Motif ID: CRX.p2

Z-value: 2.961


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox



Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_559129 5.273


chr1_+_559618 5.077


chr1_-_239865724 5.023 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr16_+_56567839 5.008 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr9_-_99740243 4.682 NM_197978
HEMGN
hemogen
chr20_-_48165886 3.594 NM_022442
NM_021988
NM_199144
UBE2V1


ubiquitin-conjugating enzyme E2 variant 1


chr12_-_69434330 3.389 PTPRR
protein tyrosine phosphatase, receptor type, R
chr17_+_35718948 3.235 NM_000964
RARA
retinoic acid receptor, alpha
chr11_+_61473931 3.213 NM_001139443
NM_004183
BEST1

bestrophin 1

chr5_-_134290789 3.117


chr3_+_63928459 2.955 NM_001128149
ATXN7
ataxin 7
chr6_-_49712483 2.931 NM_000324
RHAG
Rh-associated glycoprotein
chr10_-_76538859 2.888 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chrX_-_24600661 2.863 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr1_+_226399026 2.857 NM_001159391
GUK1
guanylate kinase 1
chr11_-_118405288 2.855 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr11_-_5110383 2.852 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chrX_-_70248022 2.785 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr11_+_61279436 2.773 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr19_-_12858956 2.757 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr7_-_99115454 2.738 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr18_+_53865455 2.730 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_+_186529376 2.599 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr12_+_130004404 2.476 NM_198827
GPR133
G protein-coupled receptor 133
chr7_+_111850367 2.473 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr15_+_21361546 2.382 NM_005664
MKRN3
makorin ring finger protein 3
chr19_-_56585603 2.354 NM_001193623
LOC147646
hypothetical protein LOC147646
chr1_-_156923111 2.320 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr6_+_132000134 2.295 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr3_+_82117978 2.220


chr20_-_48686832 2.140 NM_080829
FAM65C
family with sequence similarity 65, member C
chr6_+_163904564 2.127 QKI
quaking homolog, KH domain RNA binding (mouse)
chr12_+_56114724 2.055 NM_005538
INHBC
inhibin, beta C
chr8_+_77928372 2.035 ZFHX4
zinc finger homeobox 4
chrX_-_129347101 1.940 NM_178471
GPR119
G protein-coupled receptor 119
chrX_-_48655978 1.932 PIM2
pim-2 oncogene
chr7_+_128367961 1.882 NM_001098627
IRF5
interferon regulatory factor 5
chr10_+_70745615 1.864 NM_033496
HK1
hexokinase 1
chr3_-_19950675 1.852 NM_144715
EFHB
EF-hand domain family, member B
chr11_-_36576352 1.852 NM_000536
RAG2
recombination activating gene 2
chr16_+_56286212 1.793 NM_032269
CCDC135
coiled-coil domain containing 135
chrX_-_11194015 1.791 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr3_-_47073910 1.766 SETD2
SET domain containing 2
chr7_-_142369519 1.755 KEL
Kell blood group, metallo-endopeptidase
chr22_+_21359175 1.721 IGLV3-25
immunoglobulin lambda variable 3-25
chr2_-_158008763 1.716 NM_004288
CYTIP
cytohesin 1 interacting protein
chr12_-_1898063 1.708 NM_172364
CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr6_+_147568795 1.703 STXBP5
syntaxin binding protein 5 (tomosyn)
chr4_+_110968594 1.699 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr6_-_149847809 1.697 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr21_-_38415273 1.692 NM_005867
DSCR4
Down syndrome critical region gene 4
chr6_+_105511615 1.653 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr1_+_116744992 1.645 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr9_+_4829763 1.639 RCL1
RNA terminal phosphate cyclase-like 1
chr3_-_52712639 1.632 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr1_+_149877955 1.610 SNX27
sorting nexin family member 27
chr17_+_1586034 1.587 WDR81
WD repeat domain 81
chr2_+_201806410 1.573 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr21_+_37377116 1.553 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr1_+_152560179 1.546 NM_080429
AQP10
aquaporin 10
chr1_-_100003936 1.540 NM_001013660
FRRS1
ferric-chelate reductase 1
chr17_-_31231421 1.520 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr5_-_74568458 1.501 NM_001164443
ANKRD31
ankyrin repeat domain 31
chr6_+_146097700 1.499 LOC100507557
hypothetical LOC100507557
chr6_+_42857540 1.487 KIAA0240
KIAA0240
chr1_-_27871287 1.483 IFI6
interferon, alpha-inducible protein 6
chr19_-_60360768 1.467 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr4_+_106851415 1.458 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr16_-_46823682 1.440 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr7_+_116447499 1.440 ST7
suppression of tumorigenicity 7
chr1_-_109651140 1.435 NM_001010985
MYBPHL
myosin binding protein H-like
chr11_-_117589283 1.431 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr22_+_21370394 1.428 IGL@
immunoglobulin lambda locus
chr18_+_27210737 1.427 NM_001134453
NM_177986
DSG4

