Motif ID: FOXN1.p2

Z-value: 1.540


Transcription factors associated with FOXN1.p2:

Gene SymbolEntrez IDGene Name
FOXN1 8456 forkhead box N1



Activity profile for motif FOXN1.p2.

activity profile for motif FOXN1.p2


Sorted Z-values histogram for motif FOXN1.p2

Sorted Z-values for motif FOXN1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXN1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_109290107 2.907 KLF4
Kruppel-like factor 4 (gut)
chr1_+_82038669 2.409 NM_012302
LPHN2
latrophilin 2
chr10_+_124211353 2.286 HTRA1
HtrA serine peptidase 1
chrX_-_83329562 2.090 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr7_-_27120015 1.834 HOXA3
homeobox A3
chr17_-_28644118 1.763 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr3_-_191321367 1.683 LEPREL1
leprecan-like 1
chr8_-_11096257 1.681 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chrX_-_106846253 1.673 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr21_-_26867138 1.670 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr12_+_56406296 1.575 LOC100130776
hypothetical LOC100130776
chr15_-_57452345 1.573 MYO1E
myosin IE
chrX_-_106846684 1.555 TSC22D3
TSC22 domain family, member 3
chr19_-_58449752 1.529 ZNF677
zinc finger protein 677
chr15_-_57452357 1.523 MYO1E
myosin IE
chr15_-_57452361 1.488 NM_004998
MYO1E
myosin IE
chr4_-_156517394 1.453 MAP9
microtubule-associated protein 9
chr8_-_38245694 1.451 NM_001102559
NM_001102560
NM_032483
PPAPDC1B


phosphatidic acid phosphatase type 2 domain containing 1B


chr15_+_68971835 1.434 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr6_+_148705646 1.407 SASH1
SAM and SH3 domain containing 1
chr4_-_156517423 1.347 MAP9
microtubule-associated protein 9
chr4_+_57066131 1.312 NM_206919
ARL9
ADP-ribosylation factor-like 9
chr11_+_101423378 1.266 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr3_-_87122936 1.260 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr4_+_148621567 1.223 EDNRA
endothelin receptor type A
chr13_-_77390907 1.213 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr13_+_35903966 1.205 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr3_-_87122958 1.204 VGLL3
vestigial like 3 (Drosophila)
chr15_-_68971665 1.181 NM_020147
THAP10
THAP domain containing 10
chr11_-_133332089 1.179 NM_014987
IGSF9B
immunoglobulin superfamily, member 9B
chr11_+_65357972 1.175 NM_152760
SNX32
sorting nexin 32
chr3_+_121944247 1.157 NM_005513
GTF2E1
general transcription factor IIE, polypeptide 1, alpha 56kDa
chr14_+_75521806 1.144 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chr7_-_84654106 1.125 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr18_+_17076166 1.085 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr2_-_142605010 1.084 LRP1B
low density lipoprotein receptor-related protein 1B
chr17_+_4922445 1.081 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr3_-_121944052 1.079 NM_173825
RABL3
RAB, member of RAS oncogene family-like 3
chr3_-_49370682 1.066 GPX1
glutathione peroxidase 1
chr6_-_25019173 1.055 NM_014722
FAM65B
family with sequence similarity 65, member B
chr5_+_156819782 1.036 NIPAL4
NIPA-like domain containing 4
chr3_-_49370755 0.988 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr17_-_60208083 0.988 LOC146880
hypothetical LOC146880
chr17_+_4922478 0.983 ZFP3
zinc finger protein 3 homolog (mouse)
chr4_-_156517544 0.972 NM_001039580
MAP9
microtubule-associated protein 9
chr3_+_33293915 0.967 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr3_-_191321601 0.962 NM_018192
LEPREL1
leprecan-like 1
chr11_-_93774223 0.921 NM_016540
GPR83
G protein-coupled receptor 83
chr14_-_52487022 0.899 FERMT2
fermitin family member 2
chr17_-_74432671 0.899 TIMP2
TIMP metallopeptidase inhibitor 2
chr9_+_127550298 0.897 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr8_+_32525269 0.893 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr4_-_111763655 0.880 NM_000325
PITX2
paired-like homeodomain 2
chr3_-_121944040 0.879


