Motif ID: AIRE.p2

Z-value: 1.420


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator



Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_40454188 2.114 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_40454360 1.577 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr5_+_75734759 1.501 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr17_-_59437782 1.481 NM_000873
ICAM2
intercellular adhesion molecule 2
chr8_-_41774296 1.465 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr19_+_55627971 1.363 NM_004533
MYBPC2
myosin binding protein C, fast type
chr1_-_7895873 1.358 UTS2
urotensin 2
chr1_-_143708467 1.311 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr6_+_10629550 1.277 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr16_-_3567354 1.175 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr12_+_45896318 1.160 NM_138371
FAM113B
family with sequence similarity 113, member B
chr13_-_40491491 1.151 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr17_-_31231421 1.126 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr1_+_179269183 1.014 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr4_-_75066533 1.005 NM_002619
PF4
platelet factor 4
chr19_-_44518516 0.998 NM_004877
GMFG
glia maturation factor, gamma
chr19_+_18069596 0.993 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr11_-_73371531 0.982 NM_003355
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr4_+_69716298 0.919 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr3_-_195601283 0.907 NM_004488
GP5
glycoprotein V (platelet)
chr7_+_116238309 0.904 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr11_+_64694200 0.899 NM_001008778
SPDYC
speedy homolog C (Xenopus laevis)
chr1_-_180624494 0.890 GLUL
glutamate-ammonia ligase
chrX_+_47999740 0.875 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr3_+_173954940 0.868 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr4_-_139382672 0.862 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr8_-_102034777 0.853 NM_003406
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr16_-_28528780 0.847 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr21_-_42608774 0.842 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr13_-_40491405 0.832 ELF1
E74-like factor 1 (ets domain transcription factor)
chr17_+_38259620 0.818 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr16_+_2749934 0.793


chr19_+_13999959 0.788 NM_080864
RLN3
relaxin 3
chr16_+_20328355 0.785 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr3_-_17757402 0.779 NM_014744
TBC1D5
TBC1 domain family, member 5
chr19_-_53444733 0.769 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr11_-_64484184 0.756 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr18_+_27425727 0.754 NM_000371
TTR
transthyretin
chr1_+_20353284 0.743


chr2_-_176656935 0.731 NM_001080458
EVX2
even-skipped homeobox 2
chr10_-_93992982 0.717 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr1_-_32157845 0.710 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr4_+_170817787 0.701 CLCN3
chloride channel 3
chr1_-_159543847 0.685 MPZ
myelin protein zero
chr9_-_124329392 0.665 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr7_-_149960612 0.651 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr5_+_118993152 0.646 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr17_-_30414789 0.642 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr6_-_37575599 0.623 C6orf129
chromosome 6 open reading frame 129
chr15_-_74941339 0.614 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr11_+_73339011 0.603 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr22_+_34979118 0.603 APOL1
apolipoprotein L, 1
chr6_-_159386007 0.599 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr15_+_43036194 0.597 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr1_+_43055362 0.582 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr1_+_559129 0.582


