Motif ID: NKX2-1,4.p2

Z-value: 2.439


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4



Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_11966464 6.244 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_+_78087484 5.014 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr21_-_14840506 4.958 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_-_6621078 4.510 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr5_-_88155360 4.490 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_+_180836050 3.583


chrX_-_154216929 3.438 NM_001289
CLIC2
chloride intracellular channel 2
chr19_-_6621598 3.347 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr1_+_159817752 3.108 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_+_161701711 3.002 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr1_-_143706196 2.733 PDE4DIP
phosphodiesterase 4D interacting protein
chr15_-_81271859 2.706 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr1_+_32489426 2.668 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr1_+_159899528 2.643 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr10_-_11614279 2.392 NM_001080491
USP6NL
USP6 N-terminal like
chr2_-_100125402 2.290 NM_002285
AFF3
AF4/FMR2 family, member 3
chr21_+_37714470 2.184 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chrX_+_48427103 2.052 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_+_59979857 2.000 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr3_-_143230124 1.948 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr1_-_143706265 1.941 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_143706300 1.936 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr16_+_56567839 1.935 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr4_+_111053488 1.917 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr3_+_190831909 1.848 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr2_+_38009405 1.817 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr19_-_60458915 1.796 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr11_-_16380967 1.770 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr2_-_242205556 1.745 NM_001164356
THAP4
THAP domain containing 4
chr14_+_38772870 1.630 NM_054024
MIA2
melanoma inhibitory activity 2
chr6_-_119137923 1.589 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr12_+_54700955 1.580 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr19_-_51979838 1.565 NM_001145145
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr12_-_51887266 1.559 NM_000889
ITGB7
integrin, beta 7
chr12_-_119733062 1.533 SPPL3
signal peptide peptidase 3
chr6_-_11887265 1.506 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr16_-_69876262 1.492 FTSJD1
FtsJ methyltransferase domain containing 1
chr11_+_22646229 1.424 NM_177553
GAS2
growth arrest-specific 2
chr7_+_129634935 1.421 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr1_-_178100204 1.405


chr2_+_161980865 1.397 NM_006593
TBR1
T-box, brain, 1
chr6_+_152053323 1.375 NM_001122742
ESR1
estrogen receptor 1
chr7_+_50318801 1.359 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr19_+_45797413 1.338 LTBP4
latent transforming growth factor beta binding protein 4
chr11_+_118259684 1.329 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr4_+_90252990 1.293 NM_145715
TIGD2
tigger transposable element derived 2
chr3_-_120761092 1.247 NM_005191
CD80
CD80 molecule
chr5_-_88004891 1.234 LOC645323
hypothetical LOC645323
chr1_-_158948176 1.223 NM_001778
CD48
CD48 molecule
chr12_-_53064565 1.217 ZNF385A
zinc finger protein 385A
chr17_+_7846636 1.210 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr1_-_41398126 1.159 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr2_+_143603368 1.147 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr3_+_46386636 1.130 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr18_+_70317548 1.086 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr10_-_49152918 1.044 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr2_+_143603439 1.035 ARHGAP15
Rho GTPase activating protein 15
chr1_-_158815850 1.023 CD84
CD84 molecule
chr13_+_110637173 1.001 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chrX_+_48427137 0.999 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_-_53761119 0.981 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr2_-_37727472 0.977 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr14_+_75058518 0.961 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr6_-_32268267 0.957 GPSM3
G-protein signaling modulator 3
chr2_-_37397669 0.950 NM_005813
PRKD3
protein kinase D3
chr14_+_63752424 0.939 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr17_-_5078773 0.934 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr9_+_114671635 0.929 SNX30
sorting nexin family member 30
chr17_+_63338500 0.926 BPTF
bromodomain PHD finger transcription factor
chr2_+_28469275 0.923 NM_005253
FOSL2
FOS-like antigen 2
chr5_-_131907071 0.922 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr2_-_88946767 0.916


chr1_-_158815895 0.900 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr2_+_28469172 0.878 FOSL2
FOS-like antigen 2
chr6_+_35373632 0.874 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr13_-_98757634 0.865 NM_004951
GPR183
G protein-coupled receptor 183
chr2_+_102401580 0.855 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr15_+_40481879 0.842 NM_173088
CAPN3
calpain 3, (p94)
chr19_-_50688310 0.836 NM_206901
RTN2
reticulon 2
chr8_+_9990471 0.832 NM_001135671
MSRA
methionine sulfoxide reductase A
chr3_-_180460372 0.830 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr20_+_4650499 0.811 NM_012409
PRND
prion protein 2 (dublet)
chr12_-_51887318 0.805 ITGB7
integrin, beta 7
chr6_-_149847809 0.804 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr1_+_38033666 0.794 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr7_-_104696678 0.774 NM_182691
SRPK2
SRSF protein kinase 2
chr10_-_75005421 0.767 NM_152586
USP54
ubiquitin specific peptidase 54
chr12_+_25096755 0.767 LRMP
lymphoid-restricted membrane protein
chrX_-_137649180 0.763 NM_033642
FGF13
fibroblast growth factor 13
chr12_-_101115677 0.758 NM_002674
PMCH
pro-melanin-concentrating hormone
chr12_-_53064723 0.755 NM_015481
ZNF385A
zinc finger protein 385A
chr8_+_77928372 0.750 ZFHX4
zinc finger homeobox 4
chr2_+_28469199 0.745 FOSL2
FOS-like antigen 2
chr12_+_15590552 0.744 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr1_-_158883666 0.737 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr5_-_39306465 0.725 FYB
FYN binding protein
chr17_-_53335748 0.720 NM_017949
CUEDC1
CUE domain containing 1
chr8_-_30826074 0.720 NM_031271
TEX15
testis expressed 15
chr12_+_54132264 0.716 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chrX_-_48655978 0.714 PIM2
pim-2 oncogene
chr3_-_17757402 0.707 NM_014744
TBC1D5
TBC1 domain family, member 5
chr4_+_166350620 0.707 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr12_+_108310906 0.706 NM_001101421
MYO1H
myosin IH
chr6_-_149847718 0.706 ZC3H12D
zinc finger CCCH-type containing 12D
chr15_+_38437703 0.700 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr19_+_16691786 0.697 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr12_+_130004404 0.691 NM_198827
GPR133
G protein-coupled receptor 133
chr4_+_102954005 0.689 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr6_+_126282078 0.685 NCOA7
nuclear receptor coactivator 7
chrX_+_41468351 0.672 NM_080817
GPR82
G protein-coupled receptor 82
chr2_-_38379031 0.665 ATL2
atlastin GTPase 2
chr1_+_196874867 0.658 PTPRC
protein tyrosine phosphatase, receptor type, C
chr11_+_118463906 0.652 NM_001024382
HMBS
hydroxymethylbilane synthase
chr4_-_123761615 0.642 NM_021803
IL21
interleukin 21
chr8_+_7742811 0.625 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr12_+_117067214 0.625 PEBP1
phosphatidylethanolamine binding protein 1
chr10_-_32707549 0.620 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr6_-_88917600 0.613 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chr10_+_114125003 0.591 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_156013487 0.586 NM_030764
FCRL2
Fc receptor-like 2
chr17_+_65009986 0.585 MAP2K6
mitogen-activated protein kinase kinase 6
chr9_-_124329392 0.583 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr1_+_169747788 0.581 PRRC2C
proline-rich coiled-coil 2C
chr10_-_104201234 0.578 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr17_-_64462976 0.576 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_+_38238080 0.575 OXSR1
oxidative-stress responsive 1
chrX_+_48529905 0.565 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr1_+_146827470 0.564 NM_173638
NBPF15
neuroblastoma breakpoint family, member 15
chr9_-_99740243 0.562 NM_197978
HEMGN
hemogen
chrX_+_70682204 0.562 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr10_+_86121526 0.558 FAM190B
family with sequence similarity 190, member B
chr2_-_175170674 0.555 WIPF1
WAS/WASL interacting protein family, member 1
chr13_-_74799898 0.552 TBC1D4
TBC1 domain family, member 4
chr1_-_21310462 0.547 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr10_-_76538859 0.543 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr12_-_52980914 0.543 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr8_-_7207899 0.540 NM_001164457
ZNF705G
zinc finger protein 705G
chr10_-_6144119 0.534 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr1_+_196874759 0.533 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr12_+_111900650 0.532 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr20_-_33706532 0.530 RBM12
RNA binding motif protein 12
chr12_-_110410730 0.530 ATXN2
ataxin 2
chrX_+_49480643 0.530 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr21_-_35343065 0.523 RUNX1
runt-related transcription factor 1
chr1_+_40977092 0.522 NFYC
nuclear transcription factor Y, gamma
chr14_-_20694023 0.520 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr20_-_42561725 0.518


