Motif ID: ONECUT1,2.p2

Z-value: 2.919


Transcription factors associated with ONECUT1,2.p2:

Gene SymbolEntrez IDGene Name
ONECUT1 3175 one cut homeobox 1
ONECUT2 9480 one cut homeobox 2



Activity profile for motif ONECUT1,2.p2.

activity profile for motif ONECUT1,2.p2


Sorted Z-values histogram for motif ONECUT1,2.p2

Sorted Z-values for motif ONECUT1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ONECUT1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_30238961 18.212 NM_033229
TRIM15
tripartite motif containing 15
chr5_+_180726874 5.737 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr7_-_100077072 5.653 NM_003227
TFR2
transferrin receptor 2
chr1_-_611896 4.654 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr1_+_357502 4.572 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr7_+_116238309 4.384 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr8_-_107023 3.957 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr6_-_41823056 3.858 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chrX_-_24600661 3.815 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr7_-_13992351 3.662 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr14_+_87560646 3.472 LOC283587
hypothetical protein LOC283587
chrX_+_134803450 3.402 NM_018666
SAGE1
sarcoma antigen 1
chr1_+_196874867 3.371 PTPRC
protein tyrosine phosphatase, receptor type, C
chr11_-_118055564 3.093 NM_007180
TREH
trehalase (brush-border membrane glycoprotein)
chr4_-_145159889 3.032 NM_002100
GYPB
glycophorin B (MNS blood group)
chr6_+_32003180 2.949 NM_000063
NM_001145903
C2

complement component 2

chr17_-_64462976 2.879 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_+_171022403 2.799 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr10_+_89257569 2.799 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr15_-_100280784 2.701 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr22_+_21384862 2.670 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr11_+_62893836 2.664 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr5_+_68703036 2.652 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr7_+_143043871 2.593 NM_001130026
FAM115C
family with sequence similarity 115, member C
chrX_+_46825179 2.536 RGN
regucalcin (senescence marker protein-30)
chr6_+_105511615 2.488 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr1_+_196874759 2.472 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr2_-_95514205 2.427 NM_001164464
TRIM43
TRIM43B
tripartite motif containing 43
tripartite motif containing 43B
chr19_+_61624 2.414 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr4_+_73123712 2.360 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr1_+_196874839 2.330 PTPRC
protein tyrosine phosphatase, receptor type, C
chr7_+_99263571 2.265 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr7_+_120490054 2.198 C7orf58
chromosome 7 open reading frame 58
chr6_+_132000134 2.142 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr5_-_43448174 2.091 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr16_-_70591377 2.089 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr18_-_28606839 2.060 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr3_-_110319598 2.023 NM_014429
MORC1
MORC family CW-type zinc finger 1
chr17_+_69950782 2.015 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr4_+_74491272 2.008 ALB
albumin
chr1_-_146076704 1.999 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr17_-_53849929 1.901 NM_017763
RNF43
ring finger protein 43
chr14_-_37134050 1.861 FOXA1
forkhead box A1
chr1_-_149611768 1.833 NM_003944
SELENBP1
selenium binding protein 1
chr9_+_35663852 1.805 NM_001216
CA9
carbonic anhydrase IX
chr2_+_161980865 1.778 NM_006593
TBR1
T-box, brain, 1
chr2_+_108571336 1.772 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr16_+_68238460 1.758 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr2_+_130703384 1.755


chr8_-_86477585 1.746 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr15_-_41300316 1.709 EPB42
erythrocyte membrane protein band 4.2
chr16_-_20610078 1.651 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr12_+_45896318 1.639 NM_138371
FAM113B
family with sequence similarity 113, member B
chr6_+_64344307 1.620 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_-_17638797 1.611 NM_018715
RCC2
regulator of chromosome condensation 2
chr4_+_22608252 1.610


chr7_-_135263737 1.607 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr6_+_28032997 1.558 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr7_-_23476497 1.554 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr16_-_73708118 1.533 LDHD
lactate dehydrogenase D
chr12_-_52975777 1.531 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_-_198643885 1.520 ZNF281
zinc finger protein 281
chr3_-_156876798 1.514 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr15_-_41300526 1.513 NM_000119
NM_001114134
EPB42

