Motif ID: FOXO1,3,4.p2

Z-value: 1.172


Transcription factors associated with FOXO1,3,4.p2:

Gene SymbolEntrez IDGene Name
FOXO1 2308 forkhead box O1
FOXO3 2309 forkhead box O3
FOXO4 4303 forkhead box O4



Activity profile for motif FOXO1,3,4.p2.

activity profile for motif FOXO1,3,4.p2


Sorted Z-values histogram for motif FOXO1,3,4.p2

Sorted Z-values for motif FOXO1,3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO1,3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_27099138 2.154 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr5_-_58607673 2.070 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_59100194 2.050 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_32578513 1.955 FGD4
FYVE, RhoGEF and PH domain containing 4
chr16_+_54070302 1.892 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr3_+_171621721 1.860 NM_001185056
CLDN11
claudin 11
chr6_-_152744143 1.838 SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_+_162795538 1.809 PBX1
pre-B-cell leukemia homeobox 1
chr7_+_134114957 1.760 CALD1
caldesmon 1
chr4_-_152368492 1.712 SH3D19
SH3 domain containing 19
chr10_+_86174665 1.641 FAM190B
family with sequence similarity 190, member B
chrX_-_19598912 1.520 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr8_-_13178399 1.466 DLC1
deleted in liver cancer 1
chr13_-_37341859 1.428 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr2_-_192419896 1.330 SDPR
serum deprivation response
chr3_+_100840129 1.318 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr8_-_13178327 1.312


chr13_-_98428244 1.292 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr9_-_16717887 1.264 BNC2
basonuclin 2
chrX_+_28515479 1.263 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr9_+_74956614 1.254 ANXA1
annexin A1
chr5_+_66160359 1.250 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr2_-_162808123 1.242 NM_004460
FAP
fibroblast activation protein, alpha
chr4_-_186934059 1.208 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr3_-_150569574 1.202 TM4SF1
transmembrane 4 L six family member 1
chr3_-_150533948 1.168 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr8_-_93144366 1.165 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr8_-_6407882 1.074 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr1_+_161308318 1.070 NM_001113380
RGS4
regulator of G-protein signaling 4
chr17_-_64649608 1.061 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr6_-_152744022 1.056 SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_-_170346760 1.034 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr4_-_159311959 1.030 FAM198B
family with sequence similarity 198, member B
chr16_+_54072969 1.022 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr8_+_70567634 1.013 SULF1
sulfatase 1
chr3_+_62280435 1.002 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr16_+_68516401 1.001 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr9_+_102231616 0.990 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr2_-_192420168 0.974 NM_004657
SDPR
serum deprivation response
chr9_+_119506428 0.965 TLR4
toll-like receptor 4
chr3_-_170347019 0.936 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr6_-_48186868 0.933 C6orf138
chromosome 6 open reading frame 138
chr9_+_119506446 0.930 TLR4
toll-like receptor 4
chr6_+_121798443 0.922 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_+_162795328 0.918 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr7_-_95063738 0.895 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr18_-_20105900 0.887 OSBPL1A
oxysterol binding protein-like 1A
chr7_+_134114912 0.887 CALD1
caldesmon 1
chr6_-_46997579 0.885 NM_001098518
GPR116
G protein-coupled receptor 116
chr7_-_124192265 0.878 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr9_+_119506274 0.877 NM_138554
TLR4
toll-like receptor 4
chr5_-_42847716 0.867 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chrX_+_12066505 0.867 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr3_+_156280497 0.866 MME
membrane metallo-endopeptidase
chr5_-_125956996 0.854 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr3_+_156280539 0.848 MME
membrane metallo-endopeptidase
chr9_-_94226380 0.821 NM_005014
OMD
osteomodulin
chr6_-_131333173 0.808 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr8_+_19215279 0.804 NM_001174160
NM_022071
NM_001174159
SH2D4A


