Motif ID: HMGA1,2.p2

Z-value: 1.403


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2



Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_89257569 3.407 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr7_-_16471817 3.394 NM_015464
SOSTDC1
sclerostin domain containing 1
chr12_+_97513644 3.347 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr3_+_123526700 2.836 NM_005213
CSTA
cystatin A (stefin A)
chr22_-_41685827 2.695 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr7_+_143043871 2.659 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr11_-_5130174 2.516 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr14_-_19867372 2.482 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr7_-_112545840 2.465 LOC401397
hypothetical LOC401397
chr4_+_170817787 2.463 CLCN3
chloride channel 3
chr1_-_143708467 2.445 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr7_-_112545847 2.437 LOC401397
hypothetical LOC401397
chr4_+_159350850 2.436 NM_018342
TMEM144
transmembrane protein 144
chr7_+_123036312 2.372 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr1_-_158815850 2.366 CD84
CD84 molecule
chr4_+_75393053 2.268 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr1_-_158815895 2.169 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr3_-_120761092 2.153 NM_005191
CD80
CD80 molecule
chr1_+_239762179 2.121 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr5_+_96237399 2.104 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr1_-_205272619 2.083 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr1_+_196874867 2.063 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_194887630 2.027 NM_000186
NM_001014975
CFH

complement factor H

chr20_-_45410033 1.991 ZMYND8
zinc finger, MYND-type containing 8
chr10_+_118177371 1.977 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chrX_+_73080887 1.964 NCRNA00183
non-protein coding RNA 183
chr4_+_75449720 1.939 NM_001432
EREG
epiregulin
chr8_+_26206648 1.929 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr9_+_74956601 1.929 ANXA1
annexin A1
chr6_+_147568795 1.912 STXBP5
syntaxin binding protein 5 (tomosyn)
chr8_+_107807415 1.859 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr8_+_107529327 1.851 NM_001198532
OXR1
oxidation resistance 1
chr13_-_48873735 1.850 NM_030925
CAB39L
calcium binding protein 39-like
chr7_+_116447499 1.843 ST7
suppression of tumorigenicity 7
chr14_-_62638336 1.791 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr6_-_43703024 1.787 GTPBP2
GTP binding protein 2
chr3_-_17757402 1.780 NM_014744
TBC1D5
TBC1 domain family, member 5
chr10_+_5976354 1.730 NM_032807
FBXO18
F-box protein, helicase, 18
chr7_-_48035169 1.725 NM_001030019
NM_152782
SUN3

Sad1 and UNC84 domain containing 3

chr10_-_5035967 1.697 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr2_+_165860528 1.684 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr3_-_42818221 1.680


chr2_-_232034638 1.673 NCL
nucleolin
chr9_+_74956614 1.656 ANXA1
annexin A1
chr7_-_20223467 1.651 NM_182762
MACC1
metastasis associated in colon cancer 1
chr6_-_43703057 1.647 GTPBP2
GTP binding protein 2
chr11_+_113671744 1.624 NM_006169
NNMT
nicotinamide N-methyltransferase
chr1_+_234624266 1.618 NM_145861
EDARADD
EDAR-associated death domain
chr2_-_157892391 1.602 NM_001009959
ERMN
ermin, ERM-like protein
chr2_+_161701711 1.590 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr12_-_101396459 1.566 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr2_+_157822355 1.565 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chrX_-_78509662 1.560 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr2_+_169637255 1.524 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_21310462 1.512 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr12_+_9713472 1.506 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr4_-_100070808 1.494 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr7_+_116447527 1.492 ST7
suppression of tumorigenicity 7
chr1_-_158948176 1.489 NM_001778
CD48
CD48 molecule
chrX_-_138742050 1.482 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr2_-_95846109 1.478 LOC150759
hypothetical LOC150759
chr3_-_152517204 1.447 NM_023915
GPR87
G protein-coupled receptor 87
chr10_+_70517863 1.441 SRGN
serglycin
chr4_-_40211324 1.439 RBM47
RNA binding motif protein 47
chr5_+_40877053 1.420 NM_032587
CARD6
caspase recruitment domain family, member 6
chr9_-_99740243 1.416 NM_197978
HEMGN
hemogen
chr18_+_3584056 1.412 FLJ35776
hypothetical LOC649446
chr10_+_74540215 1.408 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr17_-_72151314 1.407 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr4_-_74704964 1.403 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chrX_-_70243362 1.394 NM_001025265
CXorf65
chromosome X open reading frame 65
chr1_+_84539876 1.375 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr7_-_104696678 1.366 NM_182691
SRPK2
SRSF protein kinase 2
chr15_-_74091817 1.341 NM_138573
NRG4
neuregulin 4
chr7_-_13992351 1.331 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr10_+_70517823 1.327 NM_002727
SRGN
serglycin
chrX_+_65300803 1.314 NM_001130860
NM_014799
HEPH

