Motif ID: SRY.p2

Z-value: 1.629


Transcription factors associated with SRY.p2:

Gene SymbolEntrez IDGene Name
SRY 6736 sex determining region Y



Activity profile for motif SRY.p2.

activity profile for motif SRY.p2


Sorted Z-values histogram for motif SRY.p2

Sorted Z-values for motif SRY.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_32398220 2.449 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr18_+_3584056 2.103 FLJ35776
hypothetical LOC649446
chr4_-_74307637 2.047 ANKRD17
ankyrin repeat domain 17
chr2_+_201756048 2.045 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr3_+_190990142 1.920 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr9_+_126460511 1.817


chr3_+_152970904 1.684 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr13_-_47885248 1.646 LPAR6
lysophosphatidic acid receptor 6
chr5_+_40877053 1.437 NM_032587
CARD6
caspase recruitment domain family, member 6
chr13_-_47885018 1.400 LPAR6
lysophosphatidic acid receptor 6
chr2_+_201755865 1.370 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr8_-_110724594 1.365 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr17_-_53847937 1.356 RNF43
ring finger protein 43
chr7_-_26202626 1.331 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr5_-_98290117 1.329 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr12_+_14429499 1.308 ATF7IP
activating transcription factor 7 interacting protein
chr1_-_108032645 1.308 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_+_179736917 1.304 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr13_-_47885653 1.302 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr11_-_16380967 1.273 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr10_+_63331018 1.268 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_-_69317441 1.229 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr1_+_84540921 1.227 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr19_-_53444733 1.215 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr1_-_47468029 1.207 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr17_-_36570508 1.181 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr20_+_31613800 1.176 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr7_-_83662152 1.155 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr7_+_113853790 1.150 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr11_+_57285809 1.147 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr14_+_57964462 1.092 NM_014749
KIAA0586
KIAA0586
chr10_-_105835525 1.076 COL17A1
collagen, type XVII, alpha 1
chr20_+_10363949 1.072 NM_001009608
C20orf94
chromosome 20 open reading frame 94
chr4_-_104240413 1.049 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr14_-_30927931 1.037 NM_015473
HEATR5A
HEAT repeat containing 5A
chr13_+_48582389 1.019 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr2_+_183290912 1.007 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr1_+_66570363 0.982 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr17_-_64649608 0.981 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr7_+_106292932 0.978 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr10_-_105835609 0.969 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr9_+_74956614 0.951 ANXA1
annexin A1
chr6_+_105511615 0.941 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr6_-_56615544 0.929 NM_001723
NM_015548
DST

dystonin

chr1_+_185064654 0.924 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr7_-_104696678 0.921 NM_182691
SRPK2
SRSF protein kinase 2
chr13_-_40491405 0.919 ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_-_39310176 0.919 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr13_-_40454360 0.907 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_+_28692122 0.894 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr1_-_171286634 0.878 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr13_-_40491491 0.861 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_-_158304062 0.857 ESYT2
extended synaptotagmin-like protein 2
chrX_+_107569671 0.854 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr17_-_1195096 0.851 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr5_-_178977441 0.851 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr7_+_106293112 0.848 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr11_-_101292462 0.844 NM_178127
ANGPTL5
angiopoietin-like 5
chr13_-_74799898 0.841 TBC1D4
TBC1 domain family, member 4
chr4_-_38482805 0.819 NM_003263
TLR1
toll-like receptor 1
chr5_-_64813459 0.816 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr2_-_242205556 0.811 NM_001164356
THAP4
THAP domain containing 4
chr12_-_15005761 0.807 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr4_-_139382672 0.805 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chrX_-_85189194 0.804 NM_000390
NM_001145414
CHM

choroideremia (Rab escort protein 1)

chr4_+_166350620 0.804 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr3_+_173954940 0.804 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr9_+_74956494 0.802 NM_000700
ANXA1
annexin A1
chr8_-_102029997 0.800 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr4_-_101658094 0.800 NM_001159694
NM_016242
EMCN

endomucin

chr10_-_91092410 0.796 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr10_-_116241572 0.795


