Motif ID: ETS1,2.p2

Z-value: 3.964


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)



Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_29581783 8.451 NM_001030288
SPN
sialophorin
chr7_+_50318801 7.420 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr10_+_49562866 7.013 WDFY4
WDFY family member 4
chr19_-_10311262 6.712 NM_002162
ICAM3
intercellular adhesion molecule 3
chr3_-_184756101 6.548 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chrX_+_65152004 6.120


chr19_+_17723285 5.893 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr7_-_3049872 5.518 NM_032415
CARD11
caspase recruitment domain family, member 11
chr1_-_31003260 5.514 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr1_-_31003181 5.442 LAPTM5
lysosomal protein transmembrane 5
chr6_-_11490487 5.288 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_+_113648020 5.264 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chr9_-_129707392 5.106 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr16_+_29582065 5.070 SPN
sialophorin
chr16_+_29582069 5.051 NM_003123
SPN
sialophorin
chr3_+_47004457 4.899 NBEAL2
neurobeachin-like 2
chr19_+_16860871 4.846 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr2_+_113648036 4.783 PSD4
pleckstrin and Sec7 domain containing 4
chr19_+_54530546 4.746 CD37
CD37 molecule
chr19_+_16860807 4.716 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr1_+_111217244 4.652 NM_000560
CD53
CD53 molecule
chr9_+_94766379 4.610 FGD3
FYVE, RhoGEF and PH domain containing 3
chr15_+_79376295 4.444 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr7_-_44985175 4.376 MYO1G
myosin IG
chr1_+_111217314 4.352 CD53
CD53 molecule
chr7_-_44985084 4.298 MYO1G
myosin IG
chr14_+_20319049 4.239 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr7_-_44985202 4.231 NM_033054
MYO1G
myosin IG
chr13_-_45654327 4.229 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_159306037 4.161 ARHGAP30
Rho GTPase activating protein 30
chr21_-_14840506 4.052 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr1_+_159899528 4.016 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr16_-_29664765 3.961 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr11_+_65164767 3.961 SIPA1
signal-induced proliferation-associated 1
chr21_-_45165249 3.919 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr7_+_150065594 3.916 GIMAP5
GTPase, IMAP family member 5
chr13_-_45654296 3.872 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr10_+_26767698 3.841 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr13_-_45654292 3.820 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_54530512 3.786 CD37
CD37 molecule
chr21_-_45165302 3.785 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr16_-_49272617 3.774 SNX20
sorting nexin 20
chr9_+_263025 3.757 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr10_+_26767657 3.670 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr3_-_180460372 3.659 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr19_+_54530497 3.529 CD37
CD37 molecule
chr19_+_54530485 3.514 NM_001040031
NM_001774
CD37

CD37 molecule

chr12_-_53153613 3.497 GTSF1
gametocyte specific factor 1
chr11_+_66927955 3.493 TBC1D10C
TBC1 domain family, member 10C
chr12_-_53153639 3.488 NM_144594
GTSF1
gametocyte specific factor 1
chr19_+_54530458 3.473 CD37
CD37 molecule
chr16_+_28413421 3.454 NM_018690
APOBR
apolipoprotein B receptor
chr22_+_42908589 3.419 NM_001137606
PARVG
parvin, gamma
chr2_-_242205556 3.358 NM_001164356
THAP4
THAP domain containing 4
chr22_-_35875890 3.358 NM_000878
IL2RB
interleukin 2 receptor, beta
chr22_+_42908548 3.350 PARVG
parvin, gamma
chr1_-_155788775 3.335 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr22_+_35586950 3.304 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_-_159306210 3.289 ARHGAP30
Rho GTPase activating protein 30
chr1_-_200395741 3.258 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr1_-_159306273 3.224 ARHGAP30
Rho GTPase activating protein 30
chr12_-_53044495 3.153 NM_020370
GPR84
G protein-coupled receptor 84
chr22_+_42908612 3.130 PARVG
parvin, gamma
chr21_-_45165204 3.116 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr9_-_133141726 3.079 NM_033387
FAM78A
family with sequence similarity 78, member A
chr4_+_2783764 3.073 SH3BP2
SH3-domain binding protein 2
chr3_-_123223658 3.068 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr4_+_2783743 3.034 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr1_+_6008956 2.994 NM_003636
NM_172130
KCNAB2

