• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: TFEB.p2

Z-value: 2.198

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_-_27162688	4.531	NM_006896	HOXA7	homeobox A7
chr1_-_68470585	4.075	NM_001002292 NM_001193334 NM_024911	WLS	wntless homolog (Drosophila)
chr13_+_112999538	3.532		LAMP1	lysosomal-associated membrane protein 1
chrX_-_34585287	3.372	NM_031442	TMEM47	transmembrane protein 47
chr1_-_239587090	3.299	NM_002924	RGS7	regulator of G-protein signaling 7
chr13_+_112999590	3.272		LAMP1	lysosomal-associated membrane protein 1
chr13_+_112999462	3.252	NM_005561	LAMP1	lysosomal-associated membrane protein 1
chr10_-_14090459	3.181		FRMD4A	FERM domain containing 4A
chr22_+_34107087	3.164		HMOX1	heme oxygenase (decycling) 1
chr22_+_34107051	3.137	NM_002133	HMOX1	heme oxygenase (decycling) 1
chrX_+_101862297	3.056	NM_001142524 NM_001142525 NM_001142526 NM_001142527 NM_001142528 NM_030639	BHLHB9	basic helix-loop-helix domain containing, class B, 9
chr9_-_16860719	2.906	NM_017637	BNC2	basonuclin 2
chr2_+_223625105	2.889	NM_080671	KCNE4	potassium voltage-gated channel, Isk-related family, member 4
chr1_+_201364050	2.830		ADORA1	adenosine A1 receptor
chr2_-_133144094	2.827		LYPD1	LY6/PLAUR domain containing 1
chr6_+_87921980	2.766	NM_015021	ZNF292	zinc finger protein 292
chr2_+_238060602	2.695	NM_001042467 NM_024101	MLPH	melanophilin
chr1_-_239587007	2.682		RGS7	regulator of G-protein signaling 7
chr1_-_197173159	2.513		LOC100131234	familial acute myelogenous leukemia related factor
chr6_-_80713589	2.501	NM_022726	ELOVL4	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr1_+_148521852	2.470	NM_144697	C1orf51	chromosome 1 open reading frame 51
chr9_-_16860664	2.338		BNC2	basonuclin 2
chrX_+_102471769	2.330	NM_152278	TCEAL7	transcription elongation factor A (SII)-like 7
chrX_-_114703273	2.308
chr1_-_152459667	2.256		C1orf43	chromosome 1 open reading frame 43
chr3_+_114948550	2.147	NM_001690	ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr7_-_47588160	2.111		TNS3	tensin 3
chr16_-_69277355	2.103	NM_138383	MTSS1L	metastasis suppressor 1-like
chr3_+_33293915	2.093	NM_012157 NM_001171713	FBXL2	F-box and leucine-rich repeat protein 2
chr3_+_134239860	2.046	NM_001136469 NM_023943	TMEM108	transmembrane protein 108
chr1_+_66772393	2.028	NM_032291	SGIP1	SH3-domain GRB2-like (endophilin) interacting protein 1
chrX_+_100549839	2.027	NM_001032393 NM_019597	HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')
chr2_-_192767844	2.026	NM_016192	TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2
chr1_-_151775221	2.014	NM_014624	S100A6	S100 calcium binding protein A6
chrX_+_100549861	1.997		HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')
chr3_-_171786468	1.964	NM_020949	SLC7A14	solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
chr11_-_85457736	1.962		PICALM	phosphatidylinositol binding clathrin assembly protein
chr9_-_89779413	1.946	NM_001039803 NM_001170639 NM_001170640 NM_012119 NM_178432	CDK20	cyclin-dependent kinase 20
chr1_+_208178160	1.930	NM_001146261 NM_001146262 NM_001146264 NM_153262	SYT14	synaptotagmin XIV
chr3_+_157491469	1.910	NM_172159	KCNAB1	potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_-_94475840	1.901	NM_004815	ARHGAP29	Rho GTPase activating protein 29
chrX_+_100549885	1.895		HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')
chrX_+_102749489	1.890	NM_001006933 NM_032926	TCEAL3	transcription elongation factor A (SII)-like 3
chr4_+_128773529	1.880	NM_015693	INTU	inturned planar cell polarity effector homolog (Drosophila)
