Motif ID: EGR1..3.p2

Z-value: 1.880


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3



Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_29725311 2.972 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr16_+_29725597 2.196


chr16_-_53520208 2.128 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr22_+_38183262 2.005 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr16_+_29725665 1.785


chrX_-_152592450 1.729 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr2_+_181553333 1.687 NM_182678
NM_006357
UBE2E3

ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)

chr16_+_88305743 1.566 LOC100128881
hypothetical LOC100128881
chr7_-_150283794 1.439 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr9_+_130491370 1.410 SET
SET nuclear oncogene
chr9_-_122679387 1.380 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr1_-_51198328 1.379 FAF1
Fas (TNFRSF6) associated factor 1
chr1_+_65763978 1.338 LEPR
leptin receptor
chr1_+_65763945 1.272 NM_001198687
NM_001198688
NM_001198689
LEPR


leptin receptor


chr1_+_224317030 1.252 H3F3A
H3 histone, family 3A
chr6_-_85530617 1.249 NM_001080508
TBX18
T-box 18
chr20_-_61600834 1.228 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr19_+_540849 1.213 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr14_-_60022487 1.213 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr1_+_224317056 1.211 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr17_+_63252704 1.210 BPTF
bromodomain PHD finger transcription factor
chr1_-_51198506 1.202 NM_007051
FAF1
Fas (TNFRSF6) associated factor 1
chr14_-_64416307 1.190 SPTB
spectrin, beta, erythrocytic
chr19_-_3737382 1.170 NM_139354
NM_139355
MATK

megakaryocyte-associated tyrosine kinase

chr9_+_130491340 1.151 SET
SET nuclear oncogene
chr17_+_77582774 1.151 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr2_+_102602579 1.145 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr16_+_1143241 1.133 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr17_+_63252668 1.123 BPTF
bromodomain PHD finger transcription factor
chr1_-_31154023 1.119 NM_014654
SDC3
syndecan 3
chr1_+_224317036 1.117 NM_002107
H3F3A
H3 histone, family 3A
chr9_-_100510657 1.110 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chrX_-_48699702 1.107 OTUD5
OTU domain containing 5
chr14_-_104705753 1.094 JAG2
jagged 2
chr22_-_20551937 1.090 MAPK1
mitogen-activated protein kinase 1
chr10_+_134893766 1.087 NM_003577
UTF1
undifferentiated embryonic cell transcription factor 1
chr7_+_128257698 1.082 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr22_+_38183480 1.068 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr1_-_51198417 1.066 FAF1
Fas (TNFRSF6) associated factor 1
chr4_-_25473528 1.064 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr22_-_20551722 1.061 MAPK1
mitogen-activated protein kinase 1
chr22_+_20101661 1.061 NM_015094
HIC2
hypermethylated in cancer 2
chr2_+_181553783 1.057 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr14_-_104706159 1.054 NM_002226
NM_145159
JAG2

jagged 2

chr2_+_181553613 1.039 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chrX_-_152591936 1.034 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr1_+_41022066 1.033 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr1_+_224317044 1.026 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chrX_-_48699797 1.014 NM_001136157
NM_001136158
NM_017602
OTUD5


OTU domain containing 5


chr22_+_18081968 1.010 NM_002688
SEPT5
septin 5
chr6_-_79844618 1.008 PHIP
pleckstrin homology domain interacting protein
chr1_+_224317062 0.993 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr5_+_176493233 0.991 NM_022455
NSD1
nuclear receptor binding SET domain protein 1
chr1_+_42920946 0.990 YBX1
Y box binding protein 1
chr20_-_30636535 0.985 LOC284804
hypothetical protein LOC284804
chr16_-_695719 0.980 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr21_-_39642712 0.953 HMGN1
high-mobility group nucleosome binding domain 1
chr9_-_122679283 0.948 PHF19
PHD finger protein 19
chr1_-_54644566 0.946 NM_018070
NM_145716
SSBP3

