Motif ID: LMO2.p2

Z-value: 1.718


Transcription factors associated with LMO2.p2:

Gene SymbolEntrez IDGene Name
LMO2 4005 LIM domain only 2 (rhombotin-like 1)



Activity profile for motif LMO2.p2.

activity profile for motif LMO2.p2


Sorted Z-values histogram for motif LMO2.p2

Sorted Z-values for motif LMO2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LMO2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_817584 2.473 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr22_+_20068039 2.262 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr22_-_20235372 2.225 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr13_+_77170470 2.149 NM_001040153
SLAIN1
SLAIN motif family, member 1
chr3_-_184316553 2.126 MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr14_+_30413393 2.031 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr9_-_96441567 2.013 FBP1
fructose-1,6-bisphosphatase 1
chr17_-_18890963 2.005 NM_006613
GRAP
GRB2-related adaptor protein
chr20_+_60744268 1.938 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr10_-_98470164 1.914 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr20_+_60744231 1.853 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr1_-_1840564 1.842 NM_178545
TMEM52
transmembrane protein 52
chr22_-_36212160 1.809 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr9_-_96441409 1.760 FBP1
fructose-1,6-bisphosphatase 1
chr6_+_36206239 1.749 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr6_-_3172775 1.724 NM_178012
TUBB2B
tubulin, beta 2B
chr9_-_96441654 1.708 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr15_+_86983038 1.698 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr20_-_3097070 1.691 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr22_-_49317408 1.687 ODF3B
outer dense fiber of sperm tails 3B
chr4_-_2390050 1.664 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr11_+_63864263 1.646 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr3_+_39826032 1.623 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr9_-_139183675 1.615


chr14_-_22358752 1.550 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr11_-_684842 1.545 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr8_+_11599119 1.517 NM_002052
GATA4
GATA binding protein 4
chr19_+_14405216 1.468 PKN1
protein kinase N1
chr15_-_50375143 1.466 NM_018728
MYO5C
myosin VC
chr22_+_23153529 1.446 NM_000675
ADORA2A
adenosine A2a receptor
chr10_+_94823221 1.444 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr17_+_18971506 1.436 NM_001129778
GRAPL
GRB2-related adaptor protein-like
chr17_-_70480345 1.427


chr1_-_92724181 1.408 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr7_-_130891861 1.398 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr20_+_36867708 1.374 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr1_-_40555413 1.367 COL9A2
collagen, type IX, alpha 2
chr2_+_171280944 1.365 SP5
Sp5 transcription factor
chr1_+_42619014 1.342 NM_173642
RIMKLA
ribosomal modification protein rimK-like family member A
chr1_-_23729871 1.288 E2F2
E2F transcription factor 2
chr10_+_70881322 1.274


chr17_-_70480385 1.274 NM_030630
C17orf28
chromosome 17 open reading frame 28
chr2_-_6923215 1.272 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr14_-_99695684 1.267 NM_206918
DEGS2
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
chr10_+_70257568 1.262 NM_001130162
STOX1
storkhead box 1
chr1_-_40555511 1.258 NM_001852
COL9A2
collagen, type IX, alpha 2
chr16_-_55875953 1.253 PLLP
plasmolipin
chr2_-_25328452 1.242 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_-_27113018 1.238 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr5_+_168996816 1.224 NM_004946
DOCK2
dedicator of cytokinesis 2
chr4_-_647424 1.217


chr3_-_13436802 1.210 NM_024923
NUP210
nucleoporin 210kDa
chr5_+_168996852 1.208 DOCK2
dedicator of cytokinesis 2
chr14_+_71468902 1.184 RGS6
regulator of G-protein signaling 6
chr2_+_222997529 1.181 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr15_+_89228668 1.179 NM_001143785
NM_002005
FES

feline sarcoma oncogene

chr11_-_124137260 1.175 NM_138961
ESAM
endothelial cell adhesion molecule
chr17_+_58908152 1.168 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr1_-_45444812 1.164 NM_020883
ZSWIM5
zinc finger, SWIM-type containing 5
chr17_-_34015631 1.154 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr20_-_23014828 1.151 NM_012072
CD93
CD93 molecule
chr16_-_30301357 1.147 SEPT1
septin 1
chr16_-_87570716 1.145 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr11_+_70915960 1.145 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr11_+_70926718 1.144 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr2_+_190753833 1.140 NM_001042519
NM_032321
C2orf88