potassium voltage-gated channel, shaker-related subfamily, beta member 2

chr3_-_13032130 2.977


chr16_+_30391460 2.953 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr6_+_37081387 2.945 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr1_+_6008999 2.823 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr6_+_31661934 2.794 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr1_-_181826086 2.789 NCF2
neutrophil cytosolic factor 2
chrX_-_130792297 2.779 LOC286467
hypothetical LOC286467
chr22_+_36008465 2.768 CYTH4
cytohesin 4
chr12_-_6615348 2.721 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr10_-_98021144 2.709 NM_001114094
NM_013314
BLNK

B-cell linker

chr22_+_36008511 2.680 CYTH4
cytohesin 4
chr14_+_105024576 2.680 CRIP1
cysteine-rich protein 1 (intestinal)
chr16_-_65108605 2.659 TK2
thymidine kinase 2, mitochondrial
chr16_+_30391550 2.641 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr10_-_98470164 2.637 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr17_-_44058612 2.634 NM_024017
HOXB9
homeobox B9
chr16_-_30301634 2.624 NM_052838
SEPT1
septin 1
chr15_-_38387410 2.619 NM_004573
PLCB2
phospholipase C, beta 2
chr19_+_17495109 2.612 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr1_+_26744893 2.587 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_-_40843530 2.549 ARHGAP27
Rho GTPase activating protein 27
chr7_+_150065376 2.546 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr1_-_158883666 2.505 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr10_+_49563520 2.500 NM_020945
WDFY4
WDFY family member 4
chr1_+_26744929 2.479 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr3_+_188197029 2.464


chr12_-_56157898 2.438 NM_001080156
ARHGAP9
Rho GTPase activating protein 9
chr22_+_36008369 2.402 NM_013385
CYTH4
cytohesin 4
chr1_-_205161821 2.397 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr15_-_38387164 2.363 PLCB2
phospholipase C, beta 2
chr17_-_35975227 2.363 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr11_+_59979857 2.362 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr10_+_114125955 2.347 ACSL5
acyl-CoA synthetase long-chain family member 5
chr21_+_41663853 2.336 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr2_+_143603439 2.306 ARHGAP15
Rho GTPase activating protein 15
chr19_-_17377383 2.301 NM_004335
BST2
bone marrow stromal cell antigen 2
chr19_-_56825400 2.299 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr19_+_17377502 2.291 LOC100507535
hypothetical LOC100507535
chr7_-_149960218 2.288 GIMAP6
GTPase, IMAP family member 6
chr12_+_6926014 2.286 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_-_56422120 2.282 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr15_-_38387357 2.277 PLCB2
phospholipase C, beta 2
chr19_+_47073029 2.267 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr12_+_6925997 2.266 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr22_-_36212160 2.237 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr19_+_59820413 2.237 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr1_+_202000906 2.222 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr22_+_22435207 2.213 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr2_+_143603368 2.206 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr12_-_8271460 2.196 NM_018088
FAM90A1
family with sequence similarity 90, member A1
chr2_+_102401580 2.187 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr3_+_120799411 2.176 NM_015900
PLA1A
phospholipase A1 member A
chr12_+_53178834 2.171 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr12_-_6611075 2.169 NM_001142961
LPAR5
lysophosphatidic acid receptor 5
chr19_-_13074973 2.166 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr14_-_22354457 2.159 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr10_+_114126004 2.152 ACSL5
acyl-CoA synthetase long-chain family member 5
chr15_+_89274413 2.142 NM_001039675
UNC45A
unc-45 homolog A (C. elegans)
chr11_-_66961709 2.139 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr16_+_30391609 2.124