single stranded DNA binding protein 3

chr5_+_176493488 0.945 NSD1
nuclear receptor binding SET domain protein 1
chr14_+_106009489 0.930 NCRNA00221
non-protein coding RNA 221
chr9_+_130491644 0.921 SET
SET nuclear oncogene
chr19_+_40451720 0.915 NM_003367
NM_207291
USF2

upstream transcription factor 2, c-fos interacting

chr20_-_49592444 0.911 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr9_+_130491668 0.907 SET
SET nuclear oncogene
chr16_-_1862162 0.904 NM_001163560
C16orf73
chromosome 16 open reading frame 73
chr1_-_38243716 0.891 FHL3
four and a half LIM domains 3
chr1_-_51198383 0.890 FAF1
Fas (TNFRSF6) associated factor 1
chr1_-_40027097 0.887 BMP8B
bone morphogenetic protein 8b
chr1_-_51198052 0.884 FAF1
Fas (TNFRSF6) associated factor 1
chr6_-_79844503 0.884 PHIP
pleckstrin homology domain interacting protein
chr19_+_7834124 0.880 EVI5L
ecotropic viral integration site 5-like
chr18_-_51406359 0.879 TCF4
transcription factor 4
chr17_-_44010543 0.876 NM_024015
HOXB4
homeobox B4
chr1_-_40026718 0.867 BMP8B
bone morphogenetic protein 8b
chr6_-_79844606 0.848 PHIP
pleckstrin homology domain interacting protein
chr6_+_143423738 0.847 AIG1
androgen-induced 1
chr1_-_38243747 0.845 NM_004468
FHL3
four and a half LIM domains 3
chr9_+_130491291 0.842 NM_003011
SET
SET nuclear oncogene
chr8_+_15442100 0.836 NM_006765
NM_178234
TUSC3

tumor suppressor candidate 3

chr22_-_18807805 0.836 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr16_-_1862080 0.832 NM_152764
C16orf73
chromosome 16 open reading frame 73
chr1_+_32992131 0.831


chr19_+_34995290 0.827 NM_057182
CCNE1
cyclin E1
chr4_+_2031036 0.826 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr6_+_79844267 0.825 PHIP
pleckstrin homology domain interacting protein
chr6_+_84799969 0.825 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr19_+_45799060 0.825 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chr11_-_64302564 0.821 SF1
splicing factor 1
chr22_+_18091065 0.821 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr11_-_32413486 0.820 WT1
Wilms tumor 1
chr19_-_6375782 0.819 KHSRP
KH-type splicing regulatory protein
chr4_+_995395 0.818 FGFRL1
fibroblast growth factor receptor-like 1
chr12_+_119562737 0.813 NM_001033677
CABP1
calcium binding protein 1
chr2_+_181554048 0.812 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr3_-_50515857 0.810 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr6_-_84197573 0.810 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_+_99389318 0.809 POU3F2
POU class 3 homeobox 2
chr19_-_6375820 0.804 NM_003685
KHSRP
KH-type splicing regulatory protein
chr3_+_14964080 0.801 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr17_+_63252087 0.801 NM_004459
NM_182641
BPTF

bromodomain PHD finger transcription factor

chrX_+_152606945 0.791 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr7_-_100331417 0.791 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr21_-_39642935 0.788 HMGN1
high-mobility group nucleosome binding domain 1
chr9_-_139027435 0.787 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr1_-_54644663 0.786 NM_001009955
SSBP3
single stranded DNA binding protein 3
chr1_-_6218576 0.786 ICMT
isoprenylcysteine carboxyl methyltransferase
chr4_+_995609 0.783 NM_001004356
NM_001004358
FGFRL1

