Motif ID: HIC1.p2

Z-value: 6.195


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1



Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_109757442 13.036 NM_001845
COL4A1
collagen, type IV, alpha 1
chr13_+_109757593 12.839 NM_001846
COL4A2
collagen, type IV, alpha 2
chr11_+_101485946 11.597 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr2_-_112907577 11.047 NM_001164463
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr2_+_9532087 9.343 NM_001039613
IAH1
isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
chr8_+_32525269 9.085 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr1_-_48235148 8.999 NM_001194986
LOC388630
UPF0632 protein A
chr15_-_49174107 8.606 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr2_+_238200922 8.223 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr9_-_135847106 8.157 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr7_-_81910956 7.185 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr16_-_79395379 7.076 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr4_-_141896920 6.922 NM_015130
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr9_+_123501186 6.896 DAB2IP
DAB2 interacting protein
chr9_-_21549696 6.890 LOC554202
hypothetical LOC554202
chr5_+_92946348 6.857 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr6_+_147871477 6.729 NM_001030060
SAMD5
sterile alpha motif domain containing 5
chr9_+_115958051 6.699 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr2_+_238060602 6.694 NM_001042467
NM_024101
MLPH

melanophilin

chr15_+_99237527 6.645 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr13_-_43259032 6.624 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr9_+_17568952 6.605 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr14_+_92049396 6.556 NM_024832
RIN3
Ras and Rab interactor 3
chr20_+_8997660 6.531 NM_001172646
PLCB4
phospholipase C, beta 4
chr2_-_224612177 6.495 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr10_+_128583984 6.426 NM_001380
DOCK1
dedicator of cytokinesis 1
chr2_+_29191711 6.293 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr14_+_85069217 6.288


chr13_-_100866839 6.279 NALCN
sodium leak channel, non-selective
chr3_+_61522310 6.273 PTPRG
protein tyrosine phosphatase, receptor type, G
chr10_+_116843108 6.133 NM_207303
ATRNL1
attractin-like 1
chr1_+_208472817 6.101 NM_019605
SERTAD4
SERTA domain containing 4
chr4_-_177950658 6.066 NM_005429
VEGFC
vascular endothelial growth factor C
chr10_+_71232281 6.035 COL13A1
collagen, type XIII, alpha 1
chr15_+_66658626 6.031 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr20_-_17459973 5.997 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr2_+_109112428 5.985 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr2_+_235525355 5.969 NM_014521
SH3BP4
SH3-domain binding protein 4
chr18_+_7557313 5.909 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr12_-_41269679 5.903 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr17_+_52026058 5.900 NM_005450
NOG
noggin
chr13_-_100866706 5.883 NM_052867
NALCN
sodium leak channel, non-selective
chr12_+_20413445 5.849 NM_000921
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr4_+_95898098 5.834 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr13_-_39075304 5.822 LHFP
lipoma HMGIC fusion partner
chrX_+_9943793 5.815 NM_015691
WWC3
WWC family member 3
chr17_-_74432671 5.790 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_-_94708477 5.750 NTN4
netrin 4
chr1_+_17738863 5.681 NM_018125
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_-_85703198 5.667 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr13_+_97593711 5.662 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr2_-_98919109 5.627 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr7_-_27136876 5.577 NM_002141
HOXA4
homeobox A4
chr18_-_24011349 5.452 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr10_-_118022707 5.399 NM_001145453
GFRA1
GDNF family receptor alpha 1
chr18_-_42590989 5.391 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr2_-_165406173 5.368 NM_014900
COBLL1
COBL-like 1
chr12_-_29827952 5.350 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr20_+_8997791 5.303 PLCB4
phospholipase C, beta 4
chr2_-_175255717 5.301 NM_001077269
WIPF1
WAS/WASL interacting protein family, member 1
chr15_-_81744469 5.298 NM_001717
BNC1
basonuclin 1
chr1_-_95165089 5.253 NM_001839
CNN3
calponin 3, acidic
chr2_-_160972606 5.235 RBMS1
RNA binding motif, single stranded interacting protein 1
chr11_-_44928803 5.200 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr18_+_29412538 5.191 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr6_+_72055197 5.159 NM_024576
OGFRL1
opioid growth factor receptor-like 1
chr7_-_81910740 5.140 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr18_-_68361742 5.139 CBLN2
cerebellin 2 precursor
chr6_-_170441493 5.135 NM_005618
DLL1
delta-like 1 (Drosophila)
chr7_-_29995809 5.128 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr14_+_105012106 5.116 NM_001312
CRIP2
cysteine-rich protein 2
chr5_-_58370693 5.075 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr2_+_23461802 5.048 NM_052920
KLHL29
kelch-like 29 (Drosophila)
chr3_+_11171213 5.032 NM_001098212
HRH1
histamine receptor H1
chr7_-_32077504 5.018 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr7_+_55054416 4.998 EGFR
epidermal growth factor receptor
chr3_+_53504070 4.985 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr22_+_47263919 4.962 NM_001082967
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr8_-_41286088 4.956 NM_003012
SFRP1
secreted frizzled-related protein 1
chr7_-_32076985 4.955 NM_001191056
NM_001191057
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr2_+_54537842 4.951 SPTBN1
spectrin, beta, non-erythrocytic 1
chr4_+_19864332 4.924 NM_004787
SLIT2
slit homolog 2 (Drosophila)
chr3_+_61522219 4.922 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr6_-_153494076 4.920 NM_012419
RGS17
regulator of G-protein signaling 17
chr10_+_124211353 4.920 HTRA1
HtrA serine peptidase 1
chr2_+_100802923 4.919 NM_002518
NPAS2
neuronal PAS domain protein 2
chr17_+_26322168 4.897 RNF135
ring finger protein 135
chr7_+_55054152 4.883 NM_005228
NM_201282
NM_201283
NM_201284
EGFR



