Motif ID: PDX1.p2

Z-value: 0.570


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1



Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_158008763 1.476 NM_004288
CYTIP
cytohesin 1 interacting protein
chr15_-_38185578 1.272 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr12_+_45896318 1.135 NM_138371
FAM113B
family with sequence similarity 113, member B
chr1_+_157441133 0.922 NM_002036
DARC
Duffy blood group, chemokine receptor
chr12_+_45896511 0.897 FAM113B
family with sequence similarity 113, member B
chr19_-_7672978 0.842 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr1_+_40635058 0.787 NM_001198980
SMAP2
small ArfGAP2
chr1_+_62835759 0.579 NM_014495
ANGPTL3
angiopoietin-like 3
chr7_-_92615593 0.537 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr15_-_42756377 0.516 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr15_-_38185865 0.509 NM_033503
BMF
Bcl2 modifying factor
chr16_-_66075216 0.455 NM_001138
AGRP
agouti related protein homolog (mouse)
chr16_+_29582480 0.339 SPN
sialophorin
chr10_+_63478974 0.327 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr5_+_68703036 0.293 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr12_-_52306348 0.287 NM_001130060
NM_006856
ATF7

activating transcription factor 7

chr19_-_55539769 0.266 NAPSB
napsin B aspartic peptidase pseudogene
chr6_-_133076873 0.263 NM_004666
VNN1
vanin 1
chr4_+_86615275 0.254 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr2_+_185171480 0.243 ZNF804A
zinc finger protein 804A
chr16_-_69114931 0.232 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr17_+_7900926 0.218


chr12_-_52305900 0.211 ATF7
activating transcription factor 7
chr7_-_128330615 0.204 KCP
kielin/chordin-like protein
chr2_+_227900471 0.196 NM_020194
MFF
mitochondrial fission factor
chr7_+_129057152 0.194 NM_001040110
NRF1
nuclear respiratory factor 1
chr6_-_131333173 0.185 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chrX_+_110252960 0.176 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr13_-_40491491 0.168 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chrX_-_48655978 0.160 PIM2
pim-2 oncogene
chr11_-_5130174 0.159 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr5_-_142795269 0.152 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr1_+_184532027 0.151 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr7_+_147918589 0.150 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr17_+_7423662 0.150 CD68
CD68 molecule
chr16_+_18986721 0.147 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr3_+_101720753 0.143 TMEM45A
transmembrane protein 45A
chr9_+_33016482 0.140 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr6_-_32227695 0.140 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr4_+_123380569 0.134 KIAA1109
KIAA1109
chr4_-_176970407 0.132 GPM6A
glycoprotein M6A
chr3_-_145049853 0.132 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr6_-_32227645 0.130 PRRT1
proline-rich transmembrane protein 1
chr12_+_74071145 0.125 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr6_+_147566559 0.122 STXBP5
syntaxin binding protein 5 (tomosyn)
chr11_+_61732715 0.119 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr19_-_14646626 0.119 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr17_+_7423685 0.114 CD68
CD68 molecule
chr2_+_185171537 0.112 ZNF804A
zinc finger protein 804A
chr4_-_176970372 0.111 GPM6A
glycoprotein M6A
chr17_-_39500512 0.110 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr1_+_78858675 0.107 NM_006820
IFI44L
interferon-induced protein 44-like
chr1_-_246869181 0.106 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr12_-_56159631 0.106 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr5_+_140181405 0.102 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr2_+_169634330 0.097 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr21_-_45173061 0.096 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_+_41872141 0.093 NM_152603
ZNF567
zinc finger protein 567
chr9_-_139084833 0.093 NM_178448
C9orf140
chromosome 9 open reading frame 140
chr5_+_34720368 0.091 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr12_-_101835510 0.090 NM_000277
PAH
phenylalanine hydroxylase
chr17_+_7423528 0.089 NM_001251
NM_001040059
CD68

