Motif ID: MTF1.p2

Z-value: 5.520


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1



Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_124211353 11.551 HTRA1
HtrA serine peptidase 1
chr16_+_55217180 9.645 MT1E
metallothionein 1E
chr16_+_55217085 8.496 NM_175617
MT1E
metallothionein 1E
chr2_-_40532651 7.633 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr3_+_160964574 7.322 SCHIP1
schwannomin interacting protein 1
chr10_+_124210980 7.288 NM_002775
HTRA1
HtrA serine peptidase 1
chr1_+_208472817 7.053 NM_019605
SERTAD4
SERTA domain containing 4
chr15_-_68933481 7.023 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr2_+_238060602 6.685 NM_001042467
NM_024101
MLPH

melanophilin

chr10_-_725522 6.405 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr2_+_54537842 6.252 SPTBN1
spectrin, beta, non-erythrocytic 1
chr14_-_24588916 6.183 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr15_+_77511912 6.034 NM_015206
KIAA1024
KIAA1024
chr19_+_38377329 6.031 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr19_-_36531958 5.975 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr13_-_25523164 5.890 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr6_-_153494076 5.689 NM_012419
RGS17
regulator of G-protein signaling 17
chr8_-_121893468 5.673 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr7_+_288195 5.660 FAM20C
family with sequence similarity 20, member C
chr13_-_109757442 5.586 NM_001845
COL4A1
collagen, type IV, alpha 1
chr9_+_90339835 5.433 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr3_-_185025989 5.425 NM_024871
MAP6D1
MAP6 domain containing 1
chr15_-_23659329 5.371 NM_024490
ATP10A
ATPase, class V, type 10A
chr7_+_288051 5.261 NM_020223
FAM20C
family with sequence similarity 20, member C
chr10_+_128583984 5.145 NM_001380
DOCK1
dedicator of cytokinesis 1
chr4_+_108965167 5.130 NM_001136258
SGMS2
sphingomyelin synthase 2
chr20_+_34206070 5.089 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr3_+_191714533 5.067 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr8_-_120033240 4.979 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr6_+_142664490 4.967 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr12_-_105056577 4.960 NUAK1
NUAK family, SNF1-like kinase, 1
chr9_-_111300350 4.959 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr3_+_61522219 4.950 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr7_-_27136876 4.942 NM_002141
HOXA4
homeobox A4
chr13_-_105985313 4.939 NM_004093
EFNB2
ephrin-B2
chr10_-_128884411 4.916 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr3_+_61522310 4.753 PTPRG
protein tyrosine phosphatase, receptor type, G
chr12_+_56406296 4.749 LOC100130776
hypothetical LOC100130776
chr8_-_121893449 4.739 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr10_+_133850325 4.624 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr8_+_1699418 4.537 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr9_-_83493415 4.509 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr16_+_55224034 4.485 NM_176870
MT1M
metallothionein 1M
chr6_-_170442090 4.477


chr13_-_43259032 4.475 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr2_+_207016525 4.451 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr9_-_83494198 4.431 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr20_+_6696744 4.403 NM_001200
BMP2
bone morphogenetic protein 2
chr16_+_12902955 4.395 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr2_-_210798232 4.340 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr14_+_95575319 4.312 C14orf132
chromosome 14 open reading frame 132
chr14_+_85069217 4.235


chr8_+_121892719 4.225


chr14_+_105012106 4.198 NM_001312
CRIP2
cysteine-rich protein 2
chr9_+_115958051 4.195 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr7_-_81910956 4.152 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr8_-_121892877 4.148 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr19_+_61742111 4.130 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr8_+_32525269 4.125 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr6_-_170441493 4.105 NM_005618
DLL1
delta-like 1 (Drosophila)
chr5_-_146869811 4.092 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr10_-_131652364 4.062 EBF3
early B-cell factor 3
chr14_+_99181232 4.008 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr10_-_116517945 3.981 ABLIM1
actin binding LIM protein 1
chr3_-_48607596 3.966 NM_000094
COL7A1
collagen, type VII, alpha 1
chr18_-_72336133 3.934 NM_014643
ZNF516
zinc finger protein 516
chr12_-_29827952 3.932 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr3_-_135575925 3.916 NM_016201
AMOTL2
angiomotin like 2
chr6_+_170441715 3.905 FAM120B
family with sequence similarity 120B
chr4_+_95898098 3.889 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr10_+_71232281 3.860 COL13A1
collagen, type XIII, alpha 1
chr3_+_61522922 3.853 PTPRG
protein tyrosine phosphatase, receptor type, G
chr8_-_121893196 3.843