chr1_-_17638729 0.567 RCC2
regulator of chromosome condensation 2
chr15_+_20287609 0.553 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chr22_+_34979062 0.541 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr19_-_53450953 0.536 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr19_-_6621078 0.534 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr1_+_157067729 0.521 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr6_+_31791063 0.517 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr19_-_14646626 0.511 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr9_+_116413443 0.508 NM_153045
C9orf91
chromosome 9 open reading frame 91
chr7_+_75947762 0.507 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr19_-_12695628 0.507 NM_001136195
TNPO2
transportin 2
chr19_-_8314120 0.504 NM_198471
KANK3
KN motif and ankyrin repeat domains 3
chr19_+_2818332 0.502 NM_024967
ZNF556
zinc finger protein 556
chr12_+_49605010 0.499 METTL7A
methyltransferase like 7A
chr2_+_65069081 0.498 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr1_+_239762179 0.493 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr2_+_172530120 0.492 HAT1
histone acetyltransferase 1
chr19_+_56958452 0.490 NM_001462
FPR2
formyl peptide receptor 2
chrX_+_153310313 0.487 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr9_+_6710862 0.486 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr7_-_99518294 0.478 ZNF3
zinc finger protein 3
chr15_-_19007127 0.475 NM_001145004
GOLGA6L6
golgin A6 family-like 6
chr22_-_34886727 0.474 NM_145640
APOL3
apolipoprotein L, 3
chr4_-_123761615 0.469 NM_021803
IL21
interleukin 21
chr6_+_53043729 0.466 NM_012347
FBXO9
F-box protein 9
chr2_-_20390601 0.461 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr1_+_158975662 0.457 NM_021181
SLAMF7
SLAM family member 7
chr17_+_63367052 0.450 BPTF
bromodomain PHD finger transcription factor
chr4_-_38710376 0.449 NM_024943
TMEM156
transmembrane protein 156
chr13_+_49100435 0.448 NM_138450
ARL11
ADP-ribosylation factor-like 11
chr11_-_62195587 0.447 C11orf48
chromosome 11 open reading frame 48
chr15_+_56217686 0.446 NM_020980
AQP9
aquaporin 9
chr1_+_15941503 0.443 NM_001013641
TMEM82
transmembrane protein 82
chr4_-_160175782 0.435 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr9_-_85761353 0.434 C9orf64
chromosome 9 open reading frame 64
chr8_-_7710547 0.434 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr10_+_49279647 0.433 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr2_+_201806410 0.431 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr20_-_33658823 0.430 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr7_+_2565238 0.428 IQCE
IQ motif containing E
chr2_-_32344192 0.427 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr4_+_39874921 0.426 NM_004310
RHOH
ras homolog gene family, member H
chr16_-_727889 0.426 NARFL
nuclear prelamin A recognition factor-like
chr11_+_65236261 0.422 KAT5
K(lysine) acetyltransferase 5
chr6_-_33864863 0.421 LEMD2
LEM domain containing 2
chr12_+_108035424 0.418


chr1_-_167947301 0.418 NM_000655
SELL
selectin L
chr17_+_63766874 0.416 NM_014960
ARSG
arylsulfatase G
chr6_-_33864876 0.414 LEMD2
LEM domain containing 2
chr1_+_51208499 0.410 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr2_-_231498184 0.408 NM_005683
GPR55
G protein-coupled receptor 55
chr6_+_163904564 0.407 QKI
quaking homolog, KH domain RNA binding (mouse)
chr6_-_33864883 0.396 NM_181336
LEMD2
LEM domain containing 2
chr6_-_99957253 0.389 SFRS18
splicing factor, arginine/serine-rich 18
chr6_+_6533932 0.384 NM_004271
LY86
lymphocyte antigen 86
chr10_-_32707549 0.379 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr10_+_22645304 0.377 NM_012071
COMMD3-BMI1
COMMD3
COMMD3-BMI1 read-through transcript
COMM domain containing 3
chr4_+_159662349 0.374 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chrX_-_102418329 0.371 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr7_+_2565202 0.369 IQCE
IQ motif containing E
chr5_-_39238818 0.368 FYB
FYN binding protein
chr8_-_30704984 0.367 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr17_+_59875623 0.363 NM_001085423
C17orf60
chromosome 17 open reading frame 60
chr22_+_21359175 0.361 IGLV3-25
immunoglobulin lambda variable 3-25
chr11_-_32772731 0.361 NM_001008391
CCDC73
coiled-coil domain containing 73
chrX_-_2892288 0.360 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr2_+_113911737 0.359 NM_172003
CBWD2
CBWD1
COBW domain containing 2
COBW domain containing 1
chr5_-_1050408 0.358 LOC100506688
hypothetical protein LOC100506688
chr13_-_45640679 0.357 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_-_38279757 0.356 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr13_-_98708549 0.355 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr6_+_36318922 0.351 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr5_-_149772563 0.350 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr17_+_28342994 0.349 NM_173847
SPACA3
sperm acrosome associated 3
chrX_-_70045285 0.348 NM_001003811
NM_031276
TEX11

testis expressed 11

chr15_-_38953628 0.347 NM_133639
RHOV
ras homolog gene family, member V
chr8_-_42742729 0.343 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr19_-_12028126 0.342 NM_001080404
ZNF878
zinc finger protein 878
chr3_-_152478843 0.342 NM_014879
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr1_+_15655809 0.337 NM_033440
CELA2A
chymotrypsin-like elastase family, member 2A
chr2_+_231829021 0.335