CD68 molecule

chr3_+_35658852 0.084 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr1_+_84540921 0.083 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr3_+_176059763 0.081 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr17_+_7423704 0.079 CD68
CD68 molecule
chr8_-_17599438 0.078 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chrX_+_48978875 0.077 CCDC22
coiled-coil domain containing 22
chr2_-_188127430 0.077 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr17_-_1195096 0.074 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr6_+_72979234 0.073 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr12_+_74071116 0.071 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr2_+_38746742 0.071 GALM
galactose mutarotase (aldose 1-epimerase)
chrX_+_118592879 0.071 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr1_+_157246305 0.068 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr20_+_43423990 0.068 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr17_-_36725470 0.067 NM_031964
KRTAP17-1
keratin associated protein 17-1
chr8_-_81155564 0.065 NM_001025252
TPD52
tumor protein D52
chr7_+_104468614 0.065 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr7_+_156128431 0.063 NM_001184997
RNF32
ring finger protein 32
chr5_+_68702617 0.063 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr11_+_22652894 0.063 NM_005256
GAS2
growth arrest-specific 2
chr1_-_33613729 0.062 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr18_+_29573152 0.062 ASXL3
additional sex combs like 3 (Drosophila)
chr2_-_121964373 0.060 CLASP1
cytoplasmic linker associated protein 1
chr4_+_71492581 0.059 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr11_+_22652957 0.058 GAS2
growth arrest-specific 2
chr3_-_51884639 0.058 NM_001145059
IQCF5
IQ motif containing F5
chr11_-_66201894 0.058 RBM4B
RNA binding motif protein 4B
chr2_+_24660849 0.056 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr21_-_30666417 0.056 NM_181621
KRTAP13-2
keratin associated protein 13-2
chr6_+_167624792 0.054 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chrX_+_118592568 0.054 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr11_+_28088406 0.053 METTL15
methyltransferase like 15
chr4_+_95595419 0.053 PDLIM5
PDZ and LIM domain 5
chr16_+_56286212 0.052 NM_032269
CCDC135
coiled-coil domain containing 135
chrX_+_48978870 0.052 NM_014008
CCDC22
coiled-coil domain containing 22
chr4_-_170314382 0.051 SH3RF1
SH3 domain containing ring finger 1
chr17_+_32807040 0.051 NM_173625
C17orf78
chromosome 17 open reading frame 78
chr2_-_188127294 0.050 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr14_+_57964462 0.050 NM_014749
KIAA0586
KIAA0586
chrX_+_123307812 0.048 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr3_+_99350859 0.048 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr1_+_100776280 0.047 NM_022049
GPR88
G protein-coupled receptor 88
chr1_-_230717850 0.047 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_+_43508251 0.045 NM_144626
TMEM125
transmembrane protein 125
chr17_-_9635325 0.045 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr11_-_57883117 0.045 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr6_-_39180390 0.044 C6orf64
chromosome 6 open reading frame 64
chr6_-_29563657 0.044 NM_052967
MAS1L
MAS1 oncogene-like
chr4_-_24590867 0.043 NM_173463
CCDC149
coiled-coil domain containing 149
chr14_-_46882144 0.043 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr17_-_36559579 0.040 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr2_+_105799354 0.040 NCK2
NCK adaptor protein 2
chrX_+_37524250 0.040 CYBB
cytochrome b-245, beta polypeptide
chr11_+_5367182 0.039 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr4_-_176970895 0.039 GPM6A
glycoprotein M6A
chr17_-_36403910 0.036 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr2_-_183095308 0.036 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr21_-_30631882 0.036 NM_001077711
KRTAP27-1
keratin associated protein 27-1
chr7_+_116182676 0.034