chromosome 2 open reading frame 88

chr12_-_61614930 1.138 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr15_+_81567327 1.137 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr1_-_218168404 1.131


chr7_-_8268292 1.130 NM_001136020
ICA1
islet cell autoantigen 1, 69kDa
chr19_-_7845325 1.123 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr7_-_37454933 1.121 NM_014800
ELMO1
engulfment and cell motility 1
chr12_-_61615124 1.110 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr4_-_15694407 1.108 PROM1
prominin 1
chr19_-_1352474 1.102 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr16_-_2330738 1.100 NM_001089
ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr6_+_11646472 1.092 NM_001100829
TMEM170B
transmembrane protein 170B
chr22_-_22511173 1.091 NM_001002862
NM_001135751
NM_198440
DERL3


Der1-like domain family, member 3


chr16_+_86194075 1.082 JPH3
junctophilin 3
chr8_+_17478214 1.081 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr10_+_70257299 1.079 NM_001130159
NM_001130160
NM_001130161
NM_152709
STOX1



storkhead box 1



chr2_+_113648020 1.063 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chr1_+_12149637 1.056 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr9_-_139084833 1.031 NM_178448
C9orf140
chromosome 9 open reading frame 140
chr19_+_5082230 1.030 KDM4B
lysine (K)-specific demethylase 4B
chr1_-_1701313 1.028 NM_001198994
NADK
NAD kinase
chr9_+_115265827 1.025 NM_017790
RGS3
regulator of G-protein signaling 3
chr1_-_32479785 1.022 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr20_+_42463279 1.011 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr22_+_16973399 1.010 NM_001193414
NM_018943
TUBA8

tubulin, alpha 8

chr16_-_55876075 0.997 NM_015993
PLLP
plasmolipin
chr4_+_2390469 0.996 NM_001193282
LOC402160
hypothetical protein LOC402160
chr17_+_73676219 0.993 NM_004710
SYNGR2
synaptogyrin 2
chr20_+_48032918 0.992 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr19_+_6723801 0.992


chr6_+_31647854 0.991 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr2_+_113648036 0.990 PSD4
pleckstrin and Sec7 domain containing 4
chr1_+_12149662 0.986 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr19_+_10392128 0.984 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr6_-_35804337 0.983 NM_001145775
FKBP5
FK506 binding protein 5
chr9_+_139292094 0.977 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr16_-_2330594 0.976 ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr2_+_222997456 0.976 SGPP2
sphingosine-1-phosphate phosphatase 2
chr1_-_51568818 0.975 TTC39A
tetratricopeptide repeat domain 39A
chr8_+_21937533 0.973 NPM2
nucleophosmin/nucleoplasmin 2
chr3_+_161426322 0.966 LOC401097
hypothetical protein LOC401097
chr2_+_231968578 0.963 NM_145236
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr7_-_8268206 0.963 NM_022307
ICA1
islet cell autoantigen 1, 69kDa
chr16_+_51690564 0.962 CHD9
chromodomain helicase DNA binding protein 9
chr5_-_94646033 0.961 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr2_-_97016027 0.959 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr1_-_218168137 0.955 SLC30A10
solute carrier family 30, member 10
chr10_+_82158186 0.955 NM_032333
C10orf58
chromosome 10 open reading frame 58
chr16_+_66022551 0.954 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr5_-_136862130 0.952 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr11_+_64635870 0.950 NM_003273
TM7SF2
transmembrane 7 superfamily member 2
chr5_+_156625629 0.946 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr6_+_44295219 0.940 NM_001078174
NM_004955
SLC29A1

