Motif ID: ZBTB16.p2

Z-value: 2.596


Transcription factors associated with ZBTB16.p2:

Gene SymbolEntrez IDGene Name
ZBTB16 7704 zinc finger and BTB domain containing 16



Activity profile for motif ZBTB16.p2.

activity profile for motif ZBTB16.p2


Sorted Z-values histogram for motif ZBTB16.p2

Sorted Z-values for motif ZBTB16.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB16.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_53444733 5.578 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr2_+_161701711 4.687 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr12_-_51887318 3.788 ITGB7
integrin, beta 7
chr4_-_38460983 3.372 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr13_-_40454360 3.285 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_-_51887266 3.131 NM_000889
ITGB7
integrin, beta 7
chr13_-_98708549 3.112 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr12_+_14429499 3.014 ATF7IP
activating transcription factor 7 interacting protein
chr8_+_86287161 2.947 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chrX_-_23955223 2.946 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr1_+_173111306 2.893 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr19_-_53450953 2.838 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr3_+_188197029 2.750


chr2_+_201755865 2.733 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr1_+_196874867 2.671 PTPRC
protein tyrosine phosphatase, receptor type, C
chr9_+_263025 2.597 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr2_-_242205556 2.595 NM_001164356
THAP4
THAP domain containing 4
chr10_+_89257569 2.552 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr3_+_173954940 2.504 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr13_-_40454188 2.492 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_40491405 2.372 ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_+_53178834 2.363 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr9_-_116196505 2.358 NM_030767
AKNA
AT-hook transcription factor
chr7_-_26202626 2.342 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr7_-_33047042 2.290 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr13_-_98757634 2.245 NM_004951
GPR183
G protein-coupled receptor 183
chr10_-_64698831 2.238 NM_004241
JMJD1C
jumonji domain containing 1C
chr12_-_78831821 2.215 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr8_-_102029997 2.201 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_+_106293112 2.191 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_-_9777126 2.175 NM_172004
CLECL1
C-type lectin-like 1
chr19_+_14554895 2.165 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr3_-_186752952 2.149 NM_139248
LIPH
lipase, member H
chr14_+_69306019 2.133 SRSF5
serine/arginine-rich splicing factor 5
chr12_-_10453409 2.111 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr10_+_70517863 2.087 SRGN
serglycin
chr13_-_40491491 2.083 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr11_+_64950074 2.069 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr16_-_45562840 2.069 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr13_-_45654292 2.053 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_100003936 2.012 NM_001013660
FRRS1
ferric-chelate reductase 1
chr21_-_14840506 2.010 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr10_-_11614279 1.959 NM_001080491
USP6NL
USP6 N-terminal like
chr9_-_133602745 1.900 NM_005312
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr1_+_239762179 1.876 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_+_196874759 1.875 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr5_+_67622242 1.866 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr10_+_70517823 1.825 NM_002727
SRGN
serglycin
chr2_+_201833467 1.776 NM_033356
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr1_+_196874839 1.768 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_165565006 1.745 POU2F1
POU class 2 homeobox 1
chr10_-_69267774 1.738 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr12_+_121218218 1.737 NM_152759
LRRC43
leucine rich repeat containing 43
chr1_+_78243181 1.732 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr16_+_20682812 1.729 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr5_+_96237923 1.713 ERAP2
endoplasmic reticulum aminopeptidase 2
chr10_+_35524060 1.706 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr9_-_70780574 1.704


chr3_+_99733432 1.684 NM_005290
GPR15
G protein-coupled receptor 15
chr14_+_34583863 1.673 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr12_+_63510481 1.662


chr1_-_143708467 1.658 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr4_+_106851415 1.633 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr20_-_33783409 1.597 RBM39
RNA binding motif protein 39
chr3_-_152585226 1.573 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr21_+_29374743 1.568 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr14_-_19867372 1.567 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr13_-_48873735 1.542 NM_030925
CAB39L
calcium binding protein 39-like
chr6_-_33149244 1.535 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr2_+_183290912 1.518 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr4_-_38710376 1.507 NM_024943
TMEM156
transmembrane protein 156
chr10_+_97505398 1.495 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr11_+_64950402 1.488