chr20_-_10360569 0.335 NM_018848
MKKS
McKusick-Kaufman syndrome
chr4_-_176970895 0.330 GPM6A
glycoprotein M6A
chr2_-_85490997 0.326 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr2_+_38009405 0.324 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr6_-_37575666 0.323 NM_138493
C6orf129
chromosome 6 open reading frame 129
chr16_-_73258218 0.323 RFWD3
ring finger and WD repeat domain 3
chr4_+_53986759 0.323 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr12_+_132124125 0.322 ZNF84
zinc finger protein 84
chr7_+_111908143 0.320 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr19_+_21056792 0.318 NM_182515
ZNF714
zinc finger protein 714
chr10_-_101831579 0.318 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr19_+_17499064 0.312 FAM129C
family with sequence similarity 129, member C
chrX_-_100193747 0.311 NM_001167970
NM_001167971
NM_001167972
NM_024917
TRMT2B



TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)



chr19_-_44014228 0.311 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chrX_-_100193698 0.303 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr1_-_9052207 0.301 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr16_+_20682812 0.299 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr9_-_135923373 0.298 BRD3
bromodomain containing 3
chr16_+_80370400 0.298 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr12_-_53064723 0.298 NM_015481
ZNF385A
zinc finger protein 385A
chr6_+_33352886 0.298 NM_003782
B3GALT4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr17_-_74361620 0.296 TIMP2
TIMP metallopeptidase inhibitor 2
chr11_-_104274606 0.291 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr19_+_4104593 0.290 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr19_+_59866237 0.286 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr2_+_73864823 0.283 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chr2_+_215885053 0.283 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr12_+_132124211 0.281 ZNF84
zinc finger protein 84
chr6_-_33085329 0.278 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr18_-_46600295 0.278 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr8_+_86287161 0.274 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr7_-_64104441 0.274 NM_001007253
ERV3
ZNF117
endogenous retroviral sequence 3
zinc finger protein 117
chr6_+_31698447 0.273


chr4_+_39084867 0.272 NM_175737
KLB
klotho beta
chr1_+_246087230 0.268 TRIM58
tripartite motif containing 58
chr1_-_89437098 0.264 NM_052941
GBP4
guanylate binding protein 4
chr19_-_6375801 0.261 KHSRP
KH-type splicing regulatory protein
chr4_+_88187215 0.261 AFF1
AF4/FMR2 family, member 1
chrX_-_70243362 0.260 NM_001025265
CXorf65
chromosome X open reading frame 65
chr6_+_41996971 0.259 BYSL
bystin-like
chr2_-_170138558 0.259 NM_024622
FASTKD1
FAST kinase domains 1
chr21_+_39674112 0.258 WRB
tryptophan rich basic protein
chr6_-_31668476 0.255 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr11_-_73371452 0.255 UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr22_-_20419975 0.255 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr4_+_109791181 0.254 NM_021227
OSTC
oligosaccharyltransferase complex subunit
chr4_+_106851415 0.254 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr6_-_31938572 0.253 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr6_-_11490487 0.253 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr15_+_64372876 0.253 NM_001143688
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chrX_-_19443299 0.251 NM_001001671
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr19_-_55358091 0.250 NM_152358
IZUMO2
IZUMO family member 2
chr4_+_123380569 0.250 KIAA1109
KIAA1109
chr4_+_109791229 0.249 OSTC
oligosaccharyltransferase complex subunit
chr7_-_38341697 0.246 TRGV7
T cell receptor gamma variable 7 pseudogene
chr3_-_15357878 0.244 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr2_+_169637255 0.243 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr19_-_6375820 0.242 NM_003685
KHSRP
KH-type splicing regulatory protein
chr16_-_1434490 0.241 NM_001143980
CCDC154
coiled-coil domain containing 154
chr11_-_6418705 0.240 NM_000613
HPX
hemopexin
chr1_-_158759606 0.239 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr2_+_215884923 0.239 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr16_+_65552600 0.238 NM_001185177
NM_024922
CES3

carboxylesterase 3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.33 2.63e-04 GO:0002682 regulation of immune system process
2.07 3.54e-03 GO:0006952 defense response
2.51 3.88e-03 GO:0050776 regulation of immune response
1.78 1.27e-02 GO:0002376 immune system process
2.04 1.45e-02 GO:0006955 immune response
2.38 2.32e-02 GO:0002684 positive regulation of immune system process

Nothing significant found in compartment category.

Nothing significant found in function category.