Motif ID: bHLH_family.p2

Z-value: 2.270


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3



Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_38720881 4.518 NM_138435
FAM83F
family with sequence similarity 83, member F
chr8_+_120289735 3.964 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr16_+_67236699 3.776 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr16_-_66827449 3.536 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr8_+_95722448 3.276 ESRP1
epithelial splicing regulatory protein 1
chr12_+_52618815 2.821 NM_017410
HOXC13
homeobox C13
chr8_-_17702991 2.735


chr8_+_95722575 2.609 ESRP1
epithelial splicing regulatory protein 1
chr8_+_95722516 2.445 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr17_+_9489578 2.240 NM_153210
USP43
ubiquitin specific peptidase 43
chr12_+_52653176 2.218 NM_014212
HOXC11
homeobox C11
chr16_+_67236730 2.216 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr7_-_27149750 1.736 NM_019102
HOXA5
homeobox A5
chr7_-_27162688 1.631 NM_006896
HOXA7
homeobox A7
chr16_-_52876390 1.623 IRX3
iroquois homeobox 3
chr11_+_384199 1.605 NM_007183
PKP3
plakophilin 3
chr4_-_158111504 1.589 PDGFC
platelet derived growth factor C
chr12_+_52806103 1.582 LOC400043
hypothetical LOC400043
chr1_+_148521852 1.553 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr13_-_19665036 1.543 GJB2
gap junction protein, beta 2, 26kDa
chr11_+_384238 1.537 PKP3
plakophilin 3
chr17_-_35911340 1.521 NM_032865
TNS4
tensin 4
chr12_+_52634950 1.520 NM_173860
HOXC12
homeobox C12
chr1_-_199635057 1.476 LAD1
ladinin 1
chr16_-_4528380 1.433 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr14_+_64240902 1.432 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chrX_-_114703273 1.423


chr16_+_70217564 1.409 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr7_-_1562272 1.397 NM_001097620
TMEM184A
transmembrane protein 184A
chr13_+_112999590 1.386 LAMP1
lysosomal-associated membrane protein 1
chr16_+_65790514 1.386 NM_024712
ELMO3
engulfment and cell motility 3
chr13_+_27392136 1.377 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr1_-_199635240 1.367 NM_005558
LAD1
ladinin 1
chr3_-_126414252 1.349 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr5_+_3649167 1.337 NM_024337
IRX1
iroquois homeobox 1
chr12_-_47604930 1.331 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr13_+_112999538 1.317 LAMP1
lysosomal-associated membrane protein 1
chr16_-_4528739 1.312 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr1_-_199635339 1.310 LAD1
ladinin 1
chr9_+_696744 1.308 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr8_+_22492198 1.289 NM_021630
PDLIM2
PDZ and LIM domain 2 (mystique)
chr7_-_22363036 1.270 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr4_-_158111916 1.266 PDGFC
platelet derived growth factor C
chr1_+_208178160 1.251 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr1_-_31942142 1.250 COL16A1
collagen, type XVI, alpha 1
chr12_+_52713098 1.247 NM_018953
HOXC5
homeobox C5
chr4_-_158111995 1.247 NM_016205
PDGFC
platelet derived growth factor C
chr8_-_75396016 1.245 NM_020647
JPH1
junctophilin 1
chr7_+_74862838 1.241 NM_198924
TRIM73
TRIM74
tripartite motif containing 73
tripartite motif containing 74
chr2_+_176680251 1.237 NM_021192
HOXD11
homeobox D11
chr17_+_35148084 1.236 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr14_+_23855291 1.227 LTB4R
leukotriene B4 receptor
chr14_+_64240996 1.224 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr6_+_96570565 1.217 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr10_+_101079099 1.216 CNNM1
cyclin M1
chr4_-_17392232 1.209 NM_015688
FAM184B
family with sequence similarity 184, member B
chr19_-_19599973 1.191 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr2_+_27518736 1.160 NM_001168364
NM_173853
KRTCAP3

keratinocyte associated protein 3

chr19_+_43447262 1.149 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr13_+_112999462 1.139 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr2_+_223625105 1.135 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr7_+_55054416 1.134 EGFR
epidermal growth factor receptor
chr2_-_166358951 1.133 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr2_-_166358792 1.130 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr17_-_74487527 1.107 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr20_+_13924263 1.100 MACROD2
MACRO domain containing 2
chr1_+_35020425 1.099 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr9_+_17124974 1.077 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr6_-_30151526 1.075 NM_170769
NM_025236
RNF39

