Motif ID: TFAP4.p2

Z-value: 1.777


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)



Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_154873344 2.620 CNKSR3
CNKSR family member 3
chr6_-_154873480 2.237 CNKSR3
CNKSR family member 3
chr1_-_21868380 2.016 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr5_+_176726918 1.962 RGS14
regulator of G-protein signaling 14
chr9_+_133154896 1.854 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr4_+_4912272 1.800 NM_002448
MSX1
msh homeobox 1
chr9_+_139292094 1.670 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr6_-_154873396 1.644 NM_173515
CNKSR3
CNKSR family member 3
chr1_-_925332 1.525 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr16_-_87405817 1.490 NM_000485
NM_001030018
APRT

adenine phosphoribosyltransferase

chr17_+_78286687 1.363 NM_022158
FN3K
fructosamine 3 kinase
chr12_+_56135353 1.355 NM_031479
INHBE
inhibin, beta E
chr22_-_20235372 1.284 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr11_-_47427263 1.261 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr11_+_74629597 1.250 NM_001195528
LOC441617
hypothetical LOC441617
chr6_-_35804337 1.243 NM_001145775
FKBP5
FK506 binding protein 5
chr12_+_54361685 1.225 METTL7B
methyltransferase like 7B
chr7_-_158073121 1.220 NM_002847
NM_130842
NM_130843
PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr22_+_19649417 1.216 NM_001018060
NM_144704
AIFM3

apoptosis-inducing factor, mitochondrion-associated, 3

chr12_+_52105131 1.182 AMHR2
anti-Mullerian hormone receptor, type II
chr12_+_106236281 1.174 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr19_-_60412624 1.172 NM_001161440
NM_002842
PTPRH

protein tyrosine phosphatase, receptor type, H

chr19_-_54350457 1.153 NM_002152
HRC
histidine rich calcium binding protein
chr12_+_54361596 1.088 NM_152637
METTL7B
methyltransferase like 7B
chr17_+_14145051 1.083 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr6_+_37245860 1.053 NM_002648
PIM1
pim-1 oncogene
chr22_+_20068039 1.049 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr3_+_127725851 1.042 NM_152889
CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr6_+_43565192 0.996 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr19_+_21056792 0.995 NM_182515
ZNF714
zinc finger protein 714
chr8_-_145187553 0.994 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr3_-_9786623 0.990 CAMK1
calcium/calmodulin-dependent protein kinase I
chr8_-_88955340 0.988 NM_152418
DCAF4L2
DDB1 and CUL4 associated factor 4-like 2
chr19_-_60350122 0.985 TNNT1
troponin T type 1 (skeletal, slow)
chr12_+_79995927 0.977 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr13_+_112704077 0.977 MCF2L
MCF.2 cell line derived transforming sequence-like
chr21_-_44836811 0.976 NM_198688
KRTAP10-6
keratin associated protein 10-6
chr4_-_977163 0.968 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr2_-_20075889 0.946 MATN3
matrilin 3
chr1_-_218168137 0.940 SLC30A10
solute carrier family 30, member 10
chr2_-_20075929 0.935 NM_002381
MATN3
matrilin 3
chr3_-_12983959 0.931 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr3_-_195553297 0.929 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr13_+_112704028 0.927 MCF2L
MCF.2 cell line derived transforming sequence-like
chr16_+_170334 0.923 NM_005331
HBQ1
hemoglobin, theta 1
chr3_-_9786583 0.922 CAMK1
calcium/calmodulin-dependent protein kinase I
chr6_+_45498354 0.916 RUNX2
runt-related transcription factor 2
chr8_-_145090892 0.907 NM_201381
PLEC
plectin
chr2_+_70981233 0.903 VAX2
ventral anterior homeobox 2
chr13_+_112704051 0.902 MCF2L
MCF.2 cell line derived transforming sequence-like
chr2_+_70981223 0.901 NM_012476
VAX2
ventral anterior homeobox 2
chr16_+_30903963 0.895 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr2_-_220144511 0.894 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr1_-_42978320 0.890 NM_001123395
NM_001185117
NM_148960
CLDN19


