Motif ID: ALX1.p2

Z-value: 1.469


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1



Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_224974954 2.926 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr5_+_61910318 2.633 NM_181506
LRRC70
leucine rich repeat containing 70
chr21_-_38792173 1.982 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr1_+_194887630 1.644 NM_000186
NM_001014975
CFH

complement factor H

chr7_+_22733290 1.574 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr19_-_53444733 1.364 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr2_-_188127430 1.344 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr7_-_115458047 1.338 TFEC
transcription factor EC
chr7_-_115458010 1.286 NM_001018058
NM_012252
TFEC

transcription factor EC

chr2_-_218516950 1.222 NM_022648
TNS1
tensin 1
chr10_+_94584449 1.203 NM_001013848
EXOC6
exocyst complex component 6
chr16_+_54072969 1.036 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr19_-_4510713 1.000 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr4_-_159312973 0.989 FAM198B
family with sequence similarity 198, member B
chr3_-_113495763 0.976 NM_183061
SLC9A10
solute carrier family 9, member 10
chr6_+_153060722 0.960 NM_025107
MYCT1
myc target 1
chr12_-_52939584 0.949 NM_001127322
CBX5
chromobox homolog 5
chr9_+_27099138 0.937 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr12_-_52939636 0.935 NM_001127321
CBX5
chromobox homolog 5
chr7_-_107667728 0.933 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr2_-_188127294 0.881 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr13_-_22905822 0.853 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr2_-_199922047 0.807 SATB2
SATB homeobox 2
chr4_-_159313613 0.796 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr17_-_44006808 0.783 NM_002146
HOXB3
homeobox B3
chr2_+_102320148 0.757 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr13_-_37070862 0.757 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr4_+_156807311 0.757 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr9_+_124835608 0.734 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chr3_-_170347019 0.726 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr9_+_99807257 0.720


chr10_+_69539255 0.710 NM_032578
MYPN
myopalladin
chr19_-_11355882 0.642 NM_000121
EPOR
erythropoietin receptor
chr11_+_55362802 0.642 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr4_-_75083160 0.642 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr3_+_64645819 0.632 LOC100507098
hypothetical LOC100507098
chr7_+_156677777 0.624


chr7_-_149960218 0.615 GIMAP6
GTPase, IMAP family member 6
chr10_+_81882477 0.611 PLAC9
placenta-specific 9
chr21_+_30929425 0.594 NM_181616
KRTAP20-2
keratin associated protein 20-2
chr7_-_115458064 0.574 TFEC
transcription factor EC
chr11_-_85103438 0.571 NM_032379
SYTL2
synaptotagmin-like 2
chr10_-_21226536 0.549 NM_006393
NEBL
nebulette
chr22_-_15682555 0.543 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr4_+_43185 0.540 NM_182524
ZNF595
ZNF718
zinc finger protein 595
zinc finger protein 718
chr6_-_50045296 0.530 NM_001037729
DEFB113
defensin, beta 113
chr11_-_5212168 0.516 NM_000519
HBD
hemoglobin, delta
chr20_-_1420004 0.515 SIRPB2
signal-regulatory protein beta 2
chr3_+_49210864 0.505 NM_178173
CCDC36
coiled-coil domain containing 36
chr15_-_40537002 0.496 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr1_-_89364273 0.494 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chrX_+_77889861 0.493 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr10_+_81882409 0.482 PLAC9
placenta-specific 9
chr8_+_107807415 0.475 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr11_+_111551417 0.471 NM_031938
BCO2
beta-carotene oxygenase 2
chr19_+_59158101 0.470 NM_031895
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr10_-_28611020 0.470 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr12_+_16391795 0.469 NM_020300
NM_145791
MGST1

microsomal glutathione S-transferase 1

chr8_+_38704860 0.465 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr16_+_15503623 0.462 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr19_-_4509471 0.441 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr3_-_170864111 0.439 NM_004991
MECOM
MDS1 and EVI1 complex locus
chr3_+_122769467 0.431 NM_001012659
ARGFX
arginine-fifty homeobox
chr9_-_106407728 0.428 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr4_-_91979113 0.428 NM_183049
TMSL3
thymosin-like 3
chr4_+_120276386 0.426 NM_016599
MYOZ2
myozenin 2
chr19_-_61431470 0.405 NM_024303
ZSCAN5A
zinc finger and SCAN domain containing 5A
chrX_-_6156655 0.401 NM_181332
NLGN4X
neuroligin 4, X-linked
chr4_-_120462705 0.401 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr11_-_59707074 0.400 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr3_+_8750485 0.400 NM_033337
NM_001234
CAV3