chr16_+_55180767 3.780 NM_005954
MT3
metallothionein 3
chr13_+_109757593 3.729 NM_001846
COL4A2
collagen, type IV, alpha 2
chr4_+_187302988 3.718 NM_015398
FAM149A
family with sequence similarity 149, member A
chr5_-_146869613 3.684 DPYSL3
dihydropyrimidinase-like 3
chr5_+_148631636 3.681 AFAP1L1
actin filament associated protein 1-like 1
chr5_+_148631588 3.639 NM_001146337
NM_152406
AFAP1L1

actin filament associated protein 1-like 1

chr11_-_11986704 3.600 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr2_+_120820140 3.584 NM_002193
INHBB
inhibin, beta B
chr19_+_39664706 3.584 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr11_+_35596310 3.565 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr2_+_235525355 3.530 NM_014521
SH3BP4
SH3-domain binding protein 4
chr18_+_11679135 3.519 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr19_+_58733144 3.517 NM_001079906
ZNF331
zinc finger protein 331
chr5_+_65927895 3.514 NM_001164664
NM_198828
MAST4

microtubule associated serine/threonine kinase family member 4

chr17_+_77780177 3.514 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr17_-_5344898 3.487 NM_001162371
LOC728392
hypothetical protein LOC728392
chr15_+_90738108 3.477 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr5_-_16670085 3.458 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr12_-_41269679 3.435 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr4_-_22126437 3.425 NM_145290
GPR125
G protein-coupled receptor 125
chr15_+_78483624 3.402 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr4_+_30330963 3.373 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr11_+_17697685 3.373 NM_002478
MYOD1
myogenic differentiation 1
chr1_-_239587007 3.372 RGS7
regulator of G-protein signaling 7
chr6_+_142665057 3.369 GPR126
G protein-coupled receptor 126
chr14_+_69415880 3.357 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr7_-_42243142 3.336 NM_000168
GLI3
GLI family zinc finger 3
chr6_+_17501589 3.317 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr16_-_63713382 3.313 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr7_+_27102508 3.283


chr16_-_63713466 3.268 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr6_+_17389752 3.254 NM_001143942
RBM24
RNA binding motif protein 24
chr16_-_63713485 3.244 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr21_+_41461924 3.244 BACE2
beta-site APP-cleaving enzyme 2
chr10_-_33663984 3.196 NRP1
neuropilin 1
chr3_-_64648370 3.195 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr13_-_19665100 3.190 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr6_+_160689355 3.160 NM_021977
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
chr5_+_72452131 3.144 NM_001161342
NM_173490
TMEM171

transmembrane protein 171

chrX_-_132376660 3.134 NM_001448
GPC4
glypican 4
chr4_+_30331289 3.129 PCDH7
protocadherin 7
chr13_+_97593411 3.126 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr7_-_81910740 3.117 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr6_+_53767697 3.093 NM_018214
LRRC1
leucine rich repeat containing 1
chr14_+_73073570 3.081 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr19_-_41787999 3.073 NM_001145649
NM_001145650
ZNF529