chr5_-_100266769 0.865 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr12_+_3470685 0.850 NM_019854
PRMT8
protein arginine methyltransferase 8
chr2_-_165406098 0.837 COBLL1
COBL-like 1
chr17_-_10042579 0.836 NM_201433
GAS7
growth arrest-specific 7
chr6_-_75972286 0.822 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr19_+_39664706 0.802 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr22_+_47263919 0.771 NM_001082967
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr1_-_158091760 0.761 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr12_+_70952729 0.749 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr15_+_76343540 0.746 NM_018602
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chrX_+_105856531 0.745 NM_194463
RNF128
ring finger protein 128
chrX_+_101267315 0.738 NM_080390
TCEAL2
transcription elongation factor A (SII)-like 2
chr7_-_131911768 0.736 PLXNA4
plexin A4
chr9_+_8848130 0.735


chr4_-_141896920 0.721 NM_015130
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr14_+_73128162 0.711 NM_152331
ACOT4
acyl-CoA thioesterase 4
chr12_-_79855580 0.689 LIN7A
lin-7 homolog A (C. elegans)
chr14_-_88087575 0.685 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr5_+_156819604 0.683 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr15_+_45796802 0.678 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr12_-_50502474 0.675 NM_001013690
FIGNL2
fidgetin-like 2
chr15_+_43209422 0.672 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr13_-_95094920 0.672 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr5_+_110587546 0.654 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr16_-_3295375 0.653


chr14_+_64086366 0.648 NM_172365
C14orf50
chromosome 14 open reading frame 50
chrX_-_99778340 0.645 NM_003270
TSPAN6
tetraspanin 6
chr2_-_219614481 0.644 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr12_+_121825021 0.642 NM_032573
NM_201435
CCDC62

coiled-coil domain containing 62

chr12_-_70952572 0.641 LOC283392
hypothetical LOC283392
chr17_+_7883076 0.637 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr12_+_52653176 0.635 NM_014212
HOXC11
homeobox C11
chr16_+_3295433 0.634 NM_153028
ZNF75A
zinc finger protein 75a
chr7_+_113513828 0.623 FOXP2
forkhead box P2
chr5_-_115938305 0.621 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr5_+_174084137 0.620 NM_002449
MSX2
msh homeobox 2
chr15_-_43209348 0.617 NM_144565
DUOXA1
dual oxidase maturation factor 1
chr7_+_29200850 0.617 CHN2
chimerin (chimaerin) 2
chr19_+_41980248 0.611 LOC284408
hypothetical LOC284408
chr10_-_30065760 0.606 SVIL
supervillin
chr12_+_77782579 0.596 NM_005639
SYT1
synaptotagmin I
chr6_+_116798791 0.596 NM_013352
DSE
dermatan sulfate epimerase
chr2_-_39040981 0.590 LOC375196
hypothetical LOC375196
chr11_+_7997366 0.586 TUB
tubby homolog (mouse)
chrX_+_17665483 0.582 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr10_+_103103797 0.579 NM_003939
NM_033637
BTRC

beta-transducin repeat containing

chr12_+_94861201 0.578 NM_152435
AMDHD1
amidohydrolase domain containing 1
chr1_-_40009513 0.578 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr1_-_181654027 0.577