chr7_-_100078270 2.124 TFR2
transferrin receptor 2
chr17_+_18971506 2.097 NM_001129778
GRAPL
GRB2-related adaptor protein-like
chr19_-_4491078 2.089 LRG1
leucine-rich alpha-2-glycoprotein 1
chr1_-_27825178 2.076 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr9_-_138387903 2.062 CARD9
caspase recruitment domain family, member 9
chr17_-_3766708 2.057 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr6_-_119137923 2.052 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr11_+_63864263 2.052 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr19_-_61324412 2.031 ZNF787
zinc finger protein 787
chr15_+_72861470 2.028 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr9_-_113977285 2.022 NM_022486
SUSD1
sushi domain containing 1
chr2_+_230798687 2.014 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chr9_+_139292094 2.011 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr1_+_32489426 2.006 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr2_-_175170674 1.995 WIPF1
WAS/WASL interacting protein family, member 1
chr19_-_43800374 1.968 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr16_+_48857962 1.966 ADCY7
adenylate cyclase 7
chr19_-_4491024 1.963 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr2_-_120697148 1.959 TMEM185B
transmembrane protein 185B (pseudogene)
chr7_-_149960612 1.954 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr4_-_38710376 1.944 NM_024943
TMEM156
transmembrane protein 156
chr11_+_65164963 1.920


chr19_-_47328399 1.916 NM_002698
POU2F2
POU class 2 homeobox 2
chr8_-_21827057 1.913 NM_003974
DOK2
docking protein 2, 56kDa
chr11_+_66927976 1.906 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr12_-_101396459 1.896 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_27825633 1.890 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr19_+_41085221 1.888 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr19_+_10258642 1.871 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr14_+_99601498 1.870 NM_016337
EVL
Enah/Vasp-like
chr2_+_68815416 1.869 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr3_-_122862447 1.828 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_+_208008517 1.827 TRAF3IP3
TRAF3 interacting protein 3
chr18_+_70318001 1.821 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr19_-_18058632 1.820 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr16_+_19329557 1.820 NM_001105248
NM_001105249
TMC5

transmembrane channel-like 5

chr22_-_28992787 1.814 NM_020530
OSM
oncostatin M
chr9_-_122728173 1.814 TRAF1
TNF receptor-associated factor 1
chr7_+_732831 1.807 NM_017802
HEATR2
HEAT repeat containing 2
chr1_-_158815895 1.758 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr12_-_109611277 1.754 NM_032369
HVCN1
hydrogen voltage-gated channel 1
chrX_+_128741578 1.739 SASH3
SAM and SH3 domain containing 3
chr17_-_20311411 1.727 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr12_+_91620749 1.727 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr3_-_122862391 1.723 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr17_-_5078773 1.710 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr17_-_59451662 1.707 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr14_+_99601517 1.705 EVL
Enah/Vasp-like
chr15_-_38387317 1.704 PLCB2
phospholipase C, beta 2
chr7_+_149779011 1.702 GIMAP8
GTPase, IMAP family member 8
chr12_-_50004102 1.700 BIN2
bridging integrator 2
chr19_-_6432765 1.699 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr5_+_95092384 1.680 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr15_-_38387266 1.679 PLCB2
phospholipase C, beta 2
chr2_+_233633279 1.670 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr7_-_37454933 1.669 NM_014800
ELMO1
engulfment and cell motility 1
chr19_-_61324456 1.657 NM_001002836
ZNF787
zinc finger protein 787
chr5_-_149772469 1.654 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr6_-_32892705 1.652 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chrX_+_128741562 1.652 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_-_153107084 1.649