desmoglein 4

chr21_+_39745649 1.421 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr10_+_35524060 1.419 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr20_+_41621079 1.419 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_153537362 1.409 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr20_-_43972061 1.403 PLTP
phospholipid transfer protein
chr6_-_11887265 1.402 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr12_-_53153613 1.400 GTSF1
gametocyte specific factor 1
chr4_+_17125885 1.395 NM_001079827
CLRN2
clarin 2
chr20_+_55338221 1.381 NM_012444
NM_198265
SPO11

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

chr16_+_29597965 1.378 QPRT
quinolinate phosphoribosyltransferase
chr19_+_41872141 1.376 NM_152603
ZNF567
zinc finger protein 567
chr6_-_2696152 1.376 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr2_+_211050653 1.373 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr3_+_47004457 1.363 NBEAL2
neurobeachin-like 2
chr13_-_45654296 1.361 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_73781974 1.360 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chr19_-_17377383 1.354 NM_004335
BST2
bone marrow stromal cell antigen 2
chr5_-_34020445 1.350 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr15_-_50270856 1.343 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr13_-_45654292 1.336 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr11_-_46569489 1.331 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr5_-_169657192 1.327 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr19_+_17377502 1.317 LOC100507535
hypothetical LOC100507535
chr2_-_65013070 1.315 LOC400958
hypothetical LOC400958
chr1_-_93030538 1.311 NM_005665
EVI5
ecotropic viral integration site 5
chr1_+_154386358 1.308 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr7_-_142369534 1.306 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr9_+_132990760 1.305 NM_005085
NUP214
nucleoporin 214kDa
chr7_+_142692165 1.304 NM_153345
TMEM139
transmembrane protein 139
chr16_+_29597829 1.290 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr2_+_3605611 1.288 RPS7
ribosomal protein S7
chr10_-_82039158 1.282 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr2_+_157822355 1.281 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr20_+_41621119 1.280 SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_96311367 1.279 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr10_-_30958631 1.275 NM_183058
LYZL2
lysozyme-like 2
chr15_-_32398220 1.274 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr5_-_169657360 1.251 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_-_9804682 1.249 NM_001781
CD69
CD69 molecule
chr17_-_39500512 1.247 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr12_-_47735373 1.241 NM_003482
MLL2
myeloid/lymphoid or mixed-lineage leukemia 2
chrX_-_135783496 1.239


chr4_-_184480572 1.238 NM_001185149
CLDN24
claudin 24
chr5_+_76181581 1.234 NM_130772
S100Z
S100 calcium binding protein Z
chr19_+_43616167 1.225 NM_000540
NM_001042723
RYR1

ryanodine receptor 1 (skeletal)

chr20_-_33706532 1.222 RBM12
RNA binding motif protein 12
chr9_+_124177421 1.216 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_60283571 1.215 NM_017729
EPS8L1
EPS8-like 1
chr6_+_112775224 1.214 NM_001013734
RFPL4B
ret finger protein-like 4B
chr1_+_202033273 1.196 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr1_-_36338436 1.192 NM_005202
COL8A2
collagen, type VIII, alpha 2
chr22_+_23329113 1.180 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr14_+_87560646 1.166 LOC283587
hypothetical protein LOC283587
chr12_+_108038774 1.160 ACACB
acetyl-CoA carboxylase beta
chr10_+_4995685 1.159 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_-_26266571 1.155 NM_032588
TRIM63
tripartite motif containing 63
chr4_+_39874921 1.152 NM_004310
RHOH
ras homolog gene family, member H
chr7_+_129057152 1.151 NM_001040110
NRF1
nuclear respiratory factor 1
chr6_-_25940247 1.150 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr12_-_52975823 1.146 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr20_+_42417752 1.146 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr4_-_186969041 1.142 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr9_+_134884627 1.132 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr19_-_53914768 1.126 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr8_-_38324809 1.125 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr15_+_89248423 1.121 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr1_+_144152864 1.109 TXNIP
thioredoxin interacting protein
chr4_+_107456215 1.107 NM_001142415
NM_004757
AIMP1

