Motif ID: SOX2.p2

Z-value: 2.317


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_101658094 3.292 NM_001159694
NM_016242
EMCN

endomucin

chr10_+_70517823 3.140 NM_002727
SRGN
serglycin
chr10_+_70517863 3.116 SRGN
serglycin
chr7_+_106292975 2.990 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr3_-_150533948 2.984 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr6_-_74284522 2.826 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr7_+_106292932 2.821 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr10_+_11246934 2.621 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr10_+_11247059 2.594 CELF2
CUGBP, Elav-like family member 2
chr17_-_44006808 2.433 NM_002146
HOXB3
homeobox B3
chr3_-_143230124 2.306 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr10_-_61570665 2.290 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_+_86918882 2.140 ARHGAP24
Rho GTPase activating protein 24
chr1_-_47468029 2.135 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr8_-_6407882 2.129 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr10_-_32707549 2.096 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chrX_+_86659370 2.010 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr7_+_102340579 1.987 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chrX_+_28515479 1.981 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr12_-_6103945 1.962 NM_000552
VWF
von Willebrand factor
chr5_+_15553736 1.938 FBXL7
F-box and leucine-rich repeat protein 7
chr2_-_198248828 1.917 NM_144629
RFTN2
raftlin family member 2
chrX_+_15428820 1.860 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr2_+_108637916 1.843 LIMS1
LIMS3
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 3
chr4_-_74307637 1.815 ANKRD17
ankyrin repeat domain 17
chr2_-_110665188 1.815 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr17_-_59817456 1.805 PECAM1
platelet/endothelial cell adhesion molecule
chr7_+_106293112 1.801 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_108637698 1.799 NM_001193485
LIMS1
LIM and senescent cell antigen-like domains 1
chr8_-_93144039 1.723


chr17_-_59817575 1.702 PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_59817654 1.690 PECAM1
platelet/endothelial cell adhesion molecule
chr1_-_32574185 1.681 NM_023009
MARCKSL1
MARCKS-like 1
chr17_-_59817722 1.676 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr5_+_15553539 1.672 FBXL7
F-box and leucine-rich repeat protein 7
chr6_+_153060722 1.666 NM_025107
MYCT1
myc target 1
chr5_+_15553288 1.661 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr1_+_22107137 1.660 RPL21
ribosomal protein L21
chr9_+_115303527 1.633 NM_130795
RGS3
regulator of G-protein signaling 3
chr8_-_108579270 1.630 NM_001146
ANGPT1
angiopoietin 1
chr1_+_66570363 1.621 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr13_-_98757634 1.599 NM_004951
GPR183
G protein-coupled receptor 183
chr9_+_18464090 1.566 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr3_+_182900081 1.563 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr2_-_188021117 1.559 NM_005795
CALCRL
calcitonin receptor-like
chr2_+_110013297 1.548 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr9_+_18464138 1.508 ADAMTSL1
ADAMTS-like 1
chr5_+_140181405 1.460 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr7_-_27186400 1.455 NM_153715
HOXA10
homeobox A10
chr5_-_71838875 1.443 NM_152625
ZNF366
zinc finger protein 366
chr11_-_85107569 1.418 NM_206929
SYTL2
synaptotagmin-like 2
chr14_+_76298693 1.407 VASH1
vasohibin 1
chr21_-_38792173 1.387 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr1_+_242283129 1.384 NM_006352
ZNF238
zinc finger protein 238
chr17_-_59818033 1.380 PECAM1
platelet/endothelial cell adhesion molecule
chr9_+_100745531 1.343 NM_001855
COL15A1
collagen, type XV, alpha 1
chr12_-_9804682 1.339 NM_001781
CD69
CD69 molecule
chr8_-_93176819 1.338 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_+_71806538 1.337 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr8_-_93176618 1.330 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr6_-_56824371 1.318 DST
dystonin
chr15_-_68781662 1.297 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_+_33213111 1.296 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr13_+_110653407 1.289 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr17_+_63252704 1.288 BPTF
bromodomain PHD finger transcription factor
chr1_+_242281199 1.286 ZNF238
zinc finger protein 238
chr11_+_129496792 1.277 APLP2
amyloid beta (A4) precursor-like protein 2
chr6_+_21774624 1.262 FLJ22536
hypothetical locus LOC401237
chr7_+_116447499 1.244 ST7
suppression of tumorigenicity 7
chr10_+_11247467 1.241 CELF2
CUGBP, Elav-like family member 2
chr4_-_138673078 1.238 NM_019035
PCDH18
protocadherin 18
chr10_+_11247243 1.229 CELF2
CUGBP, Elav-like family member 2
chr9_+_27099138 1.208 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr5_+_15553768 1.204 FBXL7
F-box and leucine-rich repeat protein 7
chr1_+_84540921 1.194 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr1_+_43539239 1.194 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr3_+_174598937 1.191 NM_014932
NLGN1
neuroligin 1
chr11_-_16380967 1.189 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr10_+_11247449 1.186 CELF2
CUGBP, Elav-like family member 2
chr10_+_11247419 1.172 CELF2
CUGBP, Elav-like family member 2
chr10_-_25281510 1.170 NM_020200
PRTFDC1
phosphoribosyl transferase domain containing 1
chr1_-_51660328 1.165 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr17_-_18890963 1.139 NM_006613
GRAP
GRB2-related adaptor protein
chr10_-_88707299 1.135 NM_024756
MMRN2
multimerin 2
chr3_+_44665220 1.131 NM_003420
ZNF35
zinc finger protein 35
chr11_-_85108030 1.130 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr5_-_111119846 1.112 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr5_-_39460687 1.102 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_+_148593911 1.072