chr5_-_149772563 1.649 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr21_+_44597911 1.648 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr10_+_26767268 1.646 NM_019043
APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr9_+_92629525 1.644 NM_001174167
SYK
spleen tyrosine kinase
chr1_+_26517045 1.627 CD52
CD52 molecule
chr16_-_49272741 1.627 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr9_-_138387926 1.623 NM_052813
NM_052814
CARD9

caspase recruitment domain family, member 9

chr6_-_133126278 1.617 NM_078488
VNN2
vanin 2
chr12_+_69148120 1.614


chr18_+_70317548 1.607 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 7.69e-10 GO:0002376 immune system process
1.78 4.37e-09 GO:0001775 cell activation
1.56 2.20e-06 GO:0002682 regulation of immune system process
1.69 8.58e-06 GO:0002684 positive regulation of immune system process
1.68 9.29e-06 GO:0050776 regulation of immune response
1.96 2.77e-05 GO:0051249 regulation of lymphocyte activation
1.50 3.41e-05 GO:0006955 immune response
1.89 7.10e-05 GO:0002694 regulation of leukocyte activation
2.05 1.05e-04 GO:0051251 positive regulation of lymphocyte activation
1.87 1.07e-04 GO:0045321 leukocyte activation
2.41 1.75e-04 GO:0050851 antigen receptor-mediated signaling pathway
1.84 1.84e-04 GO:0050865 regulation of cell activation
1.97 2.07e-04 GO:0050867 positive regulation of cell activation
1.86 2.24e-04 GO:0030168 platelet activation
2.30 2.41e-04 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.97 2.65e-04 GO:0002696 positive regulation of leukocyte activation
1.27 3.09e-04 GO:0043412 macromolecule modification
4.34 3.12e-04 GO:0050853 B cell receptor signaling pathway
1.94 3.15e-04 GO:0046649 lymphocyte activation
1.16 4.71e-04 GO:0044260 cellular macromolecule metabolic process
2.27 7.09e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
2.53 7.30e-04 GO:0042113 B cell activation
1.56 8.97e-04 GO:0007596 blood coagulation
1.56 8.97e-04 GO:0050817 coagulation
1.27 1.26e-03 GO:0006464 protein modification process
1.55 1.31e-03 GO:0007599 hemostasis
1.92 1.31e-03 GO:0002764 immune response-regulating signaling pathway
1.92 2.77e-03 GO:0050863 regulation of T cell activation
1.89 3.29e-03 GO:0002757 immune response-activating signal transduction
1.69 3.35e-03 GO:0050778 positive regulation of immune response
1.21 7.30e-03 GO:0006950 response to stress
1.98 8.62e-03 GO:0050870 positive regulation of T cell activation
1.13 9.85e-03 GO:0043170 macromolecule metabolic process
1.46 1.41e-02 GO:0050878 regulation of body fluid levels
1.67 1.59e-02 GO:0010740 positive regulation of intracellular protein kinase cascade
1.24 1.84e-02 GO:0048583 regulation of response to stimulus
1.44 2.20e-02 GO:0042060 wound healing
2.45 2.24e-02 GO:0050864 regulation of B cell activation
1.56 2.36e-02 GO:0044419 interspecies interaction between organisms
1.09 3.22e-02 GO:0065007 biological regulation
1.36 3.38e-02 GO:0048584 positive regulation of response to stimulus
2.06 4.00e-02 GO:0050670 regulation of lymphocyte proliferation
1.34 4.93e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.07 6.76e-05 GO:0044424 intracellular part
1.06 1.43e-04 GO:0005622 intracellular
1.07 9.71e-03 GO:0043229 intracellular organelle
1.07 1.32e-02 GO:0043226 organelle
1.77 2.00e-02 GO:0031300 intrinsic to organelle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 3.04e-07 GO:0005515 protein binding
1.06 2.15e-03 GO:0005488 binding
2.80 7.84e-03 GO:0003823 antigen binding
1.36 4.81e-02 GO:0046983 protein dimerization activity