epidermal growth factor receptor



chr6_+_3696224 4.858


chr4_-_122063118 4.832 NM_018699
PRDM5
PR domain containing 5
chr6_+_1556543 4.765 FOXC1
forkhead box C1
chr4_-_24523605 4.764 NM_001130726
CCDC149
coiled-coil domain containing 149
chr6_+_72055229 4.744 OGFRL1
opioid growth factor receptor-like 1
chr19_+_38377329 4.741 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr12_-_94708641 4.740 NM_021229
NTN4
netrin 4
chr13_-_39075355 4.735 NM_005780
LHFP
lipoma HMGIC fusion partner
chr16_+_85158357 4.727 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr14_+_104402626 4.725 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr14_+_58174489 4.698 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr1_-_95165037 4.681 CNN3
calponin 3, acidic
chr1_-_8008934 4.676 ERRFI1
ERBB receptor feedback inhibitor 1
chr6_+_170441715 4.674 FAM120B
family with sequence similarity 120B
chr17_+_8865547 4.669 NM_004822
NTN1
netrin 1
chr5_+_178419938 4.666 NM_014594
ZNF354C
zinc finger protein 354C
chr21_+_45318861 4.630 NM_001112
NM_001160230
NM_015833
NM_015834
ADARB1



adenosine deaminase, RNA-specific, B1



chr6_-_105691235 4.589 NM_007073
BVES
blood vessel epicardial substance
chr6_+_72055235 4.558 OGFRL1
opioid growth factor receptor-like 1
chr2_-_96174502 4.556 DUSP2
dual specificity phosphatase 2
chr15_+_99237555 4.537 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr7_-_107883929 4.533 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr19_+_15079141 4.526 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr7_-_44331544 4.505 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr4_+_158216631 4.502 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr14_+_95575319 4.475 C14orf132
chromosome 14 open reading frame 132
chr18_-_7107757 4.470 NM_005559
LAMA1
laminin, alpha 1
chr2_-_127580975 4.468 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr14_+_104226769 4.463 NM_001031714
NM_022489
NM_032714
INF2