caveolin 3

chr4_-_70661018 0.400 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr7_+_77307382 0.392 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr17_-_34377150 0.388 NM_001008777
FBXO47
F-box protein 47
chr7_+_63305015 0.381 NM_001159524
ZNF735
zinc finger protein 735
chr7_-_149960612 0.381 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr12_-_90097384 0.378 NM_133503
DCN
decorin
chr3_-_195553297 0.369 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr1_-_42738535 0.368 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr5_-_176258920 0.367 NM_002115
HK3
hexokinase 3 (white cell)
chr12_-_61832856 0.366 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr6_+_12825818 0.362 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr18_-_68362702 0.359 NM_182511
CBLN2
cerebellin 2 precursor
chr20_-_1420126 0.356 SIRPB2
signal-regulatory protein beta 2
chr6_-_66346417 0.356 NM_198283
EYS
eyes shut homolog (Drosophila)
chr21_-_26867138 0.347 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr5_+_140200995 0.346 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chrX_-_10504852 0.342 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr3_-_71625318 0.342 FOXP1
forkhead box P1
chr11_+_113351006 0.342 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr15_-_70838703 0.341


chr3_+_69895310 0.340 NM_001184967
MITF
microphthalmia-associated transcription factor
chr11_-_7906784 0.338 NM_001004461
OR10A6
olfactory receptor, family 10, subfamily A, member 6
chr9_+_79158164 0.335 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr19_+_52908412 0.335 NM_014601
EHD2
EH-domain containing 2
chr7_+_143043871 0.330 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr8_-_86477585 0.323 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr1_+_190394214 0.322 NM_130782
RGS18
regulator of G-protein signaling 18
chr1_+_166516901 0.315 NM_005149
TBX19
T-box 19
chr10_+_5126556 0.310 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr9_-_73865318 0.308 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr11_+_64949365 0.304 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr19_-_4486202 0.301 NM_001013706
PLIN5
perilipin 5
chr11_+_12265022 0.300 NM_032867
MICALCL
MICAL C-terminal like
chr10_+_90414125 0.300 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr4_+_158361185 0.298 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr5_+_57823017 0.297 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr10_-_13316333 0.293 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr9_+_102380156 0.283 NM_001018116
MURC
muscle-related coiled-coil protein
chr5_+_147775652 0.281 FBXO38
F-box protein 38
chr1_-_172199799 0.276 RC3H1
ring finger and CCCH-type domains 1
chr3_+_108578877 0.276 NM_032600
CCDC54
coiled-coil domain containing 54
chrX_-_21686079 0.274 NM_014332
SMPX
small muscle protein, X-linked
chr19_-_21438525 0.272


chr1_-_171286634 0.271 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr5_+_140762551 0.269 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr18_-_3835295 0.267 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr4_+_70831387 0.265 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr1_+_64442077 0.264 NM_152489
UBE2U
ubiquitin-conjugating enzyme E2U (putative)
chr5_+_40877053 0.264 NM_032587
CARD6
caspase recruitment domain family, member 6
chr21_+_30895276 0.259 NM_181620
KRTAP22-1
keratin associated protein 22-1
chr3_-_161584137 0.259 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr8_-_125252884 0.257 C8orf78
chromosome 8 open reading frame 78
chr14_+_100365390 0.255 MEG3
maternally expressed 3 (non-protein coding)
chr7_-_81237162 0.253 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr12_-_7547552 0.253 NM_004244
NM_203416
CD163

CD163 molecule

chr4_-_107508040 0.252 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr7_-_98983924 0.251 FAM200A
family with sequence similarity 200, member A
chr2_-_190635566 0.251 NM_005259
MSTN
myostatin
chr19_-_8953017 0.249 NM_024690
MUC16
mucin 16, cell surface associated
chrX_+_51562894 0.245 NM_001005332
MAGED1
melanoma antigen family D, 1
chr7_+_143423073 0.245 NM_001004135
OR2A12
olfactory receptor, family 2, subfamily A, member 12
chr2_-_87102453 0.245 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr14_+_93455010 0.242 NM_138344
FAM181A
family with sequence similarity 181, member A
chr8_-_12220195 0.241 NM_001195257
NM_001037804
LOC100133267
DEFB130
defensin, beta 130-like
defensin, beta 130
chr11_+_93940121 0.239 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr14_+_100365162 0.239 MEG3
maternally expressed 3 (non-protein coding)
chr2_+_225973845 0.238 NM_020864
KIAA1486
KIAA1486
chr1_-_197173159 0.237 LOC100131234
familial acute myelogenous leukemia related factor
chr2_-_46600599 0.237 NM_080653
ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr1_+_12149662 0.236 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr1_+_74473672 0.236 NM_015978
TNNI3K
TNNI3 interacting kinase
chr11_-_128242342 0.236 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr11_+_101423378 0.234 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr3_+_35658852 0.233 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr8_+_133060353 0.233 EFR3A
EFR3 homolog A (S. cerevisiae)
chr18_+_30589937 0.233 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr17_+_29707583 0.230 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr12_+_26239535 0.230 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr19_+_20138991 0.230 NM_052852
ZNF486
zinc finger protein 486
chr20_-_1420168 0.228 NM_001122962
NM_001134836
SIRPB2

