Motif ID: EOMES.p2

Z-value: 1.115


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin



Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_47004457 2.117 NBEAL2
neurobeachin-like 2
chr11_-_65070625 1.741 LTBP3
latent transforming growth factor beta binding protein 3
chr16_+_11966464 1.713 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr6_+_105511615 1.638 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr6_+_167456230 1.346 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr17_-_40858775 1.233 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr1_-_199259133 1.224 KIF21B
kinesin family member 21B
chr7_+_50318801 1.181 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr17_+_53761293 1.148 LOC100506779
hypothetical LOC100506779
chr11_-_33870411 1.127 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_5227611 1.015 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr6_-_130578110 1.003 NM_152552
SAMD3
sterile alpha motif domain containing 3
chrX_+_57329834 0.977 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr1_-_155053124 0.973 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr12_+_97513644 0.959 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr7_-_150283794 0.943 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr7_+_113853790 0.941 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr10_+_114125955 0.894 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_42920946 0.860 YBX1
Y box binding protein 1
chr1_-_153098811 0.841 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr4_-_186969041 0.829 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr14_-_23107106 0.809 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr2_-_74606819 0.803 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr4_-_186969202 0.775 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr1_-_239865724 0.738 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr17_-_53761119 0.732 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr14_-_23106372 0.705 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr2_+_171280046 0.704 NM_001003845
SP5
Sp5 transcription factor
chr14_-_23106779 0.683 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr7_-_16471817 0.667 NM_015464
SOSTDC1
sclerostin domain containing 1
chr2_+_171280182 0.647


chr10_+_4995685 0.631 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chrX_-_135783496 0.621


chr10_+_114125927 0.619 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_-_39306465 0.616 FYB
FYN binding protein
chr3_-_42818221 0.610


chr17_+_22823151 0.599 NM_014238
KSR1
kinase suppressor of ras 1
chr7_-_20793028 0.599 NM_182700
NM_198956
SP8

Sp8 transcription factor

chr20_+_55338221 0.598 NM_012444
NM_198265
SPO11

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

chr1_+_93072947 0.597 RPL5
ribosomal protein L5
chr15_+_38849450 0.591 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr11_+_60858611 0.587 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr4_+_109763119 0.580 RPL34
ribosomal protein L34
chr2_-_25328452 0.570 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_+_42920635 0.570 NM_004559
YBX1
Y box binding protein 1
chr4_+_100957003 0.564 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr10_+_50177192 0.559 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr16_+_67697622 0.556 NM_138612
HAS3
hyaluronan synthase 3
chr10_+_4995597 0.553 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_+_42920755 0.545 YBX1
Y box binding protein 1
chr1_+_148496792 0.538 NM_012113
CA14
carbonic anhydrase XIV
chr3_+_195336631 0.532 HES1
hairy and enhancer of split 1, (Drosophila)
chr1_-_114215768 0.531 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr19_+_10242763 0.527 ICAM1
intercellular adhesion molecule 1
chr1_+_42920718 0.522 YBX1
Y box binding protein 1
chr9_+_134884627 0.517 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr1_+_559129 0.512