chr5_-_142795269 0.514 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr17_-_3407780 0.513 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr5_-_156468614 0.512 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chrX_-_131989963 0.506 NM_031907
USP26
ubiquitin specific peptidase 26
chr6_-_2696152 0.505 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr14_+_75058591 0.504 BATF
basic leucine zipper transcription factor, ATF-like
chr3_+_188397967 0.500 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr13_+_45174446 0.496 NM_152719
SPERT
spermatid associated
chr6_+_88021644 0.496 ZNF292
zinc finger protein 292
chr6_+_26476384 0.487 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr17_+_7900926 0.487


chr16_+_29982941 0.485 ALDOA
aldolase A, fructose-bisphosphate
chr6_+_88024152 0.471 ZNF292
zinc finger protein 292
chr4_-_185963859 0.470 ACSL1
acyl-CoA synthetase long-chain family member 1
chr12_-_10853940 0.470 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr11_+_61732715 0.466 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr4_-_186969041 0.461 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr14_-_94669547 0.457 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr19_-_53950458 0.452 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr7_-_16471817 0.448 NM_015464
SOSTDC1
sclerostin domain containing 1
chr11_+_61279436 0.440 NM_013279
C11orf9
chromosome 11 open reading frame 9
chrX_-_110542040 0.439 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr3_-_48646282 0.439 NM_001040454
SLC26A6
solute carrier family 26, member 6
chr5_-_88235624 0.439 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr16_+_31446703 0.437 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr4_-_176970407 0.432 GPM6A
glycoprotein M6A
chr4_-_176970372 0.432 GPM6A
glycoprotein M6A
chr15_-_48192804 0.431 ATP8B4
ATPase, class I, type 8B, member 4
chr21_+_29322100 0.431 USP16
ubiquitin specific peptidase 16
chr19_-_60360768 0.424 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr19_-_11549508 0.423 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr19_+_43847049 0.422


chr2_+_105320440 0.415 NM_024093
C2orf49
chromosome 2 open reading frame 49
chr8_+_74369647 0.405 NM_172037
RDH10
retinol dehydrogenase 10 (all-trans)
chr6_-_11219932 0.404 NM_207582
ERVFRDE1
HERV-FRD provirus ancestral Env polyprotein
chrX_-_48101044 0.404 NM_021014
NM_175711
SSX3

synovial sarcoma, X breakpoint 3

chr3_-_57209319 0.403 NM_003865
HESX1
HESX homeobox 1
chr6_+_30212488 0.403 NM_138700
TRIM40
tripartite motif containing 40
chr10_+_70650064 0.401 NM_025130
HKDC1
hexokinase domain containing 1
chr17_+_20048890 0.401 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chrX_+_119622570 0.396 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr8_-_59575249 0.395 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr1_-_9052207 0.394 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr4_-_46086150 0.391 NM_001114175
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr20_+_56455866 0.388 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_-_42574116 0.376 NM_001198850
FOXJ3
forkhead box J3
chr4_+_130236731 0.374 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr2_-_157890400 0.374 NM_020711
ERMN
ermin, ERM-like protein
chr17_-_31353196 0.370 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr21_+_37713076 0.369 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr7_-_7724762 0.358 NM_002947
RPA3
replication protein A3, 14kDa
chr4_-_186969202 0.355 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr20_+_32926452 0.353 ACSS2
acyl-CoA synthetase short-chain family member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.67 6.54e-03 GO:0046649 lymphocyte activation

Nothing significant found in compartment category.

Nothing significant found in function category.