zinc finger protein 529

chr15_-_27650218 3.066 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr12_+_6179736 3.059 NM_001769
CD9
CD9 molecule
chr18_+_42168180 3.054 NM_152470
C18orf23
RNF165
chromosome 18 open reading frame 23
ring finger protein 165
chr2_+_20510312 3.045 NM_004040
RHOB
ras homolog gene family, member B
chr10_-_79067552 3.039 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr12_-_22378833 2.987 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr6_-_165996031 2.974 LOC100132188
LP7097
chr9_-_112840064 2.973 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr1_+_77520190 2.943 AK5
adenylate kinase 5
chr4_+_148872902 2.933 NM_024605
ARHGAP10
Rho GTPase activating protein 10
chr2_+_112529270 2.906 NM_032824
TMEM87B
transmembrane protein 87B
chr14_-_69725342 2.905 NM_033262
NM_058240
NM_182932
NM_183002
SLC8A3



solute carrier family 8 (sodium/calcium exchanger), member 3



chr10_-_131652007 2.897 NM_001005463
EBF3
early B-cell factor 3
chr8_-_125809559 2.878 MTSS1
metastasis suppressor 1
chr1_-_239587090 2.864 NM_002924
RGS7
regulator of G-protein signaling 7
chr15_+_66658626 2.861 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr16_-_55259405 2.858 NM_005950
MT1G
metallothionein 1G
chr18_-_20105814 2.850 OSBPL1A
oxysterol binding protein-like 1A
chr12_-_70952410 2.848 LOC283392
hypothetical LOC283392
chr2_-_224612177 2.847 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr2_-_98919109 2.838 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr20_-_4752067 2.810 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr20_+_13924263 2.809 MACROD2
MACRO domain containing 2
chr19_+_41788042 2.766 NM_032825
ZNF382
zinc finger protein 382
chr22_-_32646325 2.763 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr16_-_79395379 2.752 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr1_+_156229934 2.745 KIRREL
kin of IRRE like (Drosophila)
chr11_+_110675175 2.734 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr1_-_3437834 2.724 MEGF6
multiple EGF-like-domains 6
chr19_+_41788065 2.719 ZNF382
zinc finger protein 382
chr8_-_82186832 2.697 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr11_+_124438217 2.688 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr4_+_30331543 2.679 PCDH7
protocadherin 7
chr9_-_109291130 2.669 KLF4
Kruppel-like factor 4 (gut)
chr17_-_8474733 2.648 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr12_+_5411534 2.642 NM_001102654
NTF3
neurotrophin 3
chr11_+_128266460 2.642 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr21_+_36429079 2.642 NM_001236
CBR3
carbonyl reductase 3
chr20_+_13150417 2.641 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr4_+_72271218 2.639 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr13_+_43845977 2.638 NM_001010897
SERP2
stress-associated endoplasmic reticulum protein family member 2
chr9_+_90796169 2.630 NM_005226
S1PR3
sphingosine-1-phosphate receptor 3
chr15_+_97010219 2.629 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr9_-_23811477 2.620 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr8_-_75396016 2.610 NM_020647
JPH1
junctophilin 1
chr8_+_1699276 2.608 NM_018941
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr2_+_85834111 2.583 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr13_+_97593469 2.578 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr16_+_85169615 2.575 NM_005250
FOXL1
forkhead box L1
chr11_-_8849485 2.556 ST5
suppression of tumorigenicity 5
chr10_+_105243724 2.553 NM_004210
NEURL
neuralized homolog (Drosophila)
chr18_-_44731078 2.551 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr10_-_133971136 2.546 NM_173575
STK32C
serine/threonine kinase 32C
chr5_+_68824143 2.541 OCLN
occludin
chr10_-_79067476 2.540 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr10_-_125843092 2.535 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr11_-_44928803 2.532 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr8_-_26427304 2.530 NM_007257
PNMA2
paraneoplastic antigen MA2
chr18_+_42167904 2.524 RNF165
ring finger protein 165
chr2_+_242322645 2.524 NM_152783
D2HGDH
D-2-hydroxyglutarate dehydrogenase
chr17_+_46067114 2.520 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr18_-_72973698 2.511 MBP
myelin basic protein
chr11_+_131285747 2.500 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr2_+_36436316 2.494 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr8_-_6680429 2.493 NM_207411
XKR5
XK, Kell blood group complex subunit-related family, member 5
chr19_-_60573552 2.492 NM_000641
IL11
interleukin 11
chr11_-_114880275 2.491 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr22_-_45311730 2.483 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr2_+_152900076 2.478 FMNL2
