Motif ID: TBP.p2

Z-value: 2.015


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein



Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_27139143 3.059 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr21_-_27139563 2.924 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr4_+_74953971 2.686 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr10_+_53744043 2.540 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr4_-_75183700 2.463 CXCL2
chemokine (C-X-C motif) ligand 2
chr19_+_18357966 2.451 NM_004864
GDF15
growth differentiation factor 15
chr2_-_151052391 2.257 NM_005168
RND3
Rho family GTPase 3
chr8_-_23317571 2.196 LOXL2
lysyl oxidase-like 2
chr8_-_23317577 2.107 LOXL2
lysyl oxidase-like 2
chr15_+_78858763 2.092 NM_018689
KIAA1199
KIAA1199
chr21_+_46342440 2.039 NM_001849
NM_058174
NM_058175
COL6A2


collagen, type VI, alpha 2


chr8_-_23317536 1.949 LOXL2
lysyl oxidase-like 2
chr5_-_179712920 1.827 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr7_+_100557098 1.798 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr10_-_92670764 1.690 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_62279707 1.655 C3orf14
chromosome 3 open reading frame 14
chr9_+_123088217 1.578 GSN
gelsolin
chr12_+_12935759 1.574 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr16_+_55217180 1.562 MT1E
metallothionein 1E
chr17_+_76623540 1.519 NM_001144888
NM_006340
NM_017450
NM_017451
BAIAP2



BAI1-associated protein 2



chr3_-_24511456 1.488 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr17_-_37144408 1.464 NM_001079870
NM_001079871
NM_177977
HAP1


huntingtin-associated protein 1


chr1_-_16355013 1.437 NM_004431
EPHA2
EPH receptor A2
chr8_-_24869945 1.434 NM_006158
NEFL
neurofilament, light polypeptide
chr17_+_76623553 1.426 BAIAP2
BAI1-associated protein 2
chr12_-_123568781 1.392


chr16_+_55217085 1.388 NM_175617
MT1E
metallothionein 1E
chr17_+_29606408 1.369 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr21_+_44729875 1.315


chr12_+_12935619 1.307 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr8_-_23317620 1.299 NM_002318
LOXL2
lysyl oxidase-like 2
chr1_+_161305558 1.298 NM_001113381
RGS4
regulator of G-protein signaling 4
chr12_-_87498225 1.242 NM_000899
NM_003994
KITLG

KIT ligand

chr15_-_32875040 1.216 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr14_-_52487558 1.202 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr6_-_169395847 1.193 THBS2
thrombospondin 2
chr16_-_55259405 1.170 NM_005950
MT1G
metallothionein 1G
chr17_-_37034288 1.139 NM_000422
KRT17
keratin 17
chrX_+_17303798 1.134 NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr6_+_32021831 1.119 CFB
complement factor B
chr17_-_76622967 1.086 FLJ90757
hypothetical LOC440465
chr3_+_52504391 1.062 NM_015136
STAB1
stabilin 1
chr17_-_71287417 1.056 NM_005324
H3F3B
H3 histone, family 3B (H3.3B)
chr1_+_15957832 1.045 NM_017556
FBLIM1
filamin binding LIM protein 1
chrX_+_17303727 1.045 NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr11_-_93774223 1.036 NM_016540
GPR83
G protein-coupled receptor 83
chr9_-_116920232 1.023 NM_002160
TNC
tenascin C
chr4_-_75183860 0.977 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chrX_+_17303458 0.972 NM_198270
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr9_+_138677197 0.958 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr1_-_199732323 0.952 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr2_-_216009015 0.950 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr15_+_37660568 0.943 NM_003246
THBS1
thrombospondin 1
chr22_-_34566276 0.943 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr17_-_45901173 0.931 NM_001267
CHAD
chondroadherin
chr15_-_61461127 0.930 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr3_+_149898347 0.928 NM_000685
NM_004835
NM_009585
NM_031850
AGTR1