chr3_+_134239906	1.871		TMEM108	transmembrane protein 108
chrX_+_100549869	1.864		HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')
chr18_+_75967902	1.863	NM_014913	ADNP2	ADNP homeobox 2
chr14_+_37746937	1.857	NM_001049	SSTR1	somatostatin receptor 1
chr16_+_31132842	1.847	NM_001008274	TRIM72	tripartite motif containing 72
chr1_-_152459506	1.829		C1orf43	chromosome 1 open reading frame 43
chr19_+_10625987	1.800		ILF3	interleukin enhancer binding factor 3, 90kDa
chr7_-_47588266	1.751		TNS3	tensin 3
chr10_+_70553936	1.750		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr10_+_70553993	1.739		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chrX_+_102518064	1.728		NGFRAP1	nerve growth factor receptor (TNFRSF16) associated protein 1
chr11_-_47427263	1.697	NM_005055 NM_032645	RAPSN	receptor-associated protein of the synapse
chr1_-_151775087	1.694		S100A6	S100 calcium binding protein A6
chr13_-_95094920	1.685	NM_014934 NM_198968	DZIP1	DAZ interacting protein 1
chr4_+_120167721	1.684		SYNPO2	synaptopodin 2
chr7_+_27191534	1.664		HOXA11-AS1	HOXA11 antisense RNA 1 (non-protein coding)
chrX_+_100692071	1.616	NM_016608	ARMCX1	armadillo repeat containing, X-linked 1
chr5_+_72957736	1.609	NM_001080479 NM_001177693	RGNEF	190 kDa guanine nucleotide exchange factor
chr1_-_151775119	1.589		S100A6	S100 calcium binding protein A6
chr4_+_71806538	1.580	NM_001037442 NM_014961	RUFY3	RUN and FYVE domain containing 3
chr6_-_33822659	1.572	NM_001142883 NM_054111	IP6K3	inositol hexakisphosphate kinase 3
chr1_-_202595666	1.572	NM_014935	PLEKHA6	pleckstrin homology domain containing, family A member 6
chr3_+_114948591	1.537		ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr19_+_54149941	1.534		BAX	BCL2-associated X protein
chr2_-_192767494	1.533		TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2
chr12_-_57600336	1.527	NM_153377	LRIG3	leucine-rich repeats and immunoglobulin-like domains 3
chr10_+_70553983	1.521		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr3_-_20202622	1.476	NM_001012409 NM_001012410 NM_001012411 NM_001012412 NM_001012413 NM_138484	SGOL1	shugoshin-like 1 (S. pombe)
chr7_+_17304707	1.475	NM_001621	AHR	aryl hydrocarbon receptor
chr5_+_148766632	1.465		LOC728264	hypothetical LOC728264
chr7_-_27191287	1.454	NM_005523	HOXA11	homeobox A11
chr17_+_3486753	1.453		CTNS	cystinosis, nephropathic
chr9_-_89779180	1.449		CDK20	cyclin-dependent kinase 20
chr11_-_8849485	1.448		ST5	suppression of tumorigenicity 5
chr8_+_1759502	1.443	NM_014629	ARHGEF10	Rho guanine nucleotide exchange factor (GEF) 10
chr8_-_126173055	1.443		KIAA0196	KIAA0196
chr1_-_184916044	1.439	NM_000963	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr8_-_126173186	1.434		KIAA0196	KIAA0196
chr10_+_52420936	1.431	NM_001098512	PRKG1	protein kinase, cGMP-dependent, type I
chr5_+_34692352	1.422	NM_001145520	RAI14	retinoic acid induced 14
chr14_-_67353046	1.421	NM_015346	ZFYVE26	zinc finger, FYVE domain containing 26
chr6_-_109810354	1.411		CD164	CD164 molecule, sialomucin
chr7_-_47588652	1.395		TNS3	tensin 3
chr1_-_94475504	1.390		ARHGAP29	Rho GTPase activating protein 29
chr1_-_152459697	1.389	NM_001098616 NM_015449 NM_138740	C1orf43	chromosome 1 open reading frame 43
chr11_-_85457753	1.380	NM_001008660 NM_007166	PICALM	phosphatidylinositol binding clathrin assembly protein
chr8_-_126173189	1.357		KIAA0196	KIAA0196
chr6_-_109810296	1.354		CD164	CD164 molecule, sialomucin