inverted formin, FH2 and WH2 domain containing


chr10_+_124210980 4.453 NM_002775
HTRA1
HtrA serine peptidase 1
chr1_+_234372454 4.452 NM_003272
GPR137B
G protein-coupled receptor 137B
chr17_+_26322081 4.450 NM_001184992
NM_032322
NM_197939
RNF135


ring finger protein 135


chr2_+_120820140 4.441 NM_002193
INHBB
inhibin, beta B
chr1_-_56817568 4.381 PPAP2B
phosphatidic acid phosphatase type 2B
chr11_+_131285747 4.377 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr18_-_24010944 4.360 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr13_-_109236897 4.345 NM_003749
IRS2
insulin receptor substrate 2
chr18_+_65219114 4.342 NM_152721
DOK6
docking protein 6
chr2_-_235070431 4.340 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr12_-_78608154 4.338 PAWR
PRKC, apoptosis, WT1, regulator
chr13_+_95541093 4.336 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr22_-_41446740 4.310 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr12_+_26003218 4.302 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr8_-_485330 4.288 NM_175075
C8orf42
chromosome 8 open reading frame 42
chr17_-_10042579 4.287 NM_201433
GAS7
growth arrest-specific 7
chr8_+_27547379 4.287 NM_016240
NM_182826
SCARA3

scavenger receptor class A, member 3

chr8_+_17398940 4.280 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr13_+_97593469 4.274 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr18_+_19523402 4.264 LAMA3
laminin, alpha 3
chr9_-_139060377 4.241 NPDC1
neural proliferation, differentiation and control, 1
chr18_+_19523526 4.230 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr2_+_241586927 4.219 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr5_-_146869811 4.213 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr22_-_19122047 4.207 SCARF2
scavenger receptor class F, member 2
chr10_-_128066935 4.204 ADAM12
ADAM metallopeptidase domain 12
chrX_+_73557809 4.180 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr8_+_38733913 4.175 TACC1
transforming, acidic coiled-coil containing protein 1
chr14_+_63389360 4.162 NM_015180
NM_182914
SYNE2

spectrin repeat containing, nuclear envelope 2

chr4_+_151218862 4.160 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr19_+_61742111 4.149 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr7_+_288195 4.138 FAM20C
family with sequence similarity 20, member C
chr1_-_234294997 4.115 NID1
nidogen 1
chr12_-_62348506 4.106 NM_173812
DPY19L2
dpy-19-like 2 (C. elegans)
chr5_-_146869613 4.082 DPYSL3
dihydropyrimidinase-like 3
chr9_-_139060285 4.077 NPDC1
neural proliferation, differentiation and control, 1
chr6_-_105691675 4.069 BVES
blood vessel epicardial substance
chr9_-_71476917 4.056 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr22_-_19122107 4.012 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr16_-_71639670 4.009 NM_006885
ZFHX3
zinc finger homeobox 3
chr8_-_125809559 3.989 MTSS1
metastasis suppressor 1
chr11_+_86189138 3.978 NM_007173
PRSS23
protease, serine, 23
chr12_+_3056781 3.968 NM_001168320
NM_006675
TSPAN9