erythrocyte membrane protein band 4.2

chr16_-_73708165 1.510 NM_153486
NM_194436
LDHD

lactate dehydrogenase D

chr13_-_45654292 1.500 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr9_-_122852356 1.499 NM_001735
C5
complement component 5
chrX_+_123307812 1.484 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr12_+_53178834 1.473 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr14_-_37133927 1.463 FOXA1
forkhead box A1
chr15_-_41300488 1.459 EPB42
erythrocyte membrane protein band 4.2
chr2_+_135312655 1.448 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chrX_+_49718954 1.445 NM_000084
CLCN5
chloride channel 5
chr4_-_155731288 1.439 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr9_+_101717278 1.438 STX17
syntaxin 17
chr12_-_101036407 1.427 NM_024057
NUP37
nucleoporin 37kDa
chr3_-_150422474 1.421 NM_000096
CP
ceruloplasmin (ferroxidase)
chr13_-_45654296 1.401 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_92144146 1.399 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr11_+_89624017 1.397


chr5_+_159546951 1.383 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr21_-_42608774 1.375 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr1_-_144779601 1.372 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr9_-_14076901 1.368 NFIB
nuclear factor I/B
chr16_+_54782802 1.358 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr3_+_144165470 1.334 U2SURP
U2 snRNP-associated SURP domain containing
chr2_+_113601608 1.331 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr2_+_113601616 1.329 IL1RN
interleukin 1 receptor antagonist
chr16_-_29797172 1.324 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr6_+_34312906 1.323 HMGA1
high mobility group AT-hook 1
chr15_+_70477707 1.317 NM_001080462
TMEM202
transmembrane protein 202
chr7_+_128099581 1.311 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr6_+_34312979 1.299 HMGA1
high mobility group AT-hook 1
chr3_-_198784590 1.298 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr2_+_172530120 1.293 HAT1
histone acetyltransferase 1
chr7_+_6583560 1.290 NM_001134387
NM_001134388
NM_001134389
NM_018106
ZDHHC4



zinc finger, DHHC-type containing 4



chr3_+_173043832 1.266 NM_001164436
TMEM212
transmembrane protein 212
chr20_+_42417502 1.264 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_+_108571177 1.261 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_108571209 1.260 LIMS1
LIM and senescent cell antigen-like domains 1
chr16_+_21152516 1.256 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr3_-_17757402 1.232 NM_014744
TBC1D5
TBC1 domain family, member 5
chr9_+_263025 1.219 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr14_+_66901237 1.209 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr10_-_73953699 1.201 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr14_-_23090606 1.201 NM_033400
ZFHX2
zinc finger homeobox 2
chr1_-_32054164 1.190 NM_144569
SPOCD1
SPOC domain containing 1
chr1_+_147006065 1.183 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr13_-_45654327 1.174 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr16_+_68156497 1.165 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NFAT5




nuclear factor of activated T-cells 5, tonicity-responsive




chr20_+_186376 1.159 NM_207469
DEFB132
defensin, beta 132
chr5_+_147754467 1.137 FBXO38
F-box protein 38
chr2_-_21106291 1.133 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_17638729 1.130 RCC2
regulator of chromosome condensation 2
chr12_-_52975823 1.118 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr4_-_116254381 1.117 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr6_+_27400518 1.113 NM_032030
FKSG83
FKSG83
chr1_-_42549347 1.110


chr5_+_140719773 1.109 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr9_-_115877104 1.105 AMBP
alpha-1-microglobulin/bikunin precursor
chr5_-_149772563 1.098 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr10_-_45131061 1.078 NM_001004297
OR13A1
olfactory receptor, family 13, subfamily A, member 1
chr5_+_68702617 1.075 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr5_+_176449156 1.063 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr10_+_7785347 1.059 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_+_114390975 1.054 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr11_-_74478405 1.043 NM_001005285
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr9_+_95886625 1.040 PTPDC1
protein tyrosine phosphatase domain containing 1
chr18_+_27425727 1.033 NM_000371
TTR
transthyretin
chr6_+_69401660 1.020 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr10_+_7785360 1.019 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_+_82117978 1.017


chr7_-_86433139 1.009 NM_152748
KIAA1324L
KIAA1324-like
chr20_+_43423990 1.008 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr15_+_91244563 0.997 CHD2
chromodomain helicase DNA binding protein 2
chr5_-_149772528 0.993


chrX_+_30143595 0.977 NM_002364
MAGEB2
melanoma antigen family B, 2
chr1_+_158636987 0.964 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr1_-_171838802 0.951 NM_178527
SLC9A11
solute carrier family 9, member 11
chr11_+_62813947 0.950 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr17_+_7682355 0.943


chr7_+_128136347 0.942 FAM71F1
family with sequence similarity 71, member F1
chr12_-_55979413 0.940


chr10_+_7785235 0.938 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_32344192 0.936 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr1_+_146843980 0.933 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr7_+_94135384 0.930 PEG10
paternally expressed 10
chrX_-_74921704 0.926 NM_138703
MAGEE2
melanoma antigen family E, 2
chr22_-_20667211 0.924 TOP3B
topoisomerase (DNA) III beta
chr10_+_7785290 0.921 ITIH2
inter-alpha (globulin) inhibitor H2
chr8_-_30121741 0.919 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr6_+_53043729 0.918 NM_012347
FBXO9
F-box protein 9
chr7_-_25234582 0.910 NM_022150
NPVF
neuropeptide VF precursor
chr1_+_58899 0.905 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr4_+_69716298 0.903 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr19_+_58239802 0.895 NM_001191055
HERV-V2
envelope glycoprotein ENVV2
chr1_+_62835759 0.889 NM_014495
ANGPTL3
angiopoietin-like 3
chr9_+_95886558 0.884 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr1_+_117098579 0.881 NM_001767
CD2
CD2 molecule
chrX_-_15198093 0.875 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr14_-_22496196 0.874 HAUS4
HAUS augmin-like complex, subunit 4
chr1_+_35623688 0.867 ZMYM4
zinc finger, MYM-type 4
chr6_+_45404031 0.865 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr20_+_42417752 0.859 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr3_-_49435114 0.859 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr1_-_51660328 0.859 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr6_-_49820030 0.855 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr18_+_31488530 0.855 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chrX_-_131401319 0.850 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr17_+_28342994 0.849 NM_173847
SPACA3
sperm acrosome associated 3
chr6_-_50124322 0.847 NM_001037498
DEFB112
defensin, beta 112
chr1_+_22107137 0.846 RPL21
ribosomal protein L21
chr13_-_45577144 0.843 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr21_-_46849413 0.840 NM_006272
S100B
S100 calcium binding protein B
chr2_-_88208650 0.822 NM_001443
FABP1
fatty acid binding protein 1, liver
chr2_+_132196533 0.820 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr2_-_171796069 0.816 NM_001136554
TLK1
tousled-like kinase 1
chr14_-_37134191 0.814 NM_004496
FOXA1
forkhead box A1
chr1_-_100003936 0.801 NM_001013660
FRRS1
ferric-chelate reductase 1
chr19_+_45563594 0.800 PLD3
phospholipase D family, member 3
chr16_-_65510230 0.797 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr19_+_45563607 0.792 PLD3
phospholipase D family, member 3
chr10_+_7785331 0.786 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_80384997 0.780 NM_178839
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr3_-_180452096 0.774 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr1_+_198263352 0.774 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr11_+_22652957 0.773 GAS2
growth arrest-specific 2
chr2_+_218978375 0.771 CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr4_+_74496575 0.771 ALB
albumin
chr1_+_32485404 0.770 NM_032648
FAM167B
family with sequence similarity 167, member B
chr6_+_32021831 0.769 CFB
complement factor B
chr1_-_156923111 0.768 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr19_+_45563603 0.765 PLD3
phospholipase D family, member 3
chr3_+_142525744 0.765 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr12_-_69434650 0.763 PTPRR
protein tyrosine phosphatase, receptor type, R
chr11_-_16953135 0.761 RPL36A
ribosomal protein L36a
chr10_+_63331018 0.760 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr9_-_113561613 0.759 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr5_-_75044001 0.758 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr1_+_20353284 0.755



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.43 9.52e-07 GO:0007606 sensory perception of chemical stimulus
2.47 2.82e-06 GO:0007608 sensory perception of smell
1.76 3.65e-03 GO:0007600 sensory perception
1.22 2.71e-02 GO:0032501 multicellular organismal process
1.51 3.12e-02 GO:0050877 neurological system process
3.96 3.39e-02 GO:0072376 protein activation cascade

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 3.06e-02 GO:0005886 plasma membrane
1.23 3.28e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.03 1.12e-07 GO:0004930 G-protein coupled receptor activity
2.59 1.32e-07 GO:0004984 olfactory receptor activity
1.62 2.67e-04 GO:0004888 transmembrane receptor activity
1.49 1.35e-03 GO:0004872 receptor activity
1.40 6.47e-03 GO:0004871 signal transducer activity
1.40 6.47e-03 GO:0060089 molecular transducer activity
4.23 4.54e-02 GO:0043498 cell surface binding