Motif ID: HLF.p2

Z-value: 2.603


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor



Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113601608 7.008 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr9_+_116125123 4.472 NM_000607
ORM1
orosomucoid 1
chr2_+_113601616 4.452 IL1RN
interleukin 1 receptor antagonist
chr9_+_116131889 3.816 NM_000608
ORM2
orosomucoid 2
chr1_-_177106702 3.487 NM_004673
ANGPTL1
angiopoietin-like 1
chr16_+_70654625 3.225 NM_020995
HPR
haptoglobin-related protein
chr16_+_55963899 3.052 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr1_+_149221122 3.011 NM_003568
ANXA9
annexin A9
chr9_-_129752687 2.926 NM_203305
FAM102A
family with sequence similarity 102, member A
chr1_-_62557655 2.923 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr6_-_30151526 2.888 NM_170769
NM_025236
RNF39

ring finger protein 39

chr3_-_49701085 2.857 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr1_-_228916486 2.846 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr16_+_70646008 2.844 NM_001126102
NM_005143
HP

haptoglobin

chr10_-_52315436 2.801 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr17_-_31352643 2.777 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr2_-_113310796 2.774 NM_000576
IL1B
interleukin 1, beta
chr3_-_12561962 2.770 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr12_-_28016182 2.746 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr22_+_49272078 2.655 NM_017584
MIOX
myo-inositol oxygenase
chr9_+_676640 2.653


chr19_+_40465249 2.612 NM_021175
HAMP
hepcidin antimicrobial peptide
chr3_+_120984246 2.604 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr2_-_73723001 2.601 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr17_-_31352720 2.585 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr3_-_121883647 2.558 HGD
homogentisate 1,2-dioxygenase
chr8_-_145187553 2.374 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr1_-_228916470 2.362 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_+_187917791 2.099 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr10_-_95350949 2.017 NM_006744
RBP4
retinol binding protein 4, plasma
chr8_+_124264054 2.001 FAM83A
family with sequence similarity 83, member A
chr14_+_20493467 1.977 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr10_-_82039158 1.949 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_-_228916559 1.920 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr5_-_138746840 1.888 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr3_+_187813538 1.879 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr4_+_187424336 1.878 F11
coagulation factor XI
chr13_-_45577144 1.863 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr6_+_32003180 1.859 NM_000063
NM_001145903
C2

complement component 2

chr17_-_36346240 1.838 KRT23
keratin 23 (histone deacetylase inducible)
chr1_-_62557559 1.832 KANK4
KN motif and ankyrin repeat domains 4
chr8_+_124263932 1.809 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_-_32344192 1.790 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr17_-_17426416 1.712 PEMT
phosphatidylethanolamine N-methyltransferase
chr6_+_32003380 1.686 C2
complement component 2
chr9_+_102987137 1.679 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr11_-_66431910 1.597 NM_022172
PC
pyruvate carboxylase
chr5_+_73145098 1.587 RGNEF
190 kDa guanine nucleotide exchange factor
chr14_-_69333624 1.583 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr5_-_138746917 1.579 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr2_+_65517316 1.531 FLJ16124
FLJ16124 protein
chr3_+_187813553 1.491 AHSG
alpha-2-HS-glycoprotein
chr11_-_116168316 1.469 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr17_-_31353196 1.465 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr18_+_54039779 1.411 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_-_87989291 1.397 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr3_+_46591048 1.391 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr20_+_41621079 1.380 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr17_-_17426469 1.378 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr6_+_131936057 1.367 NM_000045
ARG1
arginase, liver
chr6_-_2785682 1.363 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr1_+_239762179 1.354 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr22_+_23309717 1.350 NM_013430
GGT1
gamma-glutamyltransferase 1
chr20_+_61842880 1.328 SLC2A4RG
SLC2A4 regulator
chr16_-_54424517 1.320 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr10_+_70650064 1.319 NM_025130
HKDC1
hexokinase domain containing 1
chr12_-_51132129 1.313 NM_005555
KRT6B
keratin 6B
chr2_-_31491102 1.308 NM_000379
XDH
xanthine dehydrogenase
chr19_-_52308848 1.307 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr11_+_93394025 1.298 NM_001098672
HEPHL1
hephaestin-like 1
chr10_+_85994788 1.282 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr9_+_674193 1.280