solute carrier family 29 (nucleoside transporters), member 1

chr2_-_198359182 0.939 NM_197970
BOLL
bol, boule-like (Drosophila)
chr16_+_66022520 0.932 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr2_-_232499202 0.927 NM_024409
NPPC
natriuretic peptide C
chr7_-_3049872 0.926 NM_032415
CARD11
caspase recruitment domain family, member 11
chr7_-_960534 0.925 ADAP1
ArfGAP with dual PH domains 1
chr20_+_42463419 0.924 HNF4A
hepatocyte nuclear factor 4, alpha
chr19_-_44060729 0.924 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr4_+_39874921 0.916 NM_004310
RHOH
ras homolog gene family, member H
chr20_+_62158882 0.915 NM_198723
TCEA2
transcription elongation factor A (SII), 2
chr7_+_140420500 0.913 NM_001195278
LOC100131199
transmembrane protein 178-like
chr19_-_11550765 0.913 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr5_-_176868483 0.906 DOK3
docking protein 3
chr2_-_135193011 0.905 NM_030923
TMEM163
transmembrane protein 163
chr1_+_90060131 0.903 LRRC8D
leucine rich repeat containing 8 family, member D
chr2_+_72998111 0.901 NM_004097
EMX1
empty spiracles homeobox 1
chr7_+_149696901 0.901 REPIN1
replication initiator 1
chr14_+_105027236 0.899 NM_001198983
C14orf80
chromosome 14 open reading frame 80
chr1_-_24112345 0.899 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr2_+_10779191 0.896 NM_001039362
NM_144583
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr9_-_91302707 0.894 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr11_-_33847507 0.894 LMO2
LIM domain only 2 (rhombotin-like 1)
chr20_+_61839931 0.885 LIME1
Lck interacting transmembrane adaptor 1
chr20_-_62081752 0.884 SAMD10
sterile alpha motif domain containing 10
chr7_-_72822471 0.883 NM_001306
CLDN3
claudin 3
chr19_-_6621078 0.883 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr14_-_26136799 0.882 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr16_-_55876099 0.880 PLLP
plasmolipin
chr13_-_71338144 0.878 DACH1
dachshund homolog 1 (Drosophila)
chr20_-_62081434 0.874 NM_080621
SAMD10
sterile alpha motif domain containing 10
chr8_+_104452877 0.870 CTHRC1
collagen triple helix repeat containing 1
chr20_+_42463350 0.864 HNF4A
hepatocyte nuclear factor 4, alpha
chrX_+_115481774 0.860 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr20_+_42463387 0.855 HNF4A
hepatocyte nuclear factor 4, alpha
chr16_-_1369613 0.854 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr19_-_40325194 0.851 LGI4
leucine-rich repeat LGI family, member 4
chr15_-_46257745 0.851 NM_016132
MYEF2
myelin expression factor 2
chr1_-_159257567 0.849 F11R
F11 receptor
chr11_-_66945190 0.849 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr1_-_51583281 0.848 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chrX_+_152562013 0.847 DUSP9
dual specificity phosphatase 9
chr17_-_17050326 0.843 PLD6
phospholipase D family, member 6
chr1_-_159257486 0.843 F11R
F11 receptor
chr19_-_11550576 0.843 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr17_-_71747867 0.840 NM_052916
RNF157
ring finger protein 157
chr22_-_49317873 0.840 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr19_+_60851207 0.836 CCDC106
coiled-coil domain containing 106
chr21_-_38792173 0.836 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr17_-_8809656 0.834 NM_001142633
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr5_-_95794416 0.831 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr16_-_2330712 0.830 ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr5_-_1348103 0.825 NM_001193376
NM_198253
TERT

telomerase reverse transcriptase

chr15_+_48261649 0.822 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr16_+_56616782 0.816 NM_002428
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr3_-_13436725 0.815 NUP210
nucleoporin 210kDa
chr2_+_219453487 0.813 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr7_+_50314801 0.810 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr16_+_84204424 0.810 NM_014615
KIAA0182
KIAA0182
chr17_+_7393098 0.807 NM_172089
NM_003809
TNFSF12-TNFSF13
TNFSF12
TNFSF12-TNFSF13 readthrough
tumor necrosis factor (ligand) superfamily, member 12
chr9_+_115303527 0.806 NM_130795
RGS3
regulator of G-protein signaling 3
chr2_-_74583850 0.806 NM_001009812
LBX2
ladybird homeobox 2
chr17_+_45008473 0.803 NXPH3
neurexophilin 3
chrX_+_115481848 0.803 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr17_-_17050355 0.803 NM_178836
PLD6
phospholipase D family, member 6
chr9_-_122731263 0.800 NM_001190945
TRAF1
TNF receptor-associated factor 1
chr5_-_136862317 0.800 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr9_+_128716867 0.796 NM_001190729
NM_001190730
NM_014636
RALGPS1