tetraspanin 9

chr16_-_52877467 3.962 IRX3
iroquois homeobox 3
chr4_+_156899575 3.940 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr20_+_56701224 3.939 NM_024663
NPEPL1
aminopeptidase-like 1
chr5_+_129268352 3.936 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr3_+_44878380 3.930 NM_144638
TMEM42
transmembrane protein 42
chr18_-_5620629 3.910 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr10_+_133850325 3.906 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr5_-_16989371 3.899 NM_012334
MYO10
myosin X
chr13_-_39075200 3.898 LHFP
lipoma HMGIC fusion partner
chr14_+_54104099 3.892 SAMD4A
sterile alpha motif domain containing 4A
chr14_+_64240996 3.880 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr15_+_77511912 3.880 NM_015206
KIAA1024
KIAA1024
chr14_+_64240902 3.850 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr7_+_288051 3.843 NM_020223
FAM20C
family with sequence similarity 20, member C
chr17_-_6400470 3.824 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr10_+_112247614 3.814 NM_004419
DUSP5
dual specificity phosphatase 5
chr9_+_131974506 3.807 NM_014286
NCS1
neuronal calcium sensor 1
chr20_-_4177519 3.799 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr5_-_16989290 3.796 MYO10
myosin X
chr3_+_128874458 3.752 NM_172027
ABTB1
ankyrin repeat and BTB (POZ) domain containing 1
chr11_-_8849485 3.752 ST5
suppression of tumorigenicity 5
chr18_-_29412148 3.740


chr7_+_79602023 3.738 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr2_-_165406098 3.736 COBLL1
COBL-like 1
chr4_+_77829634 3.726 SHROOM3
shroom family member 3
chr10_-_128067001 3.709 ADAM12
ADAM metallopeptidase domain 12
chrX_+_147389825 3.703 NM_001169122
NM_001169123
NM_001169124
NM_001169125
NM_002025
AFF2




AF4/FMR2 family, member 2




chr17_+_78303202 3.702 NM_005993
TBCD
tubulin folding cofactor D
chr20_+_59260847 3.697 NM_001794
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr12_+_66328760 3.690 NM_003583
NM_006482
DYRK2

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

chr14_-_29466562 3.680 NM_002742
PRKD1
protein kinase D1
chr3_+_141136691 3.680 NM_022131
CLSTN2
calsyntenin 2
chr5_-_171813960 3.674 SH3PXD2B
SH3 and PX domains 2B
chr10_-_118022965 3.658 NM_005264
GFRA1
GDNF family receptor alpha 1
chr10_-_30065760 3.652 SVIL
supervillin
chr1_-_223907283 3.645 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr20_-_55718351 3.641 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr1_+_213323182 3.638 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr21_+_45649719 3.638