chr3_-_71262426 1.036 FOXP1
forkhead box P1
chr19_-_17236522 1.030 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr1_+_161305558 1.024 NM_001113381
RGS4
regulator of G-protein signaling 4
chr3_+_25444837 1.024 NM_000965
RARB
retinoic acid receptor, beta
chr3_+_186563529 1.020 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr9_+_126460511 1.020


chr1_-_171441234 1.016 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chrX_+_133952633 1.015 NM_001163438
LOC644538
hypothetical protein LOC644538
chr3_-_71262405 1.004 FOXP1
forkhead box P1
chr6_+_116939500 1.003 NM_153711
FAM26E
family with sequence similarity 26, member E
chr16_+_64958060 0.999 CDH5
cadherin 5, type 2 (vascular endothelium)
chr16_+_64958086 0.997 CDH5
cadherin 5, type 2 (vascular endothelium)
chr4_+_134292630 0.988 PCDH10
protocadherin 10
chrX_+_100220491 0.986 NM_021637
TMEM35
transmembrane protein 35
chr16_+_64958025 0.980 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr3_+_19164973 0.978 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr10_+_80672842 0.971 ZMIZ1
zinc finger, MIZ-type containing 1
chr3_+_25444753 0.971 NM_016152
RARB
retinoic acid receptor, beta
chr12_-_52939584 0.968 NM_001127322
CBX5
chromobox homolog 5
chr7_+_50314801 0.966 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr1_+_194887630 0.964 NM_000186
NM_001014975
CFH

complement factor H

chr13_-_32658215 0.960 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_-_53941835 0.958 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr7_-_112515035 0.947 GPR85
G protein-coupled receptor 85
chr11_-_6633427 0.946 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr3_-_170347019 0.944 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr12_-_52939636 0.927 NM_001127321
CBX5
chromobox homolog 5
chr6_+_44295219 0.924 NM_001078174
NM_004955
SLC29A1

solute carrier family 29 (nucleoside transporters), member 1

chr8_+_32623792 0.924 NM_013959
NRG1
neuregulin 1
chr1_-_197173159 0.923 LOC100131234
familial acute myelogenous leukemia related factor
chr7_-_11838260 0.918 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chrX_+_12904207 0.911 TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr7_+_22733626 0.908 IL6
interleukin 6 (interferon, beta 2)
chr4_+_91035025 0.906 NM_007351
MMRN1
multimerin 1
chr2_-_128138435 0.904 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr17_-_44058612 0.902 NM_024017
HOXB9
homeobox B9
chr17_-_1195096 0.894 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr17_+_71095733 0.894 MYO15B
myosin XVB pseudogene
chr7_+_150321771 0.893 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr7_-_112515068 0.885 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr12_-_23995220 0.882 SOX5
SRY (sex determining region Y)-box 5
chr17_+_63252668 0.880 BPTF
bromodomain PHD finger transcription factor
chr4_+_160408447 0.876 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr5_-_178977441 0.875 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr15_+_94670160 0.867 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr19_-_45016587 0.867 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr2_+_198377561 0.867 NM_006226
PLCL1
phospholipase C-like 1
chr12_-_23995109 0.862 SOX5
SRY (sex determining region Y)-box 5
chr18_-_21186107 0.852 NM_015461
ZNF521
zinc finger protein 521
chr8_+_39890484 0.852 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr4_+_86918870 0.848 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr1_+_161305188 0.848 NM_005613
RGS4
regulator of G-protein signaling 4
chr3_-_69254226 0.846 NM_198271
LMOD3
leiomodin 3 (fetal)
chr7_-_112514990 0.843 GPR85
G protein-coupled receptor 85
chr7_-_13997574 0.843 NM_001163148
ETV1
ets variant 1
chr14_+_62740878 0.841 NM_020663
RHOJ
ras homolog gene family, member J
chr8_-_93144366 0.839 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_115678365 0.838 NM_133374
ZNF618
zinc finger protein 618
chr5_-_150306298 0.836 ZNF300P1
zinc finger protein 300 pseudogene 1
chr8_-_93184629 0.833 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr7_+_22733290 0.829 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr3_+_153469421 0.827 MBNL1
muscleblind-like (Drosophila)
chr3_-_58538110 0.825 FAM107A
family with sequence similarity 107, member A
chr9_+_124835608 0.820 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chr5_+_40877053 0.820 NM_032587
CARD6
caspase recruitment domain family, member 6
chr6_-_56824672 0.819 DST
dystonin
chr13_-_22905822 0.818 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr5_+_88220846 0.817


