Motif ID: PBX1.p2

Z-value: 1.354


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1



Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_189752575 3.510 NM_000393
COL5A2
collagen, type V, alpha 2
chr12_+_77782719 3.318 SYT1
synaptotagmin I
chr7_-_27108826 3.153 NM_006735
HOXA2
homeobox A2
chr18_+_42780784 2.300 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr5_+_3649167 1.990 NM_024337
IRX1
iroquois homeobox 1
chr13_-_32757835 1.864 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_-_58607673 1.850 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_+_113671744 1.794 NM_006169
NNMT
nicotinamide N-methyltransferase
chr1_+_162795328 1.757 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr4_-_177950658 1.445 NM_005429
VEGFC
vascular endothelial growth factor C
chr3_-_21767819 1.434 NM_024697
ZNF385D
zinc finger protein 385D
chr13_+_38159172 1.432 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr3_-_113495763 1.339 NM_183061
SLC9A10
solute carrier family 9, member 10
chr18_+_45342398 1.292 NM_006033
LIPG
lipase, endothelial
chr10_+_63092724 1.280 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr9_-_83494198 1.258 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr1_-_147665783 1.224 HIST2H2BF
histone cluster 2, H2bf
chr6_-_166960496 1.224 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr6_-_26125939 1.186 NM_005325
HIST1H1A
histone cluster 1, H1a
chr8_+_107807415 1.164 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr14_+_51025604 1.129 NM_001042481
FRMD6
FERM domain containing 6
chr6_-_166960649 1.084 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chrX_-_10548458 1.080 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr12_+_77782648 1.075 SYT1
synaptotagmin I
chr13_+_94052022 1.066 NM_180989
GPR180
G protein-coupled receptor 180
chr14_+_75197303 1.065 NM_015072
TTLL5
tubulin tyrosine ligase-like family, member 5
chr21_+_29439768 1.053 C21orf7
chromosome 21 open reading frame 7
chr6_-_166960690 1.050 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr21_-_35174742 1.049 RUNX1
runt-related transcription factor 1
chr14_+_75197409 1.045 TTLL5
tubulin tyrosine ligase-like family, member 5
chrX_+_46581418 1.021 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr18_+_30427279 0.997 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr8_+_69027277 0.990 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr14_+_75197345 0.976 TTLL5
tubulin tyrosine ligase-like family, member 5
chr16_+_81218074 0.970 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chrX_-_92815222 0.967 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr7_+_29569913 0.955 NM_175887
PRR15
proline rich 15
chr11_+_13646839 0.934 FAR1
fatty acyl CoA reductase 1
chr11_+_13646727 0.922 NM_032228
FAR1
fatty acyl CoA reductase 1
chr5_-_94442941 0.905 MCTP1
multiple C2 domains, transmembrane 1
chr1_+_24518501 0.905 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chrX_+_92815667 0.897 NM_001171109
NM_001171110
NM_001171111
NM_173698
FAM133A



family with sequence similarity 133, member A



chr6_-_26379567 0.891 NM_003534
HIST1H3G
histone cluster 1, H3g
chrX_+_46581368 0.890 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr3_+_157877146 0.861 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr11_+_13646822 0.848 FAR1
fatty acyl CoA reductase 1
chr8_+_69027143 0.808 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr16_+_81218142 0.807 CDH13
cadherin 13, H-cadherin (heart)
chr8_+_69027166 0.806 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_24518398 0.789 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr5_+_15553288 0.784 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr14_-_75196911 0.779 C14orf1
chromosome 14 open reading frame 1
chr13_-_60887210 0.766 PCDH20
protocadherin 20
chrX_+_46581290 0.760 NM_006915
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr16_+_15503623 0.751 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr6_+_26333361 0.738 NM_003532
HIST1H3E
histone cluster 1, H3e
chr8_-_25371708 0.736 KCTD9
potassium channel tetramerisation domain containing 9
chr8_-_49996353 0.735 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr4_+_87734489 0.731 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr20_+_43874735 0.710 UBE2C
ubiquitin-conjugating enzyme E2C
chr13_-_109236897 0.709 NM_003749
IRS2
insulin receptor substrate 2
chr8_+_69026895 0.668 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr5_-_171814026 0.666 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr4_-_118226119 0.663 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr3_+_138063764 0.662 NCK1
NCK adaptor protein 1
chr9_-_14303509 0.646 NFIB
nuclear factor I/B
chr8_-_25371858 0.638 NM_017634
KCTD9
potassium channel tetramerisation domain containing 9
chr3_-_130641460 0.605 MBD4
methyl-CpG binding domain protein 4
chr8_-_25371663 0.603 KCTD9
potassium channel tetramerisation domain containing 9
chr8_-_108579270 0.585 NM_001146
ANGPT1
angiopoietin 1
chr11_+_13646806 0.584 FAR1
fatty acyl CoA reductase 1
chr3_-_130641539 0.581 NM_003925
MBD4
methyl-CpG binding domain protein 4
chr5_-_171813960 0.576 SH3PXD2B
SH3 and PX domains 2B
chr19_-_63092099 0.574 NM_001144989
ZNF814
zinc finger protein 814
chr4_+_77575276 0.574 NM_020859
SHROOM3
shroom family member 3
chr18_+_58005494 0.567 NM_020854
KIAA1468
KIAA1468
chr3_-_150578023 0.563 TM4SF1
transmembrane 4 L six family member 1
chr14_-_22722680 0.559 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr4_+_86968069 0.555 ARHGAP24
Rho GTPase activating protein 24
chr20_+_56455866 0.555 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr19_+_54691445 0.551 NM_001015
RPS11
ribosomal protein S11
chrX_-_10605726 0.551 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr19_+_14501413 0.540 TECR
trans-2,3-enoyl-CoA reductase
chr21_-_46473113 0.528 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr18_+_58005519 0.522 KIAA1468
KIAA1468
chrX_-_107568211 0.521 NM_033641
COL4A6
collagen, type IV, alpha 6
chr20_-_45848043 0.517 NM_018837
SULF2
sulfatase 2
chr6_+_151603346 0.512 AKAP12
A kinase (PRKA) anchor protein 12
chr2_+_166034402 0.512 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr2_-_162808123 0.508 NM_004460
FAP
fibroblast activation protein, alpha
chr8_-_23768242 0.507 NM_003155
STC1
stanniocalcin 1
chr14_+_93455010 0.503 NM_138344
FAM181A
family with sequence similarity 181, member A
chr3_+_138132006 0.498 NM_001190796
NCK1
NCK adaptor protein 1
chr21_-_46473143 0.498 NM_001001438
NM_001145436
NM_001145437
NM_002340
LSS



lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)



chr3_+_185762233 0.493 NM_004443
EPHB3
EPH receptor B3
chr1_+_149493861 0.489 PSMD4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr3_+_130641639 0.489 NM_018262
NM_052985
NM_052989
NM_052990
IFT122



intraflagellar transport 122 homolog (Chlamydomonas)



chr2_+_218843358 0.489 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr11_+_6904167 0.487 NM_013250
ZNF215
zinc finger protein 215
chr5_+_15553539 0.485 FBXL7
F-box and leucine-rich repeat protein 7
chr1_-_171442937 0.485 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr22_+_28164571 0.480 NM_021026
RFPL1
ret finger protein-like 1
chr12_-_8993460 0.480 M6PR
mannose-6-phosphate receptor (cation dependent)
chr4_+_81325447 0.478 NM_020226
PRDM8
PR domain containing 8
chr3_+_195336625 0.477 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr12_+_77782579 0.476 NM_005639
SYT1
synaptotagmin I
chr17_-_36436979 0.473 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr1_+_149493833 0.472 PSMD4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr6_-_46728188 0.470 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr20_+_43874654 0.459 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr6_+_54281161 0.458 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr18_-_58005159 0.457 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr9_+_73716189 0.454 NM_182505
C9orf85
chromosome 9 open reading frame 85
chr8_-_12033677 0.451 NM_201402
USP17L2
ubiquitin specific peptidase 17-like 2
chr3_+_171621721 0.449 NM_001185056
CLDN11
claudin 11
chr10_-_79067296 0.447 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr3_-_130641365 0.445 MBD4
methyl-CpG binding domain protein 4
chr11_-_102174032 0.445 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr3_-_71196696 0.433 FOXP1
forkhead box P1
chr14_-_91642641 0.428 ATXN3
ATXN8
ataxin 3
ataxin 8
chr17_+_56884560 0.428 TBX4
T-box 4
chr14_-_91642703 0.427 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr15_+_39032927 0.426 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr13_-_47885248 0.415 LPAR6
lysophosphatidic acid receptor 6
chr3_+_174598937 0.413 NM_014932
NLGN1
neuroligin 1
chr3_+_173951163 0.410 ECT2
epithelial cell transforming sequence 2 oncogene
chr5_-_22248630 0.407 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr17_+_43480674 0.406 NM_003204
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr18_-_58005195 0.406 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr19_+_54691499 0.406 RPS11
ribosomal protein S11
chr3_+_138063697 0.403 NM_006153
NCK1
NCK adaptor protein 1
chr19_+_54691494 0.400 RPS11
ribosomal protein S11
chr2_-_108972100 0.396 NM_022336
EDAR
ectodysplasin A receptor
chr9_-_73715927 0.395 NM_001025780
NM_016014
FAM108B1

family with sequence similarity 108, member B1

chr10_+_99390459 0.394 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr20_+_56369012 0.394


chr17_+_72380323 0.384 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr13_-_60887655 0.377 NM_022843
PCDH20
protocadherin 20
chr3_+_130641765 0.374 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr11_+_113436438 0.373 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr2_-_219614481 0.373 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr17_+_7699100 0.372 NM_203411
TMEM88
transmembrane protein 88
chr11_-_85115105 0.372 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr22_-_37520092 0.371 NM_005740
DNAL4
dynein, axonemal, light chain 4
chr10_-_44794146 0.371 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr1_+_149493812 0.362 NM_002810
PSMD4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr18_-_58005209 0.362 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr8_+_18123456 0.361 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr1_+_170656450 0.361 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr4_-_72868598 0.360 NM_000583
GC
group-specific component (vitamin D binding protein)
chr4_-_70115037 0.359 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr5_+_162797149 0.354 NM_004060
NM_199246
CCNG1

cyclin G1

chr17_-_36456949 0.354 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr11_-_30562324 0.354 MPPED2
metallophosphoesterase domain containing 2
chr7_+_133982070 0.354 NM_001724
NM_199186
BPGM