chr1_-_243092581 0.506 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr10_+_114126004 0.498 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_74284522 0.497 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr21_+_39745649 0.487 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr3_-_186752952 0.486 NM_139248
LIPH
lipase, member H
chr11_-_5232480 0.479 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr1_+_42920692 0.476 YBX1
Y box binding protein 1
chr1_-_51198052 0.471 FAF1
Fas (TNFRSF6) associated factor 1
chr1_+_42920685 0.471 YBX1
Y box binding protein 1
chr20_-_22513050 0.469 NM_021784
FOXA2
forkhead box A2
chr5_+_61750467 0.462 NM_001134779
IPO11
importin 11
chr10_+_44726635 0.454 NM_001123376
TMEM72
transmembrane protein 72
chr11_+_73036241 0.454 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr20_+_32926452 0.451 ACSS2
acyl-CoA synthetase short-chain family member 2
chr19_-_45947667 0.450 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr11_+_46358909 0.448 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr12_+_56435042 0.445 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr2_-_61551350 0.444 NM_014709
USP34
ubiquitin specific peptidase 34
chr1_-_51198383 0.443 FAF1
Fas (TNFRSF6) associated factor 1
chr12_+_55896844 0.443 NM_007224
NXPH4
neurexophilin 4
chr1_+_26609819 0.432 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr17_-_39700960 0.432 NM_000342
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr6_+_88024152 0.430 ZNF292
zinc finger protein 292
chr1_+_42920683 0.429 YBX1
Y box binding protein 1
chr7_+_107008439 0.428 NM_001008405
BCAP29
B-cell receptor-associated protein 29
chr1_+_210848726 0.426 ATF3
activating transcription factor 3
chrX_+_152608159 0.424 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr14_+_20319049 0.417 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr20_-_61669550 0.414 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr12_-_51173238 0.414 NM_005554
KRT6A
keratin 6A
chr12_+_6424293 0.411 NM_001242
CD27
CD27 molecule
chr20_+_35406497 0.409 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr2_+_228386800 0.403 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr2_-_113259441 0.403 NM_000575
IL1A
interleukin 1, alpha
chr1_+_224477941 0.401 NM_031944
MIXL1
Mix1 homeobox-like 1 (Xenopus laevis)
chr1_+_32489426 0.401 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr3_+_139211639 0.400 NM_016369
CLDN18
claudin 18
chr19_+_60283571 0.399 NM_017729
EPS8L1
EPS8-like 1
chr5_+_133478252 0.399 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr11_-_110755112 0.397 POU2AF1
POU class 2 associating factor 1
chr6_-_159386007 0.396 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr9_+_126460511 0.396


chr1_-_51198417 0.392 FAF1
Fas (TNFRSF6) associated factor 1
chr3_-_140879463 0.391 NM_178177
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chrX_-_15783015 0.389 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chrX_+_23595579 0.386 PRDX4
peroxiredoxin 4
chr17_+_22982383 0.382 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_+_198263352 0.382 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr16_+_23754822 0.382 PRKCB
protein kinase C, beta
chr22_-_39189369 0.376 MKL1
megakaryoblastic leukemia (translocation) 1
chr12_+_73219826 0.375


chr20_+_43943254 0.372 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr20_-_54013418 0.372 NM_080617
CBLN4
cerebellin 4 precursor
chr7_-_104696678 0.370 NM_182691
SRPK2
SRSF protein kinase 2
chr2_+_171280944 0.369 SP5
Sp5 transcription factor
chr3_-_197549588 0.368 TM4SF19
transmembrane 4 L six family member 19
chr1_+_26609893 0.366 LIN28A
lin-28 homolog A (C. elegans)
chrX_-_154216929 0.362 NM_001289
CLIC2
chloride intracellular channel 2
chr10_+_114125003 0.360 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr15_-_81271859 0.356 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr10_+_70517823 0.355 NM_002727
SRGN
serglycin
chr21_-_46528594 0.354 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr1_+_210848763 0.354 ATF3
activating transcription factor 3
chr5_-_34078991 0.349 NM_030945
NM_181435
C1QTNF3

C1q and tumor necrosis factor related protein 3

chr5_-_138753443 0.348 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr1_+_180836050 0.346


chr2_+_65070030 0.345 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr16_+_28850760 0.345 NM_001178098
NM_001770
CD19

CD19 molecule

chr19_+_50863341 0.342 NM_000164
GIPR
gastric inhibitory polypeptide receptor
chr2_-_61551403 0.339 USP34
ubiquitin specific peptidase 34
chr11_-_118405288 0.338 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chrX_-_16797895 0.338 NM_001198719
RBBP7
retinoblastoma binding protein 7
chr1_+_151867483 0.332 NM_006271
S100A1
S100 calcium binding protein A1
chr15_+_64481270 0.330 MAP2K1
mitogen-activated protein kinase kinase 1
chr8_-_42353719 0.328 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr7_-_137271191 0.326 CREB3L2
cAMP responsive element binding protein 3-like 2
chr7_-_22518200 0.326 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr1_-_25129305 0.325 RUNX3
runt-related transcription factor 3
chr3_-_49701085 0.324 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr5_-_110090264 0.323 NM_001039763
TMEM232
transmembrane protein 232
chr2_+_218954995 0.321 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr21_+_42697058 0.321 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr6_+_135544214 0.320 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_-_114925734 0.318 NM_005872
BCAS2
breast carcinoma amplified sequence 2
chr17_+_22982344 0.316 LGALS9
lectin, galactoside-binding, soluble, 9
chr11_-_111255354 0.315 NM_138378
ALG9
FDXACB1
asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae)
ferredoxin-fold anticodon binding domain containing 1
chr8_-_146173531 0.314 ZNF252
zinc finger protein 252
chr1_-_26505653 0.314 NM_001077262
NM_183008
UBXN11