chr9_+_33614214 0.033 ANXA2P2
annexin A2 pseudogene 2
chr11_-_55684368 0.033 NM_001004058
OR8K5
olfactory receptor, family 8, subfamily K, member 5
chr15_+_46285789 0.031 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr12_-_10853940 0.030 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr12_+_4569504 0.030 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr9_+_96561750 0.027 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr11_+_123639909 0.026 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr19_-_56229808 0.025 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr21_-_44824907 0.025 NM_198694
KRTAP10-5
keratin associated protein 10-5
chr2_+_203763649 0.025 RPL12
ribosomal protein L12
chr7_+_143423073 0.024 NM_001004135
OR2A12
olfactory receptor, family 2, subfamily A, member 12
chrX_+_77041612 0.024 NM_001866
COX7B
cytochrome c oxidase subunit VIIb
chr6_-_134540666 0.023 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr1_-_159867781 0.023 NM_000570
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr4_-_39199527 0.023 UGDH
UDP-glucose 6-dehydrogenase
chrX_-_131375217 0.022 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr1_+_28637247 0.022 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr16_-_70339666 0.021 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr2_-_27215781 0.021 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr7_+_128099581 0.020 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr11_-_70971556 0.018 NM_001005405
KRTAP5-11
keratin associated protein 5-11
chr14_-_80934523 0.017 NM_033104
STON2
stonin 2
chr11_+_6823458 0.017 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr12_+_103677388 0.016 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr17_+_73511843 0.016 NM_001142640
NM_018996
TNRC6C

trinucleotide repeat containing 6C

chr11_+_88550687 0.016 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr18_-_28247193 0.015


chr7_-_11643113 0.015 THSD7A
thrombospondin, type I, domain containing 7A
chr11_+_123945102 0.014 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr19_-_40711034 0.014 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr5_+_179934143 0.014 CNOT6
CCR4-NOT transcription complex, subunit 6
chr13_-_93929719 0.014 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr18_+_606671 0.012 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr1_+_157676135 0.012 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr21_-_30460841 0.011 NM_012131
CLDN17
claudin 17
chr8_+_92330691 0.011 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr16_+_18986417 0.010 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr5_-_180099663 0.009 NM_001001657
OR2Y1
olfactory receptor, family 2, subfamily Y, member 1
chr1_+_69998445 0.008 NM_020794
LRRC7
leucine rich repeat containing 7
chr6_+_160247962 0.008 NM_002377
MAS1
MAS1 oncogene
chr6_-_55848317 0.008 NM_021073
BMP5
bone morphogenetic protein 5
chrX_+_123062143 0.007 STAG2
stromal antigen 2
chrX_-_131923092 0.006 NM_001077188
NM_147175
HS6ST2

heparan sulfate 6-O-sulfotransferase 2

chr4_+_53975597 0.006 FIP1L1
FIP1 like 1 (S. cerevisiae)
chrX_-_71709622 0.005 NM_001166418
NM_001166419
NM_001166420
NM_001166422
NM_001166448
NM_018486
HDAC8





histone deacetylase 8





chr6_-_46933901 0.005 GPR116
G protein-coupled receptor 116
chr12_-_48902692 0.005 NM_001113547
LIMA1
LIM domain and actin binding 1
chr9_+_137553104 0.005 NM_002297
LCN1
lipocalin 1 (tear prealbumin)
chr14_+_38653177 0.005 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr3_+_35697432 0.005 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr17_-_36444626 0.005 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr10_+_80942362 0.005 NM_001099692
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr2_-_46988449 0.003 MCFD2
multiple coagulation factor deficiency 2
chr10_-_56230953 0.003 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr10_+_90474280 0.003 NM_001080518
LIPK
lipase, family member K
chr17_-_36409632 0.003 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr5_+_140698537 0.003 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr12_+_79362256 0.003 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr6_+_144654565 0.002 NM_007124
UTRN
utrophin
chr1_-_245942679 0.001 NM_001005286
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr3_+_185253528 0.001 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr6_-_138581319 0.001 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr10_+_86174665 0.000 FAM190B
family with sequence similarity 190, member B
chr4_+_169250281 0.000 NM_007193
ANXA10
annexin A10
chr18_+_19286784 0.000 NM_003831
RIOK3
RIO kinase 3 (yeast)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
38.35 2.76e-02 GO:0006570 tyrosine metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.93 2.11e-03 GO:0004930 G-protein coupled receptor activity
4.02 3.07e-03 GO:0004984 olfactory receptor activity