Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 2.357


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein



Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_187422141 4.189 NM_182521
ZSWIM2
zinc finger, SWIM-type containing 2
chr5_-_179712920 3.222 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chrX_+_53095230 3.183 NM_018969
GPR173
G protein-coupled receptor 173
chr7_-_139987044 3.031 DENND2A
DENN/MADD domain containing 2A
chr12_-_62348506 2.846 NM_173812
DPY19L2
dpy-19-like 2 (C. elegans)
chr1_-_167663278 2.737 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr14_+_23908141 2.729 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr14_-_88087575 2.674 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr18_+_30544193 2.445 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr11_+_133444175 2.370 JAM3
junctional adhesion molecule 3
chr19_-_63643400 2.360 NM_003433
ZNF132
zinc finger protein 132
chr12_+_46863632 2.331 NM_001013635
C12orf68
chromosome 12 open reading frame 68
chr17_-_16413188 2.284 NM_020653
ZNF287
zinc finger protein 287
chr1_+_42701460 2.263 CCDC30
coiled-coil domain containing 30
chr11_+_133444029 2.251 NM_032801
JAM3
junctional adhesion molecule 3
chr10_+_63092724 2.120 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr8_+_13468722 2.082 NM_001007090
C8orf48
chromosome 8 open reading frame 48
chr11_+_101423378 2.004 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr11_+_7997366 1.992 TUB
tubby homolog (mouse)
chr6_+_43720744 1.981 NM_001193341
NM_152732
RSPH9

radial spoke head 9 homolog (Chlamydomonas)

chr19_-_63301402 1.872 ZSCAN18
zinc finger and SCAN domain containing 18
chr7_-_156125876 1.861 C7orf13
chromosome 7 open reading frame 13
chr19_-_63301418 1.838 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr7_-_35192177 1.804 DPY19L2P1
dpy-19-like 2 pseudogene 1 (C. elegans)
chr19_-_63301386 1.763 ZSCAN18
zinc finger and SCAN domain containing 18
chr4_+_114433551 1.753 ANK2
ankyrin 2, neuronal
chr4_-_156517423 1.712 MAP9
microtubule-associated protein 9
chr8_-_101187346 1.667 RGS22
regulator of G-protein signaling 22
chr12_+_120840829 1.623 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr7_+_156126157 1.601 NM_030936
NM_001184996
RNF32

ring finger protein 32

chr11_-_118716244 1.601 MFRP
membrane frizzled-related protein
chr15_-_68971665 1.597 NM_020147
THAP10
THAP domain containing 10
chr6_-_152744143 1.589 SYNE1
spectrin repeat containing, nuclear envelope 1
chr21_-_45532176 1.586 NM_015227
NM_133635
POFUT2

protein O-fucosyltransferase 2

chr11_+_85763425 1.550 NM_001156474
NM_021827
CCDC81

coiled-coil domain containing 81

chr16_-_65984836 1.548 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr8_-_49810270 1.505 NM_001142857
NM_024593
EFCAB1

EF-hand calcium binding domain 1

chr11_-_65860450 1.481 NM_004292
RIN1
Ras and Rab interactor 1
chr3_-_30911156 1.464 NM_207359
GADL1
glutamate decarboxylase-like 1
chr17_-_5344898 1.450 NM_001162371
LOC728392
hypothetical protein LOC728392
chr1_+_153413675 1.450 TRIM46
tripartite motif containing 46
chr19_+_63237211 1.444 NM_182572
ZSCAN1
zinc finger and SCAN domain containing 1
chr11_+_131285747 1.440 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr6_-_152744022 1.437 SYNE1
spectrin repeat containing, nuclear envelope 1
chr17_-_15185623 1.425 NM_031898
TEKT3
tektin 3
chr5_-_157031022 1.413 SOX30
SRY (sex determining region Y)-box 30
chr3_+_49002774 1.409 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr6_-_165643064 1.372 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr14_+_99329198 1.369 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr4_-_156517394 1.364 MAP9
microtubule-associated protein 9
chr1_+_84402962 1.363 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr8_+_120497732 1.358 NM_002514
NOV
nephroblastoma overexpressed gene
chr5_+_157031138 1.349 NM_001145132
C5orf52
chromosome 5 open reading frame 52
chr11_-_10671873 1.346 MRVI1
murine retrovirus integration site 1 homolog
chr8_-_101187519 1.313 NM_015668
RGS22
regulator of G-protein signaling 22
chr17_-_5345167 1.310 LOC728392
hypothetical protein LOC728392
chr2_+_228444570 1.309 NM_178821
WDR69
WD repeat domain 69
chr4_-_156517544 1.298 NM_001039580
MAP9
microtubule-associated protein 9
chr12_-_80676562 1.289 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr19_+_59062962 1.288 MYADM
myeloid-associated differentiation marker
chr3_+_156280129 1.288 NM_000902
MME
membrane metallo-endopeptidase
chr3_+_9826643 1.279 NM_001025930
TTLL3
tubulin tyrosine ligase-like family, member 3
chr6_+_14033402 1.274 NM_001165033
RNF182
ring finger protein 182
chr11_+_61204392 1.264 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr13_+_30404809 1.263 NM_152325
C13orf26
chromosome 13 open reading frame 26
chr3_+_120904555 1.259 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr13_+_23451919 1.242 SPATA13
spermatogenesis associated 13
chr7_+_129919330 1.240 MEST
mesoderm specific transcript homolog (mouse)
chr1_+_37795101 1.235 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr11_-_132318741 1.232 OPCML
opioid binding protein/cell adhesion molecule-like
chr19_+_59062937 1.223 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr11_-_10671736 1.219 MRVI1
murine retrovirus integration site 1 homolog
chr16_+_56219802 1.213 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_-_86634511 1.186 NM_001007022
NM_001184765
NM_001184766
NM_020729
ODF2L



outer dense fiber of sperm tails 2-like



chr4_+_87734489 1.181 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr19_-_45016587 1.176 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr6_+_14033076 1.171 NM_001165032
NM_152737
RNF182

ring finger protein 182

chr11_-_10671608 1.164 NM_001100167
MRVI1
murine retrovirus integration site 1 homolog
chr15_+_79213660 1.157 NM_173528
C15orf26
chromosome 15 open reading frame 26
chr9_+_111442888 1.155 NM_001037293
PALM2
paralemmin 2
chr11_+_6998275 1.143 NM_176822
NLRP14
NLR family, pyrin domain containing 14
chr15_+_68971835 1.141 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr12_-_52939636 1.139 NM_001127321
CBX5
chromobox homolog 5
chr13_-_95092283 1.136 DZIP1
DAZ interacting protein 1
chr11_+_102485293 1.135 NM_001080463
NM_001377
DYNC2H1

dynein, cytoplasmic 2, heavy chain 1

chr12_+_6800950 1.131 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr13_-_43259032 1.128 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr3_+_185538998 1.125 FAM131A
family with sequence similarity 131, member A
chr3_-_171013000 1.120 LRRC34
leucine rich repeat containing 34
chr19_+_59062982 1.114 MYADM
myeloid-associated differentiation marker
chr7_-_102707901 1.093 DPY19L2P2
dpy-19-like 2 pseudogene 2 (C. elegans)
chr14_-_73250094 1.087 NM_006029
PNMA1
paraneoplastic antigen MA1
chr11_-_6998041 1.083 NM_013249
ZNF214
zinc finger protein 214
chr9_+_123501186 1.082 DAB2IP
DAB2 interacting protein
chrX_+_135079461 1.065 NM_001167819
FHL1
four and a half LIM domains 1
chr3_-_139315011 1.064 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr9_+_115396020 1.061 NM_144489
RGS3
regulator of G-protein signaling 3
chr17_+_19255083 1.046 NM_007148
RNF112
ring finger protein 112
chr1_-_118529303 1.034 NM_206996
SPAG17
sperm associated antigen 17
chr9_-_109291866 1.031 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr7_-_4889772 1.030 NM_018059
RADIL
Ras association and DIL domains
chr9_-_109291575 1.030 KLF4
Kruppel-like factor 4 (gut)
chr11_+_26310253 1.018 NM_031418
ANO3
anoctamin 3
chr1_+_201711578 1.017 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr1_+_201711505 1.008 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr9_+_99109730 0.999 NM_020893
C9orf174
chromosome 9 open reading frame 174
chr3_-_114643008 0.999 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr16_-_674357 0.998 NM_001005920
JMJD8
jumonji domain containing 8
chr8_-_98359248 0.993 TSPYL5
TSPY-like 5
chr7_+_48041632 0.992 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr1_-_51660328 0.991 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr2_-_233501069 0.968 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr1_-_36688556 0.957 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr3_+_48482213 0.951 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr8_-_98359347 0.945 NM_033512
TSPYL5
TSPY-like 5
chr6_-_161614962 0.940 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr6_-_32227695 0.938 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr16_-_66007650 0.937 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr8_-_98359366 0.927 TSPYL5
TSPY-like 5
chr7_+_129919134 0.927 MEST
mesoderm specific transcript homolog (mouse)
chr8_+_16929116 0.916 NM_181723
EFHA2
EF-hand domain family, member A2
chr3_-_124822113 0.905 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr7_+_129919157 0.900 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr1_+_201862845 0.900 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr7_-_124192265 0.900 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr2_-_175578156 0.894 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr12_-_52939584 0.880 NM_001127322
CBX5
chromobox homolog 5
chr4_-_87500201 0.878 MAPK10
mitogen-activated protein kinase 10
chr3_+_9826930 0.869 TTLL3
tubulin tyrosine ligase-like family, member 3
chr12_+_50104936 0.857 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr3_-_42789738 0.855 NM_144719
CCDC13
coiled-coil domain containing 13
chr17_+_55854636 0.855 NM_181707
C17orf64
chromosome 17 open reading frame 64
chr3_-_49030920 0.855 NM_001009996
DALRD3
DALR anticodon binding domain containing 3
chr7_-_44195405 0.852 NM_000162
GCK
glucokinase (hexokinase 4)
chr3_-_171013145 0.852 NM_001172779
NM_001172780
NM_153353
LRRC34


leucine rich repeat containing 34


chr14_-_59407103 0.847 NM_021136
RTN1
reticulon 1
chr2_+_74502364 0.844 NM_032118
WDR54
WD repeat domain 54
chr1_-_38097811 0.838 NM_005955
MTF1
metal-regulatory transcription factor 1
chr3_-_124821868 0.833 MYLK
myosin light chain kinase
chr12_+_79362256 0.828 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr22_-_43272567 0.827 NM_032287
LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr20_-_49612745 0.827 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr1_-_33669190 0.821 PHC2
polyhomeotic homolog 2 (Drosophila)
chrX_-_71268475 0.818 NM_001024455
RGAG4
retrotransposon gag domain containing 4
chr22_-_42539399 0.814 NM_022785
NM_198856
EFCAB6

EF-hand calcium binding domain 6

chr16_-_674318 0.811 JMJD8
jumonji domain containing 8
chr14_+_105012106 0.809 NM_001312
CRIP2
cysteine-rich protein 2
chr4_-_148086413 0.808 NM_031956
TTC29
tetratricopeptide repeat domain 29
chr4_+_128773529 0.805 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr16_-_56393871 0.787 KIFC3
kinesin family member C3
chr17_+_45940911 0.786 MYCBPAP
MYCBP associated protein
chr19_-_13909877 0.783 PODNL1
podocan-like 1
chr19_-_6344005 0.782 NM_002096
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chr3_+_38055699 0.775 NM_007335
NM_007337
DLEC1

deleted in lung and esophageal cancer 1

chr14_+_105063975 0.773 NM_025268
TMEM121
transmembrane protein 121
chr1_+_45046740 0.773 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr13_-_59223074 0.767


chr22_+_21817512 0.766 NM_004914
RAB36
RAB36, member RAS oncogene family
chr15_+_96304911 0.763 NM_183376
ARRDC4
arrestin domain containing 4
chr19_-_13910167 0.763 NM_024825
PODNL1
podocan-like 1
chr7_+_149696901 0.762 REPIN1
replication initiator 1
chr2_-_182229977 0.762 NM_001030311
NM_001030312
NM_001030313
NM_001160277
NM_201548
CERKL




ceramide kinase-like




chr12_+_51979721 0.762 NM_021640
C12orf10
chromosome 12 open reading frame 10
chr6_-_32227645 0.760 PRRT1
proline-rich transmembrane protein 1
chr2_-_26717713 0.746 NM_001029881
CIB4
calcium and integrin binding family member 4
chr19_-_63584194 0.746 NM_001129730
NM_138466
ZNF837