2,3-bisphosphoglycerate mutase

chr14_+_73621408 0.351 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr7_-_121571472 0.351 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr18_-_45272840 0.351 NM_000985
NM_001035006
RPL17

ribosomal protein L17

chr12_-_67643286 0.349 NM_001874
CPM
carboxypeptidase M
chr3_+_130641840 0.348 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr3_-_32519362 0.345 NM_017801
CMTM6
CKLF-like MARVEL transmembrane domain containing 6
chr10_+_17310263 0.343 NM_003380
VIM
vimentin
chr11_+_122258600 0.341 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr12_-_54150188 0.341 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr14_-_57834558 0.341 FLJ31306
hypothetical LOC379025
chr11_-_27679175 0.337 NM_001143808
NM_001143809
NM_001143810
NM_001143811
BDNF



brain-derived neurotrophic factor



chr20_+_11846536 0.336 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr16_-_70306198 0.336 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr9_+_36180956 0.335 CLTA
clathrin, light chain A
chr4_+_70180805 0.335 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr14_-_22722658 0.334 SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr18_-_58005268 0.333 NM_012327
NM_176787
PIGN

phosphatidylinositol glycan anchor biosynthesis, class N

chr5_-_171643247 0.332 UBTD2
ubiquitin domain containing 2
chr11_-_129803515 0.332 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr12_+_11694172 0.329 ETV6
ets variant 6
chr16_+_3433606 0.327 NM_001083601
NAT15
N-acetyltransferase 15 (GCN5-related, putative)
chr5_-_89741233 0.326 NM_004365
CETN3
centrin, EF-hand protein, 3
chr9_+_36180927 0.325 CLTA
clathrin, light chain A
chr17_-_43977273 0.324 NM_002145
HOXB2
homeobox B2
chr18_-_45272775 0.324 RPL17
ribosomal protein L17
chr5_+_147562531 0.321 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr22_-_37520049 0.317 DNAL4
dynein, axonemal, light chain 4
chr18_-_45272820 0.317 RPL17
ribosomal protein L17
chr10_+_63331401 0.315 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr4_+_37638450 0.312 NM_006607
PTTG2
pituitary tumor-transforming 2
chr4_+_8935987 0.310 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr12_+_63090008 0.309 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr1_+_15862887 0.308


chr9_+_36180936 0.306 CLTA
clathrin, light chain A
chr9_+_36181015 0.303 CLTA
clathrin, light chain A
chr12_+_64982542 0.303 NM_033647
HELB
helicase (DNA) B
chr1_-_226712140 0.303 NM_033445
HIST3H2A
histone cluster 3, H2a
chr21_-_31012965 0.302 NM_001164435
KRTAP21-3
keratin associated protein 21-3
chr14_-_90596665 0.301 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr3_+_130641779 0.300 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr3_-_32519323 0.298 CMTM6
CKLF-like MARVEL transmembrane domain containing 6
chr2_-_108972048 0.297 EDAR
ectodysplasin A receptor
chr10_+_69539255 0.296 NM_032578
MYPN
myopalladin
chr12_-_14982708 0.295 NM_152321
ERP27
endoplasmic reticulum protein 27
chr2_-_192767494 0.294 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.90 1.03e-02 GO:0065004 protein-DNA complex assembly
3.45 1.36e-02 GO:0006333 chromatin assembly or disassembly
3.69 2.03e-02 GO:0071824 protein-DNA complex subunit organization
3.47 2.28e-02 GO:0006323 DNA packaging
2.36 2.63e-02 GO:0034622 cellular macromolecular complex assembly
3.88 4.40e-02 GO:0006334 nucleosome assembly
1.36 4.53e-02 GO:0016043 cellular component organization
1.35 4.58e-02 GO:0071840 cellular component organization or biogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 7.52e-05 GO:0043229 intracellular organelle
1.17 9.59e-05 GO:0043226 organelle
1.12 3.36e-03 GO:0044424 intracellular part
1.11 5.86e-03 GO:0005622 intracellular
1.16 8.50e-03 GO:0043231 intracellular membrane-bounded organelle
1.16 9.51e-03 GO:0043227 membrane-bounded organelle
4.48 1.70e-02 GO:0000786 nucleosome
3.44 4.65e-02 GO:0032993 protein-DNA complex

Nothing significant found in function category.