formin-like 2
chr16_+_76379901 2.466 NM_020927
VAT1L
vesicle amine transport protein 1 homolog (T. californica)-like
chr9_-_37566248 2.460 NM_012166
FBXO10
F-box protein 10
chr3_-_16530132 2.460 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr8_+_26427378 2.451 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr17_-_40263124 2.448 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr4_+_151218862 2.448 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr2_-_56004366 2.444 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr13_-_31900218 2.438 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr3_+_112273464 2.435 NM_015480
PVRL3
poliovirus receptor-related 3
chr3_+_127905727 2.427 NM_032343
CHCHD6
coiled-coil-helix-coiled-coil-helix domain containing 6
chrX_-_8660132 2.416 KAL1
Kallmann syndrome 1 sequence
chr10_-_30065760 2.403 SVIL
supervillin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.56 2.81e-25 GO:0007399 nervous system development
1.75 1.37e-24 GO:0048699 generation of neurons
1.72 5.01e-24 GO:0022008 neurogenesis
1.77 1.15e-20 GO:0030182 neuron differentiation
1.29 1.67e-17 GO:0007275 multicellular organismal development
1.32 2.39e-17 GO:0048731 system development
1.26 1.15e-16 GO:0032502 developmental process
1.43 3.15e-16 GO:0023051 regulation of signaling
1.81 1.26e-15 GO:0031175 neuron projection development
1.29 2.85e-15 GO:0048856 anatomical structure development
1.45 3.44e-15 GO:0009966 regulation of signal transduction
1.84 5.11e-15 GO:0048812 neuron projection morphogenesis
1.73 9.76e-15 GO:0048666 neuron development
1.82 6.49e-14 GO:0048667 cell morphogenesis involved in neuron differentiation
1.77 7.33e-14 GO:0000904 cell morphogenesis involved in differentiation
1.35 7.65e-14 GO:0030154 cell differentiation
1.42 1.02e-13 GO:0009653 anatomical structure morphogenesis
1.83 1.03e-13 GO:0007409 axonogenesis
1.67 1.17e-13 GO:0030030 cell projection organization
1.14 2.27e-13 GO:0065007 biological regulation
1.16 2.29e-13 GO:0050794 regulation of cellular process
1.34 2.91e-13 GO:0048869 cellular developmental process
1.14 1.09e-12 GO:0050789 regulation of biological process
1.24 1.55e-12 GO:0023052 signaling
1.72 2.61e-12 GO:0048858 cell projection morphogenesis
1.72 3.17e-12 GO:0032990 cell part morphogenesis
1.32 7.24e-12 GO:0048523 negative regulation of cellular process
1.60 8.48e-12 GO:0045595 regulation of cell differentiation
1.64 1.61e-11 GO:0000902 cell morphogenesis
1.50 2.78e-11 GO:0048468 cell development
1.61 3.30e-11 GO:0032989 cellular component morphogenesis
1.29 6.80e-11 GO:0048519 negative regulation of biological process
1.55 1.12e-10 GO:2000026 regulation of multicellular organismal development
1.23 1.59e-10 GO:0007165 signal transduction
1.49 2.59e-10 GO:0050793 regulation of developmental process
1.82 3.74e-10 GO:0007411 axon guidance
1.08 4.87e-10 GO:0009987 cellular process
1.44 7.82e-10 GO:0010646 regulation of cell communication
1.32 1.55e-09 GO:0048583 regulation of response to stimulus
1.54 1.46e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.37 1.59e-08 GO:0051239 regulation of multicellular organismal process
1.26 1.72e-08 GO:0048522 positive regulation of cellular process
1.77 2.77e-08 GO:0060284 regulation of cell development
1.83 2.78e-07 GO:0050767 regulation of neurogenesis
1.29 3.10e-07 GO:0007166 cell surface receptor linked signaling pathway
1.70 4.51e-07 GO:0045597 positive regulation of cell differentiation
1.60 6.75e-07 GO:0051094 positive regulation of developmental process
1.56 7.20e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.17 8.32e-07 GO:0051716 cellular response to stimulus
1.22 1.14e-06 GO:0048518 positive regulation of biological process
1.88 1.83e-06 GO:0045664 regulation of neuron differentiation
1.57 2.36e-06 GO:0048646 anatomical structure formation involved in morphogenesis
1.19 3.17e-06 GO:0016043 cellular component organization
1.73 4.39e-06 GO:0051960 regulation of nervous system development
1.56 8.92e-06 GO:0010648 negative regulation of cell communication
1.58 9.99e-06 GO:0009968 negative regulation of signal transduction
1.48 1.20e-05 GO:0009887 organ morphogenesis
1.52 1.28e-05 GO:0007417 central nervous system development
1.55 1.42e-05 GO:0023057 negative regulation of signaling
2.32 2.42e-05 GO:0050769 positive regulation of neurogenesis
2.03 2.60e-05 GO:0022604 regulation of cell morphogenesis
1.39 3.03e-05 GO:0051128 regulation of cellular component organization
1.38 3.23e-05 GO:0040011 locomotion
1.43 3.37e-05 GO:0009790 embryo development
1.20 3.63e-05 GO:0071842 cellular component organization at cellular level
1.17 4.75e-05 GO:0071840 cellular component organization or biogenesis
1.17 4.81e-05 GO:0031323 regulation of cellular metabolic process