chr11_+_5667494 0.810 NM_006074
TRIM22
tripartite motif containing 22
chr15_-_81667169 0.810 NM_016073
HDGFRP3
hepatoma-derived growth factor, related protein 3
chr3_-_3127057 0.808 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chrX_+_12903145 0.806 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr17_-_1029758 0.804 NM_021962
ABR
active BCR-related gene
chr13_-_37341859 0.803 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr10_-_64698831 0.791 NM_004241
JMJD1C
jumonji domain containing 1C
chr5_+_140154627 0.791 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr22_-_17892859 0.789 NM_001130861
NM_003277
CLDN5

claudin 5

chr3_-_58538530 0.788 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr19_-_55008172 0.786 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr5_-_88155360 0.782 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chrX_-_134013644 0.781 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr6_-_76259976 0.781 NM_015687
FILIP1
filamin A interacting protein 1
chr10_+_17310475 0.781 VIM
vimentin
chr12_-_10142779 0.776 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr18_+_13601664 0.776 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr5_+_162862808 0.772 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr7_-_5533621 0.770 ACTB
actin, beta
chr1_-_229058404 0.766 NM_001136495
C1orf198
chromosome 1 open reading frame 198
chr21_+_29593607 0.766 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr17_+_18971506 0.763 NM_001129778
GRAPL
GRB2-related adaptor protein-like
chr3_-_192531018 0.761 NM_198152
UTS2D
urotensin 2 domain containing
chr6_+_121798443 0.754 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_-_199259133 0.753 KIF21B
kinesin family member 21B
chr15_+_21361546 0.749 NM_005664
MKRN3
makorin ring finger protein 3
chr7_-_13997389 0.748 NM_001163149
ETV1
ets variant 1
chr5_-_137502975 0.748 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr17_-_64649608 0.745 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr19_-_11166186 0.743 NM_015493
KANK2
KN motif and ankyrin repeat domains 2
chr3_-_14964861 0.742 LOC100505673
hypothetical LOC100505673
chr5_-_110090264 0.739 NM_001039763
TMEM232
transmembrane protein 232
chr8_+_40130143 0.739 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr1_+_61642287 0.738 NFIA
nuclear factor I/A
chr3_+_134239860 0.736 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr4_-_138673014 0.734 PCDH18
protocadherin 18
chr1_+_81544432 0.729 LPHN2
latrophilin 2
chr3_+_179736917 0.729 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_-_50661716 0.729 NM_032110
DMRTA2
DMRT-like family A2
chr2_+_181554048 0.726 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr17_+_55269974 0.726


chr15_+_65217412 0.723 NM_001145103
SMAD3
SMAD family member 3
chr5_-_98290117 0.715 NM_001270
CHD1
chromodomain helicase DNA binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 1.89e-03 GO:0048523 negative regulation of cellular process
1.11 8.12e-03 GO:0050794 regulation of cellular process
1.61 3.23e-02 GO:0016568 chromatin modification
1.22 3.43e-02 GO:0048519 negative regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 2.11e-05 GO:0005634 nucleus
1.04 6.72e-04 GO:0044464 cell part
1.04 7.02e-04 GO:0005623 cell
1.25 4.90e-03 GO:0031981 nuclear lumen
2.65 9.92e-03 GO:0035770 RNA granule
1.19 1.25e-02 GO:0043228 non-membrane-bounded organelle
1.19 1.25e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.06 1.51e-02 GO:0044424 intracellular part
1.44 2.48e-02 GO:0005694 chromosome
1.05 2.66e-02 GO:0005622 intracellular
1.21 2.91e-02 GO:0044428 nuclear part
1.48 3.02e-02 GO:0044427 chromosomal part
2.02 3.69e-02 GO:0030055 cell-substrate junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.21 7.72e-05 GO:0003676 nucleic acid binding
1.23 2.89e-03 GO:0003677 DNA binding