Motif ID: TP53.p2

Z-value: 1.654


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53



Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_62151216 1.973 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr19_+_17766907 1.443 NM_014256
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr1_-_38185291 1.431 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr19_+_17766935 1.315 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr19_-_47438583 1.270 GSK3A
glycogen synthase kinase 3 alpha
chr1_-_38185307 1.260 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr19_+_17766609 1.225 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr1_-_38185312 1.212 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr3_-_44494160 1.209 NM_181489
ZNF445
zinc finger protein 445
chr9_-_114814286 1.181 NM_001101338
ZNF883
zinc finger protein 883
chr1_-_38185254 1.164 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr1_+_25471470 1.160 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr3_-_44494108 1.147 ZNF445
zinc finger protein 445
chr2_-_74610325 1.120 AUP1
ancient ubiquitous protein 1
chr15_-_62242352 1.102 NM_000942
PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr2_-_74610331 1.090 AUP1
ancient ubiquitous protein 1
chr2_-_74610332 1.078 AUP1
ancient ubiquitous protein 1
chr19_-_47438518 1.076 GSK3A
glycogen synthase kinase 3 alpha
chr19_-_47438384 1.064 GSK3A
glycogen synthase kinase 3 alpha
chr2_-_74610323 1.061 AUP1
ancient ubiquitous protein 1
chr4_-_40211324 1.012 RBM47
RNA binding motif protein 47
chr19_-_47438548 1.008 GSK3A
glycogen synthase kinase 3 alpha
chr19_-_47438563 0.993 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr8_-_145671947 0.982 FOXH1
forkhead box H1
chr22_-_37569962 0.982 NM_014293
NPTXR
neuronal pentraxin receptor
chr2_-_74610346 0.982 AUP1
ancient ubiquitous protein 1
chr1_-_25619863 0.979 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr11_-_47356642 0.965 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47356650 0.965 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr2_-_74610263 0.959 AUP1
ancient ubiquitous protein 1
chr11_-_47356672 0.958 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr3_-_52454082 0.939 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr2_+_74610395 0.918 HTRA2
HtrA serine peptidase 2
chr2_+_47021816 0.912 NM_020458
TTC7A
tetratricopeptide repeat domain 7A
chr2_+_74610333 0.893 HTRA2
HtrA serine peptidase 2
chr19_+_61344501 0.881 ZNF444
zinc finger protein 444
chr20_-_47238082 0.879 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr2_+_47021866 0.856 TTC7A
tetratricopeptide repeat domain 7A
chr17_+_73721924 0.846 BIRC5
baculoviral IAP repeat containing 5
chr22_-_16637221 0.842 BID
BH3 interacting domain death agonist
chrX_-_152938441 0.825 IRAK1
interleukin-1 receptor-associated kinase 1
chr2_-_74610481 0.821 NM_181575
AUP1
ancient ubiquitous protein 1
chrX_+_38548316 0.808 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chrX_+_38548373 0.801 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr11_+_817584 0.788 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr19_-_12807221 0.764 NM_031429
RTBDN
retbindin
chr12_-_14887648 0.758 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr11_-_47356562 0.756 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr20_-_47238310 0.743 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr2_+_74610494 0.739 HTRA2
HtrA serine peptidase 2
chr1_+_42920946 0.732 YBX1
Y box binding protein 1
chr15_-_62242243 0.732 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr22_-_16637194 0.731 BID
BH3 interacting domain death agonist
chrX_+_40325173 0.725 ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr8_-_23138517 0.714 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr2_+_112372651 0.699 NM_006343
MERTK
c-mer proto-oncogene tyrosine kinase
chr15_-_62242259 0.693 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr15_-_62242237 0.686 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr11_-_47356479 0.683 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chrX_-_152938456 0.682 IRAK1
interleukin-1 receptor-associated kinase 1
chr2_+_11213053 0.676 PQLC3
PQ loop repeat containing 3
chr2_+_241193492 0.676 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr12_-_52980914 0.676 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr3_+_9919511 0.657 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr22_-_16637160 0.657 BID
BH3 interacting domain death agonist
chr2_+_74610624 0.644 HTRA2
HtrA serine peptidase 2
chr20_-_33007243 0.640 NM_000178
GSS
glutathione synthetase
chr19_+_61344341 0.632 NM_018337
ZNF444
zinc finger protein 444
chr18_+_9904032 0.624 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr13_-_99422163 0.617 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr18_+_9904017 0.611 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr1_-_10455100 0.609 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr20_-_33007242 0.606 GSS
glutathione synthetase
chr15_+_76952210 0.602 NM_006791
NM_206839
MORF4L1

mortality factor 4 like 1

chr16_+_387176 0.600 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr22_-_21231421 0.595 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr19_+_44379440 0.595 NM_001001414
NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chrX_+_40325089 0.592 NM_005765
ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr17_+_73721871 0.585 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr15_+_76952250 0.582 MORF4L1
mortality factor 4 like 1
chr15_+_76952398 0.582 MORF4L1
mortality factor 4 like 1
chr1_-_54256390 0.577 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr19_+_15644885 0.574 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr15_-_62242145 0.573 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr20_-_33007209 0.570 GSS
glutathione synthetase
chr2_+_74610635 0.566 HTRA2
HtrA serine peptidase 2
chr2_+_171998988 0.565 NM_001164821
NM_025000
DCAF17