angiotensin II receptor, type 1



chr8_-_143692814 0.927 NM_015193
ARC
activity-regulated cytoskeleton-associated protein
chr16_-_4232053 0.920 NM_001098814
SRL
sarcalumenin
chr12_-_51585004 0.908 NM_002273
KRT8
keratin 8
chr1_-_228916486 0.891 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr9_+_129951552 0.887 NM_005564
LCN2
lipocalin 2
chr8_+_24827181 0.860 NEFM
neurofilament, medium polypeptide
chr12_+_50913274 0.857 KRT7
keratin 7
chr4_-_75123193 0.848 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr8_-_23077392 0.834 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr20_-_43410437 0.830 NM_002999
SDC4
syndecan 4
chr1_-_228916470 0.821 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr16_+_55523526 0.807 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr7_-_45927263 0.779 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr8_+_24827173 0.777 NM_005382
NEFM
neurofilament, medium polypeptide
chr5_+_15553288 0.775 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr2_-_21120420 0.772 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr8_-_134378630 0.764 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr2_+_39746141 0.756 NM_001167959
TMEM178
transmembrane protein 178
chr1_-_148080888 0.740 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr1_-_226679648 0.738 NM_003493
HIST3H3
histone cluster 3, H3
chr17_-_45633986 0.736 NM_000088
COL1A1
collagen, type I, alpha 1
chrX_-_103386215 0.736 NM_153448
ESX1
ESX homeobox 1
chr21_+_33320080 0.733 NM_005806
OLIG2
oligodendrocyte lineage transcription factor 2
chr19_-_44386731 0.721 NM_001080468
SYCN
syncollin
chr17_+_35425139 0.716 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr2_-_21120314 0.711 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_-_36436979 0.700 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr20_+_29656744 0.699 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr1_-_32940850 0.698 SYNC
syncoilin, intermediate filament protein
chr3_+_110338250 0.697 FLJ22763
hypothetical LOC401081
chr17_-_45633873 0.696 COL1A1
collagen, type I, alpha 1
chr6_+_132170847 0.695 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr20_-_1922701 0.679 NM_001190899
NM_001190898
NM_024411
PDYN


prodynorphin


chr8_-_27528105 0.677 CLU
clusterin
chr1_-_150599105 0.667 NM_001014342
FLG2
filaggrin family member 2
chr1_-_8008934 0.665 ERRFI1
ERBB receptor feedback inhibitor 1
chr2_+_33514896 0.663 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_-_33879734 0.663 NM_001040109
NM_001184698
NM_002418
MLN


motilin


chr6_+_64340388 0.660 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr22_+_28206180 0.659 NM_021076
NEFH
neurofilament, heavy polypeptide
chr10_+_17891348 0.659 NM_001009567
NM_002438
MRC1L1
MRC1
mannose receptor, C type 1-like 1
mannose receptor, C type 1
chr5_-_57791544 0.656 NM_006622
PLK2
polo-like kinase 2
chr8_+_70567634 0.654 SULF1
sulfatase 1
chr17_-_36469869 0.653 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr15_-_61460967 0.652 CA12
carbonic anhydrase XII
chr21_-_44795769 0.647 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr4_-_140317686 0.646 ELF2
E74-like factor 2 (ets domain transcription factor)
chr1_+_16203317 0.641 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr10_-_1061797 0.640 NM_033261
IDI2
isopentenyl-diphosphate delta isomerase 2
chr19_-_50517971 0.638 CKM
creatine kinase, muscle
chr16_+_70654625 0.634 NM_020995
HPR
haptoglobin-related protein
chr12_+_50686990 0.634 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chrX_-_30237403 0.627 NM_000475
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr19_+_627346 0.624 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr10_+_118370441 0.624 NM_005396
PNLIPRP2
pancreatic lipase-related protein 2
chr11_-_1576057 0.623 NM_001004325
KRTAP5-2
keratin associated protein 5-2
chr19_+_810658 0.617 NM_001928
CFD
complement factor D (adipsin)
chr19_-_50518072 0.615 NM_001824
CKM
creatine kinase, muscle
chr14_-_88087575 0.605 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr11_-_2907169 0.602 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr12_-_51173238 0.600 NM_005554
KRT6A
keratin 6A
chr2_-_227952249 0.597 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr17_-_36938025 0.593 KRT19
keratin 19
chr17_-_36807322 0.585 NM_002277
KRT31
keratin 31
chr2_-_238813365 0.584 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr21_+_18539016 0.581 NM_024944
CHODL
chondrolectin
chr1_-_167969802 0.580 NM_000450
SELE
selectin E
chr1_-_35431329 0.579 NM_005066
SFPQ
splicing factor proline/glutamine-rich
chr11_+_60765219 0.575 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr7_+_93862137 0.575 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr22_+_36412277 0.575 NM_024313
NOL12
nucleolar protein 12
chr5_-_153837975 0.568 HAND1
heart and neural crest derivatives expressed 1
chr2_-_219566364 0.567 NM_005209
NM_057093
NM_057094
CRYBA2