zinc finger protein 837

chr17_+_65612589 0.731 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr22_+_35777561 0.727 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr5_+_92944680 0.725 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr8_-_485330 0.724 NM_175075
C8orf42
chromosome 8 open reading frame 42
chr7_+_21549357 0.723 NM_003777
DNAH11
dynein, axonemal, heavy chain 11
chr8_-_133756943 0.719 NM_012472
LRRC6
leucine rich repeat containing 6
chr17_-_61618276 0.712 NM_145036
CCDC46
coiled-coil domain containing 46
chr20_-_49612574 0.711 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr7_+_44110527 0.710 AEBP1
AE binding protein 1
chr11_-_85074848 0.709 NM_152723
CCDC89
coiled-coil domain containing 89
chr16_+_2016807 0.706 NM_001130012
NM_004785
SLC9A3R2

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

chrX_-_99778340 0.705 NM_003270
TSPAN6
tetraspanin 6
chr17_+_52026058 0.702 NM_005450
NOG
noggin
chr20_-_36322587 0.695 NM_001029864
KIAA1755
KIAA1755
chr11_-_64641700 0.688 NM_014205
ZNHIT2
zinc finger, HIT-type containing 2
chr6_+_14032655 0.684 NM_001165034
RNF182
ring finger protein 182
chr13_+_35904408 0.682 NM_001111045
NM_003914
CCNA1

cyclin A1

chr19_-_7896974 0.677 NM_206833
CTXN1
cortexin 1
chr4_-_76774594 0.677 NM_003948
CDKL2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr3_+_159771646 0.677 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr7_-_102708076 0.671 DPY19L2P2
dpy-19-like 2 pseudogene 2 (C. elegans)
chr7_+_76589869 0.670 NM_020879
CCDC146
coiled-coil domain containing 146
chrX_+_135079120 0.668 NM_001159704
FHL1
four and a half LIM domains 1
chr17_+_17339059 0.668


chr10_-_116382089 0.667 ABLIM1
actin binding LIM protein 1
chr15_+_96304942 0.655 ARRDC4
arrestin domain containing 4
chr5_-_147142444 0.651 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr3_-_50357994 0.645 NM_015896
ZMYND10
zinc finger, MYND-type containing 10
chr22_-_22646602 0.644 NM_001084392
DDT
D-dopachrome tautomerase
chr8_+_39084206 0.643 NM_145004
ADAM32
ADAM metallopeptidase domain 32
chr18_+_42780784 0.630 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr18_+_50049846 0.627 NM_007195
POLI
polymerase (DNA directed) iota
chr5_-_14064846 0.626 DNAH5
dynein, axonemal, heavy chain 5
chrX_+_103243762 0.624 NM_001143978
ZCCHC18
zinc finger, CCHC domain containing 18

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.72 1.03e-03 GO:0007017 microtubule-based process
3.48 1.06e-02 GO:0007018 microtubule-based movement
14.46 1.10e-02 GO:0035082 axoneme assembly
3.72 3.07e-02 GO:0030031 cell projection assembly

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.36 2.45e-08 GO:0015630 microtubule cytoskeleton
6.45 1.60e-07 GO:0005930 axoneme
3.02 7.14e-07 GO:0005874 microtubule
3.74 1.03e-06 GO:0005929 cilium
5.53 5.96e-06 GO:0044441 cilium part
6.31 7.47e-05 GO:0035085 cilium axoneme
1.61 3.56e-04 GO:0005856 cytoskeleton
1.18 1.64e-03 GO:0005737 cytoplasm
1.68 3.18e-03 GO:0044430 cytoskeletal part
1.39 4.11e-03 GO:0043228 non-membrane-bounded organelle
1.39 4.11e-03 GO:0043232 intracellular non-membrane-bounded organelle
5.26 4.51e-03 GO:0005932 microtubule basal body
2.26 5.28e-03 GO:0005815 microtubule organizing center
5.78 5.31e-03 GO:0030286 dynein complex
2.06 1.49e-02 GO:0044463 cell projection part
3.45 1.61e-02 GO:0005875 microtubule associated complex
6.48 2.13e-02 GO:0044447 axoneme part
1.10 4.32e-02 GO:0044424 intracellular part
8.90 4.55e-02 GO:0005858 axonemal dynein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.93 4.48e-02 GO:0030695 GTPase regulator activity
2.81 4.61e-02 GO:0003774 motor activity