Motif ID: HSF1,2.p2

Z-value: 0.855


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2



Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_188127294 1.539 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_188127430 1.503 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr13_+_48582389 1.475 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr10_+_94584449 1.412 NM_001013848
EXOC6
exocyst complex component 6
chr12_-_14887648 1.336 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr5_-_110090264 1.185 NM_001039763
TMEM232
transmembrane protein 232
chr7_+_120416680 0.884 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr8_+_40130143 0.882 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr11_+_68818175 0.875 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr17_-_59817456 0.871 PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_57023322 0.864 NM_199290
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr15_+_94670160 0.852 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr17_-_59817722 0.850 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_59817654 0.841 PECAM1
platelet/endothelial cell adhesion molecule
chr9_-_100510657 0.795 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr17_-_59817575 0.773 PECAM1
platelet/endothelial cell adhesion molecule
chr1_-_78217278 0.759 FUBP1
far upstream element (FUSE) binding protein 1
chr19_-_53941835 0.736 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr4_-_101658094 0.733 NM_001159694
NM_016242
EMCN

endomucin

chr6_+_153060722 0.704 NM_025107
MYCT1
myc target 1
chr1_+_45046740 0.703 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr20_+_55338221 0.670 NM_012444
NM_198265
SPO11

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

chr12_-_121577410 0.652 NM_023012
RSRC2
arginine/serine-rich coiled-coil 2
chr4_-_152366970 0.644 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr8_-_13018123 0.643 NM_001164271
DLC1
deleted in liver cancer 1
chr14_+_62740878 0.642 NM_020663
RHOJ
ras homolog gene family, member J
chr10_+_104525877 0.639 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr12_+_49604782 0.635 NM_014033
METTL7A
methyltransferase like 7A
chrX_+_80344253 0.629 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr11_+_65027721 0.621


chr15_+_47249700 0.618 NM_002044
GALK2
galactokinase 2
chr12_+_49605010 0.614 METTL7A
methyltransferase like 7A
chrX_-_102828238 0.602 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr17_-_78599695 0.596 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr6_+_10663934 0.592 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr6_-_109521969 0.573 NM_014454
SESN1
sestrin 1
chrX_+_80344215 0.572 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chrX_-_154216929 0.566 NM_001289
CLIC2
chloride intracellular channel 2
chr7_-_150283794 0.558 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr4_+_111053488 0.558 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr2_+_66516196 0.552 MEIS1
Meis homeobox 1
chr5_+_76181581 0.550 NM_130772
S100Z
S100 calcium binding protein Z
chr6_+_14032655 0.548 NM_001165034
RNF182
ring finger protein 182
chr1_+_202033273 0.535 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr10_-_69267774 0.523 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr3_+_142569988 0.521 ZBTB38
zinc finger and BTB domain containing 38
chr20_-_17487480 0.519 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr7_-_6441109 0.500 DAGLB
diacylglycerol lipase, beta
chr12_-_52975823 0.495 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr6_-_109522207 0.491 SESN1
sestrin 1
chr1_+_221168388 0.490 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr4_-_74307637 0.486 ANKRD17
ankyrin repeat domain 17
chr19_+_4442610 0.472 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr1_+_143807876 0.470 SEC22B
SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
chr3_-_115585178 0.469 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_68369322 0.466 NM_152439
BEST3
bestrophin 3
chr6_+_126143971 0.451 NCOA7
nuclear receptor coactivator 7
chr7_+_134114701 0.451 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr1_-_173979292 0.448 NM_003285
TNR
tenascin R (restrictin, janusin)
chr3_+_195336625 0.440 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr7_-_27133163 0.439 NM_153631
HOXA3
homeobox A3
chr11_+_12265022 0.439 NM_032867
MICALCL
MICAL C-terminal like
chr15_+_45263517 0.439 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr3_-_15814678 0.436 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr12_-_21818881 0.433 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr1_+_153232685 0.431 NM_018655
LENEP
lens epithelial protein
chr4_+_128773529 0.414 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr7_-_75280962 0.411 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr5_+_169592523 0.410 NM_001102609
C5orf58
chromosome 5 open reading frame 58
chr11_-_33870411 0.409 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_+_134114957 0.406 CALD1
caldesmon 1
chr13_-_45577144 0.401 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr6_+_116939500 0.393 NM_153711
FAM26E
family with sequence similarity 26, member E
chr1_-_148174722 0.392 NM_181873
MTMR11
myotubularin related protein 11
chr2_+_201756048 0.391 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr6_+_28342766 0.391 NM_001023560
NM_001111039
NM_152736
ZNF187