fibroblast growth factor receptor-like 1

chr19_-_772966 0.783 LPPR3
lipid phosphate phosphatase-related protein type 3
chr12_+_46133 0.781 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr19_-_56260135 0.781 NM_015596
KLK13
kallikrein-related peptidase 13
chr19_+_1704661 0.781 NM_001080488
ONECUT3
one cut homeobox 3
chr19_-_772913 0.778 NM_024888
LPPR3
lipid phosphate phosphatase-related protein type 3
chr10_+_45189617 0.773 NM_000698
ALOX5
arachidonate 5-lipoxygenase
chr5_-_10814341 0.767 DAP
death-associated protein
chr17_-_44058612 0.764 NM_024017
HOXB9
homeobox B9
chr1_-_21375939 0.764 NM_001198801
NM_001198802
EIF4G3

eukaryotic translation initiation factor 4 gamma, 3

chr12_+_50586958 0.760 ACVRL1
activin A receptor type II-like 1
chr5_-_10814344 0.756 NM_004394
DAP
death-associated protein
chr1_+_69806543 0.755


chr19_+_659766 0.754 NM_001040134
NM_002579
PALM

paralemmin

chr3_-_187025438 0.754 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr4_+_996251 0.754 NM_021923
FGFRL1
fibroblast growth factor receptor-like 1
chr6_+_34312906 0.752 HMGA1
high mobility group AT-hook 1
chr6_+_99389300 0.750 NM_005604
POU3F2
POU class 3 homeobox 2
chrX_-_48700032 0.750 OTUD5
OTU domain containing 5
chrX_-_47364173 0.747 NM_006950
NM_133499
SYN1

synapsin I

chr10_-_74925653 0.742 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr3_-_187025501 0.740 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr1_-_149214063 0.738 NM_022075
NM_181746
LASS2

LAG1 homolog, ceramide synthase 2

chr3_-_45242808 0.737 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr10_-_74925753 0.732 NM_001142353
NM_001142354
NM_021132
PPP3CB


protein phosphatase 3, catalytic subunit, beta isozyme


chr11_-_63770716 0.731 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr7_+_154720547 0.730 INSIG1
insulin induced gene 1
chr19_+_60487578 0.730 BRSK1
BR serine/threonine kinase 1
chr6_-_15356865 0.729


chr6_+_135544170 0.729 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_-_15723279 0.719 CASP9
caspase 9, apoptosis-related cysteine peptidase
chr1_-_1812353 0.718 NM_002074
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr18_+_12397894 0.716 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr7_+_116380790 0.716 ST7
suppression of tumorigenicity 7
chr14_+_28306633 0.713 FOXG1
forkhead box G1
chr6_+_143423723 0.708 AIG1
androgen-induced 1
chr6_+_135544138 0.706 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr2_-_100305626 0.703 NM_198461
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr1_+_35507145 0.703 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr6_+_143423656 0.702 NM_016108
AIG1
androgen-induced 1
chr13_-_107317460 0.702 NM_001080396
FAM155A
family with sequence similarity 155, member A
chr7_+_64975596 0.702 NM_173517
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr16_+_1299180 0.698 NM_194261
UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr11_-_64302440 0.696 SF1
splicing factor 1
chr11_-_32413635 0.693 NM_000378
NM_024424
NM_024426
WT1


Wilms tumor 1


chr7_+_106472243 0.692 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr3_-_24511456 0.690 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr10_+_69314714 0.687 SIRT1
sirtuin 1
chr21_-_39642808 0.686 HMGN1
high-mobility group nucleosome binding domain 1
chr4_+_134292630 0.680 PCDH10
protocadherin 10
chr15_-_99847109 0.679 PCSK6
proprotein convertase subtilisin/kexin type 6
chrX_-_135161185 0.678 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr19_+_4920126 0.676 KDM4B
lysine (K)-specific demethylase 4B
chr1_+_69806617 0.673 LRRC7
leucine rich repeat containing 7
chr10_-_74925724 0.672 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr20_-_49592654 0.664 NM_012340
NM_173091
NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

chr11_-_64302509 0.662 NM_001178030
SF1
splicing factor 1
chr4_-_38342824 0.661 FLJ13197
hypothetical FLJ13197
chr1_+_246087230 0.657 TRIM58
tripartite motif containing 58
chr22_-_20551953 0.649 NM_002745
NM_138957
MAPK1