chr3_+_114948600	1.353		ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr19_+_54149843	1.350	NM_004324 NM_138761 NM_138763 NM_138764	BAX	BCL2-associated X protein
chr4_+_120167770	1.350		SYNPO2	synaptopodin 2
chrX_-_100549561	1.342	NM_000169	GLA	galactosidase, alpha
chr19_-_52710129	1.337	NM_003827	NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
chr8_-_126173108	1.335		KIAA0196	KIAA0196
chr5_+_34692239	1.333		RAI14	retinoic acid induced 14
chr9_+_71129307	1.333	NM_001127608	FAM189A2	family with sequence similarity 189, member A2
chr6_+_151688327	1.325	NM_144497	AKAP12	A kinase (PRKA) anchor protein 12
chr5_-_154210341	1.324		C5orf4	chromosome 5 open reading frame 4
chr2_+_176761552	1.319	NM_024501	HOXD1	homeobox D1
chr6_-_109810310	1.319		CD164	CD164 molecule, sialomucin
chr8_-_126173203	1.313		KIAA0196	KIAA0196
chr10_-_93382837	1.306	NM_005398	PPP1R3C	protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr5_-_154210350	1.296		C5orf4	chromosome 5 open reading frame 4
chr11_-_85457469	1.295		PICALM	phosphatidylinositol binding clathrin assembly protein
chr12_-_57600564	1.293		LRIG3	leucine-rich repeats and immunoglobulin-like domains 3
chr13_-_73605914	1.270	NM_007249	KLF12	Kruppel-like factor 12
chr11_+_18300689	1.258		GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr14_-_19993032	1.246	NM_017807	OSGEP	O-sialoglycoprotein endopeptidase
chr1_+_68070573	1.243
chr5_-_154210405	1.242	NM_032385	C5orf4	chromosome 5 open reading frame 4
chr5_+_52812165	1.230		FST	follistatin
chr14_-_91642703	1.219	NM_001127696 NM_001127697 NM_001164774 NM_001164776 NM_001164777 NM_001164778 NM_001164779 NM_001164780 NM_001164781 NM_001164782 NM_004993 NM_030660	ATXN3	ataxin 3
chr19_+_54149963	1.219		BAX	BCL2-associated X protein
chr10_+_70553862	1.216	NM_001035260 NM_004896	VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr6_-_109810246	1.213		CD164	CD164 molecule, sialomucin
chr8_+_126173264	1.189	NM_173685	NSMCE2	non-SMC element 2, MMS21 homolog (S. cerevisiae)
chr10_+_70553949	1.188		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chrX_-_100801472	1.187	NM_014782 NM_177949	ARMCX2	armadillo repeat containing, X-linked 2
chr4_-_23500706	1.171	NM_013261	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr7_+_27102197	1.158
chr14_+_19993181	1.155		APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1
chr8_+_76059262	1.154	NM_031461	CRISPLD1	cysteine-rich secretory protein LCCL domain containing 1
chr7_-_27149750	1.152	NM_019102	HOXA5	homeobox A5
chr10_+_70553945	1.148		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr5_+_52812236	1.147	NM_006350 NM_013409	FST	follistatin
chr14_-_91642641	1.141		ATXN3 ATXN8	ataxin 3 ataxin 8
chr3_+_129927723	1.129		RAB7A	RAB7A, member RAS oncogene family
chr2_+_85834111	1.124	NM_032827	ATOH8	atonal homolog 8 (Drosophila)
chr17_-_44022595	1.124		HOXB3	homeobox B3
chr6_+_151603201	1.121		AKAP12	A kinase (PRKA) anchor protein 12
chr1_+_17121012	1.118	NM_014675	CROCC	ciliary rootlet coiled-coil, rootletin
chr9_-_103289154	1.112	NM_032342	C9orf125	chromosome 9 open reading frame 125
chr3_+_129927726	1.103		RAB7A	RAB7A, member RAS oncogene family
chr11_+_101485946	1.097	NM_001130145 NM_001195044 NM_006106	YAP1	Yes-associated protein 1
chr12_-_54409015	1.097		CD63	CD63 molecule
chr5_+_34692124	1.091	NM_001145522 NM_015577	RAI14	retinoic acid induced 14
chr18_+_54682261	1.085		ZNF532	zinc finger protein 532
chr3_+_148609841	1.078	NM_003412	ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)
chr12_-_54409059	1.076		CD63	CD63 molecule
chr5_-_131160589	1.066		FNIP1	folliculin interacting protein 1
chr4_-_164473107	1.064	NM_000909	NPY1R	neuropeptide Y receptor Y1
chr13_-_35818603	1.062	NM_001142296 NM_015087	SPG20	spastic paraplegia 20 (Troyer syndrome)
chr7_-_27108826	1.062	NM_006735	HOXA2	homeobox A2
chr19_-_45546250	1.059		C19orf47	chromosome 19 open reading frame 47
chr1_+_152459918	1.058	NM_014847	UBAP2L	ubiquitin associated protein 2-like
chr7_+_28415495	1.058		LOC401317	hypothetical LOC401317
chr7_+_27102508	1.049
chr6_-_109810396	1.043	NM_001142401 NM_001142402 NM_001142403 NM_001142404 NM_006016	CD164	CD164 molecule, sialomucin
chr8_-_126173227	1.043	NM_014846	KIAA0196	KIAA0196
chr8_+_71744153	1.039	NM_001011720	XKR9	XK, Kell blood group complex subunit-related family, member 9
chr10_-_93382779	1.036		PPP1R3C	protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr12_+_6363482	1.036	NM_002342	LTBR	lymphotoxin beta receptor (TNFR superfamily, member 3)
chr13_-_109236897	1.033	NM_003749	IRS2	insulin receptor substrate 2
chr3_+_129927716	1.012		RAB7A	RAB7A, member RAS oncogene family
chr12_+_52653176	1.010	NM_014212	HOXC11	homeobox C11
chr6_+_151603346	1.001		AKAP12	A kinase (PRKA) anchor protein 12
chr18_+_75968133	0.993		ADNP2	ADNP homeobox 2
chr12_+_64504408	0.991	NM_003483 NM_003484	HMGA2	high mobility group AT-hook 2
chr17_+_59933322	0.977		CCDC45	coiled-coil domain containing 45
chr6_+_151603264	0.969
chr9_-_21984414	0.963	NM_058195	CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr5_+_150807380	0.963		SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr5_+_150807331	0.959	NM_078483	SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr5_-_1165106	0.955	NM_006598	SLC12A7	solute carrier family 12 (potassium/chloride transporters), member 7
chrX_+_55760774	0.955	NM_006064 NM_016656	RRAGB	Ras-related GTP binding B
chr7_-_13997389	0.953	NM_001163149	ETV1	ets variant 1
chr12_+_52806103	0.938		LOC400043	hypothetical LOC400043
chr7_-_27102049	0.937	NM_005522 NM_153620	HOXA1	homeobox A1
chr5_+_80292313	0.923	NM_006909	RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2
chr9_-_34038887	0.914	NM_018449	UBAP2	ubiquitin associated protein 2
chr3_+_129927714	0.913		RAB7A	RAB7A, member RAS oncogene family
chr1_+_208178198	0.907		SYT14	synaptotagmin XIV
chr7_-_135083906	0.905	NM_205855	FAM180A	family with sequence similarity 180, member A
chr14_+_19993204	0.902		APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1
chr3_+_129927668	0.894	NM_004637	RAB7A	RAB7A, member RAS oncogene family
chr7_+_882704	0.893	NM_015949	GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr19_+_10625896	0.892	NM_001137673 NM_004516 NM_012218 NM_017620 NM_153464	ILF3	interleukin enhancer binding factor 3, 90kDa
chr2_-_196744546	0.886	NM_004226	STK17B	serine/threonine kinase 17b
chrX_+_102498035	0.882	NM_001006612 NM_001006613 NM_001006614 NM_016303	WBP5	WW domain binding protein 5
chr5_-_131160614	0.879	NM_001008738 NM_133372	FNIP1	folliculin interacting protein 1
chr13_-_35818491	0.875		SPG20	spastic paraplegia 20 (Troyer syndrome)
chr1_+_109810743	0.874		SYPL2	synaptophysin-like 2
chr11_-_71492019	0.873	NM_017907	LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr1_-_203557379	0.857	NM_030952	NUAK2	NUAK family, SNF1-like kinase, 2
chr5_-_159730196	0.856	NM_031908	C1QTNF2	C1q and tumor necrosis factor related protein 2
chrX_+_101267315	0.854	NM_080390	TCEAL2	transcription elongation factor A (SII)-like 2
chr13_-_49057629	0.846		RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr12_-_47604930	0.843	NM_001143781	FKBP11	FK506 binding protein 11, 19 kDa