chr12_-_25041639 1.474 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr5_-_75044001 1.471 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr20_+_56903595 1.466 GNAS
GNAS complex locus
chr12_+_12829807 1.465 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr2_-_232034638 1.460 NCL
nucleolin
chr14_+_69305265 1.455 SRSF5
serine/arginine-rich splicing factor 5
chr5_+_68703036 1.454 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr6_-_159386007 1.430 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr20_-_51633042 1.408 NM_006526
ZNF217
zinc finger protein 217
chr4_-_83566802 1.391 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr7_+_99263571 1.385 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr17_+_19917420 1.358 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr11_-_104332631 1.355 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chrX_-_153698930 1.353 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr2_+_24660849 1.344 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr4_+_74825138 1.338 NM_000584
IL8
interleukin 8
chr22_-_15682555 1.322 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr4_-_17415918 1.318 DCAF16
DDB1 and CUL4 associated factor 16
chr8_-_102005697 1.310 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chrX_+_12795111 1.302 NM_016562
TLR7
toll-like receptor 7
chr8_+_39890484 1.296 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr7_+_149895390 1.286 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr11_+_4965996 1.282 NM_021801
MMP26
matrix metallopeptidase 26
chr5_-_88155360 1.280 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr6_-_74284522 1.263 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr3_-_173723754 1.255 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr7_-_149960218 1.247 GIMAP6
GTPase, IMAP family member 6
chr19_-_1601246 1.237 NM_001136139
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr9_+_122923864 1.223 CEP110
centrosomal protein 110kDa
chr19_+_53450743 1.180


chr12_+_9713472 1.169 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr1_+_169549996 1.165 NM_002022
FMO4
flavin containing monooxygenase 4
chr17_-_64462976 1.163 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_-_184756101 1.160 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr17_-_26672757 1.154 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr6_+_105511615 1.152 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr3_-_17757402 1.149 NM_014744
TBC1D5
TBC1 domain family, member 5
chr1_+_76024466 1.147 NM_004582
RABGGTB
Rab geranylgeranyltransferase, beta subunit
chr19_-_56612653 1.145 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr6_+_147568795 1.142 STXBP5
syntaxin binding protein 5 (tomosyn)
chr11_+_70926718 1.139 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr1_+_53253161 1.131 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chrX_-_153903963 1.129 NM_000132
F8
coagulation factor VIII, procoagulant component
chr1_+_100099353 1.126 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr6_+_112775224 1.121 NM_001013734
RFPL4B
ret finger protein-like 4B
chr11_-_5212168 1.115 NM_000519
HBD
hemoglobin, delta
chr1_-_180624494 1.112 GLUL
glutamate-ammonia ligase
chr5_-_64813459 1.100 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr1_+_178232379 1.094 CEP350
centrosomal protein 350kDa
chr12_+_97513644 1.091 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr8_-_66863841 1.091 NM_002603
PDE7A
phosphodiesterase 7A
chr12_-_88573949 1.085 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr2_-_231697999 1.081 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr13_-_44812246 1.079 TPT1
tumor protein, translationally-controlled 1
chr8_-_95298706 1.061 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr2_-_44440358 1.051 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr7_-_124357272 1.034 NM_001042594
NM_015450
POT1

protection of telomeres 1 homolog (S. pombe)

chr11_+_65023218 1.027


chr16_+_80370400 1.027 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr3_+_32968069 1.025 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr4_-_47709717 1.023 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr17_+_63766874 1.022 NM_014960
ARSG
arylsulfatase G
chr6_-_88095714 1.017 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr7_-_124217978 1.014 NM_001024603
LOC154872
hypothetical protein LOC154872
chr1_-_204455269 1.013 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr2_-_207291364 1.011 NM_001093730
DYTN
dystrotelin
chr2_-_17563186 1.009 NM_001099218
RAD51AP2
RAD51 associated protein 2
chr13_-_40735619 1.008 NM_004294
MTRF1
mitochondrial translational release factor 1
chr6_+_26476384 1.007 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr4_-_77176163 0.999 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr4_+_39874921 0.981 NM_004310
RHOH
ras homolog gene family, member H
chr4_-_145159889 0.979 NM_002100
GYPB
glycophorin B (MNS blood group)
chr4_-_83566045 0.970