zinc finger protein 187


chr8_+_110621485 0.391 NM_004215
EBAG9
estrogen receptor binding site associated, antigen, 9
chr1_-_226679648 0.388 NM_003493
HIST3H3
histone cluster 3, H3
chr1_-_92144146 0.388 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr10_+_82163568 0.383 C10orf58
chromosome 10 open reading frame 58
chr1_-_198644111 0.382 ZNF281
zinc finger protein 281
chr1_+_109450116 0.378


chr7_-_102873747 0.377 NM_001167962
NM_198999
NM_206883
NM_206884
NM_206885
SLC26A5




solute carrier family 26, member 5 (prestin)




chr9_-_90983195 0.376 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr1_+_144188375 0.374 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr12_-_7172641 0.372 NM_031491
RBP5
retinol binding protein 5, cellular
chr17_+_27493680 0.372 RHOT1
ras homolog gene family, member T1
chr11_-_65081967 0.372 LTBP3
latent transforming growth factor beta binding protein 3
chr12_+_61645361 0.370 RPL14
ribosomal protein L14
chr21_-_29367820 0.366 CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr12_-_14611820 0.364 PLBD1
phospholipase B domain containing 1
chr2_-_192419896 0.363 SDPR
serum deprivation response
chr11_+_66764060 0.362 LOC100131150
hypothetical protein LOC100131150
chr21_-_29367784 0.362 CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr17_-_74361975 0.361 TIMP2
TIMP metallopeptidase inhibitor 2
chr4_+_47403107 0.361


chr17_-_36915329 0.361 NM_002274
NM_153490
KRT13

keratin 13

chr3_+_52504410 0.357 STAB1
stabilin 1
chr6_+_32229278 0.354 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr13_+_96672541 0.354 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr2_-_113259441 0.353 NM_000575
IL1A
interleukin 1, alpha
chr21_-_29367839 0.351 NM_006585
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr6_+_27323458 0.351 NM_005865
PRSS16
protease, serine, 16 (thymus)
chr9_-_74757735 0.348 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_+_112775224 0.347 NM_001013734
RFPL4B
ret finger protein-like 4B
chr2_-_136592099 0.344 NM_003467
CXCR4
chemokine (C-X-C motif) receptor 4
chr10_+_70517863 0.342 SRGN
serglycin
chr2_+_128119908 0.341 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr3_+_46514488 0.341 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr22_+_19458378 0.339 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr8_+_39890484 0.337 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr20_+_29598848 0.337 HM13
histocompatibility (minor) 13
chr5_+_171553780 0.336 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr11_+_28088406 0.336 METTL15
methyltransferase like 15
chr18_-_50776276 0.335 NM_001143829
CCDC68
coiled-coil domain containing 68
chr5_+_67622242 0.335 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_78217360 0.334 NM_003902
FUBP1
far upstream element (FUSE) binding protein 1
chr3_+_45705845 0.334 SACM1L
SAC1 suppressor of actin mutations 1-like (yeast)
chr19_-_14490160 0.331 NM_006145
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr10_+_70517823 0.331 NM_002727
SRGN
serglycin
chr7_+_134114912 0.330 CALD1
caldesmon 1
chr13_+_96672705 0.328 MBNL2
muscleblind-like 2 (Drosophila)
chrX_-_80344096 0.328 NM_030763
HMGN5
high-mobility group nucleosome binding domain 5
chr12_+_50633430 0.327 NM_020327
ACVR1B
activin A receptor, type IB
chr14_-_22458199 0.326 RBM23
RNA binding motif protein 23
chr18_-_50777634 0.324 NM_025214
CCDC68
coiled-coil domain containing 68
chr14_-_22610572 0.323 ACIN1
apoptotic chromatin condensation inducer 1
chrX_+_47999740 0.322 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr11_+_66764064 0.320 KDM2A
lysine (K)-specific demethylase 2A
chr12_-_14612057 0.319 NM_024829
PLBD1
phospholipase B domain containing 1
chr19_-_14121728 0.318 LPHN1
latrophilin 1
chr13_-_40454188 0.318 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_180621272 0.317 GLUL
glutamate-ammonia ligase
chr12_+_118100977 0.316 NM_014365
HSPB8
heat shock 22kDa protein 8
chr8_-_110689396 0.314 SYBU
syntabulin (syntaxin-interacting)
chr6_-_111995213 0.314 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr3_-_124893875 0.313 MYLK
myosin light chain kinase
chr14_-_22458220 0.311 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr3_+_45705918 0.311 SACM1L
SAC1 suppressor of actin mutations 1-like (yeast)
chr4_+_91035025 0.311 NM_007351
MMRN1
multimerin 1
chr3_-_184756101 0.311 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr12_-_69317441 0.311 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr15_+_40481879 0.309 NM_173088
CAPN3
calpain 3, (p94)
chr1_-_148175345 0.308 MTMR11
myotubularin related protein 11
chr1_+_154095883 0.308 NM_152280
SYT11
synaptotagmin XI
chr2_+_26768894 0.307 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr12_-_52975777 0.307 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr11_+_65526462 0.304 BANF1
barrier to autointegration factor 1
chr14_-_22458134 0.304 RBM23
RNA binding motif protein 23
chr2_+_201755865 0.304 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr3_-_19950675 0.303 NM_144715
EFHB
EF-hand domain family, member B
chr1_+_15858950 0.301 NM_006511
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr6_-_161614962 0.301 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr3_+_69871252 0.301 NM_198159
MITF
microphthalmia-associated transcription factor
chr8_-_93181091 0.300 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr15_-_54175954 0.300 RFX7
regulatory factor X, 7
chr3_+_52504391 0.299 NM_015136
STAB1
stabilin 1
chr3_+_45705681 0.299 NM_014016
SACM1L
SAC1 suppressor of actin mutations 1-like (yeast)
chr13_-_40735619 0.297 NM_004294
MTRF1
mitochondrial translational release factor 1
chr10_+_74540215 0.297 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chrX_-_102829595 0.297 MORF4L2
mortality factor 4 like 2
chr7_+_134483305 0.296 NM_018295
TMEM140
transmembrane protein 140
chr16_+_4842077 0.296 NM_016936
UBN1
ubinuclein 1
chr1_+_114295289 0.294 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr17_-_74361620 0.294 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_+_27493654 0.289 RHOT1
ras homolog gene family, member T1
chr2_+_160180092 0.289 LOC643072
hypothetical LOC643072
chr10_+_18280773 0.287 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr6_-_76010231 0.287 NM_001865
COX7A2
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
chr13_-_40454360 0.287 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr8_-_31010772 0.287 NM_001015508
PURG
purine-rich element binding protein G
chr1_-_232810111 0.286 IRF2BP2
interferon regulatory factor 2 binding protein 2
chr6_-_68655708 0.286