chr17_+_77780177 3.600 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.47 1.52e-23 GO:0007399 nervous system development
1.59 1.43e-22 GO:0022008 neurogenesis
1.60 2.71e-21 GO:0048699 generation of neurons
1.36 1.55e-19 GO:0030154 cell differentiation
1.35 1.75e-19 GO:0048869 cellular developmental process
1.26 5.36e-19 GO:0007275 multicellular organismal development
1.41 1.86e-18 GO:0009653 anatomical structure morphogenesis
1.62 3.74e-18 GO:0030182 neuron differentiation
1.24 7.87e-18 GO:0032502 developmental process
1.39 1.02e-17 GO:0023051 regulation of signaling
1.15 1.40e-17 GO:0050794 regulation of cellular process
1.72 4.61e-17 GO:0000904 cell morphogenesis involved in differentiation
1.28 4.79e-17 GO:0048731 system development
1.76 1.24e-16 GO:0048667 cell morphogenesis involved in neuron differentiation
1.66 1.24e-16 GO:0048666 neuron development
1.64 2.60e-16 GO:0000902 cell morphogenesis
1.74 6.29e-16 GO:0048812 neuron projection morphogenesis
1.40 7.18e-16 GO:0009966 regulation of signal transduction
1.75 1.38e-15 GO:0007409 axonogenesis
1.50 1.38e-15 GO:0048468 cell development
1.25 2.77e-15 GO:0048856 anatomical structure development
1.67 4.03e-15 GO:0032990 cell part morphogenesis
1.68 4.26e-15 GO:0031175 neuron projection development
1.67 6.10e-15 GO:0048858 cell projection morphogenesis
1.59 6.73e-15 GO:0030030 cell projection organization
1.58 3.25e-14 GO:0032989 cellular component morphogenesis
1.08 3.34e-13 GO:0009987 cellular process
1.13 1.09e-12 GO:0050789 regulation of biological process
1.12 8.57e-12 GO:0065007 biological regulation
1.74 1.16e-11 GO:0007411 axon guidance
1.19 2.92e-09 GO:0007165 signal transduction
1.27 3.64e-09 GO:0048583 regulation of response to stimulus
1.25 3.88e-09 GO:0048523 negative regulation of cellular process
1.18 4.59e-09 GO:0023052 signaling
1.23 1.03e-08 GO:0048519 negative regulation of biological process
1.61 1.92e-08 GO:0051056 regulation of small GTPase mediated signal transduction
1.22 3.64e-08 GO:0048522 positive regulation of cellular process
1.31 3.74e-08 GO:0035556 intracellular signal transduction
1.35 5.08e-08 GO:0010646 regulation of cell communication
1.72 1.05e-07 GO:0046578 regulation of Ras protein signal transduction
1.46 1.10e-07 GO:0009887 organ morphogenesis
1.17 2.35e-07 GO:0031323 regulation of cellular metabolic process
1.43 2.98e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.36 3.16e-07 GO:0050793 regulation of developmental process
1.42 3.59e-07 GO:0045595 regulation of cell differentiation
1.39 6.00e-07 GO:2000026 regulation of multicellular organismal development
1.20 9.77e-07 GO:0071842 cellular component organization at cellular level
1.16 1.08e-06 GO:0080090 regulation of primary metabolic process
1.36 1.10e-06 GO:0040011 locomotion
1.49 1.25e-06 GO:0072358 cardiovascular system development
1.49 1.25e-06 GO:0072359 circulatory system development
1.59 1.77e-06 GO:0060284 regulation of cell development
1.19 3.02e-06 GO:0048518 positive regulation of biological process
1.45 7.56e-06 GO:0007417 central nervous system development
1.61 8.51e-06 GO:0035295 tube development
1.87 1.51e-05 GO:0030111 regulation of Wnt receptor signaling pathway
1.51 3.16e-05 GO:0048598 embryonic morphogenesis
1.17 3.17e-05 GO:0071841 cellular component organization or biogenesis at cellular level
1.96 3.21e-05 GO:0010720 positive regulation of cell development
1.26 3.89e-05 GO:0051239 regulation of multicellular organismal process
1.30 4.09e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.13 4.47e-05 GO:0051716 cellular response to stimulus
1.57 4.89e-05 GO:0001944 vasculature development
1.15 6.31e-05 GO:0016043 cellular component organization
1.42 6.55e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.42 7.94e-05 GO:0006935 chemotaxis
1.42 7.94e-05 GO:0042330 taxis
2.03 8.45e-05 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.53 8.63e-05 GO:0001501 skeletal system development
1.13 1.21e-04 GO:0019222 regulation of metabolic process
1.54 1.57e-04 GO:0048729 tissue morphogenesis
1.21 1.62e-04 GO:0007166 cell surface receptor linked signaling pathway
1.43 1.94e-04 GO:0051094 positive regulation of developmental process
1.15 2.05e-04 GO:0060255 regulation of macromolecule metabolic process
1.45 2.11e-04 GO:0009968 negative regulation of signal transduction
1.20 2.13e-04 GO:0048513 organ development
1.17 2.18e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.42 2.59e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.16 3.20e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.43 4.00e-04 GO:0023057 negative regulation of signaling
1.51 4.40e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.48 4.51e-04 GO:0007389 pattern specification process
1.30 4.72e-04 GO:0009888 tissue development
1.34 4.76e-04 GO:0009890 negative regulation of biosynthetic process
1.42 4.87e-04 GO:0010648 negative regulation of cell communication
1.49 5.00e-04 GO:0045597 positive regulation of cell differentiation
1.34 6.43e-04 GO:0051254 positive regulation of RNA metabolic process
1.39 7.78e-04 GO:0048585 negative regulation of response to stimulus
1.53 9.03e-04 GO:0001568 blood vessel development
