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• Activity deltas table
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Motif ID: NFE2.p2

Z-value: 1.462

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chrX_-_100527799	3.006	NM_000061	BTK	Bruton agammaglobulinemia tyrosine kinase
chrX_-_154216929	2.620	NM_001289	CLIC2	chloride intracellular channel 2
chr22_+_21370394	2.573		IGL@	immunoglobulin lambda locus
chr1_+_12046020	2.511	NM_001243	TNFRSF8	tumor necrosis factor receptor superfamily, member 8
chr11_+_118463906	2.489	NM_001024382	HMBS	hydroxymethylbilane synthase
chr17_-_35975227	2.466	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chr22_+_21495273	2.460
chr1_+_153232685	2.290	NM_018655	LENEP	lens epithelial protein
chr1_-_93030538	2.201	NM_005665	EVI5	ecotropic viral integration site 5
chr12_-_15005761	2.131	NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr1_-_156923111	2.124	NM_003126	SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr5_-_141041982	1.932	NM_022481	ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr3_-_197549640	1.926	NM_138461	TM4SF19	transmembrane 4 L six family member 19
chr1_+_173111306	1.863	NM_001035230	RABGAP1L	RAB GTPase activating protein 1-like
chr3_-_197549588	1.833		TM4SF19	transmembrane 4 L six family member 19
chr6_+_106653429	1.812	NM_182907	PRDM1	PR domain containing 1, with ZNF domain
chr19_-_53935648	1.762	NM_017805	RASIP1	Ras interacting protein 1
chr11_+_10434056	1.750	NM_001025390	AMPD3	adenosine monophosphate deaminase 3
chr22_+_21393107	1.713		IGLJ3	immunoglobulin lambda joining 3
chrX_+_65299352	1.687		HEPH	hephaestin
chr4_-_174687104	1.667		HAND2	heart and neural crest derivatives expressed 2
chr22_+_20715340	1.633
chr7_-_86526880	1.606	NM_001142749	KIAA1324L	KIAA1324-like
chr22_+_21053972	1.603
chr13_-_98757634	1.569	NM_004951	GPR183	G protein-coupled receptor 183
chr6_-_28429950	1.566	NM_145909	ZNF323	zinc finger protein 323
chr5_-_141041933	1.557		ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr5_-_169657312	1.533		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr4_-_38710376	1.526	NM_024943	TMEM156	transmembrane protein 156
chr8_-_42742729	1.511	NM_004198	CHRNA6	cholinergic receptor, nicotinic, alpha 6
chrX_+_9391314	1.501	NM_001139466 NM_001139467 NM_001139468	TBL1X	transducin (beta)-like 1X-linked
chrX_+_65299157	1.479	NM_138737	HEPH	hephaestin
chr6_-_84197573	1.474	NM_002395	ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr1_+_221955876	1.458	NM_001146068	CAPN2	calpain 2, (m/II) large subunit
chr5_-_169657395	1.453	NM_005565	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr19_-_54350457	1.453	NM_002152	HRC	histidine rich calcium binding protein
chr18_+_54039818	1.441		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_20342262	1.421	NM_001098523	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr18_+_54039779	1.411		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr4_-_977163	1.392	NM_022042 NM_134425 NM_213613	SLC26A1	solute carrier family 26 (sulfate transporter), member 1
chr2_+_169634330	1.391		DHRS9	dehydrogenase/reductase (SDR family) member 9
chr18_+_54039730	1.377	NM_001144966	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr17_-_77474597	1.363	NM_032711	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr1_+_17507276	1.355	NM_012387	PADI4	peptidyl arginine deiminase, type IV