DDB1 and CUL4 associated factor 17

chr4_+_103641585 0.564 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr17_+_69939130 0.563 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr7_-_100077072 0.559 NM_003227
TFR2
transferrin receptor 2
chr7_+_72206961 0.558 GTF2IP1
general transcription factor IIi, pseudogene 1
chr22_+_21852551 0.556 NM_004327
NM_021574
BCR

breakpoint cluster region

chr18_+_9903992 0.554 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr3_-_24511456 0.549 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr18_+_9904000 0.545 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr3_-_49435114 0.541 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chrX_+_151837064 0.535 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr7_-_74291367 0.522 GTF2IP1
general transcription factor IIi, pseudogene 1
chr22_-_16637238 0.521 NM_001196
NM_197967
BID

BH3 interacting domain death agonist

chr15_-_53487748 0.512 NM_004748
NM_020739
CCPG1

cell cycle progression 1

chr2_+_74610039 0.511 NM_013247
NM_145074
HTRA2

HtrA serine peptidase 2

chr18_+_9903954 0.511 NM_003574
NM_194434
VAPA

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

chr4_-_9727598 0.508 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr20_+_34667566 0.507 NM_018840
NM_199483
C20orf24

chromosome 20 open reading frame 24

chr20_+_30409649 0.501 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr20_+_34667590 0.501 C20orf24
chromosome 20 open reading frame 24
chr9_-_103200697 0.500 NM_019051
MRPL50
mitochondrial ribosomal protein L50
chr19_+_7859380 0.497 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr1_-_45578193 0.496 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
MUTYH





mutY homolog (E. coli)





chr1_-_10455190 0.490 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr21_-_42172476 0.487 NM_001040424
NM_022115
PRDM15

PR domain containing 15

chr12_+_108038774 0.487 ACACB
acetyl-CoA carboxylase beta
chr20_+_56900116 0.483 NM_001077488
GNAS
GNAS complex locus
chr20_+_34667624 0.483 C20orf24
chromosome 20 open reading frame 24
chrX_+_40325205 0.477 ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr11_+_124944583 0.476 EI24
etoposide induced 2.4 mRNA
chrX_+_152565849 0.470 DUSP9
dual specificity phosphatase 9
chr11_+_124944580 0.470 EI24
etoposide induced 2.4 mRNA
chr4_-_9727542 0.464 WDR1
WD repeat domain 1
chrX_+_38548394 0.462 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr1_-_43055631 0.460 NM_199342
CCDC23
coiled-coil domain containing 23
chr1_+_32417909 0.456 NM_175852
TXLNA
taxilin alpha
chr2_+_171999042 0.455 DCAF17
DDB1 and CUL4 associated factor 17
chr20_+_56899904 0.454 GNAS
GNAS complex locus
chr8_-_145672525 0.445 NM_003923
FOXH1
forkhead box H1
chr11_-_74337747 0.445 XRRA1
X-ray radiation resistance associated 1
chr18_+_9904060 0.442 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr9_+_129962292 0.442 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr12_+_67489063 0.435 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr1_+_114249429 0.433 NM_022836
DCLRE1B
DNA cross-link repair 1B
chr11_+_124944573 0.431 EI24
etoposide induced 2.4 mRNA
chr2_-_166940710 0.421 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr1_+_114249549 0.420 DCLRE1B
DNA cross-link repair 1B
chr7_-_139744725 0.407 NM_032295
NM_207113
SLC37A3

solute carrier family 37 (glycerol-3-phosphate transporter), member 3

chr11_-_74337798 0.407 XRRA1
X-ray radiation resistance associated 1
chr9_+_115077752 0.404 PRPF4
PRP4 pre-mRNA processing factor 4 homolog (yeast)
chr12_-_121277972 0.404 NM_019887
NM_138929
DIABLO

diablo homolog (Drosophila)

chr4_-_9727394 0.402 WDR1
WD repeat domain 1
chr20_-_44713466 0.401 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr1_+_153799637 0.401 LOC645676
hypothetical LOC645676
chr2_-_55413253 0.396 CCDC88A
coiled-coil domain containing 88A
chr7_-_100091912 0.396 ACTL6B
actin-like 6B
chr20_+_42417752 0.395 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr10_-_118755077 0.387 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr4_-_9727456 0.384 WDR1
WD repeat domain 1
chr2_-_171998681 0.381 METTL8
methyltransferase like 8
chr1_-_93418491 0.380 TMED5
transmembrane emp24 protein transport domain containing 5
chr1_-_52936573 0.379 C1orf163
chromosome 1 open reading frame 163
chr4_-_9727384 0.376