UBX domain protein 11

chrX_-_18600108 0.312 NM_000330
RS1
retinoschisin 1
chr6_+_34867794 0.310 UHRF1BP1
UHRF1 binding protein 1
chr1_-_151867338 0.308 NM_005979
S100A13
S100 calcium binding protein A13
chr5_+_132037271 0.306 NM_000589
NM_172348
IL4

interleukin 4

chr10_+_70517863 0.303 SRGN
serglycin
chr4_-_54152480 0.300 NM_001126328
LNX1
ligand of numb-protein X 1
chr1_-_25129354 0.297 NM_004350
RUNX3
runt-related transcription factor 3
chr3_-_197549640 0.296 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr1_+_210848592 0.296 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chr9_-_129580732 0.295 NM_170600
SH2D3C
SH2 domain containing 3C
chr7_+_142723340 0.294 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr12_+_130004404 0.294 NM_198827
GPR133
G protein-coupled receptor 133
chr17_-_74244539 0.293


chr4_+_75393053 0.287 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr1_+_51208499 0.287 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr5_+_147754467 0.286 FBXO38
F-box protein 38
chr5_-_138746917 0.285 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr11_+_73037382 0.285 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr16_+_23754772 0.284 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr5_+_67622242 0.284 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_+_131936057 0.281 NM_000045
ARG1
arginase, liver
chr17_+_22982372 0.280 LGALS9
lectin, galactoside-binding, soluble, 9
chr19_+_2240996 0.280


chr6_+_135544170 0.280 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr5_+_96237399 0.279 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr15_-_50270856 0.278 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr5_-_168204430 0.278


chr6_+_31651319 0.276 NM_000594
TNF
tumor necrosis factor
chr12_-_23995220 0.276 SOX5
SRY (sex determining region Y)-box 5
chr17_-_59312892 0.273 NM_002059
NM_022556
NM_022557
NM_022558
GH2



growth hormone 2



chr13_+_51496679 0.273 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr22_-_20551953 0.272 NM_002745
NM_138957
MAPK1

mitogen-activated protein kinase 1

chr4_-_56153135 0.271 NM_152401
PDCL2
phosducin-like 2
chr11_+_65164167 0.270 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr7_-_92686773 0.270 NM_198151
HEPACAM2
HEPACAM family member 2
chr1_+_42920889 0.269 YBX1
Y box binding protein 1
chr17_+_27795633 0.268 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr16_-_66523255 0.268 NM_001907
CTRL
chymotrypsin-like
chr1_+_39229474 0.267 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr17_-_36232366 0.267 NM_000421
KRT10
keratin 10
chr8_-_8276598 0.267 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr5_-_138746840 0.266 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr3_+_10832867 0.265 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr16_-_30301634 0.263 NM_052838
SEPT1
septin 1
chr7_+_69869099 0.263 AUTS2
autism susceptibility candidate 2
chr2_+_183651713 0.263 DUSP19
dual specificity phosphatase 19
chr1_-_51198328 0.261 FAF1
Fas (TNFRSF6) associated factor 1
chr12_-_7172641 0.260 NM_031491
RBP5
retinol binding protein 5, cellular
chr17_+_22982319 0.259 LGALS9
lectin, galactoside-binding, soluble, 9
chr19_-_49523747 0.259 ZFP112
zinc finger protein 112 homolog (mouse)
chr16_-_79811475 0.257 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr17_+_22982278 0.255 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr15_-_38644521 0.255 NM_001080791
NM_001080792
NM_052849
C15orf57


chromosome 15 open reading frame 57


chr6_+_135544138 0.254 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr11_-_5110383 0.253 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 2.62e-03 GO:0023052 signaling

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.55 3.64e-03 GO:0046873 metal ion transmembrane transporter activity
1.50 1.05e-02 GO:0005102 receptor binding