chr3_+_70131572	1.347
chr6_-_84197477	1.340		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr16_-_87570716	1.332	NM_005187	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr6_-_84197463	1.329		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr5_-_169657192	1.326		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr10_+_70745615	1.319	NM_033496	HK1	hexokinase 1
chr6_-_84197370	1.318		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr22_+_21042091	1.316		IGLV1-44 IGL@	immunoglobulin lambda variable 1-44 immunoglobulin lambda locus
chr6_+_34314545	1.297	NM_145905	HMGA1	high mobility group AT-hook 1
chr1_-_159257567	1.283		F11R	F11 receptor
chrX_-_152863251	1.268	NM_002910	RENBP	renin binding protein
chr16_-_70763849	1.248	NM_001160213	PMFBP1	polyamine modulated factor 1 binding protein 1
chr19_+_45564549	1.248		PLD3	phospholipase D family, member 3
chr5_-_169657360	1.231		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr10_-_76538859	1.228	NM_001007271 NM_001007272 NM_001007273	DUSP13	dual specificity phosphatase 13
chr22_+_19699441	1.226	NM_001159554 NM_005446	P2RX6	purinergic receptor P2X, ligand-gated ion channel, 6
chr6_+_44302973	1.190		SLC29A1	solute carrier family 29 (nucleoside transporters), member 1
chr16_+_28413421	1.187	NM_018690	APOBR	apolipoprotein B receptor
chr4_-_77163609	1.173	NM_001565	CXCL10	chemokine (C-X-C motif) ligand 10
chr7_+_139175420	1.172	NM_001061 NM_001166253 NM_030984	TBXAS1	thromboxane A synthase 1 (platelet)
chr22_-_25343959	1.161	NM_001887	CRYBB1	crystallin, beta B1
chr4_+_22608252	1.149
chr12_-_51629874	1.148		KRT8	keratin 8
chr1_-_7923464	1.135	NM_001561	TNFRSF9	tumor necrosis factor receptor superfamily, member 9
chr22_+_21340757	1.135
chr6_-_29563657	1.131	NM_052967	MAS1L	MAS1 oncogene-like
chr11_+_384199	1.128	NM_007183	PKP3	plakophilin 3
chr11_+_20341900	1.125	NM_001098522	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr19_-_4510713	1.100		SEMA6B	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr11_+_67107641	1.099	NM_000852	GSTP1	glutathione S-transferase pi 1
chr11_+_20341806	1.099	NM_006410 NM_001098521	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr7_+_26298018	1.093	NM_013322	SNX10	sorting nexin 10
chr22_+_43451600	1.077		PRR5	proline rich 5 (renal)
chr11_+_60039461	1.073	NM_001012417 NM_001100909	MS4A13	membrane-spanning 4-domains, subfamily A, member 13
chr11_+_20341835	1.069	NM_001098520	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr4_+_111053488	1.065	NM_001178130 NM_001178131 NM_001963	EGF	epidermal growth factor
chr22_-_25344037	1.051		CRYBB1	crystallin, beta B1
chrX_+_12903145	1.051	NM_021109 NM_183049	TMSB4X TMSL3	thymosin beta 4, X-linked thymosin-like 3
chr11_+_65026382	1.046
chr11_+_67107852	1.045		GSTP1	glutathione S-transferase pi 1
chr17_+_72827185	1.041	NM_006640	SEPT9	septin 9
chr7_-_128330615	1.037		KCP	kielin/chordin-like protein
chr1_-_159257486	1.025		F11R	F11 receptor
chr19_-_48976852	1.015		KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr4_-_145159889	1.011	NM_002100	GYPB	glycophorin B (MNS blood group)
chr1_+_226399026	1.008	NM_001159391	GUK1	guanylate kinase 1
chrX_-_15421279	1.008	NM_001018109 NM_003662	PIR	pirin (iron-binding nuclear protein)