hephaestin

chr12_-_8271460 1.302 NM_018088
FAM90A1
family with sequence similarity 90, member A1
chr6_-_68655708 1.297


chr10_-_5436781 1.292 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr9_+_74956494 1.290 NM_000700
ANXA1
annexin A1
chr2_+_165858586 1.289 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr9_+_126460511 1.285


chr2_-_158008763 1.276 NM_004288
CYTIP
cytohesin 1 interacting protein
chr3_+_115099007 1.276 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr1_-_158759606 1.268 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr3_-_152529999 1.263 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr16_-_21221872 1.256 NM_001014444
NM_001888
CRYM

crystallin, mu

chr6_+_126282078 1.245 NCOA7
nuclear receptor coactivator 7
chr3_+_171112053 1.232 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr20_+_56904042 1.228 GNAS
GNAS complex locus
chr3_-_15814678 1.227 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr4_-_139382672 1.224 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr2_-_65447267 1.221 SPRED2
sprouty-related, EVH1 domain containing 2
chrX_+_118598325 1.215 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr1_+_84540921 1.211 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr12_+_14429499 1.193 ATF7IP
activating transcription factor 7 interacting protein
chr19_+_45973139 1.190 NM_006533
MIA
melanoma inhibitory activity
chr19_-_6991183 1.188 NM_001164419
MBD3L4
methyl-CpG-binding domain protein 3-like 4-like
chr15_-_70350609 1.185 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr10_+_4995597 1.166 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr19_-_61431470 1.165 NM_024303
ZSCAN5A
zinc finger and SCAN domain containing 5A
chr1_-_160648429 1.164 NM_053282
SH2D1B
SH2 domain containing 1B
chr7_+_838663 1.160 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr2_+_151922350 1.155 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_+_196874759 1.144 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr2_+_158559936 1.142 NM_001135098
UPP2
uridine phosphorylase 2
chr11_-_5110383 1.133 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr5_-_64813459 1.123 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr1_+_151015471 1.119 NM_178354
LCE1F
late cornified envelope 1F
chr16_+_20682812 1.117 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr19_+_61624 1.109 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr13_-_35686665 1.107 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr6_-_119137923 1.106 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr1_+_185064654 1.104 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr11_+_67107852 1.101 GSTP1
glutathione S-transferase pi 1
chr6_-_29120930 1.096 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr6_-_42293564 1.094 MRPS10
mitochondrial ribosomal protein S10
chr3_-_191650291 1.094 NM_207316
TMEM207
transmembrane protein 207
chr4_+_100957003 1.094 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr22_-_39189369 1.085 MKL1
megakaryoblastic leukemia (translocation) 1
chr2_+_102401580 1.084 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr16_+_83349816 1.083 USP10
ubiquitin specific peptidase 10
chr13_+_96672705 1.081 MBNL2
muscleblind-like 2 (Drosophila)
chr12_-_53153613 1.074 GTSF1
gametocyte specific factor 1
chr10_-_11614279 1.072 NM_001080491
USP6NL
USP6 N-terminal like
chr10_+_35524060 1.071 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr12_+_46802695 1.069 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr11_+_65027721 1.064


chr2_-_65447370 1.061 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr1_+_78858675 1.058 NM_006820
IFI44L
interferon-induced protein 44-like
chr10_+_4995453 1.057 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr5_-_39238818 1.051 FYB
FYN binding protein
chr6_+_16251260 1.050 MYLIP
myosin regulatory light chain interacting protein
chr1_+_116727514 1.047 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr10_-_50066386 1.045 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr11_-_33139449 1.045 NM_001033505
NM_001033506
NM_001326
CSTF3


cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa


chr17_-_30909219 1.041 NM_001129820
SLFN14
schlafen family member 14
chr4_-_83566802 1.039 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr11_+_123491313 1.039 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr1_+_205344200 1.035 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr1_+_557269 1.032


