Motif ID: PITX1..3.p2

Z-value: 6.404


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3



Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_73654028 11.733 NM_001163075
C17orf99
chromosome 17 open reading frame 99
chr12_-_116021473 10.763 NM_001168325
NM_017899
TESC

tescalcin

chr3_+_188222337 10.266 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr16_+_29597829 9.866 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr19_-_56585603 9.311 NM_001193623
LOC147646
hypothetical protein LOC147646
chr4_-_38710376 8.803 NM_024943
TMEM156
transmembrane protein 156
chr19_-_2036227 8.275 MOBKL2A
MOB1, Mps One Binder kinase activator-like 2A (yeast)
chr3_-_197726587 8.252 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr1_-_92144146 8.175 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr2_+_105834635 7.750 NM_001004720
NCK2
NCK adaptor protein 2
chr12_-_120220493 7.640 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chr16_+_65552600 7.353 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr1_-_24112345 7.316 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr19_+_17723285 7.159 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr19_+_16860807 7.036 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr19_-_53515143 6.953 NM_144577
CCDC114
coiled-coil domain containing 114
chr16_+_170334 6.934 NM_005331
HBQ1
hemoglobin, theta 1
chr19_+_16115454 6.917 HSH2D
hematopoietic SH2 domain containing
chr12_+_45896318 6.894 NM_138371
FAM113B
family with sequence similarity 113, member B
chr16_+_11966464 6.828 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr12_+_53178834 6.743 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr19_-_60241424 6.622 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr2_+_218992053 6.404 NM_007127
VIL1
villin 1
chr7_-_99518294 6.358 ZNF3
zinc finger protein 3
chr16_-_18705578 6.302


chr5_-_43029180 6.279 FLJ32255
hypothetical LOC643977
chr16_+_65918220 6.262 NM_018296
LRRC36
leucine rich repeat containing 36
chrX_+_9391314 6.244 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr16_+_30118036 6.200 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr19_+_52532210 6.177 NM_018485
GPR77
G protein-coupled receptor 77
chr9_+_263025 6.136 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr19_+_40465249 5.920 NM_021175
HAMP
hepcidin antimicrobial peptide
chr19_-_54093749 5.871 NM_003323
TULP2
tubby like protein 2
chrX_-_18600108 5.690 NM_000330
RS1
retinoschisin 1
chr17_-_78599695 5.640 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr4_-_40212670 5.565 NM_019027
RBM47
RNA binding motif protein 47
chr6_-_32268615 5.555 GPSM3
G-protein signaling modulator 3
chr13_+_49100435 5.527 NM_138450
ARL11
ADP-ribosylation factor-like 11
chr17_-_76897590 5.519 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr15_+_26876480 5.473


chr16_-_30301634 5.432 NM_052838
SEPT1
septin 1
chr12_-_55042793 5.026 NM_001638
APOF
apolipoprotein F
chr22_-_20314274 4.992 NM_001017964
YDJC
YdjC homolog (bacterial)
chr21_-_38415273 4.902 NM_005867
DSCR4
Down syndrome critical region gene 4
chr11_-_117718532 4.890 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr6_-_143874463 4.835 NM_032020
FUCA2
fucosidase, alpha-L- 2, plasma
chr4_+_73123712 4.811 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr2_+_38746555 4.810 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr16_+_29378694 4.700 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr6_-_31871530 4.646 NM_006295
VARS
valyl-tRNA synthetase
chr19_-_12858956 4.628 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr22_-_16080265 4.618 CECR1
cat eye syndrome chromosome region, candidate 1
chr20_-_43972061 4.574 PLTP
phospholipid transfer protein
chr16_+_29597965 4.550 QPRT
quinolinate phosphoribosyltransferase
chrX_-_70243362 4.503 NM_001025265
CXorf65
chromosome X open reading frame 65
chr5_-_10361167 4.395 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr16_+_29581783 4.353 NM_001030288
SPN
sialophorin
chr1_+_111573855 4.316 NM_001025199
CHI3L2
chitinase 3-like 2
chr19_-_13074513 4.310 LYL1
lymphoblastic leukemia derived sequence 1
chr15_+_89274413 4.306 NM_001039675
UNC45A
unc-45 homolog A (C. elegans)
chr22_-_20314366 4.179 YDJC
YdjC homolog (bacterial)
chr6_+_35812836 4.175 NM_145028
C6orf81
chromosome 6 open reading frame 81
chr14_-_62638336 4.175 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr1_-_149004916 4.134 NM_004079
CTSS
cathepsin S
chr19_-_56564068 4.112 NM_152353
CLDND2
claudin domain containing 2
chr20_+_35445350 4.103 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr16_-_28528780 4.097 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr19_+_951295 4.092 NM_138690
GRIN3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr10_-_7701619 4.073 NM_032817
ITIH5
inter-alpha (globulin) inhibitor H5
chr17_+_1612056 4.061 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_+_171238427 4.041 NM_014373
GPR160
G protein-coupled receptor 160
chr16_+_88511787 4.038 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr19_-_44386731 4.023 NM_001080468
SYCN
syncollin
chr16_+_32660135 4.022 LOC100289574
hect domain and RLD 2 pseudogene
chr19_-_44518465 4.012 GMFG
glia maturation factor, gamma
chr1_-_149004852 3.995 CTSS
cathepsin S
chr11_-_65070625 3.975 LTBP3
latent transforming growth factor beta binding protein 3
chr19_+_12064077 3.961 ZNF788
zinc finger family member 788
chr1_-_27825178 3.957 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr11_-_64520964 3.938 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr19_+_51059357 3.854 NM_004497
FOXA3
forkhead box A3
chr16_-_1862162 3.852 NM_001163560
C16orf73
chromosome 16 open reading frame 73
chr16_-_1862080 3.841 NM_152764
C16orf73
chromosome 16 open reading frame 73
chr18_+_2896178 3.800 EMILIN2
elastin microfibril interfacer 2
chr1_-_1701313 3.785 NM_001198994
NADK
NAD kinase
chr2_-_97016027 3.776 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr17_+_1612031 3.775 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr16_+_30391609 3.762