crystallin, beta A2


chr15_-_60244773 0.555 NM_001007595
C2CD4B
C2 calcium-dependent domain containing 4B
chr5_+_53787187 0.554 NM_006308
HSPB3
heat shock 27kDa protein 3
chr1_+_85819004 0.545 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr2_-_238813284 0.542 HES6
hairy and enhancer of split 6 (Drosophila)
chr1_+_161305188 0.539 NM_005613
RGS4
regulator of G-protein signaling 4
chr10_-_62373828 0.538 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr2_-_38831901 0.538 NM_001031684
NM_001195446
SRSF7

serine/arginine-rich splicing factor 7

chr1_+_200775864 0.535 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr11_-_1026654 0.534 NM_005961
MUC6
mucin 6, oligomeric mucus/gel-forming
chr2_-_121759237 0.533 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr11_-_62213577 0.532 LRRN4CL
LRRN4 C-terminal like
chr2_+_85619797 0.530 NM_005911
MAT2A
methionine adenosyltransferase II, alpha
chr15_+_61121806 0.524 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr5_+_176744037 0.521 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr6_+_25834983 0.520 NM_170610
HIST1H2BA
histone cluster 1, H2ba
chr2_+_39746525 0.518 NM_152390
TMEM178
transmembrane protein 178
chr7_-_41709191 0.517 NM_002192
INHBA
inhibin, beta A
chr17_+_29621352 0.511 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr11_-_102331643 0.510 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr9_+_116125123 0.510 NM_000607
ORM1
orosomucoid 1
chr11_+_1675000 0.510 NM_001012416
KRTAP5-6
keratin associated protein 5-6
chr11_+_1607580 0.506 NM_001001480
KRTAP5-5
keratin associated protein 5-5
chr1_-_35431318 0.505 SFPQ
splicing factor proline/glutamine-rich
chr1_-_226202210 0.503 NM_003395
WNT9A
wingless-type MMTV integration site family, member 9A
chr6_+_64340408 0.496 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_-_147665783 0.495 HIST2H2BF
histone cluster 2, H2bf
chr11_+_70915960 0.495 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr17_-_10362583 0.495 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr13_+_30378311 0.493 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr19_+_523403 0.490 NM_001728
NM_198589
BSG

basigin (Ok blood group)

chr5_-_115180221 0.488 NM_001801
CDO1
cysteine dioxygenase, type I
chr5_+_76284435 0.484 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chrX_+_17303270 0.483 NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr12_+_6514228 0.480 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr11_+_68208583 0.480 GAL
galanin prepropeptide
chr6_+_19945578 0.477 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr2_+_65517316 0.475 FLJ16124
FLJ16124 protein
chr11_+_60746396 0.472 NM_001079808
PGA5
PGA3
PGA4
pepsinogen 5, group I (pepsinogen A)
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr16_+_55230078 0.471 NM_005946
MT1A
metallothionein 1A
chr11_-_4675524 0.470 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr4_+_25266532 0.467 NM_001177998
NM_006424
SLC34A2

solute carrier family 34 (sodium phosphate), member 2

chr12_-_55134692 0.466 NM_012064
MIP
major intrinsic protein of lens fiber
chr17_-_68100537 0.466 LOC100499467
hypothetical LOC100499467
chr19_-_46048033 0.465 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chrX_+_153279764 0.464 NM_006013
RPL10
ribosomal protein L10
chr17_-_10217046 0.464 NM_003802
MYH13
myosin, heavy chain 13, skeletal muscle
chr6_-_25834733 0.462 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr7_+_142539291 0.462 NM_002652
PIP
prolactin-induced protein
chr5_-_42847716 0.460 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr6_-_150388292 0.456 NM_130900
RAET1L
retinoic acid early transcript 1L
chr3_-_130517759 0.455 NM_006026
H1FX
H1 histone family, member X
chr16_+_69950116 0.451 NM_001740
NM_007088
CALB2