chr7_+_18296569 0.286 HDAC9
histone deacetylase 9
chr6_-_135417522 0.286 HBS1L
HBS1-like (S. cerevisiae)
chr2_-_158439868 0.286 NM_001105
ACVR1
activin A receptor, type I
chrX_+_48529905 0.282 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr19_+_13066956 0.281 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_-_54336847 0.279 NM_001003937
TSPYL6
TSPY-like 6
chr3_+_195336631 0.272 HES1
hairy and enhancer of split 1, (Drosophila)
chr2_+_160180049 0.271 LOC643072
hypothetical LOC643072
chr3_-_71262405 0.267 FOXP1
forkhead box P1
chr8_-_82769761 0.266 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr7_+_105304445 0.266 LOC100506768
CDHR3
hypothetical LOC100506768
cadherin-related family member 3
chr14_-_22610610 0.266 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr3_-_140677990 0.265 NM_004164
RBP2
retinol binding protein 2, cellular
chr1_-_94147537 0.265 GCLM
glutamate-cysteine ligase, modifier subunit
chr17_-_44058612 0.264 NM_024017
HOXB9
homeobox B9
chr5_-_180175146 0.264 MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr21_-_30720100 0.263 NM_181622
KRTAP13-3
keratin associated protein 13-3
chr1_-_196011152 0.261 NM_001195215
NM_001195216
NM_144977
DENND1B


DENN/MADD domain containing 1B


chr1_-_171442937 0.260 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_+_88026338 0.259 ZNF292
zinc finger protein 292
chr19_+_50041424 0.256 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr7_-_27125738 0.254 NM_030661
HOXA3
homeobox A3
chr1_+_66570683 0.253 PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_+_32230172 0.253 PPT2
palmitoyl-protein thioesterase 2
chr8_+_31010791 0.251 WRN
Werner syndrome, RecQ helicase-like
chrX_-_131181141 0.251 RAP2C
RAP2C, member of RAS oncogene family
chr6_+_167624792 0.251 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.40 4.75e-02 GO:0042026 protein refolding

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.38 3.33e-03 GO:0051082 unfolded protein binding
1.11 1.37e-02 GO:0005515 protein binding