chr19_+_16860871 3.755 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr17_+_37957509 3.743 NM_000413
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chr7_+_821719 3.728 NM_001171946
SUN1
Sad1 and UNC84 domain containing 1
chr14_+_104267270 3.720 NM_199165
ADSSL1
adenylosuccinate synthase like 1
chr16_-_32106907 3.716 LOC100289574
hect domain and RLD 2 pseudogene
chr22_-_40666168 3.696 NM_001110215
CENPM
centromere protein M
chr19_-_5821546 3.679 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr3_-_52712639 3.677 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr17_-_59437782 3.677 NM_000873
ICAM2
intercellular adhesion molecule 2
chr7_+_73262188 3.672 LAT2
linker for activation of T cells family, member 2
chr22_+_20715340 3.670


chr19_+_4104593 3.657 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr9_+_131291144 3.647


chr1_-_149004879 3.612 CTSS
cathepsin S
chr20_+_309272 3.589 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr17_-_59818033 3.583 PECAM1
platelet/endothelial cell adhesion molecule
chr12_-_6611075 3.578 NM_001142961
LPAR5
lysophosphatidic acid receptor 5
chr19_-_17236522 3.576 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr17_+_1611983 3.540 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr16_+_43009 3.537 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr7_+_12595672 3.535 NM_033128
SCIN
scinderin
chr19_+_14412087 3.528 PKN1
protein kinase N1
chr19_+_14412080 3.508 NM_213560
PKN1
protein kinase N1
chr4_-_1185144 3.508 LOC100130872
hypothetical LOC100130872
chr12_-_52975777 3.497 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr7_+_73262283 3.486 LAT2
linker for activation of T cells family, member 2
chr19_+_14412052 3.463 PKN1
protein kinase N1
chr19_-_5790702 3.457 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr12_+_53177806 3.453 NCKAP1L
NCK-associated protein 1-like
chr16_-_28515868 3.452 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr7_+_5886952 3.449 NM_001097622
OCM
oncomodulin
chr19_+_55123770 3.448 NM_012068
ATF5
activating transcription factor 5
chr19_-_59019240 3.440 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr19_+_14554895 3.432 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr7_+_73262264 3.431 LAT2
linker for activation of T cells family, member 2
chr3_-_50350654 3.430 NM_170712
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr12_+_38306238 3.426 NM_001031748
C12orf40
chromosome 12 open reading frame 40
chr10_+_124885556 3.425 NM_001105574
HMX3
H6 family homeobox 3
chr6_-_73991895 3.416 NM_001126063
KHDC1L
KH homology domain containing 1-like
chr19_+_811615 3.412 CFD
complement factor D (adipsin)
chr12_+_53177789 3.412 NCKAP1L
NCK-associated protein 1-like
chr12_-_120219941 3.378 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr16_+_30391550 3.366 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr12_+_53177758 3.361 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr1_-_54861656 3.346 NM_176782
FAM151A
family with sequence similarity 151, member A
chr19_-_44518516 3.333 NM_004877
GMFG
glia maturation factor, gamma
chr1_+_6191506 3.327 RNF207
ring finger protein 207
chr1_-_28375722 3.326 NM_001164723
PTAFR
platelet-activating factor receptor
chr3_+_49481083 3.323 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr17_-_36938111 3.318 NM_002276
KRT19
keratin 19
chr17_+_7180571 3.308 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chrX_-_48101044 3.306 NM_021014
NM_175711
SSX3

synovial sarcoma, X breakpoint 3

chr1_+_16203317 3.297 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr3_-_9896933 3.285 CIDEC
cell death-inducing DFFA-like effector c
chr1_-_149611768 3.284 NM_003944
SELENBP1
selenium binding protein 1
chr16_+_19375272 3.282 NM_024780
TMC5
transmembrane channel-like 5
chr1_+_22107137 3.279 RPL21
ribosomal protein L21
chr16_-_2710552 3.275 NM_031948
PRSS27
protease, serine 27
chr12_-_52975823 3.269 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr15_-_20666684 3.268 LOC283683
hypothetical LOC283683
chrX_+_138060 3.264 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr19_+_59705824 3.245 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chrX_+_134803450 3.242 NM_018666
SAGE1
sarcoma antigen 1
chr12_-_107551694 3.238 SELPLG
selectin P ligand
chrX_+_55263515 3.237 NM_130467
NM_001013435
PAGE5