chr19_+_50663089 1.278 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr10_+_89257569 1.275 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr12_-_1791146 1.263 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr1_+_205328834 1.250 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr12_-_121767272 1.250 NM_006018
GPR109B
G protein-coupled receptor 109B
chr17_-_38978772 1.246 NM_001986
ETV4
ets variant 4
chr2_+_108360798 1.238 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr2_-_31491057 1.233 XDH
xanthine dehydrogenase
chr16_-_54424473 1.203 CES1
carboxylesterase 1
chr19_-_4491078 1.202 LRG1
leucine-rich alpha-2-glycoprotein 1
chr1_-_202449659 1.152 NM_198447
GOLT1A
golgi transport 1A
chr9_-_98421894 1.140 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr22_+_33792125 1.127 NM_001008494
ISX
intestine-specific homeobox
chr3_-_172227152 1.124 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr9_-_106705867 1.115 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr20_+_43531806 1.113 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr4_-_77147625 1.107 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr20_+_31613800 1.100 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr20_+_41621119 1.095 SGK2
serum/glucocorticoid regulated kinase 2
chr11_+_76516957 1.093 NM_000260
NM_001127179
NM_001127180
MYO7A


myosin VIIA


chr6_-_64087806 1.088 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr3_+_63928459 1.070 NM_001128149
ATXN7
ataxin 7
chr18_+_54039730 1.069 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_+_161980865 1.069 NM_006593
TBR1
T-box, brain, 1
chr11_+_62893836 1.060 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr11_+_65023038 1.042 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr6_-_24491498 1.036 NM_001195610
DCDC2
doublecortin domain containing 2
chr17_+_11442472 1.034 NM_001372
DNAH9
dynein, axonemal, heavy chain 9
chr6_-_30188845 1.031 NM_007028
TRIM31
tripartite motif containing 31
chr12_-_120591938 1.028 NM_173855
MORN3
MORN repeat containing 3
chr3_+_123526700 1.021 NM_005213
CSTA
cystatin A (stefin A)
chr17_-_71352017 1.001 UNC13D
unc-13 homolog D (C. elegans)
chr14_+_95740916 0.997 BDKRB2
bradykinin receptor B2
chr9_-_94338072 0.982 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr20_+_54533191 0.977 NM_001012971
C20orf106
C20orf107
chromosome 20 open reading frame 106
chromosome 20 open reading frame 107
chrX_+_9391314 0.969 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr2_+_3683660 0.967 NM_018436
ALLC
allantoicase
chr19_-_4491024 0.949 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr10_+_114123765 0.947 ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_+_30391550 0.943 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr12_-_4624536 0.925 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr11_-_76862197 0.921 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr4_+_39084867 0.918 NM_175737
KLB
klotho beta
chr14_+_102458745 0.918 NM_030943
AMN
amnionless homolog (mouse)
chr14_-_94053933 0.908 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr19_-_411995 0.903 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr17_-_53849888 0.886 RNF43
ring finger protein 43
chr2_+_219453487 0.864 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr19_-_56147971 0.852 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr13_+_96726415 0.851 MBNL2
muscleblind-like 2 (Drosophila)
chr20_+_16676997 0.851 NM_020157
OTOR
otoraplin
chr17_-_53849929 0.849 NM_017763
RNF43
ring finger protein 43
chr8_-_101384633 0.846 NM_015435
RNF19A
ring finger protein 19A
chr2_+_161981046 0.834 TBR1
T-box, brain, 1
chr14_-_23754977 0.821 NM_138476
MDP1
magnesium-dependent phosphatase 1
chr3_-_172227223 0.813 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chrX_-_13744933 0.801 GPM6B
glycoprotein M6B
chr20_+_58064360 0.792 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr16_+_30391460 0.791 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr4_-_23500706 0.790 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr14_+_23633101 0.788 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr2_+_64540843 0.780 HSPC159
galectin-related protein
chr11_-_102081654 0.767 NM_022122
MMP27
matrix metallopeptidase 27
chr16_+_30391609 0.765


chr6_+_37511383 0.764


chr3_+_187813405 0.762 AHSG
alpha-2-HS-glycoprotein
chr5_+_140227951 0.753 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr3_-_58175437 0.750 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr2_-_110319828 0.745 NPHP1
nephronophthisis 1 (juvenile)
chr15_+_60838053 0.741 TLN2
talin 2
chr2_-_98646367 0.734 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr20_+_2030527 0.719 NM_080836
STK35
serine/threonine kinase 35
chr14_-_22354457 0.709 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr16_-_66614599 0.683 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr8_-_6722848 0.682 NM_005218
DEFB1
defensin, beta 1
chr21_-_42060266 0.671 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr7_+_45899621 0.662