Ral GEF with PH domain and SH3 binding motif 1


chr9_-_35640852 0.792 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr19_-_11355882 0.790 NM_000121
EPOR
erythropoietin receptor
chr12_-_109611277 0.789 NM_032369
HVCN1
hydrogen voltage-gated channel 1
chr1_+_26744893 0.784 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_+_109112428 0.781 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr16_+_86193993 0.780 NM_020655
JPH3
junctophilin 3
chr4_+_2783764 0.779 SH3BP2
SH3-domain binding protein 2
chr9_+_70509925 0.777 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr20_+_41576459 0.776 NM_015478
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr16_+_84202515 0.775 NM_001134473
KIAA0182
KIAA0182
chr16_-_2186465 0.773 NM_020764
CASKIN1
CASK interacting protein 1
chr16_-_76026431 0.768 NM_199355
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr11_-_65070625 0.766 LTBP3
latent transforming growth factor beta binding protein 3
chr16_+_56616970 0.766 MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr14_+_104261578 0.764 NM_152328
ADSSL1
adenylosuccinate synthase like 1
chr15_-_38332401 0.764 NM_001039905
C15orf56
chromosome 15 open reading frame 56

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 2.46e-07 GO:0009987 cellular process
1.21 4.52e-06 GO:0023052 signaling
1.20 1.17e-05 GO:0032502 developmental process
1.21 2.48e-05 GO:0007275 multicellular organismal development
1.11 6.89e-05 GO:0065007 biological regulation
1.27 1.50e-04 GO:0030154 cell differentiation
1.27 1.53e-04 GO:0048869 cellular developmental process
1.20 3.75e-04 GO:0048856 anatomical structure development
1.19 4.38e-04 GO:0007165 signal transduction
1.22 5.06e-04 GO:0048731 system development
1.29 7.75e-04 GO:0023051 regulation of signaling
1.11 1.01e-03 GO:0050794 regulation of cellular process
1.11 2.19e-03 GO:0050789 regulation of biological process
1.16 2.43e-03 GO:0051716 cellular response to stimulus
1.23 3.51e-03 GO:0065008 regulation of biological quality
1.82 6.70e-03 GO:0003013 circulatory system process
1.82 6.70e-03 GO:0008015 blood circulation
1.30 6.83e-03 GO:0051239 regulation of multicellular organismal process
1.21 8.10e-03 GO:0048519 negative regulation of biological process
1.25 9.54e-03 GO:0007166 cell surface receptor linked signaling pathway
1.28 1.03e-02 GO:0007399 nervous system development
1.22 1.18e-02 GO:0048523 negative regulation of cellular process
1.17 1.30e-02 GO:0051179 localization
1.51 1.78e-02 GO:0046903 secretion
1.24 1.79e-02 GO:0048583 regulation of response to stimulus
1.41 4.01e-02 GO:0071310 cellular response to organic substance
1.26 4.56e-02 GO:0009966 regulation of signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 2.59e-05 GO:0005737 cytoplasm
1.06 2.66e-03 GO:0044424 intracellular part
1.06 3.67e-03 GO:0005622 intracellular
1.28 4.56e-02 GO:0005794 Golgi apparatus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.54 4.29e-04 GO:0030695 GTPase regulator activity
1.47 1.82e-03 GO:0008092 cytoskeletal protein binding
1.50 1.85e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.09 1.10e-02 GO:0005515 protein binding
3.84 3.42e-02 GO:0004697 protein kinase C activity
1.05 4.59e-02 GO:0005488 binding