chrX_-_13307425 0.575


chr6_+_72949092 0.570 RIMS1
regulating synaptic membrane exocytosis 1
chr14_+_36196523 0.569 NM_006194
PAX9
paired box 9
chr10_+_124210980 0.567 NM_002775
HTRA1
HtrA serine peptidase 1
chr1_-_32479785 0.565 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr22_-_44188116 0.563 NM_148674
SMC1B
structural maintenance of chromosomes 1B
chr15_-_37999717 0.561 GPR176
G protein-coupled receptor 176
chr17_-_40866062 0.559 NM_174919
SH3D20
SH3 domain containing 20
chr11_-_88864061 0.558 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr19_+_43447262 0.551 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr14_+_92330383 0.550 NM_005113
GOLGA5
golgin A5
chr10_-_79067476 0.546 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr17_-_72045218 0.542 NM_134268
CYGB
cytoglobin
chr7_-_131911808 0.540 NM_001105543
NM_020911
PLXNA4

plexin A4

chr8_-_98359248 0.540 TSPYL5
TSPY-like 5
chr16_-_17472238 0.539 NM_022166
XYLT1
xylosyltransferase I
chr11_+_125279481 0.538 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr19_+_58750305 0.537 NM_001079907
ZNF331
zinc finger protein 331
chr6_+_148705817 0.537 SASH1
SAM and SH3 domain containing 1
chr6_+_29799095 0.536 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr7_+_100302885 0.533 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr13_+_26029879 0.528 WASF3
WAS protein family, member 3
chr19_-_58449919 0.527 NM_182609
ZNF677
zinc finger protein 677
chr19_+_22608964 0.524 NM_020855
ZNF492
zinc finger protein 492
chr6_+_30002084 0.521


chr22_+_44188205 0.519 NM_015653
RIBC2
RIB43A domain with coiled-coils 2
chr14_+_64077171 0.516 HSPA2
heat shock 70kDa protein 2
chr2_+_36436316 0.515 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr13_+_23632788 0.512 NM_001166271
NM_153023
SPATA13

spermatogenesis associated 13

chr13_-_77391525 0.510


chr11_+_124539814 0.509 PKNOX2
PBX/knotted 1 homeobox 2
chr15_-_42274529 0.506 NM_032892
FRMD5
FERM domain containing 5
chr14_-_51605695 0.505 NM_007361
NID2
nidogen 2 (osteonidogen)
chr9_+_81377419 0.504 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr14_+_99273751 0.504 EML1
echinoderm microtubule associated protein like 1
chr10_-_79067552 0.491 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr2_+_71534260 0.490 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr20_-_30534848 0.489 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr3_-_135575925 0.488 NM_016201
AMOTL2
angiomotin like 2
chr11_-_132318741 0.487 OPCML
opioid binding protein/cell adhesion molecule-like
chr6_+_108593907 0.485 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr1_-_158091296 0.478 C1orf204
chromosome 1 open reading frame 204
chr13_-_31900218 0.476 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr12_+_77782648 0.475 SYT1
synaptotagmin I
chr12_+_4889309 0.473 NM_000217
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr10_-_79067400 0.473 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr17_+_7328497 0.471 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr8_-_98359366 0.471 TSPYL5
TSPY-like 5
chrX_+_15666312 0.469 NM_007220
CA5B
carbonic anhydrase VB, mitochondrial
chr3_-_192063158 0.468 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr1_+_219026661 0.466 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr19_-_45888259 0.466 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr9_+_81377289 0.464 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr15_-_37999519 0.462


chr7_-_82629735 0.461 PCLO
piccolo (presynaptic cytomatrix protein)
chrX_-_132376660 0.460 NM_001448
GPC4
glypican 4
chr1_+_45565126 0.459 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr19_+_61711008 0.455 NM_020813
ZNF471
zinc finger protein 471
chr5_+_76418545 0.454 LOC728723
hypothetical LOC728723
chr4_-_86106567 0.448 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr3_-_181237210 0.447 NM_016559
PEX5L
peroxisomal biogenesis factor 5-like
chrX_-_21586337 0.443 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr19_+_57531309 0.441 NM_001161425
NM_001161426
NM_001161427
ZNF610