chr5_-_42847716 0.661 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr8_+_21972804 0.653 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr18_+_54039818 0.653 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_176205970 0.650 SEC16B
SEC16 homolog B (S. cerevisiae)
chr11_+_28086373 0.647 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr1_+_152644471 0.644 IL6R
interleukin 6 receptor
chr6_+_17501589 0.642 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr12_+_16391342 0.641 NM_145792
MGST1
microsomal glutathione S-transferase 1
chr14_+_74964261 0.640 NM_001135047
JDP2
Jun dimerization protein 2
chr14_-_21074875 0.635 NM_005407
SALL2
sal-like 2 (Drosophila)
chr1_-_228916958 0.633 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_-_101077605 0.632 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr12_-_121753795 0.630 NM_177551
GPR109A
G protein-coupled receptor 109A
chr18_+_59705918 0.630 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr14_+_59785723 0.629 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr7_+_80145461 0.622 CD36
CD36 molecule (thrombospondin receptor)
chr14_+_31868229 0.621 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_32206029 0.617 NM_022110
FKBPL
FK506 binding protein like
chr12_-_115803614 0.615 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr2_+_228386800 0.615 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr16_+_51690564 0.612 CHD9
chromodomain helicase DNA binding protein 9
chr11_-_28086277 0.607 NM_031217
KIF18A
kinesin family member 18A
chr17_-_61655915 0.605 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr14_-_22354389 0.601 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr5_+_150380173 0.600 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr17_-_75427644 0.596 NM_003655
CBX4
chromobox homolog 4
chr3_-_150422474 0.591 NM_000096
CP
ceruloplasmin (ferroxidase)
chr14_+_59785703 0.586 NM_021003
NM_177951
PPM1A

protein phosphatase, Mg2+/Mn2+ dependent, 1A

chr6_+_150731720 0.584 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr20_+_23290844 0.584 GZF1
GDNF-inducible zinc finger protein 1
chr20_+_47328575 0.577 NCRNA00275
non-protein coding RNA 275
chr2_+_218954995 0.576 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr16_+_9093035 0.556 NM_014117
C16orf72
chromosome 16 open reading frame 72
chrX_+_52944586 0.555 NM_014138
FAM156A
family with sequence similarity 156, member A
chrX_-_15530112 0.554 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr11_-_64403712 0.553 EHD1
EH-domain containing 1
chr17_+_39280041 0.547 NM_001168322
NM_001168323
NM_001168324
NM_145273
CD300LG



CD300 molecule-like family member g



chr14_-_49399317 0.547 RN7SL2
RNA, 7SL, cytoplasmic 2
chr11_-_6418705 0.540 NM_000613
HPX
hemopexin
chr2_+_160180049 0.534 LOC643072
hypothetical LOC643072
chr16_-_66614621 0.532 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr17_-_77824849 0.532 NM_001893
NM_139062
CSNK1D

casein kinase 1, delta

chr18_+_75967902 0.517 NM_014913
ADNP2
ADNP homeobox 2
chr16_+_66614645 0.517 NM_017803
DUS2L
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
chr19_-_59295882 0.516 NM_130771
NM_133168
NM_133169
NM_206818
OSCAR



osteoclast associated, immunoglobulin-like receptor



chr20_+_4614796 0.513 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr17_-_38530935 0.512 NM_007297
NM_007299
NM_007294
NM_007300
BRCA1



breast cancer 1, early onset



chr2_+_161981138 0.511 TBR1
T-box, brain, 1
chr6_-_56515640 0.509


chr5_-_79982584 0.509 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chr6_+_26312758 0.508 NM_003545
HIST1H4E
histone cluster 1, H4e

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.65 8.41e-03 GO:0006954 inflammatory response
1.83 1.59e-02 GO:0009611 response to wounding
1.83 3.81e-02 GO:0006952 defense response
1.44 3.87e-02 GO:0006950 response to stress

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.88 1.94e-03 GO:0005615 extracellular space
7.63 6.54e-03 GO:0034364 high-density lipoprotein particle
5.98 1.19e-02 GO:0032994 protein-lipid complex
5.98 1.19e-02 GO:0034358 plasma lipoprotein particle
1.66 1.68e-02 GO:0044421 extracellular region part

Nothing significant found in function category.