chr2_+_143351536 0.793 NM_001032998
NM_003937
KYNU

kynureninase

chr14_-_101617680 0.790 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr7_-_16471817 0.786 NM_015464
SOSTDC1
sclerostin domain containing 1
chr7_+_134483305 0.781 NM_018295
TMEM140
transmembrane protein 140
chr10_+_91051685 0.772 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr3_-_192531018 0.771 NM_198152
UTS2D
urotensin 2 domain containing
chr1_-_21373816 0.770 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr7_+_134114912 0.769 CALD1
caldesmon 1
chr7_+_116238309 0.766 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chrX_-_138742050 0.759 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr7_+_106897737 0.757 NM_005295
GPR22
G protein-coupled receptor 22
chr2_+_181554048 0.730 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr13_-_98708549 0.728 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr2_-_188021117 0.718 NM_005795
CALCRL
calcitonin receptor-like
chr17_-_59817456 0.716 PECAM1
platelet/endothelial cell adhesion molecule
chr9_+_674193 0.713


chr12_-_101396459 0.712 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_-_56824672 0.712 DST
dystonin
chr1_+_84539876 0.710 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr17_-_74244539 0.708


chr15_-_32289480 0.704 C15orf29
chromosome 15 open reading frame 29
chr6_+_21774624 0.687 FLJ22536
hypothetical locus LOC401237
chr11_+_128067598 0.686 NM_001167681
FLI1
Friend leukemia virus integration 1
chr3_-_150422474 0.683 NM_000096
CP
ceruloplasmin (ferroxidase)
chr1_+_81544432 0.675 LPHN2
latrophilin 2
chr1_+_116455898 0.672 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr5_-_22889192 0.671 CDH12
cadherin 12, type 2 (N-cadherin 2)
chrX_-_44945025 0.670 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr19_+_60879802 0.669 NM_001130071
EPN1
epsin 1
chr1_+_43539239 0.667 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr7_-_20223467 0.664 NM_182762
MACC1
metastasis associated in colon cancer 1
chr7_+_106292975 0.658 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr21_+_38550739 0.658 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr2_-_55090759 0.651 NM_007008
RTN4
reticulon 4
chr5_-_111119846 0.634 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr14_+_66901237 0.632 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr10_+_91142301 0.628 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr2_+_181553783 0.627 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr17_-_18890963 0.625 NM_006613
GRAP
GRB2-related adaptor protein
chrX_+_28515479 0.623 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr3_+_142587973 0.622


chr18_+_53863865 0.619 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_+_27099138 0.618 NM_000459
TEK
TEK tyrosine kinase, endothelial
chrX_-_16797895 0.617 NM_001198719
RBBP7
retinoblastoma binding protein 7
chr3_+_138159396 0.615 NM_144717
IL20RB
interleukin 20 receptor beta
chr17_-_59817722 0.615 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr12_+_91620749 0.614 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr17_-_59817575 0.614 PECAM1
platelet/endothelial cell adhesion molecule
chr7_+_134114957 0.613 CALD1
caldesmon 1
chr6_-_134540666 0.613 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr4_+_170817787 0.609 CLCN3
chloride channel 3
chr14_+_34583863 0.608 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr1_+_169549996 0.604 NM_002022
FMO4
flavin containing monooxygenase 4
chrX_-_19598912 0.600 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr12_-_28016182 0.598 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr7_-_33047042 0.598 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr11_-_106833715 0.594 NM_152434
CWF19L2
CWF19-like 2, cell cycle control (S. pombe)
chr9_+_74956601 0.593 ANXA1
annexin A1
chr3_-_11598829 0.591 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr10_+_63331401 0.590 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_-_368517 0.588 KDM5A
lysine (K)-specific demethylase 5A
chr16_-_21221872 0.586 NM_001014444
NM_001888
CRYM