zinc finger protein 610


chr4_+_148621694 0.441 EDNRA
endothelin receptor type A
chr21_+_41461962 0.440 BACE2
beta-site APP-cleaving enzyme 2
chr3_+_3816079 0.439 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr4_-_66218777 0.437 EPHA5
EPH receptor A5
chr8_-_98359347 0.437 NM_033512
TSPYL5
TSPY-like 5
chr5_+_80292213 0.436 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr12_-_79855618 0.436 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr13_+_26029799 0.432 NM_006646
WASF3
WAS protein family, member 3
chr1_-_181654124 0.432 NM_015039
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr13_-_72254059 0.428 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr13_-_45524846 0.427 NM_015070
ZC3H13
zinc finger CCCH-type containing 13
chr3_-_52419086 0.424 BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr11_+_124539768 0.421 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr3_-_162572441 0.420 NM_001040100
C3orf57
chromosome 3 open reading frame 57
chr12_-_78608154 0.420 PAWR
PRKC, apoptosis, WT1, regulator
chr17_+_45940743 0.420 NM_032133
MYCBPAP
MYCBP associated protein
chr13_-_72254071 0.418 NM_001128226
NM_014953
DIS3

DIS3 mitotic control homolog (S. cerevisiae)

chr9_-_21984414 0.417 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chrX_-_106846924 0.416 NM_004089
TSC22D3
TSC22 domain family, member 3
chr6_+_117693413 0.416 NM_153453
NM_182645
VGLL2

vestigial like 2 (Drosophila)

chr1_+_221633337 0.415 NM_152610
C1orf65
chromosome 1 open reading frame 65
chr13_+_72254180 0.413 NM_006346
PIBF1
progesterone immunomodulatory binding factor 1
chr17_-_40865987 0.412 SH3D20
SH3 domain containing 20
chrX_-_17789276 0.410 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr13_-_51878235 0.408 THSD1
thrombospondin, type I, domain containing 1
chr13_+_45524950 0.408


chrX_+_67965517 0.406 NM_004429
EFNB1
ephrin-B1
chr15_+_71763830 0.402 CD276
CD276 molecule
chr6_-_80713589 0.399 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr4_-_21559471 0.397 NM_147182
KCNIP4
Kv channel interacting protein 4
chr17_-_38821205 0.395 LOC100130581
hypothetical LOC100130581
chr13_+_44461657 0.393 NM_018559
KIAA1704
KIAA1704
chr1_+_176329895 0.391 RASAL2
RAS protein activator like 2
chr5_+_80292313 0.390 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 6.50e-06 GO:0044260 cellular macromolecule metabolic process
1.40 1.16e-04 GO:0044267 cellular protein metabolic process
1.11 5.33e-04 GO:0009987 cellular process
1.23 2.14e-03 GO:0043170 macromolecule metabolic process
1.19 8.77e-03 GO:0044237 cellular metabolic process
1.28 9.35e-03 GO:0071840 cellular component organization or biogenesis
1.32 1.10e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.27 2.65e-02 GO:0016043 cellular component organization
1.28 3.47e-02 GO:0019538 protein metabolic process
1.30 4.63e-02 GO:0071842 cellular component organization at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 5.97e-11 GO:0005622 intracellular
1.15 7.35e-11 GO:0044424 intracellular part
1.19 1.32e-07 GO:0005737 cytoplasm
1.26 7.43e-07 GO:0005634 nucleus
1.15 1.30e-06 GO:0043229 intracellular organelle
1.15 1.36e-06 GO:0043226 organelle
1.16 5.97e-06 GO:0043231 intracellular membrane-bounded organelle
1.16 7.43e-06 GO:0043227 membrane-bounded organelle
1.69 1.60e-03 GO:0015630 microtubule cytoskeleton
1.92 8.48e-03 GO:0005815 microtubule organizing center
1.05 1.25e-02 GO:0044464 cell part
1.05 1.28e-02 GO:0005623 cell
1.16 1.91e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 9.83e-05 GO:0005515 protein binding
1.09 1.13e-03 GO:0005488 binding