chr5_+_80292213	0.838		RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2
chr5_-_131160608	0.836		FNIP1	folliculin interacting protein 1
chr7_+_97748959	0.831		BRI3	brain protein I3
chr12_+_51686512	0.830		EIF4B	eukaryotic translation initiation factor 4B
chr3_-_113763217	0.829		ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)
chr9_-_34038869	0.829		UBAP2	ubiquitin associated protein 2
chr12_-_54409107	0.826	NM_001040034 NM_001780	CD63	CD63 molecule
chr11_+_18300370	0.821	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.00	2.38e-07	GO:0008104	protein localization
1.83	2.89e-06	GO:0033036	macromolecule localization
1.98	2.88e-05	GO:0045184	establishment of protein localization
1.99	3.03e-05	GO:0015031	protein transport
2.28	7.40e-05	GO:0034613	cellular protein localization
2.27	9.09e-05	GO:0070727	cellular macromolecule localization
1.69	8.54e-04	GO:0051641	cellular localization
1.83	6.36e-03	GO:0046907	intracellular transport
2.34	8.18e-03	GO:0071495	cellular response to endogenous stimulus
6.33	1.36e-02	GO:0015682	ferric iron transport
6.33	1.36e-02	GO:0015988	energy coupled proton transport, against electrochemical gradient
6.33	1.36e-02	GO:0015991	ATP hydrolysis coupled proton transport
6.33	1.36e-02	GO:0033572	transferrin transport
2.15	2.27e-02	GO:0006886	intracellular protein transport
1.64	2.29e-02	GO:0051649	establishment of localization in cell
4.84	2.32e-02	GO:0007033	vacuole organization
3.06	2.71e-02	GO:0008286	insulin receptor signaling pathway
7.39	4.75e-02	GO:0032006	regulation of TOR signaling cascade
16.88	4.81e-02	GO:0008612	peptidyl-lysine modification to hypusine
16.88	4.81e-02	GO:0046516	hypusine metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
3.07	6.45e-09	GO:0005773	vacuole
1.21	9.04e-09	GO:0043229	intracellular organelle
1.23	1.12e-08	GO:0043231	intracellular membrane-bounded organelle
1.21	1.30e-08	GO:0043226	organelle
1.23	1.37e-08	GO:0043227	membrane-bounded organelle
1.17	1.87e-08	GO:0044424	intracellular part
1.15	9.81e-08	GO:0005622	intracellular
1.29	1.36e-06	GO:0044444	cytoplasmic part
2.90	3.33e-06	GO:0000323	lytic vacuole
2.90	3.33e-06	GO:0005764	lysosome
1.28	2.96e-05	GO:0044446	intracellular organelle part
1.20	3.68e-05	GO:0005737	cytoplasm
1.28	4.09e-05	GO:0044422	organelle part
4.27	5.49e-05	GO:0042470	melanosome
4.27	5.49e-05	GO:0048770	pigment granule
2.26	8.09e-05	GO:0005768	endosome
3.23	1.36e-04	GO:0044437	vacuolar part
3.24	2.23e-04	GO:0005774	vacuolar membrane
2.64	2.95e-04	GO:0010008	endosome membrane
2.62	3.51e-04	GO:0044440	endosomal part
8.44	6.53e-04	GO:0033176	proton-transporting V-type ATPase complex
3.43	8.64e-04	GO:0005770	late endosome
1.78	5.12e-03	GO:0016023	cytoplasmic membrane-bounded vesicle
1.40	6.98e-03	GO:0031974	membrane-enclosed lumen
1.74	8.13e-03	GO:0031410	cytoplasmic vesicle
1.75	8.83e-03	GO:0031988	membrane-bounded vesicle
1.40	9.74e-03	GO:0070013	intracellular organelle lumen
3.12	1.03e-02	GO:0005765	lysosomal membrane
1.39	1.11e-02	GO:0043233	organelle lumen
1.71	1.11e-02	GO:0031982	vesicle
1.44	1.32e-02	GO:0031981	nuclear lumen
2.78	1.81e-02	GO:0005769	early endosome
1.38	3.20e-02	GO:0044428	nuclear part
1.20	4.10e-02	GO:0005634	nucleus
8.79	4.92e-02	GO:0030897	HOPS complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.25	3.27e-06	GO:0005515	protein binding
8.21	4.85e-03	GO:0046961	proton-transporting ATPase activity, rotational mechanism
5.63	2.62e-02	GO:0019829	cation-transporting ATPase activity