calbindin 2

chr19_+_38485583 0.448 LOC80054
hypothetical LOC80054
chr17_-_59304729 0.446 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr5_+_78443357 0.443 NM_001713
BHMT
betaine--homocysteine S-methyltransferase
chr17_-_53713265 0.438 NM_000250
MPO
myeloperoxidase
chr12_+_79634820 0.437 NM_005593
MYF5
myogenic factor 5
chr1_-_150463292 0.436 NM_001009931
HRNR
hornerin
chr1_-_26266571 0.434 NM_032588
TRIM63
tripartite motif containing 63
chr11_-_116199145 0.432 NM_000482
APOA4
apolipoprotein A-IV
chr6_-_26232109 0.429 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr15_-_53587723 0.428 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr11_-_8982107 0.426 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr7_+_27190688 0.425


chr2_-_21120398 0.425 APOB
apolipoprotein B (including Ag(x) antigen)
chr11_+_43920385 0.424 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr11_-_111287657 0.422 NM_001885
CRYAB
crystallin, alpha B
chr17_+_29707583 0.419 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr7_-_6490375 0.417 KDELR2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr2_-_179380301 0.417 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin





Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.53 3.89e-12 GO:0032501 multicellular organismal process
4.26 1.05e-10 GO:0010035 response to inorganic substance
1.68 2.18e-09 GO:0048856 anatomical structure development
1.59 3.55e-09 GO:0032502 developmental process
1.71 9.15e-09 GO:0048731 system development
1.92 1.13e-08 GO:0048513 organ development
1.62 1.23e-08 GO:0007275 multicellular organismal development
1.80 2.70e-08 GO:0042221 response to chemical stimulus
2.34 5.97e-07 GO:0009888 tissue development
2.37 7.71e-07 GO:0006952 defense response
1.70 1.05e-06 GO:0006950 response to stress
2.31 1.93e-06 GO:0043933 macromolecular complex subunit organization
8.52 1.30e-05 GO:0034614 cellular response to reactive oxygen species
5.21 1.33e-05 GO:0034728 nucleosome organization
2.16 2.57e-05 GO:0009611 response to wounding
2.63 3.35e-05 GO:0034621 cellular macromolecular complex subunit organization
5.36 6.02e-05 GO:0000302 response to reactive oxygen species
2.42 7.77e-05 GO:0009887 organ morphogenesis
5.13 1.15e-04 GO:0006334 nucleosome assembly
6.46 1.17e-04 GO:0034599 cellular response to oxidative stress
2.37 1.39e-04 GO:0009725 response to hormone stimulus
3.13 1.44e-04 GO:0006954 inflammatory response
1.88 1.58e-04 GO:0010033 response to organic substance
2.51 1.90e-04 GO:0009607 response to biotic stimulus
3.25 2.03e-04 GO:0009617 response to bacterium
4.87 2.45e-04 GO:0031497 chromatin assembly
2.06 2.79e-04 GO:0051704 multi-organism process
3.63 2.81e-04 GO:0006979 response to oxidative stress
9.59 3.34e-04 GO:0070301 cellular response to hydrogen peroxide
4.49 3.41e-04 GO:0071824 protein-DNA complex subunit organization
2.01 4.86e-04 GO:0070887 cellular response to chemical stimulus
10.84 5.51e-04 GO:0034367 macromolecular complex remodeling
10.84 5.51e-04 GO:0034368 protein-lipid complex remodeling
10.84 5.51e-04 GO:0034369 plasma lipoprotein particle remodeling
2.49 6.93e-04 GO:0072358 cardiovascular system development
2.49 6.93e-04 GO:0072359 circulatory system development
2.71 7.40e-04 GO:0034622 cellular macromolecular complex assembly
2.21 7.44e-04 GO:0009719 response to endogenous stimulus
4.46 8.53e-04 GO:0065004 protein-DNA complex assembly
3.64 9.76e-04 GO:0010038 response to metal ion
1.91 1.17e-03 GO:0022607 cellular component assembly
2.15 1.21e-03 GO:0065003 macromolecular complex assembly
3.96 2.10e-03 GO:0006323 DNA packaging
5.51 2.37e-03 GO:0042542 response to hydrogen peroxide
9.18 2.40e-03 GO:0071825 protein-lipid complex subunit organization