P antigen family, member 5 (prostate associated)

chr19_+_495026 3.229 NM_005317
GZMM
granzyme M (lymphocyte met-ase 1)
chr22_+_37747063 3.229 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr8_-_38127489 3.220 NM_000349
STAR
steroidogenic acute regulatory protein
chr12_-_107551744 3.212 SELPLG
selectin P ligand
chr8_-_101384633 3.209 NM_015435
RNF19A
ring finger protein 19A
chr22_-_22714230 3.171 NM_000853
GSTT1
glutathione S-transferase theta 1
chr16_-_4464600 3.171 NMRAL1
NmrA-like family domain containing 1
chr19_+_54583286 3.167 NM_144688
CCDC155
coiled-coil domain containing 155
chr21_+_29322100 3.151 USP16
ubiquitin specific peptidase 16
chr12_+_120132233 3.151 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr12_-_55929189 3.148


chr16_+_56286212 3.148 NM_032269
CCDC135
coiled-coil domain containing 135
chr19_+_50100843 3.147 NM_000041
APOE
apolipoprotein E
chr11_-_33870411 3.127 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr9_-_116196505 3.117 NM_030767
AKNA
AT-hook transcription factor
chr19_-_12807221 3.116 NM_031429
RTBDN
retbindin
chr6_-_26297282 3.114 NM_003539
HIST1H4D
histone cluster 1, H4d
chr19_-_18058632 3.105 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr16_-_30301357 3.091 SEPT1
septin 1
chr7_+_44045202 3.089 FLJ35390
hypothetical LOC255031
chr11_-_66961709 3.079 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr19_-_3431514 3.068 NM_001136503
C19orf77
chromosome 19 open reading frame 77
chr1_-_100003936 3.039 NM_001013660
FRRS1
ferric-chelate reductase 1
chr16_+_30391460 3.011 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr1_+_109450116 3.009


chr3_-_184316553 3.004 MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr19_-_1352474 2.985 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr1_+_40631603 2.978 NM_001198979
SMAP2
small ArfGAP2
chr7_+_138675644 2.970 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr6_-_31668476 2.964 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr6_-_3390197 2.953 NM_021945
SLC22A23
solute carrier family 22, member 23
chr1_+_28528099 2.953 NM_001127350
NM_017638
MED18

mediator complex subunit 18

chrX_-_119903553 2.950 NM_173571
NM_001080137
NM_001080138
NM_001080139
NM_001080141
NM_001080142
NM_001080143
NM_001080144
NM_001080145
NM_001080146
CT47A11
CT47A10
CT47A9
CT47A8
CT47A6
CT47A5
CT47A4
CT47A3
CT47A2
CT47A1
cancer/testis antigen family 47, member A11
cancer/testis antigen family 47, member A10
cancer/testis antigen family 47, member A9
cancer/testis antigen family 47, member A8
cancer/testis antigen family 47, member A6
cancer/testis antigen family 47, member A5
cancer/testis antigen family 47, member A4
cancer/testis antigen family 47, member A3
cancer/testis antigen family 47, member A2
cancer/testis antigen family 47, member A1
chr8_-_141537859 2.949 NM_031466
TRAPPC9
trafficking protein particle complex 9
chr19_+_10083196 2.930 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr10_-_69422391 2.925 HERC4
hect domain and RLD 4
chrX_-_119947318 2.913 NM_173571
NM_001080137
NM_001080138
NM_001080139
NM_001080141
NM_001080142
NM_001080143
NM_001080144
NM_001080145
NM_001080146
CT47A11
CT47A10
CT47A9
CT47A8
CT47A6
CT47A5
CT47A4
CT47A3
CT47A2
CT47A1
cancer/testis antigen family 47, member A11
cancer/testis antigen family 47, member A10
cancer/testis antigen family 47, member A9
cancer/testis antigen family 47, member A8
cancer/testis antigen family 47, member A6
cancer/testis antigen family 47, member A5
cancer/testis antigen family 47, member A4
cancer/testis antigen family 47, member A3
cancer/testis antigen family 47, member A2
cancer/testis antigen family 47, member A1
chr7_-_99518106 2.900


chr16_+_28850760 2.890 NM_001178098
NM_001770
CD19

CD19 molecule

chr16_-_28515195 2.887 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr11_-_118405288 2.875 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr19_+_17198012 2.859 NM_024578
OCEL1
occludin/ELL domain containing 1
chr5_+_171553780 2.847 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr2_+_38746742 2.834 GALM
galactose mutarotase (aldose 1-epimerase)
chr9_-_205892 2.815 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr16_-_4464896 2.800 NM_020677
NMRAL1
NmrA-like family domain containing 1
chr22_+_20350272 2.794 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2



Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.