1.55 9.77e-04 GO:0050767 regulation of neurogenesis
1.33 1.02e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.61 1.22e-03 GO:0045664 regulation of neuron differentiation
1.51 1.36e-03 GO:0051960 regulation of nervous system development
1.33 1.38e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.13 1.48e-03 GO:0071840 cellular component organization or biogenesis
1.39 1.68e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.34 1.87e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.26 2.12e-03 GO:0009605 response to external stimulus
1.56 2.27e-03 GO:0002009 morphogenesis of an epithelium
1.33 2.53e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.27 2.64e-03 GO:0042127 regulation of cell proliferation
1.62 2.79e-03 GO:0035239 tube morphogenesis
1.17 3.22e-03 GO:0051252 regulation of RNA metabolic process
1.55 4.34e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.32 4.61e-03 GO:0001932 regulation of protein phosphorylation
1.13 4.76e-03 GO:0051179 localization
1.29 4.92e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.31 5.03e-03 GO:0009790 embryo development
1.35 5.23e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.91 5.37e-03 GO:0050769 positive regulation of neurogenesis
1.31 5.94e-03 GO:0010628 positive regulation of gene expression
1.35 6.19e-03 GO:0051253 negative regulation of RNA metabolic process
1.33 6.28e-03 GO:0010629 negative regulation of gene expression
1.36 6.86e-03 GO:0007010 cytoskeleton organization
1.15 6.94e-03 GO:0031326 regulation of cellular biosynthetic process
1.15 7.07e-03 GO:0010468 regulation of gene expression
1.14 7.37e-03 GO:0009889 regulation of biosynthetic process
1.26 7.45e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.16 7.90e-03 GO:0006355 regulation of transcription, DNA-dependent
1.71 8.59e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.30 8.78e-03 GO:0019220 regulation of phosphate metabolic process
1.30 8.78e-03 GO:0051174 regulation of phosphorus metabolic process
1.25 9.26e-03 GO:0009892 negative regulation of metabolic process
1.27 9.73e-03 GO:0051128 regulation of cellular component organization
1.28 1.15e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.93 1.18e-02 GO:0071901 negative regulation of protein serine/threonine kinase activity
1.27 1.19e-02 GO:0031399 regulation of protein modification process
1.69 1.21e-02 GO:0022604 regulation of cell morphogenesis
1.87 1.33e-02 GO:0060485 mesenchyme development
1.38 1.33e-02 GO:0008285 negative regulation of cell proliferation
1.68 1.37e-02 GO:0051348 negative regulation of transferase activity
1.30 1.37e-02 GO:0042325 regulation of phosphorylation
1.72 1.39e-02 GO:0006469 negative regulation of protein kinase activity
1.15 1.56e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.06 1.57e-02 GO:0043407 negative regulation of MAP kinase activity
1.39 1.67e-02 GO:0007264 small GTPase mediated signal transduction
1.64 1.75e-02 GO:0001655 urogenital system development
1.64 1.75e-02 GO:0016311 dephosphorylation
1.74 1.81e-02 GO:0072001 renal system development
1.69 1.82e-02 GO:0033673 negative regulation of kinase activity
1.17 1.88e-02 GO:0006464 protein modification process
1.25 2.04e-02 GO:0031324 negative regulation of cellular metabolic process
1.72 2.10e-02 GO:0035023 regulation of Rho protein signal transduction
1.61 2.33e-02 GO:0048562 embryonic organ morphogenesis
1.67 2.33e-02 GO:0048705 skeletal system morphogenesis
1.88 2.43e-02 GO:0016331 morphogenesis of embryonic epithelium
1.30 2.66e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.74 2.74e-02 GO:0001822 kidney development
1.85 3.07e-02 GO:0021953 central nervous system neuron differentiation
1.97 3.12e-02 GO:0072175 epithelial tube formation
1.37 3.41e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.30 4.14e-02 GO:0042060 wound healing
1.64 4.38e-02 GO:0006470 protein dephosphorylation
1.34 4.45e-02 GO:0045859 regulation of protein kinase activity
1.29 4.56e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.50 4.65e-02 GO:0048514 blood vessel morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 1.72e-14 GO:0044424 intracellular part
1.08 2.47e-14 GO:0005622 intracellular
1.10 3.78e-10 GO:0005737 cytoplasm
1.07 4.53e-07 GO:0043226 organelle
1.07 6.11e-07 GO:0043229 intracellular organelle
1.39 5.10e-06 GO:0030054 cell junction
1.10 9.36e-06 GO:0044444 cytoplasmic part
1.46 9.79e-06 GO:0045202 synapse
1.07 1.44e-05 GO:0043227 membrane-bounded organelle
1.75 1.84e-05 GO:0005912 adherens junction
1.07 1.89e-05 GO:0043231 intracellular membrane-bounded organelle
1.70 2.20e-05 GO:0070161 anchoring junction
1.63 1.55e-04 GO:0031252 cell leading edge
1.26 3.24e-04 GO:0005794 Golgi apparatus
1.03 6.41e-04 GO:0044464 cell part
1.03 6.86e-04 GO:0005623 cell
1.15 4.50e-03 GO:0005829 cytosol
1.15 4.52e-03 GO:0044459 plasma membrane part
1.08 5.83e-03 GO:0005634 nucleus
1.72 8.09e-03 GO:0005925 focal adhesion
1.40 1.15e-02 GO:0044456 synapse part
1.74 2.43e-02 GO:0030027 lamellipodium
1.64 2.77e-02 GO:0030055 cell-substrate junction
1.64 4.18e-02 GO:0005924 cell-substrate adherens junction
1.48 4.56e-02 GO:0044297 cell body