chr14_+_64947592 0.957 NM_178155
NM_178156
FUT8

fucosyltransferase 8 (alpha (1,6) fucosyltransferase)

chr1_+_51340487 0.954 NM_001136508
C1orf185
chromosome 1 open reading frame 185
chr7_-_142369519 0.950 KEL
Kell blood group, metallo-endopeptidase
chr8_+_7340777 0.942 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr9_+_104797413 0.941 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr19_-_45141473 0.941 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr7_-_92615593 0.940 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr10_-_32707549 0.936 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chrX_+_134803450 0.935 NM_018666
SAGE1
sarcoma antigen 1
chr4_-_100070808 0.930 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr3_-_143230124 0.928 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr1_+_53253204 0.927 SCP2
sterol carrier protein 2
chr7_+_129634935 0.927 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr22_+_20880112 0.926


chr1_-_167969802 0.922 NM_000450
SELE
selectin E
chr15_+_70193652 0.917 NM_001166340
SENP8
SUMO/sentrin specific peptidase family member 8
chr8_-_37916803 0.914 NM_152413
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr6_+_64344307 0.908 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_+_106292932 0.903 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr11_+_59920062 0.903 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr12_+_9871343 0.902 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr1_+_158975662 0.898 NM_021181
SLAMF7
SLAM family member 7
chr4_-_110942783 0.897 NM_000204
CFI
complement factor I
chr2_-_135498716 0.885 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr12_-_74191679 0.884 NM_007043
KRR1
KRR1, small subunit (SSU) processome component, homolog (yeast)
chr11_+_65023038 0.884 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr22_-_40666168 0.884 NM_001110215
CENPM
centromere protein M
chr15_+_64481270 0.874 MAP2K1
mitogen-activated protein kinase kinase 1
chr13_+_96672541 0.867 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr16_-_4464524 0.866 NMRAL1
NmrA-like family domain containing 1
chr3_-_47073910 0.865 SETD2
SET domain containing 2
chr13_-_32678142 0.859 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_-_10360873 0.854 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr14_+_87541220 0.851 NM_003608
GPR65
G protein-coupled receptor 65
chr1_+_20227480 0.849 PLA2G5
phospholipase A2, group V
chr2_+_170370290 0.847 SSB
Sjogren syndrome antigen B (autoantigen La)
chr7_-_104696678 0.846 NM_182691
SRPK2
SRSF protein kinase 2
chr6_+_42857540 0.845 KIAA0240
KIAA0240
chr12_+_25096755 0.844 LRMP
lymphoid-restricted membrane protein
chr5_-_156468614 0.843 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chr8_-_59575249 0.840 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr7_-_142369534 0.835 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr8_-_110411283 0.832 NM_001128211
NUDCD1
NudC domain containing 1
chr8_-_27997306 0.832 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr11_+_55554470 0.824 NM_001001921
OR5AS1
olfactory receptor, family 5, subfamily AS, member 1
chr21_+_30895276 0.824 NM_181620
KRTAP22-1
keratin associated protein 22-1
chr14_+_38772870 0.817 NM_054024
MIA2
melanoma inhibitory activity 2
chr8_+_23157094 0.816 NM_152272
CHMP7
CHMP family, member 7
chr1_-_244647333 0.811 NM_022743
SMYD3
SET and MYND domain containing 3
chr4_+_130236731 0.810 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr1_-_218329773 0.808 NM_006085
BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr1_-_89437098 0.807 NM_052941
GBP4
guanylate binding protein 4
chr5_+_171553780 0.801 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr8_-_81155564 0.800 NM_001025252
TPD52
tumor protein D52

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.84 4.39e-06 GO:0006955 immune response
1.62 8.30e-06 GO:0002376 immune system process
2.09 3.86e-05 GO:0007608 sensory perception of smell
1.98 1.00e-04 GO:0007606 sensory perception of chemical stimulus
1.76 1.75e-02 GO:0009607 response to biotic stimulus
1.57 2.60e-02 GO:0006952 defense response
1.81 4.37e-02 GO:0051707 response to other organism
1.16 4.37e-02 GO:0050896 response to stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.12 8.60e-06 GO:0004984 olfactory receptor activity
1.51 1.93e-02 GO:0004930 G-protein coupled receptor activity