mitogen-activated protein kinase 1

chr7_-_140270749 0.647 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr12_+_129388543 0.646 PIWIL1
piwi-like 1 (Drosophila)
chr16_-_27982277 0.646 NM_001109763
GSG1L
GSG1-like
chr22_-_18384251 0.643 NM_001670
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr10_-_17536181 0.639 NM_001004470
ST8SIA6
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr7_-_151764004 0.635 NM_170606
MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr19_-_3737279 0.635 MATK
megakaryocyte-associated tyrosine kinase
chr5_-_10814179 0.631 DAP
death-associated protein
chr19_+_3536541 0.630 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr9_+_133259330 0.626 PRRC2B
proline-rich coiled-coil 2B
chr1_-_164402575 0.626 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr7_-_151763857 0.622 MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr14_-_68515701 0.620 ACTN1
actinin, alpha 1
chr7_-_156125876 0.619 C7orf13
chromosome 7 open reading frame 13
chr16_+_82559600 0.617 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr3_+_185515543 0.615 NM_182917
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr1_-_38046433 0.614 YRDC
yrdC domain containing (E. coli)
chr11_-_64268841 0.613 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr9_+_115678365 0.613 NM_133374
ZNF618
zinc finger protein 618
chr14_+_28305922 0.611 NM_005249
FOXG1
forkhead box G1
chr20_-_538909 0.609 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr7_-_526005 0.607 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr2_-_174537021 0.607 NM_001017371
SP3
Sp3 transcription factor
chr11_+_46359878 0.606 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr9_+_138726737 0.604 NM_152421
FAM69B
family with sequence similarity 69, member B
chr7_+_156126157 0.604 NM_030936
NM_001184996
RNF32

ring finger protein 32

chr11_-_63770840 0.603 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_-_6375804 0.603 KHSRP
KH-type splicing regulatory protein
chrX_-_47364039 0.597


chr13_+_99432258 0.595 NM_007129
ZIC2
Zic family member 2 (odd-paired homolog, Drosophila)
chr16_+_1299361 0.594 NM_194260
UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr1_-_21375891 0.591 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr6_+_76367944 0.590 SENP6
SUMO1/sentrin specific peptidase 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 2.05e-23 GO:0044260 cellular macromolecule metabolic process
1.23 1.29e-21 GO:0044237 cellular metabolic process
1.12 9.33e-19 GO:0009987 cellular process
1.25 2.89e-17 GO:0043170 macromolecule metabolic process
1.20 6.14e-16 GO:0044238 primary metabolic process
2.06 5.03e-15 GO:0016568 chromatin modification
1.35 2.69e-14 GO:0010468 regulation of gene expression
1.17 3.20e-14 GO:0008152 metabolic process
1.30 6.56e-14 GO:0060255 regulation of macromolecule metabolic process
1.18 6.81e-14 GO:0050794 regulation of cellular process
1.17 2.11e-13 GO:0050789 regulation of biological process
1.28 2.55e-13 GO:0031323 regulation of cellular metabolic process
1.26 4.45e-13 GO:0019222 regulation of metabolic process
1.32 1.08e-12 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.15 2.30e-12 GO:0065007 biological regulation
1.33 5.54e-12 GO:0044267 cellular protein metabolic process
1.33 9.34e-12 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.56 1.06e-11 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.33 1.33e-11 GO:0010556 regulation of macromolecule biosynthetic process
1.26 2.21e-11 GO:0080090 regulation of primary metabolic process
1.34 2.68e-11 GO:0051252 regulation of RNA metabolic process
1.79 9.63e-11 GO:0006325 chromatin organization
1.37 1.50e-10 GO:0006464 protein modification process
1.30 1.56e-10 GO:0009889 regulation of biosynthetic process
1.27 2.76e-10 GO:0034641 cellular nitrogen compound metabolic process
1.36 3.75e-10 GO:0043412 macromolecule modification
1.30 4.41e-10 GO:0071842 cellular component organization at cellular level
1.29 5.37e-10 GO:0031326 regulation of cellular biosynthetic process
1.38 5.89e-10 GO:0016070 RNA metabolic process
1.26 6.23e-10 GO:0006807 nitrogen compound metabolic process
1.66 7.04e-10 GO:0051276 chromosome organization
1.32 2.80e-09 GO:0090304 nucleic acid metabolic process
1.38 3.91e-09 GO:0006996 organelle organization
1.28 4.30e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.32 7.04e-09 GO:0006355 regulation of transcription, DNA-dependent
1.28 7.87e-09 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.17 1.51e-08 GO:0016569 covalent chromatin modification
1.59 2.52e-08 GO:0051254 positive regulation of RNA metabolic process
1.25 2.52e-08 GO:0019538 protein metabolic process
1.58 3.44e-08 GO:0010628 positive regulation of gene expression
1.43 5.11e-08 GO:0010604 positive regulation of macromolecule metabolic process
2.15 5.24e-08 GO:0016570 histone modification
1.26 6.42e-08 GO:0051171 regulation of nitrogen compound metabolic process
1.54 1.50e-07 GO:0010557 positive regulation of macromolecule biosynthetic process
1.49 1.54e-07 GO:0006351 transcription, DNA-dependent
1.29 3.81e-07 GO:0048523 negative regulation of cellular process
1.39 4.89e-07 GO:0009893 positive regulation of metabolic process
1.48 5.38e-07 GO:0009891 positive regulation of biosynthetic process
1.57 5.85e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.58 7.22e-07 GO:0010629 negative regulation of gene expression
1.40 1.03e-06 GO:0031325 positive regulation of cellular metabolic process
1.50 1.45e-06 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.49 1.45e-06 GO:0051173 positive regulation of nitrogen compound metabolic process
1.47 1.54e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.27 1.55e-06 GO:0048519 negative regulation of biological process
2.41 2.93e-06 GO:0040029 regulation of gene expression, epigenetic
1.30 4.50e-06 GO:0010467 gene expression
1.21 6.03e-06 GO:0016043 cellular component organization
1.20 1.91e-05 GO:0071840 cellular component organization or biogenesis
1.40 2.82e-05 GO:0032774 RNA biosynthetic process
1.24 4.60e-05 GO:0048522 positive regulation of cellular process
1.29 4.76e-05 GO:0034645 cellular macromolecule biosynthetic process
1.31 5.26e-05 GO:0007399 nervous system development
1.85 5.42e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.22 6.49e-05 GO:0048518 positive regulation of biological process
1.29 9.72e-05 GO:0009059 macromolecule biosynthetic process
1.49 1.05e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.47 1.11e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.22 1.33e-04 GO:0009058 biosynthetic process
1.23 1.48e-04 GO:0044249 cellular biosynthetic process
2.57 1.69e-04 GO:0016458 gene silencing
1.52 1.90e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.45 1.94e-04 GO:0009890 negative regulation of biosynthetic process
1.47 1.98e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
2.35 1.99e-04 GO:0018205 peptidyl-lysine modification
1.51 2.41e-04 GO:0051253 negative regulation of RNA metabolic process
1.63 2.83e-04 GO:0018193 peptidyl-amino acid modification
1.38 4.84e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.31 5.53e-04 GO:0051641 cellular localization
1.36 8.25e-04 GO:0009892 negative regulation of metabolic process
1.33 9.41e-04 GO:0051649 establishment of localization in cell
1.36 1.29e-03 GO:0022008 neurogenesis
1.51 1.30e-03 GO:0019226 transmission of nerve impulse
1.51 1.30e-03 GO:0035637 multicellular organismal signaling
2.36 1.44e-03 GO:0006473 protein acetylation
1.51 1.62e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.41 2.67e-03 GO:0018394 peptidyl-lysine acetylation
2.37 4.03e-03 GO:0006475 internal protein amino acid acetylation
2.40 4.31e-03 GO:0016573 histone acetylation
1.51 4.60e-03 GO:0007268 synaptic transmission
1.43 5.08e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 5.43e-03 GO:0048699 generation of neurons
1.38 5.62e-03 GO:0016192 vesicle-mediated transport
1.35 5.74e-03 GO:0031324 negative regulation of cellular metabolic process
1.46 5.89e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.37 6.50e-03 GO:0018393 internal peptidyl-lysine acetylation
1.25 6.78e-03 GO:0023051 regulation of signaling
1.32 6.83e-03 GO:0032268 regulation of cellular protein metabolic process
1.42 6.90e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
2.17 7.37e-03 GO:0043543 protein acylation
1.82 7.49e-03 GO:0006417 regulation of translation
1.62 9.57e-03 GO:0010608 posttranscriptional regulation of gene expression
1.17 9.78e-03 GO:0051234 establishment of localization
1.56 1.05e-02 GO:0009259 ribonucleotide metabolic process
1.17 1.10e-02 GO:0006810 transport
1.15 1.13e-02 GO:0032502 developmental process
2.70 1.29e-02 GO:0031047 gene silencing by RNA
1.15 1.30e-02 GO:0051179 localization
1.51 1.30e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
4.63 1.33e-02 GO:0045815 positive regulation of gene expression, epigenetic
1.31 1.47e-02 GO:0006793 phosphorus metabolic process
1.31 1.47e-02 GO:0006796 phosphate metabolic process
1.32 2.32e-02 GO:0048468 cell development
1.55 2.35e-02 GO:0009150 purine ribonucleotide metabolic process
1.42 2.60e-02 GO:0016071 mRNA metabolic process
1.15 3.34e-02 GO:0007275 multicellular organismal development
1.35 3.38e-02 GO:0006468 protein phosphorylation
1.37 3.79e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.28 4.09e-02 GO:0051246 regulation of protein metabolic process
3.34 4.49e-02 GO:0018107 peptidyl-threonine phosphorylation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 4.99e-45 GO:0044424 intracellular part
1.16 2.04e-43 GO:0005622 intracellular
1.19 1.46e-35 GO:0043226 organelle
1.18 6.67e-35 GO:0043229 intracellular organelle
1.20 1.03e-33 GO:0043227 membrane-bounded organelle
1.20 1.91e-33 GO:0043231 intracellular membrane-bounded organelle
1.30 1.66e-31 GO:0005634 nucleus
1.44 1.52e-20 GO:0044428 nuclear part
1.17 4.46e-20 GO:0005737 cytoplasm
1.47 3.30e-19 GO:0031981 nuclear lumen
1.22 1.43e-17 GO:0044446 intracellular organelle part
1.22 1.59e-16 GO:0044422 organelle part
1.38 2.62e-15 GO:0070013 intracellular organelle lumen