SH2 domain containing 4A


chr2_+_169367345 0.798 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr11_-_85115105 0.787 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr9_+_74956601 0.778 ANXA1
annexin A1
chr3_+_156280604 0.764 NM_007288
MME
membrane metallo-endopeptidase
chr12_-_10142779 0.763 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr7_-_87180499 0.763 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr10_+_123912930 0.747 TACC2
transforming, acidic coiled-coil containing protein 2
chr20_+_44771532 0.745 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr18_-_20106187 0.745 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr12_-_69317441 0.740 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr4_+_134292630 0.735 PCDH10
protocadherin 10
chr1_+_20788027 0.732 NM_001785
CDA
cytidine deaminase
chr4_-_107508040 0.724 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr1_-_24342158 0.721 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr12_-_23995109 0.720 SOX5
SRY (sex determining region Y)-box 5
chr4_-_155731288 0.719 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr3_+_133518900 0.716 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr12_+_55201854 0.714 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr11_+_113436438 0.709 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr3_-_71262426 0.707 FOXP1
forkhead box P1
chr3_-_71262405 0.703 FOXP1
forkhead box P1
chr2_+_138438277 0.701 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr6_-_128281434 0.699 NM_001164687
THEMIS
thymocyte selection associated
chr11_+_101488380 0.698 NM_001195045
YAP1
Yes-associated protein 1
chr1_-_7998265 0.698 ERRFI1
ERBB receptor feedback inhibitor 1
chr3_-_71376919 0.695 FOXP1
forkhead box P1
chr7_+_111908143 0.694 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr14_+_101345878 0.690 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr5_+_40877053 0.690 NM_032587
CARD6
caspase recruitment domain family, member 6
chr9_-_8723893 0.684 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr2_+_166034402 0.672 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr3_+_133518966 0.670 ACPP
acid phosphatase, prostate
chr1_+_86662356 0.669 NM_006536
CLCA2
chloride channel accessory 2
chr4_+_120167264 0.667 SYNPO2
synaptopodin 2
chr5_+_36644187 0.663 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_64709063 0.661 NM_020925
CACHD1
cache domain containing 1
chr8_-_133841988 0.658 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr8_+_70567581 0.651 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr2_+_33514896 0.646 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr9_-_36266930 0.645 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr4_+_86918870 0.636 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr17_-_64568641 0.624 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr10_+_82163568 0.613 C10orf58
chromosome 10 open reading frame 58
chr11_+_36572615 0.613 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr1_-_120155581 0.607 NM_001159352
NM_001159353
NM_032044
REG4


regenerating islet-derived family, member 4


chr1_+_144236398 0.604 ITGA10
integrin, alpha 10
chr6_+_153060722 0.604 NM_025107
MYCT1
myc target 1
chr12_-_23995220 0.600 SOX5
SRY (sex determining region Y)-box 5
chr2_-_215951161 0.590 FN1
fibronectin 1
chr3_+_156280772 0.589 NM_007289
MME
membrane metallo-endopeptidase
chr9_+_74956494 0.586 NM_000700
ANXA1
annexin A1
chr9_+_696744 0.585 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr2_+_201756048 0.581 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr1_-_199732323 0.581 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr17_-_15495534 0.579 TRIM16
tripartite motif containing 16
chr18_+_64616296 0.577 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr6_-_127822227 0.577 NM_014702
KIAA0408
KIAA0408
chr6_-_112682573 0.574 LAMA4
laminin, alpha 4
chr8_+_38704860 0.572 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr2_+_211050653 0.570 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr10_+_91077581 0.570 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr5_+_140160966 0.568 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr8_+_67096344 0.568 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr4_-_90197140 0.566 NM_014883
FAM13A
family with sequence similarity 13, member A
chr17_-_36570508 0.566 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr13_-_47885018 0.564 LPAR6
lysophosphatidic acid receptor 6
chr19_-_54557450 0.564 NM_003598
TEAD2
TEA domain family member 2
chr14_-_74669864 0.562 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr6_+_168161401 0.562 NM_005355
NM_030615
KIF25

kinesin family member 25

chr2_-_189752575 0.561 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_+_144236346 0.559 NM_003637
ITGA10
integrin, alpha 10
chr3_-_58497913 0.558 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr6_+_112481970 0.557 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr13_-_47885248 0.556 LPAR6
lysophosphatidic acid receptor 6
chr10_-_29963847 0.547


chr13_-_85271329 0.547 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr8_+_12847521 0.547 NM_020844
KIAA1456
KIAA1456
chr8_+_40130143 0.546 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr6_-_56615544 0.543 NM_001723
NM_015548
DST

dystonin

chr15_+_30721161 0.539 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr4_+_86968069 0.534 ARHGAP24
Rho GTPase activating protein 24
chr4_+_86918882 0.531 ARHGAP24
Rho GTPase activating protein 24
chr17_-_51164443 0.528 NM_001099640
TMEM100
transmembrane protein 100
chr18_+_45342398 0.524 NM_006033
LIPG
lipase, endothelial
chr1_+_169421011 0.523 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr2_-_165133239 0.521 GRB14
growth factor receptor-bound protein 14
chr3_+_42176662 0.521 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr12_-_50871953 0.521 NM_001081492
NM_182507
KRT80

keratin 80

chr12_-_55990512 0.520 NM_014925
R3HDM2
R3H domain containing 2
chr17_+_3326045 0.520 NM_000049
ASPA
aspartoacylase
chr12_+_50633430 0.519 NM_020327
ACVR1B
activin A receptor, type IB
chr8_-_130868315 0.518 NM_031415
GSDMC
gasdermin C
chr9_+_129900637 0.511 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr4_+_35962038 0.507 NM_001170700
DTHD1
death domain containing 1
chr1_+_19807168 0.503


chr2_+_36777336 0.503 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr1_+_221168388 0.501 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr6_-_29081015 0.499 NM_001010877
ZNF311
zinc finger protein 311
chr2_-_183439515 0.495 NM_001463
FRZB
frizzled-related protein
chr12_+_119224506 0.494 NM_012240
SIRT4
sirtuin 4
chr6_-_105734535 0.492 NM_022361
POPDC3
popeye domain containing 3
chr1_-_148936123 0.491 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr9_+_12764988 0.487 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr13_-_35818491 0.486 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr6_+_62341966 0.484 NM_001190706
MTRNR2L9
MT-RNR2-like 9
chr14_+_101346032 0.482 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr12_+_12935222 0.481 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr1_-_159474503 0.478 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr9_-_14303509 0.478 NFIB
nuclear factor I/B
chr6_-_112682459 0.476 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr4_-_21559471 0.475 NM_147182
KCNIP4
Kv channel interacting protein 4
chr2_-_40510923 0.475 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr13_-_35818396 0.474 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr5_+_178419938 0.472 NM_014594
ZNF354C
zinc finger protein 354C
chr7_-_13997574 0.470 NM_001163148
ETV1
ets variant 1
chr22_+_31526801 0.470 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr3_+_139550368 0.469 MRAS
muscle RAS oncogene homolog
chr20_-_7869068 0.464 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr9_+_129900590 0.463 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr6_+_123152044 0.460 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr1_+_195503956 0.460 NM_001193640
NM_201253
CRB1

crumbs homolog 1 (Drosophila)

chr7_+_120416103 0.457 C7orf58
chromosome 7 open reading frame 58
chr7_-_94902149 0.454 NM_000305
NM_001018161
PON2

paraoxonase 2

chr1_-_56817568 0.453 PPAP2B
phosphatidic acid phosphatase type 2B
chr9_-_109291575 0.451 KLF4
Kruppel-like factor 4 (gut)
chr16_+_2025922 0.449 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr5_-_125958503 0.446 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr5_-_64955905 0.446 NM_001656
NM_033227
NM_033228
TRIM23


tripartite motif containing 23


chr13_-_37070862 0.443 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr22_-_15682555 0.440 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr12_-_118725672 0.439 CIT
citron (rho-interacting, serine/threonine kinase 21)
chr2_-_180135559 0.438 NM_001113398
ZNF385B
zinc finger protein 385B
chr2_-_217267742 0.436 IGFBP5
insulin-like growth factor binding protein 5
chr15_-_100280784 0.434 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr2_-_21079145 0.433 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_242073094 0.432 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr11_+_834445 0.429 NM_001025237
TSPAN4
tetraspanin 4
chr1_-_166373434 0.423 GPR161
G protein-coupled receptor 161
chr13_+_92677012 0.419 NM_005708
GPC6
glypican 6
chr9_+_74110149 0.419


chr5_+_64956313 0.418 NM_001093755
NM_001093756
NM_024941
C5orf44


chromosome 5 open reading frame 44



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.79 3.69e-03 GO:0007608 sensory perception of smell
1.69 1.46e-02 GO:0007606 sensory perception of chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.42 4.93e-03 GO:0044420 extracellular matrix part
2.75 1.48e-02 GO:0005604 basement membrane
2.06 1.54e-02 GO:0005882 intermediate filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.79 1.43e-03 GO:0004984 olfactory receptor activity