chr13_-_47775797 0.374


chr4_+_103641511 0.373 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr1_-_52936602 0.371 C1orf163
chromosome 1 open reading frame 163
chr11_+_63758550 0.371 NM_003377
VEGFB
vascular endothelial growth factor B
chr20_+_47862656 0.368 NM_015266
SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr2_+_233443237 0.368 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr11_+_74337938 0.364 NM_014752
LOC653566
SPCS2
signal peptidase complex subunit 2 homolog pseudogene
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr7_-_74705276 0.363 NM_001145064
GATSL2
GATS protein-like 2
chr2_+_74610666 0.362 HTRA2
HtrA serine peptidase 2
chr7_+_100792841 0.362 NM_133457
EMID2
EMI domain containing 2
chr17_+_75849221 0.360 NM_020914
NM_020954
RNF213

ring finger protein 213

chr1_-_114249158 0.358 NM_006594
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr5_-_141041982 0.353 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr5_-_10360873 0.353 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr4_-_9727476 0.352 WDR1
WD repeat domain 1
chr15_+_76952356 0.351 MORF4L1
mortality factor 4 like 1
chr5_+_141328805 0.351 NM_004290
NM_183398
NM_183400
RNF14


ring finger protein 14


chr2_+_74610751 0.350 HTRA2
HtrA serine peptidase 2
chr2_+_74594093 0.350 TLX2
T-cell leukemia homeobox 2
chr10_-_21502993 0.349 NEBL
nebulette
chrX_+_38548447 0.348 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr16_+_56211410 0.348 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr12_+_54784681 0.348 PA2G4
proliferation-associated 2G4, 38kDa
chr9_-_115077504 0.347 FKBP15
FK506 binding protein 15, 133kDa
chr1_-_52936611 0.342 NM_023077
C1orf163
chromosome 1 open reading frame 163
chr11_+_133706977 0.341 NM_138342
GLB1L2
galactosidase, beta 1-like 2
chr12_-_14612057 0.340 NM_024829
PLBD1
phospholipase B domain containing 1
chr16_+_66438348 0.340 NUTF2
nuclear transport factor 2
chr22_-_16491503 0.340 ATP6V1E1
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
chr19_+_13090101 0.339 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr6_+_15353681 0.336 JARID2
jumonji, AT rich interactive domain 2
chr16_+_55963899 0.334 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr7_-_42938304 0.334 NM_002787
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr13_+_47775888 0.330 RB1
retinoblastoma 1
chr10_+_5556923 0.329 NM_005185
CALML3
calmodulin-like 3
chr13_+_47775887 0.329 RB1
retinoblastoma 1
chr20_+_47862782 0.328 SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr19_-_15869870 0.325 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr13_+_47775776 0.325 NM_000321
RB1
retinoblastoma 1
chr6_+_35881048 0.321 NM_182548
LHFPL5
lipoma HMGIC fusion partner-like 5
chr1_-_54644663 0.321 NM_001009955
SSBP3
single stranded DNA binding protein 3
chr19_-_16998449 0.320 NM_015692
CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr22_+_16491598 0.319 BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr16_+_56211150 0.318 GPR56
G protein-coupled receptor 56
chr14_-_30959487 0.316 HEATR5A
HEAT repeat containing 5A
chr17_+_7495436 0.316 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr1_+_32417846 0.316 TXLNA
taxilin alpha
chr11_+_124944559 0.315 EI24
etoposide induced 2.4 mRNA
chr1_+_45578370 0.315 TOE1
target of EGR1, member 1 (nuclear)
chr16_-_10943716 0.314 NM_014015
DEXI
Dexi homolog (mouse)
chr10_+_88404285 0.314 NM_001030015
NM_033282
OPN4

opsin 4


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 2.36e-06 GO:0044444 cytoplasmic part
1.21 1.66e-04 GO:0005737 cytoplasm
1.62 7.61e-04 GO:0012505 endomembrane system
1.28 8.25e-04 GO:0044446 intracellular organelle part
1.27 8.54e-04 GO:0044422 organelle part
1.50 1.97e-03 GO:0031090 organelle membrane
1.83 6.08e-03 GO:0031982 vesicle
1.81 1.03e-02 GO:0031410 cytoplasmic vesicle
1.16 1.34e-02 GO:0043227 membrane-bounded organelle
1.16 1.66e-02 GO:0043231 intracellular membrane-bounded organelle
1.78 3.45e-02 GO:0016023 cytoplasmic membrane-bounded vesicle

Nothing significant found in function category.