Motif ID: GATA6.p2

Z-value: 7.123


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6



Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_100077072 28.790 NM_003227
TFR2
transferrin receptor 2
chr10_+_70745615 28.068 NM_033496
HK1
hexokinase 1
chr7_-_142369534 26.478 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr7_-_142369519 26.366 KEL
Kell blood group, metallo-endopeptidase
chr12_-_52975777 24.190 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_52975823 23.558 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr9_-_99740243 16.183 NM_197978
HEMGN
hemogen
chr6_-_49712483 15.869 NM_000324
RHAG
Rh-associated glycoprotein
chr11_+_118463906 14.681 NM_001024382
HMBS
hydroxymethylbilane synthase
chr6_+_31782618 14.635 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr12_+_52105131 14.401 AMHR2
anti-Mullerian hormone receptor, type II
chr1_+_181028016 14.096 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr16_+_142853 14.061 NM_005332
HBZ
hemoglobin, zeta
chr1_+_43063817 13.460 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr1_-_156923111 13.399 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr1_-_27113018 12.896 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr17_-_59437782 12.847 NM_000873
ICAM2
intercellular adhesion molecule 2
chr16_-_87570716 12.467 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr10_-_48036698 11.796 NM_016204
GDF2
growth differentiation factor 2
chr19_+_13999959 11.613 NM_080864
RLN3
relaxin 3
chr19_-_12858956 10.951 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chrX_+_65152004 10.240


chr21_+_42697058 10.045 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr17_-_53764867 10.036


chr10_-_99521701 9.775 NM_003015
SFRP5
secreted frizzled-related protein 5
chr1_-_153537810 9.585 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr1_+_152560179 9.543 NM_080429
AQP10
aquaporin 10
chrX_+_44588192 9.419 NM_022076
DUSP21
dual specificity phosphatase 21
chr7_+_129807467 9.090 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr16_-_45339605 9.053 NM_182493
MYLK3
myosin light chain kinase 3
chr16_+_557011 9.046 NM_176677
NHLRC4
PIGQ
NHL repeat containing 4
phosphatidylinositol glycan anchor biosynthesis, class Q
chr19_-_11355882 9.008 NM_000121
EPOR
erythropoietin receptor
chr8_-_38127489 8.828 NM_000349
STAR
steroidogenic acute regulatory protein
chr19_+_10258642 8.788 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr2_+_27573206 8.505 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr1_+_200698493 8.382 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr19_-_60241424 8.332 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr8_-_86477585 8.277 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr8_+_124263932 8.255 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_+_108571336 8.045 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chrX_-_55074125 7.668 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr17_-_39822366 7.647 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr11_+_63730766 7.576 FERMT3
fermitin family member 3
chr16_+_31446703 7.537 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr8_+_124264054 7.216 FAM83A
family with sequence similarity 83, member A
chr17_-_3766708 7.120 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr1_-_153537362 7.077 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr2_-_68952006 6.963 NM_014482
BMP10
bone morphogenetic protein 10
chr19_-_13074513 6.764 LYL1
lymphoblastic leukemia derived sequence 1
chr19_-_60360768 6.730 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr17_-_3766441 6.716 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr1_-_25619863 6.650 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr2_+_220145197 6.611 NM_002191
INHA
inhibin, alpha
chr19_+_16860807 6.495 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr2_-_43919392 6.488 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr9_-_113977285 6.451 NM_022486
SUSD1
sushi domain containing 1
chr1_-_206125877 6.362


chr2_+_43919606 6.301 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr1_+_25471470 6.284 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr9_+_263025 6.262 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr1_+_157441133 6.225 NM_002036
DARC
Duffy blood group, chemokine receptor
chrX_+_152684150 6.128 PLXNB3
plexin B3
chr19_+_16860871 6.048 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr15_-_41300316 6.010 EPB42
erythrocyte membrane protein band 4.2
chr12_+_25096472 5.963 NM_006152
LRMP
lymphoid-restricted membrane protein
chr5_-_34020445 5.893 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr7_+_150321771 5.853 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr11_-_116213511 5.706 NM_000039
APOA1
apolipoprotein A-I
chr9_+_33230165 5.663 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr17_+_53761293 5.594 LOC100506779
hypothetical LOC100506779
chr3_-_52839727 5.479 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr7_+_106293112 5.396 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr19_-_13074669 5.360 LYL1
lymphoblastic leukemia derived sequence 1
chr6_-_49820030 5.323 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr2_+_220087135 5.276 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr19_+_40824486 5.254 NM_014209
ETV2
ets variant 2
chr21_+_36458708 5.226 NM_005128
DOPEY2
dopey family member 2
chr17_-_71352090 5.071 UNC13D
unc-13 homolog D (C. elegans)
chr12_-_68291208 5.033 NM_201550
LRRC10
leucine rich repeat containing 10
chr9_+_138677197 5.027 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr11_-_56914668 4.996 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr11_+_63730720 4.903 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr1_-_30969016 4.867 NM_002379
MATN1
matrilin 1, cartilage matrix protein
chr21_+_37714470 4.833 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr14_+_19681734 4.730 NM_001004724
OR4N5
olfactory receptor, family 4, subfamily N, member 5
chr15_-_48626193 4.695 NM_203494
USP50
ubiquitin specific peptidase 50
chr3_-_10309600 4.639 NM_001134944
NM_001134945
NM_001134946
GHRL