claudin 19


chr19_-_48835783 0.889 NM_145296
CADM4
cell adhesion molecule 4
chr2_+_43919606 0.886 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr16_+_51690564 0.877 CHD9
chromodomain helicase DNA binding protein 9
chr2_+_128119908 0.875 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr1_-_39871226 0.874 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr8_+_104452877 0.870 CTHRC1
collagen triple helix repeat containing 1
chr19_+_1236766 0.858 NM_001405
EFNA2
ephrin-A2
chr19_+_10392128 0.855 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr3_-_9786628 0.849 NM_003656
CAMK1
calcium/calmodulin-dependent protein kinase I
chr1_+_26220852 0.844 NM_004455
EXTL1
exostoses (multiple)-like 1
chr11_+_67534364 0.837 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chrX_+_117993342 0.831 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr11_+_70915960 0.826 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr16_-_65984836 0.824 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr2_-_220144427 0.820 OBSL1
obscurin-like 1
chr7_+_100037817 0.813 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr11_-_65395248 0.809 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr9_-_139042416 0.807 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr11_+_67534371 0.799 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr5_-_148738980 0.795 NM_014443
IL17B
interleukin 17B
chr13_-_78075683 0.793 NM_006237
POU4F1
POU class 4 homeobox 1
chr17_-_36346240 0.791 KRT23
keratin 23 (histone deacetylase inducible)
chr22_+_24468168 0.791 MYO18B
myosin XVIIIB
chrX_+_152562013 0.782 DUSP9
dual specificity phosphatase 9
chr17_-_202617 0.780 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr1_+_55277795 0.774 PCSK9
proprotein convertase subtilisin/kexin type 9
chr1_+_55277736 0.772 NM_174936
PCSK9
proprotein convertase subtilisin/kexin type 9
chr1_+_43769065 0.765 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr16_+_66244314 0.763 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr9_-_135593265 0.760 NM_001134707
SARDH
sarcosine dehydrogenase
chr1_-_155095289 0.757 NM_014215
INSRR
insulin receptor-related receptor
chr17_-_202557 0.756 RPH3AL
rabphilin 3A-like (without C2 domains)
chr20_-_61933012 0.747 ZBTB46
zinc finger and BTB domain containing 46
chr9_+_115265827 0.739 NM_017790
RGS3
regulator of G-protein signaling 3
chr11_-_44288188 0.736 NM_021926
ALX4
ALX homeobox 4
chr2_-_220144254 0.735 OBSL1
obscurin-like 1
chr1_-_182273114 0.734 GLT25D2
glycosyltransferase 25 domain containing 2
chr14_+_102636233 0.733 NM_001077594
EXOC3L4
exocyst complex component 3-like 4
chr17_+_38259620 0.731 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr19_+_11510578 0.727 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr21_+_42697058 0.726 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr19_-_60350118 0.725 TNNT1
troponin T type 1 (skeletal, slow)
chr20_+_61842880 0.724 SLC2A4RG
SLC2A4 regulator
chr1_+_17817397 0.723 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr7_+_44045202 0.722 FLJ35390
hypothetical LOC255031
chr16_+_620932 0.722 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr16_-_4106022 0.716 ADCY9
adenylate cyclase 9
chr11_-_75599433 0.716 WNT11
wingless-type MMTV integration site family, member 11
chr1_+_16203317 0.714 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr8_+_97575370 0.713 SDC2
syndecan 2
chr16_+_29378694 0.712 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr8_+_21968375 0.712 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr15_-_63502438 0.711 NM_020962
IGDCC4
immunoglobulin superfamily, DCC subclass, member 4
chr19_-_11355882 0.710 NM_000121
EPOR
erythropoietin receptor
chr17_+_77453363 0.709 NM_148896
NPB
neuropeptide B
chr1_+_3378030 0.706 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr22_-_37569679 0.702


chr8_-_38127489 0.696 NM_000349
STAR
steroidogenic acute regulatory protein
chr8_+_110443881 0.694 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr4_+_3737872 0.693 ADRA2C
adrenergic, alpha-2C-, receptor
chr12_+_119900931 0.688 NM_000545
HNF1A
HNF1 homeobox A
chr1_+_238321794 0.687 NM_020066
FMN2
formin 2
chr8_+_21968273 0.686 NM_001114136
NM_001114139
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr1_-_27113018 0.684 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr6_+_32230172 0.681 PPT2
palmitoyl-protein thioesterase 2
chr1_+_26220895 0.680 EXTL1
exostoses (multiple)-like 1
chr2_-_174538197 0.679 SP3
Sp3 transcription factor
chr2_-_43919392 0.679 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr19_-_41191423 0.678 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr8_+_98857190 0.676 LAPTM4B
lysosomal protein transmembrane 4 beta
chr11_-_106394039 0.669 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr1_-_225572419 0.668 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr15_-_35180656 0.667 NM_002399
MEIS2
Meis homeobox 2
chr3_-_10027770 0.667 NM_001008737
LOC401052
hypothetical LOC401052
chr1_-_925215 0.666 HES4
hairy and enhancer of split 4 (Drosophila)
chr6_+_160310118 0.665 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr1_+_159435728 0.663 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr8_-_145099963 0.660 NM_201379
PLEC
plectin
chr19_-_3557801 0.660 NM_001060
NM_201636
TBXA2R

thromboxane A2 receptor

chrX_-_153290697 0.658 NM_006730
DNASE1L1
deoxyribonuclease I-like 1
chr6_+_32114060 0.657 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr1_-_39877928 0.656 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr10_-_61139328 0.653 NM_194298
LOC100129721
SLC16A9
hypothetical protein LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr16_-_21197138 0.650 CRYM
crystallin, mu
chr11_-_118693021 0.648 NM_006500
MCAM
melanoma cell adhesion molecule
chr2_-_65512619 0.645 SPRED2
sprouty-related, EVH1 domain containing 2
chr17_-_36577949 0.640 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr11_+_43920385 0.637 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr7_-_16427471 0.632 NM_001101417
NM_001101426
ISPD

isoprenoid synthase domain containing

chr22_+_19649460 0.629 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr7_+_88226617 0.629 NM_181646
ZNF804B
zinc finger protein 804B
chr12_+_108636569 0.626 NM_032829
C12orf34
chromosome 12 open reading frame 34
chr14_+_23937766 0.622 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr1_+_148788410 0.620 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr22_-_19122047 0.619 SCARF2
scavenger receptor class F, member 2
chr6_-_168219380 0.618 NM_001122841
FRMD1
FERM domain containing 1
chr2_-_74634569 0.617 NM_032603
LOXL3
lysyl oxidase-like 3
chr12_+_88626770 0.617 LOC338758
hypothetical LOC338758
chr1_+_1360765 0.614 NM_022834
NM_199121
VWA1

von Willebrand factor A domain containing 1

chr11_-_66945190 0.613 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr1_-_39877883 0.612 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr14_+_99859427 0.610 NM_207117
SLC25A47
solute carrier family 25, member 47
chr8_-_41774296 0.609 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr6_-_15771239 0.608 NM_032122
NM_183040
DTNBP1

dystrobrevin binding protein 1

chr2_+_11597530 0.607 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr14_-_22521544 0.605 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr14_+_102672745 0.604 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr8_-_142307854 0.604 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr17_+_38256886 0.602


chr1_+_246087230 0.601 TRIM58
tripartite motif containing 58
chr7_+_100515439 0.601 NM_030961
TRIM56
tripartite motif containing 56
chr20_+_3399615 0.600 NM_139321
NM_139322
ATRN

attractin

chr19_+_40224480 0.600 HPN
hepsin
chr1_-_33110668 0.597 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr1_-_75854281 0.596 SLC44A5
solute carrier family 44, member 5
chr17_+_38256710 0.595 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr12_-_107257205 0.595 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chr19_-_18867868 0.594 NM_021267
NM_198207
NM_001492
LASS1

GDF1
LAG1 homolog, ceramide synthase 1

growth differentiation factor 1
chr10_-_118419459 0.594 NM_144661
C10orf82
chromosome 10 open reading frame 82
chr16_+_68765428 0.590 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr19_-_55156118 0.588 NM_001135163
NM_052884
SIGLEC11

sialic acid binding Ig-like lectin 11

chr1_+_54132447 0.585 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr9_-_138958889 0.584 FBXW5
F-box and WD repeat domain containing 5
chr5_+_129268352 0.584 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr10_+_80498782 0.580 NM_020338
ZMIZ1
zinc finger, MIZ-type containing 1
chr1_-_149611768 0.579 NM_003944
SELENBP1
selenium binding protein 1
chr19_-_40696393 0.577 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr2_+_218896219 0.576 PNKD
paroxysmal nonkinesigenic dyskinesia
chr1_-_151848039 0.574 S100A16
S100 calcium binding protein A16
chr17_+_25910709 0.574 NM_015594
TBC1D29
TBC1 domain family, member 29
chr22_+_19699441 0.570 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr1_-_6585268 0.569 KLHL21
kelch-like 21 (Drosophila)
chr22_+_22445035 0.565 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr9_-_128924819 0.563 NM_012098
ANGPTL2
angiopoietin-like 2
chr3_+_124268545 0.560 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr10_+_134108643 0.558 NM_173541
C10orf91
chromosome 10 open reading frame 91
chr17_-_77488258 0.558 NM_006907
NM_153824
PYCR1

pyrroline-5-carboxylate reductase 1

chr22_+_17539198 0.558


chr6_-_15771077 0.554 DTNBP1
dystrobrevin binding protein 1
chr16_-_21197072 0.552 CRYM
crystallin, mu
chr2_+_171381317 0.552 NM_000817
NM_013445
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr16_+_66120205 0.552 NM_024519
NM_001193522
FAM65A

family with sequence similarity 65, member A

chr11_-_310925 0.550 IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr14_+_20608179 0.549 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr12_+_112344529 0.548 NM_138432
SDSL
serine dehydratase-like
chr1_+_226937732 0.548 RHOU
ras homolog gene family, member U

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 1.64e-02 GO:0023052 signaling

Nothing significant found in compartment category.

Nothing significant found in function category.