ring finger protein 39

chrX_-_107866262 1.060 NM_003604
IRS4
insulin receptor substrate 4
chr2_-_219633481 1.056 NM_002181
IHH
Indian hedgehog
chr1_+_181422016 1.056 LAMC2
laminin, gamma 2
chr2_-_217267742 1.039 IGFBP5
insulin-like growth factor binding protein 5
chr17_+_35147697 1.039 NM_005310
GRB7
growth factor receptor-bound protein 7
chr1_+_1971762 1.035 NM_002744
PRKCZ
protein kinase C, zeta
chr4_-_15694407 1.033 PROM1
prominin 1
chr17_+_35147738 1.029 GRB7
growth factor receptor-bound protein 7
chr6_+_87921980 1.028 NM_015021
ZNF292
zinc finger protein 292
chr8_+_22492586 1.026 PDLIM2
PDZ and LIM domain 2 (mystique)
chr16_+_639278 1.009 NM_145294
WDR90
WD repeat domain 90
chr6_-_138862271 1.007 NM_001144060
NHSL1
NHS-like 1
chr3_+_50629872 0.999 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr1_-_20931288 0.997 SH2D5
SH2 domain containing 5
chr11_+_45900731 0.989 GYLTL1B
glycosyltransferase-like 1B
chr7_-_82630063 0.981 NM_014510
NM_033026
PCLO

piccolo (presynaptic cytomatrix protein)

chr12_-_83830700 0.977 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr6_-_10527772 0.967 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr12_-_83830710 0.965 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr2_+_17585462 0.952 VSNL1
visinin-like 1
chr12_-_83830670 0.949 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr12_+_94861201 0.943 NM_152435
AMDHD1
amidohydrolase domain containing 1
chr17_-_35510074 0.926 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr2_+_17585287 0.917 NM_003385
VSNL1
visinin-like 1
chr15_-_98699628 0.915 NM_139057
ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr1_-_152459697 0.915 NM_001098616
NM_015449
NM_138740
C1orf43


chromosome 1 open reading frame 43


chr12_-_57600564 0.914 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr6_-_42218692 0.914 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr1_-_158182006 0.908 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr6_-_80713589 0.907 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr18_+_17076166 0.902 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr6_-_138862273 0.895


chr3_+_10832867 0.884 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr1_-_152459667 0.878 C1orf43
chromosome 1 open reading frame 43
chr3_+_50629593 0.878 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr14_-_23106372 0.878 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr11_+_111294810 0.877 NM_080659
C11orf52
chromosome 11 open reading frame 52
chrX_+_73557809 0.871 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr1_+_95058488 0.867 NM_001114106
SLC44A3
solute carrier family 44, member 3
chr11_-_116168316 0.867 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr3_+_139636104 0.866 NM_031913
ESYT3
extended synaptotagmin-like protein 3
chr3_+_50629604 0.855 NM_004635
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr14_+_69415880 0.854 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr3_-_69674412 0.851 FRMD4B
FERM domain containing 4B
chr19_+_6415259 0.848 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr4_+_15089931 0.842 CC2D2A
coiled-coil and C2 domain containing 2A
chr9_+_128416542 0.839 NM_001174146
NM_001174147
NM_002316
LMX1B


LIM homeobox transcription factor 1, beta


chr12_-_57600336 0.832 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr5_+_59819761 0.831 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr2_-_172675480 0.827 NM_004405
DLX2
distal-less homeobox 2
chr3_+_139636111 0.826 ESYT3
extended synaptotagmin-like protein 3
chr14_+_102458745 0.826 NM_030943
AMN
amnionless homolog (mouse)
chr8_-_144726064 0.826 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr9_-_126309510 0.819 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr11_+_126378507 0.811 NCRNA00288
non-protein coding RNA 288
chr17_+_7225088 0.809 NM_003985
TNK1
tyrosine kinase, non-receptor, 1
chr2_-_220116062 0.809 NM_001195731
CHPF
chondroitin polymerizing factor
chr19_+_59077241 0.809 NM_002739
PRKCG
protein kinase C, gamma
chr8_+_32525269 0.805 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr7_-_82629735 0.803 PCLO
piccolo (presynaptic cytomatrix protein)
chr9_+_70926205 0.802 TJP2
tight junction protein 2 (zona occludens 2)
chr9_-_111300350 0.800 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr22_-_49317408 0.790 ODF3B
outer dense fiber of sperm tails 3B
chr17_-_35510431 0.789 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr11_+_32993973 0.786 NM_001077242
DEPDC7
DEP domain containing 7
chr3_-_57088332 0.785 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr17_+_71229191 0.785 ITGB4
integrin, beta 4
chr2_-_238164042 0.783 RAB17
RAB17, member RAS oncogene family
chr14_-_19999475 0.776 NM_001100814
NM_144568
TMEM55B