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

chr12_+_54172413 1.105 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr2_-_157892391 1.105 NM_001009959
ERMN
ermin, ERM-like protein
chrX_+_65152004 1.097


chr17_+_50333021 1.096 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr1_-_180621272 1.095 GLUL
glutamate-ammonia ligase
chr7_+_93373755 1.095 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr1_+_205329206 1.083 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr6_+_32515596 1.077 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr22_-_41685827 1.071 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr14_+_57964462 1.063 NM_014749
KIAA0586
KIAA0586
chr7_+_116447527 1.062 ST7
suppression of tumorigenicity 7
chr5_-_39255335 1.059 NM_001465
NM_199335
FYB

FYN binding protein

chr14_-_88948486 1.058 FOXN3
forkhead box N3
chr8_-_91164100 1.051 NM_004929
CALB1
calbindin 1, 28kDa
chr12_+_12115668 1.048 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr2_+_37282516 1.042 LOC100505876
hypothetical LOC100505876
chr12_+_53177758 1.041 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr17_+_53670785 1.035 NM_001160102
NM_006151
LPO

lactoperoxidase

chr1_+_31655607 1.034 NM_001199037
SERINC2
serine incorporator 2
chr2_+_227900471 1.030 NM_020194
MFF
mitochondrial fission factor
chrX_+_119622570 1.028 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr19_-_56018815 1.015 NM_002257
KLK1
kallikrein 1
chr13_-_45654327 1.013 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_75650355 1.010 NM_032181
FAM176A
family with sequence similarity 176, member A
chr20_-_33793593 1.008 NM_004902
NM_184234
RBM39

RNA binding motif protein 39

chr1_+_205344200 1.002 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr10_+_50177192 1.000 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr6_-_32265489 0.999 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr20_-_55368284 0.983 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chr16_-_65108605 0.979 TK2
thymidine kinase 2, mitochondrial
chr1_+_40977092 0.968 NFYC
nuclear transcription factor Y, gamma
chr5_-_88155360 0.965 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr7_-_128203079 0.964 NM_001708
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr20_-_43949644 0.961 NM_080608
C20orf165
chromosome 20 open reading frame 165
chr6_+_10693964 0.954 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr8_-_95289945 0.950 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_-_39119845 0.947 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP read-through transcript
gap junction protein, alpha 9, 59kDa
chr1_-_27871306 0.942 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr20_-_33793591 0.933 RBM39
RNA binding motif protein 39
chr2_-_55090759 0.930 NM_007008
RTN4
reticulon 4
chr2_-_73723001 0.928 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr1_+_35507145 0.925 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr8_-_110730183 0.924 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr19_-_12802206 0.924 NM_001080997
RTBDN
retbindin
chr1_-_158883666 0.922 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr12_+_53177806 0.917 NCKAP1L
NCK-associated protein 1-like
chr10_-_69267774 0.912 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr4_-_155753249 0.905 FGG
fibrinogen gamma chain
chr11_-_116168316 0.905 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr1_+_35507197 0.904 ZMYM4
zinc finger, MYM-type 4
chr20_-_29751755 0.900


chr10_+_74540215 0.896 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr18_-_41923571 0.894 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr11_+_76561471 0.893 MYO7A
myosin VIIA
chr4_-_88531245 0.889 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr1_-_158815850 0.889 CD84
CD84 molecule
chr6_-_31779099 0.887 NM_021160
ABHD16A
abhydrolase domain containing 16A
chr12_-_10464308 0.885 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.62 7.48e-04 GO:0007600 sensory perception
2.13 1.15e-02 GO:0007601 visual perception
2.13 1.15e-02 GO:0050953 sensory perception of light stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.09 3.30e-02 GO:0005882 intermediate filament

Nothing significant found in function category.