NM_001888
CRYM

crystallin, mu

chr13_+_47948586 1.996 RB1
retinoblastoma 1
chr13_+_51933228 1.986 CKAP2
cytoskeleton associated protein 2
chr21_-_35174742 1.977 RUNX1
runt-related transcription factor 1
chr20_+_42644633 1.971 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr13_-_37070862 1.949 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr7_+_18515440 1.943 HDAC9
histone deacetylase 9
chr4_-_38534802 1.942 NM_006068
TLR6
toll-like receptor 6
chr2_-_215711313 1.937 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr2_-_160764819 1.935 NM_000888
ITGB6
integrin, beta 6
chr12_+_15590811 1.935 PTPRO
protein tyrosine phosphatase, receptor type, O
chr11_-_76058542 1.934 NM_005512
LRRC32
leucine rich repeat containing 32
chr6_-_76259976 1.925 NM_015687
FILIP1
filamin A interacting protein 1
chr8_-_42742729 1.913 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr17_-_1195096 1.901 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr3_+_133798770 1.898 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr8_-_99906944 1.892 NM_006281
STK3
serine/threonine kinase 3
chr1_-_148936123 1.892 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr9_-_4656665 1.834 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr2_+_108604111 1.833 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr21_-_14840506 1.828 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr15_-_64582049 1.822 RPL4
ribosomal protein L4
chr1_-_68470585 1.822 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr2_-_231697999 1.809 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr7_+_90176647 1.808 NM_012395
CDK14
cyclin-dependent kinase 14
chr15_-_97607108 1.807 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr11_+_65027721 1.803


chr3_+_171560104 1.803 NM_001145097
SKIL
SKI-like oncogene

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.65 1.02e-02 GO:0045111 intermediate filament cytoskeleton
1.69 1.23e-02 GO:0005882 intermediate filament
1.96 4.24e-02 GO:0045095 keratin filament

Nothing significant found in function category.