chr2_-_85494664	1.001		CAPG	capping protein (actin filament), gelsolin-like
chrX_+_69314060	0.976	NM_198512	DGAT2L6	diacylglycerol O-acyltransferase 2-like 6
chr1_-_157313179	0.964	NM_004833	AIM2	absent in melanoma 2
chr1_-_159257595	0.962	NM_016946	F11R	F11 receptor
chr22_+_18388656	0.961		C22orf25	chromosome 22 open reading frame 25
chr22_+_21116283	0.955
chr17_+_77910411	0.948	NM_207459	TEX19	testis expressed 19
chr2_-_85494639	0.939		CAPG	capping protein (actin filament), gelsolin-like
chr17_-_31231421	0.936	NM_002985	CCL5	chemokine (C-C motif) ligand 5
chr16_-_1369613	0.934	NM_001193389 NM_023076	UNKL	unkempt homolog (Drosophila)-like
chrX_-_24575375	0.926	NM_001163265 NM_004845	PCYT1B	phosphate cytidylyltransferase 1, choline, beta
chr17_+_22823151	0.918	NM_014238	KSR1	kinase suppressor of ras 1
chr19_-_56260135	0.915	NM_015596	KLK13	kallikrein-related peptidase 13
chrX_-_152938528	0.912	NM_001025242 NM_001025243 NM_001569	IRAK1	interleukin-1 receptor-associated kinase 1
chr10_-_6059460	0.904	NM_002189 NM_172200	IL15RA	interleukin 15 receptor, alpha
chrX_-_152938441	0.904		IRAK1	interleukin-1 receptor-associated kinase 1
chr12_-_51585004	0.901	NM_002273	KRT8	keratin 8
chr16_-_70763524	0.896	NM_031293	PMFBP1	polyamine modulated factor 1 binding protein 1
chr9_-_139042416	0.886		ABCA2	ATP-binding cassette, sub-family A (ABC1), member 2
chr6_-_30792830	0.883		MDC1	mediator of DNA-damage checkpoint 1
chr1_-_45045543	0.883	NM_001013632	TCTEX1D4	Tctex1 domain containing 4
chr17_-_39700960	0.880	NM_000342	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr7_+_26298136	0.878		SNX10	sorting nexin 10
chr22_+_43451351	0.877	NM_001017530 NM_001198721 NM_015366	PRR5	proline rich 5 (renal)
chr3_+_185377341	0.874		AP2M1	adaptor-related protein complex 2, mu 1 subunit
chr2_+_102401580	0.873	NM_003853	IL18RAP	interleukin 18 receptor accessory protein
chr18_+_9875722	0.866	NM_001098529 NM_032243	TXNDC2	thioredoxin domain containing 2 (spermatozoa)
chr15_-_74091817	0.859	NM_138573	NRG4	neuregulin 4
chr11_+_384238	0.848		PKP3	plakophilin 3
chr4_+_74825138	0.844	NM_000584	IL8	interleukin 8
chr9_-_130006309	0.842	NM_001131015 NM_012127	CIZ1	CDKN1A interacting zinc finger protein 1
chr15_+_38318528	0.838		PAK6	p21 protein (Cdc42/Rac)-activated kinase 6
chr15_-_58477407	0.831	NM_001002857 NM_001002858 NM_001136015 NM_004039	ANXA2	annexin A2
chr9_-_139042526	0.827	NM_001606	ABCA2	ATP-binding cassette, sub-family A (ABC1), member 2
chr22_-_17846711	0.825		UFD1L	ubiquitin fusion degradation 1 like (yeast)
chr17_+_72827227	0.820		SEPT9	septin 9
chr17_+_27795633	0.815		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_+_56927665	0.815	NM_152731	BEND6	BEN domain containing 6
chrX_-_24575146	0.803		PCYT1B	phosphate cytidylyltransferase 1, choline, beta
chr4_+_170817787	0.802		CLCN3	chloride channel 3
chrX_-_10761729	0.802	NM_033290	MID1	midline 1 (Opitz/BBB syndrome)
chr4_-_80548378	0.797	NM_033214	GK2	glycerol kinase 2
chr22_+_20316968	0.789	NM_152612	CCDC116	coiled-coil domain containing 116
chr22_+_21011653	0.785
chr7_+_22733290	0.779	NM_000600	IL6	interleukin 6 (interferon, beta 2)
chr5_+_61750467	0.774	NM_001134779	IPO11	importin 11
chr6_-_50025115	0.764	NM_001166478	DEFB133	defensin, beta 133
chr10_+_17310475	0.759		VIM	vimentin