1.17 4.94e-05 GO:0080090 regulation of primary metabolic process
2.01 5.33e-05 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.34 7.68e-05 GO:0009605 response to external stimulus
1.66 1.02e-04 GO:0035295 tube development
1.15 1.13e-04 GO:0019222 regulation of metabolic process
1.42 1.19e-04 GO:0009719 response to endogenous stimulus
2.09 1.23e-04 GO:0010720 positive regulation of cell development
1.97 2.18e-04 GO:0010975 regulation of neuron projection development
1.95 2.22e-04 GO:0030111 regulation of Wnt receptor signaling pathway
1.28 2.52e-04 GO:0035556 intracellular signal transduction
1.49 2.72e-04 GO:0072358 cardiovascular system development
1.49 2.72e-04 GO:0072359 circulatory system development
1.47 3.40e-04 GO:0048585 negative regulation of response to stimulus
1.46 3.62e-04 GO:0006935 chemotaxis
1.46 3.62e-04 GO:0042330 taxis
1.60 3.81e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.54 4.00e-04 GO:0051056 regulation of small GTPase mediated signal transduction
2.48 4.71e-04 GO:0045667 regulation of osteoblast differentiation
1.18 5.79e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.39 5.92e-04 GO:0009890 negative regulation of biosynthetic process
1.16 6.12e-04 GO:0060255 regulation of macromolecule metabolic process
1.44 7.06e-04 GO:0023056 positive regulation of signaling
1.38 7.70e-04 GO:0019220 regulation of phosphate metabolic process
1.38 7.70e-04 GO:0051174 regulation of phosphorus metabolic process
1.39 7.93e-04 GO:0042325 regulation of phosphorylation
1.22 7.94e-04 GO:0048513 organ development
1.65 8.33e-04 GO:0046578 regulation of Ras protein signal transduction
1.43 1.08e-03 GO:0051253 negative regulation of RNA metabolic process
1.31 1.12e-03 GO:0009892 negative regulation of metabolic process
1.20 1.15e-03 GO:0042221 response to chemical stimulus
1.38 1.17e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.43 1.20e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.43 1.31e-03 GO:0010647 positive regulation of cell communication
1.33 1.34e-03 GO:0031324 negative regulation of cellular metabolic process
1.59 1.46e-03 GO:0001944 vasculature development
1.39 1.68e-03 GO:0001932 regulation of protein phosphorylation
1.44 2.04e-03 GO:0009967 positive regulation of signal transduction
1.93 2.38e-03 GO:0035023 regulation of Rho protein signal transduction
2.12 2.52e-03 GO:0021953 central nervous system neuron differentiation
1.32 2.67e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.22 2.90e-03 GO:0006464 protein modification process
1.52 2.91e-03 GO:0007389 pattern specification process
1.39 3.04e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.18 3.04e-03 GO:0050770 regulation of axonogenesis
2.70 3.09e-03 GO:0050772 positive regulation of axonogenesis
1.39 3.15e-03 GO:0010629 negative regulation of gene expression
1.60 3.27e-03 GO:0045596 negative regulation of cell differentiation
1.79 3.40e-03 GO:0031344 regulation of cell projection organization
1.79 4.68e-03 GO:0045165 cell fate commitment
1.30 4.79e-03 GO:0042127 regulation of cell proliferation
1.38 4.92e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.37 5.14e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.38 6.33e-03 GO:0009725 response to hormone stimulus
1.24 7.31e-03 GO:0065009 regulation of molecular function
1.37 7.50e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.55 7.88e-03 GO:0007423 sensory organ development
1.28 8.13e-03 GO:0007154 cell communication
1.52 9.54e-03 GO:0001501 skeletal system development
1.68 1.05e-02 GO:0035239 tube morphogenesis
1.59 1.10e-02 GO:0001558 regulation of cell growth
1.28 1.32e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.11 1.38e-02 GO:0032501 multicellular organismal process
1.45 1.41e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.47 1.88e-02 GO:0007420 brain development
1.43 1.97e-02 GO:0040008 regulation of growth
1.31 2.05e-02 GO:0031399 regulation of protein modification process
1.49 2.26e-02 GO:0071495 cellular response to endogenous stimulus
1.48 2.45e-02 GO:0043434 response to peptide hormone stimulus
1.18 3.13e-02 GO:0065008 regulation of biological quality
1.16 3.16e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.15 3.21e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.50 3.40e-02 GO:0048729 tissue morphogenesis
1.88 3.51e-02 GO:0030323 respiratory tube development
1.90 3.56e-02 GO:0030324 lung development
1.95 3.63e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.19 4.11e-02 GO:0043412 macromolecule modification
2.67 4.21e-02 GO:0045669 positive regulation of osteoblast differentiation
1.44 4.38e-02 GO:0090066 regulation of anatomical structure size
1.57 4.40e-02 GO:0002009 morphogenesis of an epithelium