9.18 2.40e-03 GO:0071827 plasma lipoprotein particle organization
1.57 2.42e-03 GO:0065008 regulation of biological quality
1.71 2.45e-03 GO:0009653 anatomical structure morphogenesis
2.51 2.61e-03 GO:0051707 response to other organism
7.67 2.77e-03 GO:0097006 regulation of plasma lipoprotein particle levels
1.81 2.79e-03 GO:0044085 cellular component biogenesis
1.27 3.54e-03 GO:0050896 response to stimulus
3.60 4.14e-03 GO:0071103 DNA conformation change
10.44 4.23e-03 GO:0045103 intermediate filament-based process
1.92 5.09e-03 GO:0050793 regulation of developmental process
3.70 5.45e-03 GO:0006333 chromatin assembly or disassembly
2.02 7.14e-03 GO:0071844 cellular component assembly at cellular level
2.75 7.62e-03 GO:0030029 actin filament-based process
3.14 9.88e-03 GO:0008544 epidermis development
1.55 1.08e-02 GO:0030154 cell differentiation
3.86 1.25e-02 GO:0042742 defense response to bacterium
14.91 1.62e-02 GO:0034374 low-density lipoprotein particle remodeling
1.39 1.66e-02 GO:0016043 cellular component organization
5.52 1.78e-02 GO:0051591 response to cAMP
1.52 1.98e-02 GO:0048869 cellular developmental process
2.26 2.33e-02 GO:0048646 anatomical structure formation involved in morphogenesis
3.21 3.74e-02 GO:0006936 muscle contraction
4.26 3.76e-02 GO:0001890 placenta development
6.45 4.29e-02 GO:0006953 acute-phase response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
9.46 3.58e-35 GO:0005882 intermediate filament
8.19 1.41e-31 GO:0045111 intermediate filament cytoskeleton
2.52 1.02e-28 GO:0005576 extracellular region
12.67 4.86e-27 GO:0045095 keratin filament
3.68 1.36e-26 GO:0005615 extracellular space
3.27 1.50e-26 GO:0044421 extracellular region part
2.40 1.70e-11 GO:0044430 cytoskeletal part
2.08 9.28e-11 GO:0005856 cytoskeleton
1.68 6.32e-09 GO:0043228 non-membrane-bounded organelle
1.68 6.32e-09 GO:0043232 intracellular non-membrane-bounded organelle
7.70 2.86e-08 GO:0000786 nucleosome
4.63 1.22e-05 GO:0030016 myofibril
4.92 2.84e-05 GO:0032993 protein-DNA complex
4.37 3.08e-05 GO:0043292 contractile fiber
2.64 1.14e-04 GO:0031012 extracellular matrix
6.31 2.13e-04 GO:0031983 vesicle lumen
4.22 2.43e-04 GO:0044449 contractile fiber part
11.60 2.47e-04 GO:0032982 myosin filament
1.38 1.18e-03 GO:0032991 macromolecular complex
3.96 5.19e-03 GO:0030017 sarcomere
5.59 6.02e-03 GO:0031674 I band
5.59 6.02e-03 GO:0034774 secretory granule lumen
2.69 8.46e-03 GO:0000785 chromatin
5.37 8.48e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.35 2.14e-02 GO:0005578 proteinaceous extracellular matrix
5.08 3.51e-02 GO:0031093 platelet alpha granule lumen
2.66 3.51e-02 GO:0030141 stored secretory granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.55 4.76e-18 GO:0005198 structural molecule activity
2.36 3.91e-10 GO:0005102 receptor binding
4.20 3.71e-08 GO:0005125 cytokine activity
5.72 1.92e-07 GO:0005179 hormone activity
8.43 7.04e-07 GO:0008009 chemokine activity
7.60 2.83e-06 GO:0042379 chemokine receptor binding
29.82 1.47e-05 GO:0046870 cadmium ion binding
3.55 8.22e-05 GO:0005126 cytokine receptor binding
2.59 2.57e-04 GO:0030246 carbohydrate binding
3.30 1.66e-03 GO:0001664 G-protein-coupled receptor binding
3.38 2.09e-03 GO:0008083 growth factor activity
5.74 2.48e-03 GO:0005507 copper ion binding
6.24 3.48e-03 GO:0008307 structural constituent of muscle
10.53 4.37e-03 GO:0005212 structural constituent of eye lens
1.20 6.80e-03 GO:0005515 protein binding
3.73 7.42e-03 GO:0008201 heparin binding
4.62 7.56e-03 GO:0005200 structural constituent of cytoskeleton
17.04 1.44e-02 GO:0031432 titin binding
2.98 3.15e-02 GO:0001871 pattern binding
2.98 3.15e-02 GO:0030247 polysaccharide binding
3.02 4.48e-02 GO:0005539 glycosaminoglycan binding