signal-regulatory protein beta 2

chr3_-_87408301 0.228 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr18_+_20294590 0.227 NM_001143828
NM_001160166
NM_021624
HRH4


histamine receptor H4


chr10_-_7722747 0.227 ITIH5
inter-alpha (globulin) inhibitor H5
chr2_+_173394560 0.227 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr5_-_39430180 0.226 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr1_+_156991133 0.224 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr14_-_74400288 0.222 NM_001080408
PROX2
prospero homeobox 2
chr19_-_22396915 0.221 NM_001098626
ZNF98
zinc finger protein 98
chr2_-_162717159 0.221 NM_002054
GCG
glucagon
chr1_-_156923111 0.220 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr1_-_245237977 0.219 NM_020394
ZNF695
zinc finger protein 695
chr1_-_39119845 0.218 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP read-through transcript
gap junction protein, alpha 9, 59kDa
chr4_-_186815116 0.217 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr7_-_15568099 0.217 NM_001004320
AGMO
alkylglycerol monooxygenase
chr12_-_9913199 0.216 CLEC2B
C-type lectin domain family 2, member B
chr12_+_9871343 0.216 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr15_+_36014748 0.216 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr22_-_34566367 0.215 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr3_-_15357878 0.215 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr22_-_22252376 0.214 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr4_+_70950747 0.213 NM_002159
HTN1
histatin 1
chrX_+_114734074 0.213 NM_001136025
NM_001172335
PLS3

plastin 3

chr11_-_104274606 0.212 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr4_+_71283383 0.212 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr19_+_9347991 0.212 NM_001172651
ZNF177
zinc finger protein 177
chr8_+_70567581 0.211 NM_001128205
NM_001128206
SULF1

sulfatase 1

chrX_+_43400385 0.211 MAOA
monoamine oxidase A
chr18_+_30544193 0.211 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr17_+_18566060 0.210 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr6_-_39180390 0.210 C6orf64
chromosome 6 open reading frame 64
chrX_+_43400475 0.209 MAOA
monoamine oxidase A
chr12_-_21818881 0.209 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr12_-_92001543 0.209 RPL41P5
ribosomal protein L41 pseudogene 5
chr17_+_55098280 0.206 CLTC
clathrin, heavy chain (Hc)
chr7_-_105009160 0.205 EFCAB10
EF-hand calcium binding domain 10
chr17_+_58440629 0.205 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr1_-_245237952 0.205 ZNF695
zinc finger protein 695
chr5_+_121493113 0.204 NM_207317
ZNF474
zinc finger protein 474
chr9_-_27287106 0.204 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr5_+_76470829 0.203


chrX_-_2896285 0.201 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr2_+_33514896 0.200 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_-_31756119 0.197 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr6_-_79732391 0.196 PHIP
pleckstrin homology domain interacting protein
chr2_-_98646367 0.196 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr11_-_51269023 0.196 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr4_+_53975597 0.195 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr2_-_144991556 0.195 ZEB2
zinc finger E-box binding homeobox 2
chr6_-_46401174 0.193 RCAN2
regulator of calcineurin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.53 1.94e-16 GO:0007606 sensory perception of chemical stimulus
3.59 3.85e-15 GO:0007608 sensory perception of smell
2.46 8.34e-11 GO:0007600 sensory perception
1.83 3.82e-08 GO:0003008 system process
1.89 3.86e-07 GO:0050877 neurological system process
1.29 1.58e-03 GO:0032501 multicellular organismal process
1.22 2.27e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 2.98e-05 GO:0031224 intrinsic to membrane
1.56 3.39e-05 GO:0005576 extracellular region
1.29 8.22e-05 GO:0016021 integral to membrane
1.34 1.18e-04 GO:0071944 cell periphery
1.34 1.35e-04 GO:0005886 plasma membrane
1.24 4.82e-04 GO:0044425 membrane part
1.68 3.50e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.76 8.76e-17 GO:0004984 olfactory receptor activity
2.57 8.76e-14 GO:0004930 G-protein coupled receptor activity
2.09 6.14e-11 GO:0004888 transmembrane receptor activity
1.84 2.45e-09 GO:0004872 receptor activity
1.65 5.13e-07 GO:0004871 signal transducer activity
1.65 5.13e-07 GO:0060089 molecular transducer activity