chr17_+_27795635	0.758		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr22_+_20899155	0.757
chr6_-_31853027	0.755	NM_025258	C6orf27	chromosome 6 open reading frame 27
chr19_-_54636425	0.755	NM_020309	SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr1_+_181028016	0.753	NM_030769	NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr7_+_150065594	0.752		GIMAP5	GTPase, IMAP family member 5
chr6_+_56927882	0.751		BEND6	BEN domain containing 6
chr7_-_33047042	0.748	NM_001166118 NM_016489	NT5C3	5'-nucleotidase, cytosolic III
chr1_-_199259133	0.748		KIF21B	kinesin family member 21B
chr22_-_17846621	0.747		UFD1L	ubiquitin fusion degradation 1 like (yeast)
chr10_+_17310263	0.744	NM_003380	VIM	vimentin
chr17_+_27795598	0.741		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr3_+_185377430	0.738		AP2M1	adaptor-related protein complex 2, mu 1 subunit
chr3_+_69998064	0.731	NM_198177	MITF	microphthalmia-associated transcription factor
chr3_+_154035425	0.719	NM_002563	P2RY1	purinergic receptor P2Y, G-protein coupled, 1
chr22_+_21464980	0.710
chr22_+_21079355	0.709
chr19_+_40895669	0.707	NM_014383	ZBTB32	zinc finger and BTB domain containing 32
chr22_+_21359175	0.697		IGLV3-25	immunoglobulin lambda variable 3-25
chr19_-_48977247	0.696	NM_002250	KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chrX_-_2896285	0.695		ARSE	arylsulfatase E (chondrodysplasia punctata 1)
chr7_-_38355949	0.695
chr1_+_89763030	0.684		LRRC8B	leucine rich repeat containing 8 family, member B
chr17_+_71109734	0.681		MYO15B	myosin XVB pseudogene
chrX_-_152938456	0.679		IRAK1	interleukin-1 receptor-associated kinase 1
chrX_+_153423652	0.677	NM_001099856	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr17_-_43254132	0.677	NM_145798	OSBPL7	oxysterol binding protein-like 7
chr17_+_27795632	0.675		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr9_+_130231027	0.671		CERCAM	cerebral endothelial cell adhesion molecule
chr16_+_55684030	0.671		CPNE2	copine II
chr17_+_53769659	0.671		LOC100506779	hypothetical LOC100506779
chr6_+_33151703	0.666	NM_002121	HLA-DPB1	major histocompatibility complex, class II, DP beta 1
chr7_+_150319076	0.665	NM_000603	NOS3	nitric oxide synthase 3 (endothelial cell)
chr4_-_145046109	0.663	NM_002102 NM_198682	GYPE	glycophorin E (MNS blood group)
chr6_+_32229278	0.662	NM_138717	PPT2	palmitoyl-protein thioesterase 2
chr2_-_169596078	0.659	NM_003742	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr22_+_21006814	0.657
chr22_-_17846725	0.656	NM_001035247 NM_005659	UFD1L	ubiquitin fusion degradation 1 like (yeast)
chr1_+_76024466	0.655	NM_004582	RABGGTB	Rab geranylgeranyltransferase, beta subunit
chr6_-_38778849	0.648		GLO1	glyoxalase I
chr17_+_27795645	0.641		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr19_-_61039939	0.637	NM_145007	NLRP11	NLR family, pyrin domain containing 11
chr7_+_150065376	0.635	NM_018384	GIMAP5	GTPase, IMAP family member 5
chr9_+_131291224	0.630		LOC100506190	hypothetical LOC100506190
chr8_-_13018123	0.629	NM_001164271	DLC1	deleted in liver cancer 1
chr19_+_3317575	0.628		NFIC	nuclear factor I/C (CCAAT-binding transcription factor)
chr2_-_99238001	0.625	NM_175735	LYG2	lysozyme G-like 2
chr16_+_55683995	0.624		CPNE2	copine II
chr10_-_21502993	0.624		NEBL	nebulette
chr20_+_33223434	0.623	NM_006404	PROCR	protein C receptor, endothelial
chr19_+_3317536	0.622	NM_005597	NFIC	nuclear factor I/C (CCAAT-binding transcription factor)
chrX_-_53327473	0.621	NM_015075	IQSEC2	IQ motif and Sec7 domain 2
chr3_+_142569988	0.619		ZBTB38	zinc finger and BTB domain containing 38
chr7_+_111850367	0.618	NM_001007245 NM_001197080	IFRD1	interferon-related developmental regulator 1
chr17_-_30414789	0.618	NM_001017368	RFFL	ring finger and FYVE-like domain containing 1
chr1_+_12698704	0.615	NM_001103169 NM_001103170	AADACL3	arylacetamide deacetylase-like 3
chr9_+_71009746	0.614	NM_001170415 NM_001170416	TJP2	tight junction protein 2 (zona occludens 2)
chr14_+_22422270	0.613	NM_173527	REM2	RAS (RAD and GEM)-like GTP binding 2
chr16_+_48857962	0.612		ADCY7	adenylate cyclase 7
chr8_+_145158432	0.612	NM_001134374 NM_198572	SPATC1	spermatogenesis and centriole associated 1
chr6_-_38778898	0.611		GLO1	glyoxalase I

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
4.89	1.32e-03	GO:0006521	regulation of cellular amino acid metabolic process
4.34	2.79e-03	GO:0071158	positive regulation of cell cycle arrest
1.34	3.00e-03	GO:0007165	signal transduction
1.23	3.41e-03	GO:0050896	response to stimulus
1.32	4.59e-03	GO:0023052	signaling
3.07	6.19e-03	GO:0010565	regulation of cellular ketone metabolic process
4.25	8.22e-03	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.25	8.22e-03	GO:0072395	signal transduction involved in cell cycle checkpoint
4.25	8.22e-03	GO:0072401	signal transduction involved in DNA integrity checkpoint
4.25	8.22e-03	GO:0072404	signal transduction involved in G1/S transition checkpoint
4.25	8.22e-03	GO:0072413	signal transduction involved in mitotic cell cycle checkpoint
4.25	8.22e-03	GO:0072422	signal transduction involved in DNA damage checkpoint
4.25	8.22e-03	GO:0072431	signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.25	8.22e-03	GO:0072474	signal transduction involved in mitotic cell cycle G1/S checkpoint
1.29	8.48e-03	GO:0051716	cellular response to stimulus
3.91	1.12e-02	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.05	1.50e-02	GO:0033238	regulation of cellular amine metabolic process
3.62	1.62e-02	GO:0051351	positive regulation of ligase activity
3.62	1.62e-02	GO:2000045	regulation of G1/S transition of mitotic cell cycle
3.87	2.64e-02	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
3.18	2.96e-02	GO:0090068	positive regulation of cell cycle process
3.82	3.16e-02	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint
1.61	3.16e-02	GO:0043067	regulation of programmed cell death
3.61	3.18e-02	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
3.56	3.74e-02	GO:0031575	mitotic cell cycle G1/S transition checkpoint
3.56	3.74e-02	GO:0051443	positive regulation of ubiquitin-protein ligase activity
3.56	3.74e-02	GO:0071779	G1/S transition checkpoint
1.35	4.08e-02	GO:0048518	positive regulation of biological process
1.61	4.09e-02	GO:0042981	regulation of apoptosis
3.71	4.47e-02	GO:0051352	negative regulation of ligase activity
3.71	4.47e-02	GO:0051444	negative regulation of ubiquitin-protein ligase activity

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
4.71	5.34e-05	GO:0000502	proteasome complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
2.70	1.38e-03	GO:0005126	cytokine receptor binding