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 1.67e-10 GO:0044424 intracellular part
1.08 1.71e-10 GO:0005622 intracellular
1.11 1.69e-09 GO:0005737 cytoplasm
1.52 2.61e-05 GO:0045202 synapse
1.52 2.84e-05 GO:0043005 neuron projection
1.19 6.42e-04 GO:0044459 plasma membrane part
1.03 8.28e-04 GO:0044464 cell part
1.03 8.78e-04 GO:0005623 cell
1.51 2.05e-03 GO:0044456 synapse part
1.06 2.89e-03 GO:0043226 organelle
1.06 5.03e-03 GO:0043229 intracellular organelle
1.34 6.19e-03 GO:0030054 cell junction
1.27 1.23e-02 GO:0042995 cell projection
1.41 1.76e-02 GO:0031012 extracellular matrix
1.16 1.90e-02 GO:0005829 cytosol
1.08 1.91e-02 GO:0044444 cytoplasmic part
1.06 3.02e-02 GO:0043227 membrane-bounded organelle
1.06 3.46e-02 GO:0043231 intracellular membrane-bounded organelle
1.91 3.97e-02 GO:0042383 sarcolemma

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 9.05e-09 GO:0005515 protein binding
1.06 3.66e-07 GO:0005488 binding
1.93 1.26e-03 GO:0019207 kinase regulator activity
1.29 1.36e-03 GO:0030234 enzyme regulator activity
1.32 4.22e-03 GO:0019899 enzyme binding
1.40 4.51e-03 GO:0030695 GTPase regulator activity
1.41 4.94e-03 GO:0019904 protein domain specific binding
1.40 5.26e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.36 7.34e-03 GO:0008092 cytoskeletal protein binding
1.89 1.34e-02 GO:0019887 protein kinase regulator activity