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.60 1.42e-11 GO:0030695 GTPase regulator activity
1.58 4.12e-11 GO:0060589 nucleoside-triphosphatase regulator activity
1.60 8.09e-07 GO:0005083 small GTPase regulator activity
1.05 3.97e-06 GO:0005488 binding
1.30 4.15e-06 GO:0030528 transcription regulator activity
1.30 4.31e-06 GO:0001071 nucleic acid binding transcription factor activity
1.30 4.31e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.40 1.16e-05 GO:0008092 cytoskeletal protein binding
1.47 2.31e-04 GO:0003779 actin binding
1.53 2.47e-04 GO:0005096 GTPase activator activity
1.40 2.58e-04 GO:0019904 protein domain specific binding
1.66 4.57e-04 GO:0004721 phosphoprotein phosphatase activity
1.41 7.16e-04 GO:0008047 enzyme activator activity
1.08 8.71e-04 GO:0005515 protein binding
1.25 1.36e-03 GO:0030234 enzyme regulator activity
1.62 2.33e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.42 2.78e-03 GO:0042578 phosphoric ester hydrolase activity
1.48 3.86e-03 GO:0016791 phosphatase activity
1.11 5.04e-03 GO:0046872 metal ion binding
1.28 6.71e-03 GO:0043565 sequence-specific DNA binding
1.69 7.54e-03 GO:0051020 GTPase binding
1.10 1.34e-02 GO:0043169 cation binding
1.76 1.47e-02 GO:0017016 Ras GTPase binding
1.10 1.52e-02 GO:0043167 ion binding
1.50 1.54e-02 GO:0000975 regulatory region DNA binding
1.50 1.54e-02 GO:0001067 regulatory region nucleic acid binding
1.50 1.54e-02 GO:0044212 transcription regulatory region DNA binding
1.49 3.24e-02 GO:0010843 promoter binding
1.81 3.57e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity