Motif ID: NANOG.p2

Z-value: 0.889


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox



Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_-_39189369 1.649 MKL1
megakaryoblastic leukemia (translocation) 1
chr6_+_34314545 1.598 NM_145905
HMGA1
high mobility group AT-hook 1
chr1_+_165565006 1.454 POU2F1
POU class 2 homeobox 1
chr2_+_17861266 1.453 NM_001105569
MSGN1
mesogenin 1
chr1_+_165564904 1.398 NM_001198783
POU2F1
POU class 2 homeobox 1
chr10_+_11246934 1.326 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr7_+_50318801 1.285 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr2_+_157822355 1.265 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr3_-_57209319 1.253 NM_003865
HESX1
HESX homeobox 1
chr11_-_58736897 1.224 NM_001039396
MPEG1
macrophage expressed 1
chr1_+_196874839 1.182 PTPRC
protein tyrosine phosphatase, receptor type, C
chr3_+_161040439 1.166 SCHIP1
schwannomin interacting protein 1
chr7_-_13992351 1.157 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chrX_+_134482212 1.145 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr12_+_25096755 1.129 LRMP
lymphoid-restricted membrane protein
chr1_+_196874759 1.095 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr12_+_25096472 1.072 NM_006152
LRMP
lymphoid-restricted membrane protein
chr14_+_77939845 1.048 NM_004796
NRXN3
neurexin 3
chr15_+_56217686 1.009 NM_020980
AQP9
aquaporin 9
chr2_-_144994038 1.002 ZEB2
zinc finger E-box binding homeobox 2
chr12_+_45896511 0.998 FAM113B
family with sequence similarity 113, member B
chr11_-_83071084 0.974 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr3_+_161040343 0.963 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr6_-_32605898 0.927 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr7_+_113853790 0.877 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr12_-_69434330 0.866 PTPRR
protein tyrosine phosphatase, receptor type, R
chr19_+_40632456 0.859 NM_005306
FFAR2
free fatty acid receptor 2
chr5_+_169713458 0.848 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr3_+_123279439 0.833 NM_006889
CD86
CD86 molecule
chr2_+_108604111 0.832 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_-_161614962 0.826 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr1_+_180836050 0.815


chr7_-_92686773 0.797 NM_198151
HEPACAM2
HEPACAM family member 2
chr10_+_82290554 0.779 NM_001145719
SH2D4B
SH2 domain containing 4B
chr15_+_38849450 0.775 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr12_-_15005761 0.759 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr11_-_110755112 0.754 POU2AF1
POU class 2 associating factor 1
chr7_+_63411813 0.748 ZNF736
zinc finger protein 736
chr7_-_25234582 0.747 NM_022150
NPVF
neuropeptide VF precursor
chr7_+_128802719 0.745 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr10_-_13789628 0.738 FRMD4A
FERM domain containing 4A
chr6_+_88026338 0.728 ZNF292
zinc finger protein 292
chrX_+_134482387 0.723 DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr7_-_107930170 0.720 PNPLA8
patatin-like phospholipase domain containing 8
chr18_+_19826734 0.713 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr19_-_46504831 0.713


chr6_-_32665409 0.712 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr2_+_170742900 0.698 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr15_-_91078307 0.677 FAM174B
family with sequence similarity 174, member B
chr4_+_71806538 0.651 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr13_+_108079570 0.647 NM_001198950
MYO16
myosin XVI
chr1_-_153109349 0.640 NM_002249
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr22_+_38652555 0.633 GRAP2
GRB2-related adaptor protein 2
chr8_-_40874485 0.633 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr12_+_45896318 0.629 NM_138371
FAM113B
family with sequence similarity 113, member B
chr1_-_30977931 0.621 LAPTM5
lysosomal protein transmembrane 5
chr1_+_50348052 0.600 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr17_-_39094787 0.592 NM_001040002
MEOX1
mesenchyme homeobox 1
chrX_-_135690699 0.591 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr7_+_18501876 0.591 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chrX_-_19727828 0.588 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr2_-_68952006 0.588 NM_014482
BMP10
bone morphogenetic protein 10
chr6_+_34312633 0.585 HMGA1
high mobility group AT-hook 1
chr13_-_98708549 0.578 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr11_+_59979857 0.576 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr11_-_56951628 0.567 NM_017611
SLC43A3
solute carrier family 43, member 3
chr1_-_50661716 0.558 NM_032110
DMRTA2
DMRT-like family A2
chr13_-_40491405 0.556 ELF1
E74-like factor 1 (ets domain transcription factor)
chr17_-_1195096 0.554 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr11_-_118405288 0.548 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr20_+_36365965 0.546 NM_001725
BPI
bactericidal/permeability-increasing protein
chr2_+_169465995 0.543 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr3_+_35696119 0.542 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr12_-_107551783 0.536 NM_003006
SELPLG
selectin P ligand
chr5_-_169657395 0.534 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr9_-_14076901 0.529 NFIB
nuclear factor I/B
chrX_-_19727775 0.523 SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_242283129 0.522 NM_006352
ZNF238
zinc finger protein 238
chr12_-_101398451 0.521 IGF1
insulin-like growth factor 1 (somatomedin C)
chr16_+_51690564 0.503 CHD9
chromodomain helicase DNA binding protein 9
chr15_-_75259714 0.503 PEAK1
NKF3 kinase family member
chr6_+_34312625 0.499 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr7_+_116447527 0.492 ST7
suppression of tumorigenicity 7
chr5_+_137701122 0.479 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr11_+_10433241 0.472 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr11_-_128217550 0.470 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr2_+_161980865 0.466 NM_006593
TBR1
T-box, brain, 1
chr4_+_174688183 0.461 NBLA00301
Nbla00301
chr8_+_67201684 0.459 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr13_-_40454188 0.452 ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_-_107551744 0.451 SELPLG
selectin P ligand
chr16_+_28797309 0.449 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chrX_+_41191630 0.449 NM_022567
NYX
nyctalopin
chr3_-_122862391 0.448 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_+_52105131 0.444 AMHR2
anti-Mullerian hormone receptor, type II
chr12_-_55614311 0.442 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr1_+_158636987 0.441 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr4_-_174687931 0.439 NM_021973
HAND2
heart and neural crest derivatives expressed 2
chr7_+_94135384 0.438 PEG10
paternally expressed 10
chr3_-_180467483 0.437 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr12_+_79634820 0.437 NM_005593
MYF5
myogenic factor 5
chr21_-_38415273 0.436 NM_005867
DSCR4
Down syndrome critical region gene 4
chr21_-_35343331 0.434 RUNX1
runt-related transcription factor 1
chr12_-_101398429 0.432 IGF1
insulin-like growth factor 1 (somatomedin C)
chr17_-_44010543 0.424 NM_024015
HOXB4
homeobox B4
chr12_-_101398470 0.423 IGF1
insulin-like growth factor 1 (somatomedin C)
chr7_-_92615593 0.418 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr18_+_59726183 0.416 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr6_+_32713160 0.415 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr18_+_18989786 0.415 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr12_-_101398503 0.409 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr12_-_51065629 0.408 NM_033045
KRT84
keratin 84
chr12_-_101398288 0.407 IGF1
insulin-like growth factor 1 (somatomedin C)
chr21_-_35343428 0.406 RUNX1
runt-related transcription factor 1
chr5_+_76470829 0.405


chr10_+_49279647 0.405 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr6_+_34312906 0.401 HMGA1
high mobility group AT-hook 1
chr3_+_123385219 0.401 NM_000388
CASR
calcium-sensing receptor
chr3_-_122862447 0.400 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_+_154386358 0.399 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chrX_+_66705407 0.396 NM_001011645
AR
androgen receptor
chr5_-_88215034 0.395 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr4_-_123761615 0.393 NM_021803
IL21
interleukin 21
chr10_+_70517863 0.393 SRGN
serglycin
chr13_-_40491491 0.389 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_+_34312641 0.388 HMGA1
high mobility group AT-hook 1
chr21_-_35343065 0.386 RUNX1
runt-related transcription factor 1
chr17_-_37590910 0.386 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr18_+_13601664 0.380 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr7_+_18502342 0.377 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr21_-_35343448 0.372 RUNX1
runt-related transcription factor 1
chr11_+_65164167 0.370 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr3_-_102522093 0.368 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr6_+_44076281 0.366 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr6_+_34312979 0.363 HMGA1
high mobility group AT-hook 1
chr1_+_196874867 0.362 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_-_149004852 0.358 CTSS
cathepsin S
chr10_+_11247243 0.357 CELF2
CUGBP, Elav-like family member 2
chr19_-_51829778 0.356 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr10_+_11247467 0.356 CELF2
CUGBP, Elav-like family member 2
chr10_-_21475493 0.353 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr10_-_48036698 0.349 NM_016204
GDF2
growth differentiation factor 2
chr1_+_50347188 0.342 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr13_-_83354474 0.340 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr6_-_136888771 0.340 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr12_-_14024187 0.340 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr13_+_48923688 0.336 NM_001160308
SETDB2
SET domain, bifurcated 2
chr3_+_69895651 0.336 NM_006722
MITF
microphthalmia-associated transcription factor
chr21_-_35343456 0.335 NM_001754
RUNX1
runt-related transcription factor 1
chr13_+_47948586 0.334 RB1
retinoblastoma 1
chr2_+_161981046 0.333 TBR1
T-box, brain, 1
chr4_+_169250281 0.329 NM_007193
ANXA10
annexin A10
chr15_-_53349775 0.327 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr21_-_35343500 0.325 RUNX1
runt-related transcription factor 1
chr22_+_20715340 0.322


chrX_-_137649180 0.322 NM_033642
FGF13
fibroblast growth factor 13
chr17_-_36181927 0.320 NM_181539
KRT26
keratin 26
chr8_-_86477585 0.319 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr17_-_10393664 0.318 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr20_+_2224612 0.314 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr13_-_83354425 0.313 SLITRK1
SLIT and NTRK-like family, member 1
chr7_+_129771865 0.309 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr11_+_123986661 0.304 NM_052959
PANX3
pannexin 3
chr4_-_57242492 0.303 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr3_-_145049853 0.302 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr2_-_55090759 0.302 NM_007008
RTN4
reticulon 4
chr5_-_169657312 0.301 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr7_+_128795280 0.299 AHCYL2
adenosylhomocysteinase-like 2
chr11_-_57173823 0.299 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr10_+_11247419 0.297 CELF2
CUGBP, Elav-like family member 2
chr14_-_56342097 0.297 NM_172337
OTX2
orthodenticle homeobox 2
chr11_-_123799976 0.292 NM_001005196
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chrX_+_135397790 0.291 NM_001727
BRS3
bombesin-like receptor 3
chr2_+_161981138 0.290 TBR1
T-box, brain, 1
chr7_+_128795178 0.289 NM_001130723
AHCYL2
adenosylhomocysteinase-like 2
chr12_-_16652202 0.289 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr15_+_64481270 0.288 MAP2K1
mitogen-activated protein kinase kinase 1
chr8_-_102029997 0.287 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr11_-_17147863 0.285 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr12_+_79625538 0.285 NM_002469
MYF6
myogenic factor 6 (herculin)
chr6_+_135544214 0.284 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr12_-_120725210 0.278 LOC338799
hypothetical LOC338799
chr12_-_51457371 0.277 NM_015848
KRT76
keratin 76
chr11_-_33870411 0.277 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_-_149004916 0.274 NM_004079
CTSS
cathepsin S
chrX_+_110252960 0.271 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr5_+_156628929 0.271 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr5_-_169657192 0.269 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_26343139 0.269 NM_005320
HIST1H1D
histone cluster 1, H1d
chr17_+_4795128 0.269 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr14_+_69307914 0.269 SRSF5
serine/arginine-rich splicing factor 5
chr5_+_176494690 0.268 NSD1
nuclear receptor binding SET domain protein 1
chr1_-_116185215 0.263 NM_005599
NHLH2
nescient helix loop helix 2
chr7_-_112513379 0.262 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr4_-_176971175 0.256 NM_201591
GPM6A
glycoprotein M6A
chr1_-_158098962 0.255 NM_001013661
VSIG8
V-set and immunoglobulin domain containing 8
chr3_+_2528272 0.255 CNTN4
contactin 4
chr3_-_120861959 0.253 NM_022135
POPDC2
popeye domain containing 2
chr7_-_99555399 0.253 NM_001190415
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr12_-_52281050 0.251 NM_001130059
ATF7
activating transcription factor 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.45 5.65e-10 GO:0032501 multicellular organismal process
1.76 5.84e-06 GO:0003008 system process
1.44 3.15e-05 GO:0032502 developmental process
1.43 2.26e-04 GO:0007275 multicellular organismal development
1.46 2.27e-04 GO:0048856 anatomical structure development
1.62 3.82e-04 GO:0048513 organ development
1.73 6.55e-04 GO:0050877 neurological system process
1.46 1.24e-03 GO:0048731 system development
2.03 2.92e-03 GO:0045595 regulation of cell differentiation
1.79 1.87e-02 GO:0050793 regulation of developmental process
3.34 2.31e-02 GO:0001503 ossification
1.48 2.64e-02 GO:0030154 cell differentiation
2.35 3.44e-02 GO:0045597 positive regulation of cell differentiation
2.13 3.89e-02 GO:0051094 positive regulation of developmental process
5.61 4.12e-02 GO:0051149 positive regulation of muscle cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 1.38e-04 GO:0071944 cell periphery
1.34 2.68e-04 GO:0005886 plasma membrane
8.90 4.28e-02 GO:0042613 MHC class II protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.84 2.92e-04 GO:0001071 nucleic acid binding transcription factor activity
1.84 2.92e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.92 3.29e-03 GO:0043565 sequence-specific DNA binding