ghrelin/obestatin prepropeptide


chr4_-_40212670 4.567 NM_019027
RBM47
RNA binding motif protein 47
chr9_+_124177421 4.559 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr5_-_176868483 4.538 DOK3
docking protein 3
chr11_-_123816190 4.443 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr7_-_112515068 4.442 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr17_-_71352017 4.219 UNC13D
unc-13 homolog D (C. elegans)
chr20_+_42463387 4.155 HNF4A
hepatocyte nuclear factor 4, alpha
chrX_+_65299352 4.142 HEPH
hephaestin
chr6_-_11887265 4.125 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_+_198263352 4.105 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr2_+_108571209 4.089 LIMS1
LIM and senescent cell antigen-like domains 1
chrX_+_65299157 4.088 NM_138737
HEPH
hephaestin
chr6_-_50025115 4.080 NM_001166478
DEFB133
defensin, beta 133
chr20_-_45410033 3.987 ZMYND8
zinc finger, MYND-type containing 8
chr3_-_3127057 3.956 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr7_-_107667728 3.943 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr16_+_80086454 3.939 NM_030629
CMIP
c-Maf-inducing protein
chr12_-_14887648 3.931 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr2_-_175207521 3.855 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr4_-_54152385 3.854 LNX1
ligand of numb-protein X 1
chr10_+_11246934 3.809 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr3_-_57209319 3.805 NM_003865
HESX1
HESX homeobox 1
chr16_+_24765052 3.788 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr8_-_41774296 3.755 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr7_-_112515035 3.715 GPR85
G protein-coupled receptor 85
chr1_-_109651140 3.670 NM_001010985
MYBPHL
myosin binding protein H-like
chr1_-_26266571 3.652 NM_032588
TRIM63
tripartite motif containing 63
chr5_+_1254709 3.561 NM_001003841
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chr22_+_21543671 3.556 IGLV4-3
immunoglobulin lambda variable 4-3
chr6_-_30236667 3.532 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr17_-_53761119 3.499 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr7_-_112514990 3.412 GPR85
G protein-coupled receptor 85
chr15_-_41300526 3.406 NM_000119
NM_001114134
EPB42

erythrocyte membrane protein band 4.2

chr19_-_53081383 3.404 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr15_-_41300488 3.395 EPB42
erythrocyte membrane protein band 4.2
chrX_-_10761729 3.358 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr2_+_169465995 3.327 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr2_+_138438277 3.298 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr11_+_60858611 3.273 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr1_-_154665807 3.272 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr2_+_102294393 3.262 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr19_-_53081326 3.261 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr22_-_25205376 3.255 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr11_-_47330797 3.180 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr13_-_45654296 3.167 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_+_25096755 3.130 LRMP
lymphoid-restricted membrane protein
chr16_-_69876262 3.114 FTSJD1
FtsJ methyltransferase domain containing 1
chr1_-_111848265 3.112 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr16_-_66535457 3.105 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr12_-_69434330 3.099 PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_-_119249938 3.091 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr16_+_24709922 3.062 TNRC6A
trinucleotide repeat containing 6A
chr17_-_74361620 3.044 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_+_15612706 3.036 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr12_-_55696542 3.029 NM_001178054
NM_013251
TAC3

tachykinin 3

chr11_-_16387001 3.027 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr1_-_100416358 2.997 NM_144620
LRRC39
leucine rich repeat containing 39
chr22_+_33792125 2.961 NM_001008494
ISX
intestine-specific homeobox
chr1_+_196874867 2.956 PTPRC
protein tyrosine phosphatase, receptor type, C
chr11_+_93940121 2.952 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr7_+_139175420 2.936 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr20_+_42463279 2.928 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr1_-_43509187 2.915 EBNA1BP2
EBNA1 binding protein 2
chr8_-_145672525 2.895 NM_003923
FOXH1
forkhead box H1
chr13_-_45654327 2.889 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_68678181 2.865 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr2_-_121875610 2.856 CLASP1
cytoplasmic linker associated protein 1
chr9_+_71009746 2.834 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr7_+_129634935 2.808 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr2_-_39310176 2.807 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr13_-_48873735 2.785 NM_030925
CAB39L
calcium binding protein 39-like
chr9_+_96561750 2.779 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr15_-_74091817 2.756 NM_138573
NRG4
neuregulin 4
chr15_-_32398220 2.755 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chrX_-_24600661 2.743 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr4_+_151722526 2.722 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr12_+_48784057 2.711 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr13_-_45654292 2.710 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr21_+_37377116 2.687 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr6_+_167624792 2.662 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr1_-_114231519 2.632 BCL2L15
BCL2-like 15
chr11_-_64520964 2.625 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr17_-_71352182 2.622 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr1_-_114231691 2.607 NM_001010922
BCL2L15
BCL2-like 15
chr22_-_41685827 2.595 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr8_-_38324809 2.590 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr1_-_180636373 2.572 NM_172000
TEDDM1
transmembrane epididymal protein 1
chr6_+_135558572 2.565