crystallin, mu

chr4_+_90252990 0.582 NM_145715
TIGD2
tigger transposable element derived 2
chr10_-_116276560 0.582 ABLIM1
actin binding LIM protein 1
chr2_-_148495642 0.575 NM_181742
ORC4
origin recognition complex, subunit 4
chr13_+_96672705 0.573 MBNL2
muscleblind-like 2 (Drosophila)
chr8_+_40130143 0.569 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr14_-_22722680 0.565 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr12_-_101036407 0.564 NM_024057
NUP37
nucleoporin 37kDa
chr6_-_52818851 0.559 NM_153699
GSTA5
glutathione S-transferase alpha 5
chr1_+_190811479 0.555 NM_002922
RGS1
regulator of G-protein signaling 1
chr16_-_45562840 0.554 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr7_-_19778928 0.552 NM_152774
TMEM196
transmembrane protein 196
chr5_-_22889487 0.551 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr17_-_59817654 0.549 PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_46296376 0.546 NM_005749
TOB1
transducer of ERBB2, 1
chr12_-_10142779 0.539 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr19_+_53450743 0.538


chr1_-_180624380 0.537 GLUL
glutamate-ammonia ligase
chr2_+_166034402 0.535 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr10_-_85921703 0.533 LOC642934
hypothetical LOC642934
chr1_+_183970093 0.531 NM_031935
HMCN1
hemicentin 1
chr1_+_153366928 0.530 NM_004428
NM_182685
EFNA1

ephrin-A1

chr4_+_109763119 0.529 RPL34
ribosomal protein L34
chr1_+_87567164 0.527 LMO4
LIM domain only 4
chr13_+_75232797 0.527 NM_015842
LMO7
LIM domain 7
chr4_+_102954005 0.526 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr10_-_116276651 0.524 NM_006720
ABLIM1
actin binding LIM protein 1
chr6_+_29902734 0.523 NM_002127
HLA-G
major histocompatibility complex, class I, G
chr19_-_57924946 0.521 NM_030972
ZNF611
zinc finger protein 611
chr14_-_22722658 0.519 SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr7_-_30032649 0.517 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr14_-_23874083 0.515 NM_001198568
NM_001198592
NM_139247
ADCY4


adenylate cyclase 4


chr1_-_21288259 0.515 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr20_+_23293020 0.513 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr13_-_40454188 0.512 ELF1
E74-like factor 1 (ets domain transcription factor)
chr18_+_27425727 0.510 NM_000371
TTR
transthyretin
chr10_-_93992982 0.508 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr5_+_56507029 0.506 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr5_-_137099602 0.503 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr2_-_231697999 0.502 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr16_+_4842077 0.500 NM_016936
UBN1
ubinuclein 1
chrX_+_114734074 0.497 NM_001136025
NM_001172335
PLS3

plastin 3

chr9_+_90193807 0.496 SPIN1
spindlin 1
chr6_-_28663045 0.496 NM_052923
SCAND3
SCAN domain containing 3
chr2_-_160181206 0.495 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr11_+_20005704 0.495 NAV2
neuron navigator 2
chr14_-_64479198 0.494 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr3_-_159872960 0.493 NM_020169
LXN
latexin
chr2_-_224974954 0.491 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr2_+_135312655 0.488 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr3_-_15814678 0.485 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr17_-_53849888 0.485 RNF43
ring finger protein 43
chr15_+_37330176 0.485 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr2_+_108604111 0.479 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr3_-_143230124 0.479 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr3_+_182900081 0.478 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr9_+_33016482 0.478 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr1_+_154520693 0.477 NM_032323
TMEM79
transmembrane protein 79
chr14_+_90650466 0.476 C14orf159
chromosome 14 open reading frame 159
chr20_-_33783409 0.476 RBM39
RNA binding motif protein 39
chr3_+_153468518 0.475 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr20_+_19863716 0.473 RIN2
Ras and Rab interactor 2
chr7_-_86526880 0.473 NM_001142749
KIAA1324L
KIAA1324-like
chr4_+_187227302 0.472 NM_003265
TLR3
toll-like receptor 3
chr4_-_186969041 0.471 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr10_-_13430195 0.470 NM_001195602
NM_001195604
NM_012247
SEPHS1


selenophosphate synthetase 1


chr6_-_135417522 0.469 HBS1L
HBS1-like (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 2.35e-02 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 1.16e-02 GO:0005694 chromosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 2.09e-02 GO:0005515 protein binding