transmembrane protein 55B

chr8_-_99375739 0.775 NM_024759
NIPAL2
NIPA-like domain containing 2
chr1_+_152459918 0.774 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr2_+_234266250 0.773 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr6_-_47385205 0.771 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr4_+_95898098 0.768 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr1_+_95058687 0.766 NM_152369
SLC44A3
solute carrier family 44, member 3
chr10_+_101078784 0.766 NM_020348
CNNM1
cyclin M1
chr1_+_95058781 0.764 SLC44A3
solute carrier family 44, member 3
chr6_+_7486862 0.763 NM_001008844
NM_004415
DSP

desmoplakin

chr9_+_132310068 0.763 ASS1
argininosuccinate synthase 1
chr3_-_49370682 0.761 GPX1
glutathione peroxidase 1
chr11_+_72607040 0.757 NM_176071
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr20_+_43028533 0.755 NM_006282
STK4
serine/threonine kinase 4
chr14_-_91642641 0.752 ATXN3
ATXN8
ataxin 3
ataxin 8
chr19_+_40431122 0.751 LSR
lipolysis stimulated lipoprotein receptor
chr7_+_16759845 0.749 NM_014399
TSPAN13
tetraspanin 13
chr12_-_94860504 0.747 NM_182496
CCDC38
coiled-coil domain containing 38
chr14_-_91642703 0.747 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr19_-_10625449 0.746 LOC147727
hypothetical LOC147727
chr6_+_36346214 0.743 NM_001145717
PNPLA1
patatin-like phospholipase domain containing 1
chr17_+_2627099 0.741 RAP1GAP2
RAP1 GTPase activating protein 2
chr18_-_72973750 0.741 NM_001025100
NM_001025101
MBP

myelin basic protein

chr6_+_7486836 0.741 DSP
desmoplakin
chr2_-_139254273 0.738 NM_007226
NXPH2
neurexophilin 2
chr1_-_24307514 0.738 MYOM3
myomesin family, member 3
chr9_+_70926009 0.733 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr8_+_123863075 0.733 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr11_+_111294868 0.733 C11orf52
chromosome 11 open reading frame 52
chr16_+_67328805 0.727 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_+_181421984 0.725 LAMC2
laminin, gamma 2
chr1_-_159459999 0.721 NM_001643
APOA2
apolipoprotein A-II
chr1_+_27541086 0.712 SYTL1
synaptotagmin-like 1
chr5_+_167651063 0.712 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr3_-_49370755 0.711 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr14_-_19999324 0.709 TMEM55B
transmembrane protein 55B
chr19_+_40431359 0.708 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr17_+_77478858 0.708 LOC92659
hypothetical LOC92659
chr12_+_64504408 0.707 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr19_+_10625896 0.705 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr2_+_241903395 0.705 NM_001008491
NM_006155
SEPT2

septin 2

chr20_-_2769245 0.704 NM_022760
FAM113A
family with sequence similarity 113, member A
chr1_+_27541049 0.699 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr17_-_72093739 0.695 NM_006456
ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr9_-_106730256 0.695 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr14_+_20580224 0.695 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr11_-_70641267 0.694 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_151852128 0.693 NM_080388
S100A16
S100 calcium binding protein A16
chr10_-_62163083 0.692 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr8_-_95720870 0.689 LOC100288748
hypothetical LOC100288748
chr19_+_40431618 0.683 LSR
lipolysis stimulated lipoprotein receptor
chr16_+_67328715 0.682 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr8_+_123863169 0.679 ZHX2
zinc fingers and homeoboxes 2
chr2_+_173308765 0.679 NM_007023
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr9_-_106730157 0.677 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chrX_+_95826507 0.677 DIAPH2
diaphanous homolog 2 (Drosophila)
chr5_-_1935764 0.677 NM_016358
IRX4
iroquois homeobox 4
chrX_+_105856531 0.674 NM_194463
RNF128
ring finger protein 128
chr21_+_36993302 0.672


chr1_-_27212035 0.671 FAM46B
family with sequence similarity 46, member B
chr6_-_18230829 0.671 NM_198586
NHLRC1
NHL repeat containing 1
chr17_-_68769613 0.670 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr20_+_19863716 0.670 RIN2
Ras and Rab interactor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 7.14e-07 GO:0009987 cellular process
1.22 4.56e-05 GO:0048856 anatomical structure development
1.20 1.42e-04 GO:0007275 multicellular organismal development
1.23 1.46e-04 GO:0048731 system development
1.18 9.62e-04 GO:0032502 developmental process
1.35 1.37e-02 GO:0042127 regulation of cell proliferation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.35 5.36e-03 GO:0044452 nucleolar part
1.05 9.52e-03 GO:0005622 intracellular
1.05 3.53e-02 GO:0044424 intracellular part
1.41 3.77e-02 GO:0005730 nucleolus
1.07 4.61e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 4.02e-04 GO:0005515 protein binding
1.42 2.28e-03 GO:0043565 sequence-specific DNA binding