1.36 1.21e-14 GO:0031974 membrane-enclosed lumen
1.36 1.32e-14 GO:0043233 organelle lumen
1.05 1.91e-14 GO:0044464 cell part
1.05 2.08e-14 GO:0005623 cell
1.49 5.40e-14 GO:0005654 nucleoplasm
1.28 1.00e-11 GO:0043234 protein complex
1.17 1.41e-11 GO:0044444 cytoplasmic part
1.25 2.73e-11 GO:0032991 macromolecular complex
1.31 7.42e-09 GO:0005829 cytosol
1.54 9.17e-09 GO:0044451 nucleoplasm part
2.63 1.18e-08 GO:0016585 chromatin remodeling complex
1.58 4.31e-05 GO:0045202 synapse
1.28 5.02e-05 GO:0012505 endomembrane system
1.60 8.78e-05 GO:0048471 perinuclear region of cytoplasm
4.00 9.84e-05 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.20 1.28e-04 GO:0043228 non-membrane-bounded organelle
1.20 1.28e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.39 1.64e-04 GO:0031982 vesicle
2.62 1.85e-04 GO:0035770 RNA granule
1.37 5.06e-04 GO:0031410 cytoplasmic vesicle
1.42 8.80e-04 GO:0030054 cell junction
1.37 1.33e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.57 1.41e-03 GO:0044433 cytoplasmic vesicle part
1.36 2.02e-03 GO:0031988 membrane-bounded vesicle
3.43 2.06e-03 GO:0070603 SWI/SNF-type complex
1.20 2.83e-03 GO:0031090 organelle membrane
1.61 4.13e-03 GO:0005667 transcription factor complex
1.59 4.80e-03 GO:0030659 cytoplasmic vesicle membrane
1.38 6.37e-03 GO:0044431 Golgi apparatus part
1.39 7.44e-03 GO:0005694 chromosome
2.82 8.29e-03 GO:0000932 cytoplasmic mRNA processing body
1.69 8.66e-03 GO:0031252 cell leading edge
1.46 9.38e-03 GO:0043005 neuron projection
1.55 1.03e-02 GO:0012506 vesicle membrane
1.70 1.98e-02 GO:0030136 clathrin-coated vesicle
1.50 2.65e-02 GO:0044456 synapse part
1.87 4.16e-02 GO:0019717 synaptosome
1.60 4.30e-02 GO:0030135 coated vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.25 7.55e-34 GO:0005515 protein binding
1.12 2.47e-25 GO:0005488 binding
1.31 5.17e-17 GO:0003676 nucleic acid binding
1.57 4.71e-14 GO:0030528 transcription regulator activity
1.34 2.20e-12 GO:0000166 nucleotide binding
1.32 2.13e-11 GO:0003677 DNA binding
1.45 2.70e-08 GO:0001071 nucleic acid binding transcription factor activity
1.45 2.70e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.71 2.80e-07 GO:0000988 protein binding transcription factor activity
1.71 2.80e-07 GO:0000989 transcription factor binding transcription factor activity
1.70 4.88e-07 GO:0003712 transcription cofactor activity
1.28 3.55e-06 GO:0032553 ribonucleotide binding
1.28 3.55e-06 GO:0032555 purine ribonucleotide binding
1.45 3.93e-06 GO:0016301 kinase activity
1.43 5.28e-06 GO:0003723 RNA binding
1.27 5.39e-06 GO:0017076 purine nucleotide binding
1.61 6.22e-06 GO:0004674 protein serine/threonine kinase activity
1.48 6.97e-06 GO:0043565 sequence-specific DNA binding
1.71 7.07e-06 GO:0016563 transcription activator activity
1.92 8.82e-06 GO:0003682 chromatin binding
1.28 1.25e-05 GO:0016740 transferase activity
1.40 1.28e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.27 1.31e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.42 7.58e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.46 1.13e-04 GO:0004672 protein kinase activity
1.26 8.88e-04 GO:0032559 adenyl ribonucleotide binding
1.73 1.05e-03 GO:0003924 GTPase activity
1.25 1.13e-03 GO:0030554 adenyl nucleotide binding
1.87 1.65e-03 GO:0003714 transcription corepressor activity
1.48 2.16e-03 GO:0019904 protein domain specific binding
1.58 2.49e-03 GO:0016564 transcription repressor activity
1.58 2.98e-03 GO:0008134 transcription factor binding
1.21 3.46e-03 GO:0008270 zinc ion binding
1.24 4.74e-03 GO:0005524 ATP binding
1.13 1.13e-02 GO:0046872 metal ion binding
1.63 1.38e-02 GO:0003713 transcription coactivator activity
1.13 1.45e-02 GO:0043167 ion binding
1.13 1.83e-02 GO:0043169 cation binding
2.11 1.95e-02 GO:0042393 histone binding
1.10 2.55e-02 GO:0003824 catalytic activity
1.57 2.57e-02 GO:0003702 RNA polymerase II transcription factor activity
2.65 4.18e-02 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
1.31 4.30e-02 GO:0019899 enzyme binding