chr9_-_70780574 2.552


chr20_+_43368904 2.516 NM_014276
RBPJL
recombination signal binding protein for immunoglobulin kappa J region-like
chr11_-_64267037 2.513 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr3_+_69895651 2.506 NM_006722
MITF
microphthalmia-associated transcription factor
chr20_+_55569542 2.503 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_-_96924582 2.500 NM_001172667
FAM178B
family with sequence similarity 178, member B
chr14_+_75058591 2.478 BATF
basic leucine zipper transcription factor, ATF-like
chr16_-_66535923 2.476 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr18_+_3437607 2.467 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr11_+_10434056 2.463 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr17_+_54188205 2.453 PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr22_+_24468168 2.450 MYO18B
myosin XVIIIB
chr11_-_5523328 2.436 NM_001005289
OR52H1
olfactory receptor, family 52, subfamily H, member 1
chr2_-_188127294 2.416 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_144711375 2.406 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr9_+_138810610 2.402 NM_001039374
KIAA1984
KIAA1984
chr22_+_24468110 2.384 NM_032608
MYO18B
myosin XVIIIB
chr8_-_30121741 2.354 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr1_+_158603480 2.334 NM_005598
NHLH1
nescient helix loop helix 1
chr11_+_59612712 2.330 NM_000139
MS4A2
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
chr6_+_135558744 2.319 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr4_+_39084936 2.318 KLB
klotho beta
chr22_+_21559959 2.297 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr16_-_4778317 2.289 NM_001154458
NM_144605
SEPT12

septin 12

chr17_+_70431964 2.288 NM_178160
OTOP2
otopetrin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 1.53e-13 GO:0032501 multicellular organismal process
5.52 8.23e-09 GO:0007586 digestion
1.83 8.28e-09 GO:0003008 system process
1.67 1.79e-07 GO:0065008 regulation of biological quality
2.71 3.94e-07 GO:0007608 sensory perception of smell
2.53 2.12e-06 GO:0007606 sensory perception of chemical stimulus
2.08 3.96e-06 GO:0007600 sensory perception
1.29 1.17e-05 GO:0050896 response to stimulus
1.76 2.56e-05 GO:0050877 neurological system process
2.09 4.67e-04 GO:0048878 chemical homeostasis
12.62 5.24e-04 GO:0044241 lipid digestion
2.85 6.82e-04 GO:0008202 steroid metabolic process
3.42 1.45e-03 GO:0006805 xenobiotic metabolic process
3.42 1.45e-03 GO:0071466 cellular response to xenobiotic stimulus
1.84 1.48e-03 GO:0042592 homeostatic process
3.39 1.65e-03 GO:0009410 response to xenobiotic stimulus
1.76 4.76e-03 GO:0006629 lipid metabolic process
3.99 1.61e-02 GO:0002576 platelet degranulation
2.55 2.23e-02 GO:0030168 platelet activation
5.73 3.15e-02 GO:0022600 digestive system process
1.93 3.18e-02 GO:0050878 regulation of body fluid levels

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.47 3.89e-10 GO:0071944 cell periphery
1.47 7.08e-10 GO:0005886 plasma membrane
1.25 8.14e-05 GO:0044425 membrane part
1.52 8.45e-05 GO:0005576 extracellular region
1.27 2.26e-04 GO:0031224 intrinsic to membrane
1.26 7.45e-04 GO:0016021 integral to membrane
1.66 3.00e-03 GO:0044421 extracellular region part
1.18 4.38e-03 GO:0016020 membrane
1.75 4.42e-03 GO:0005615 extracellular space
2.58 3.05e-02 GO:0016324 apical plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.75 9.53e-08 GO:0004872 receptor activity
2.73 1.99e-07 GO:0004984 olfactory receptor activity
1.83 8.28e-07 GO:0004888 transmembrane receptor activity
2.04 2.10e-06 GO:0004930 G-protein coupled receptor activity
1.59 5.99e-06 GO:0004871 signal transducer activity
1.59 5.99e-06 GO:0060089 molecular transducer activity
2.97 1.60e-02 GO:0046906 tetrapyrrole binding