chr7_-_92615593 1.028 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr10_-_69267774 1.027 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr14_+_38804226 1.027 NM_203354
CTAGE5
CTAGE family, member 5
chr21_-_31995972 1.026 SCAF4
SR-related CTD-associated factor 4
chr13_+_107753764 1.024


chr12_-_9913724 1.015 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr6_+_27215039 1.011 NM_003495
HIST1H4I
histone cluster 1, H4i
chrX_-_119593646 1.008 NM_003588
CUL4B
cullin 4B
chr11_-_5247948 1.005 NM_005330
HBE1
hemoglobin, epsilon 1
chr7_+_141124710 0.999 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr1_+_109057078 0.998 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr7_-_127771083 0.998


chr12_-_25692754 0.997 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr6_+_37511383 0.983


chr13_-_85271329 0.980 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr6_-_42293577 0.980 MRPS10
mitochondrial ribosomal protein S10
chr1_+_196874839 0.980 PTPRC
protein tyrosine phosphatase, receptor type, C
chr2_+_169645862 0.978 NM_001142271
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr4_-_74307637 0.977 ANKRD17
ankyrin repeat domain 17
chr6_-_42293581 0.964 NM_018141
MRPS10
mitochondrial ribosomal protein S10
chr10_-_113933457 0.962 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr8_-_102005697 0.957 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr10_+_4995685 0.952 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr3_+_38282301 0.951 NM_004256
SLC22A13
solute carrier family 22 (organic anion transporter), member 13
chr1_+_45789111 0.950 AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr3_-_25654659 0.943 TOP2B
topoisomerase (DNA) II beta 180kDa
chr12_+_46799279 0.938 NM_000289
PFKM
phosphofructokinase, muscle
chr8_-_95298706 0.937 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_+_227506751 0.927 NM_006542
SPHAR
S-phase response (cyclin related)
chr12_-_94469357 0.922 NM_032147
USP44
ubiquitin specific peptidase 44
chr1_-_159257567 0.920 F11R
F11 receptor
chr17_-_64462976 0.920 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr19_-_43608641 0.918 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chr2_-_169596078 0.917 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr12_-_642786 0.911 NM_016533
NINJ2
ninjurin 2
chrX_+_153908426 0.905 FUNDC2
FUN14 domain containing 2
chr7_-_92585253 0.905 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chrX_-_80344096 0.898 NM_030763
HMGN5
high-mobility group nucleosome binding domain 5
chrX_+_49250559 0.897 NM_001040663
NM_001468
GAGE1

G antigen 1

chr10_+_47875229 0.896 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr3_-_114176401 0.891 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr11_+_110890719 0.891 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr17_-_31231421 0.888 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr4_+_109763119 0.887 RPL34
ribosomal protein L34
chr12_-_9804682 0.886 NM_001781
CD69
CD69 molecule
chr13_+_48582389 0.886 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr19_+_60109319 0.879 NM_001145457
NM_001145458
NM_004829
NCR1


natural cytotoxicity triggering receptor 1


chr16_-_32596378 0.877 NM_001099687
TP53TG3B
TP53 target 3B
chr6_-_42293575 0.876 MRPS10
mitochondrial ribosomal protein S10
chr1_+_200698493 0.876 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr1_-_167969802 0.875 NM_000450
SELE
selectin E
chrX_-_55074125 0.873 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chrX_-_102829621 0.872 NM_001142419
NM_001142420
NM_001142421
NM_001142422
NM_001142427
NM_001142428
NM_001142431
NM_001142432
MORF4L2







mortality factor 4 like 2







chr7_-_135263737 0.870 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr3_+_32968069 0.867 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr19_+_6981593 0.866 NM_001136507
MBD3L5
methyl-CpG-binding domain protein 3-like 5-like
chrX_+_153644210 0.866 NM_001142463
NM_001363
DKC1

dyskeratosis congenita 1, dyskerin

chr4_+_22608252 0.865



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.04 1.58e-12 GO:0007606 sensory perception of chemical stimulus
2.10 2.46e-12 GO:0007608 sensory perception of smell
1.56 3.82e-06 GO:0007600 sensory perception

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.12 7.81e-13 GO:0004984 olfactory receptor activity
1.55 5.21e-07 GO:0004930 G-protein coupled receptor activity
1.35 5.24e-04 GO:0004888 transmembrane receptor activity
1.40 3.63e-03 GO:0003723 RNA binding