Motif ID: TEAD1.p2

Z-value: 4.950


Transcription factors associated with TEAD1.p2:

Gene SymbolEntrez IDGene Name
TEAD1 7003 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEAD2 8463 TEA domain family member 2
TEAD3 7005 TEAD3 TEA domain family member 3
TEAD4 7004 TEAD4 TEA domain family member 4



Activity profile for motif TEAD1.p2.

activity profile for motif TEAD1.p2


Sorted Z-values histogram for motif TEAD1.p2

Sorted Z-values for motif TEAD1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TEAD1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_39664706 24.375 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr6_-_132314004 19.216 NM_001901
CTGF
connective tissue growth factor
chr1_-_212791467 19.049 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr1_-_212791597 18.826 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr5_-_39460687 12.897 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr4_+_184257337 10.611 NM_024949
WWC2
WW and C2 domain containing 2
chr3_-_135575925 9.568 NM_016201
AMOTL2
angiomotin like 2
chr10_+_123862430 9.029 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_-_75972286 8.825 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr11_-_8788765 8.728 NM_213618
ST5
suppression of tumorigenicity 5
chr3_-_115825742 8.290 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_39460787 8.220 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr15_+_61122139 8.217 TPM1
tropomyosin 1 (alpha)
chr15_+_37660568 8.162 NM_003246
THBS1
thrombospondin 1
chr15_+_61121806 8.067 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr17_-_15495534 7.772 TRIM16
tripartite motif containing 16
chr6_-_42218692 7.701 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr6_-_128883125 7.446 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr1_-_16355013 6.937 NM_004431
EPHA2
EPH receptor A2
chr2_-_189752575 6.913 NM_000393
COL5A2
collagen, type V, alpha 2
chr11_-_8789457 6.376 NM_139157
ST5
suppression of tumorigenicity 5
chr2_-_192419896 6.201 SDPR
serum deprivation response
chr9_+_117955890 6.160 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr22_+_40286957 6.101 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr2_-_192420168 6.048 NM_004657
SDPR
serum deprivation response
chr12_-_94708641 5.907 NM_021229
NTN4
netrin 4
chr10_-_90702490 5.797 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr7_+_134114912 5.786 CALD1
caldesmon 1
chr8_+_1759502 5.736 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr15_+_73728402 5.561 NM_153271
SNX33
sorting nexin 33
chr7_+_134114701 5.472 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr8_-_42184194 5.339 PLAT
plasminogen activator, tissue
chr1_+_238321794 5.298 NM_020066
FMN2
formin 2
chr19_-_54063522 5.191 NM_001161354
NM_020904
PLEKHA4

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4

chr3_+_9919511 5.124 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr9_+_136673534 5.059 COL5A1
collagen, type V, alpha 1
chr7_+_134114957 5.008 CALD1
caldesmon 1
chr2_+_102125616 4.980 IL1R1
interleukin 1 receptor, type I
chr5_-_148422799 4.944 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr16_-_62573 4.920 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr19_-_13909877 4.868 PODNL1
podocan-like 1
chr5_-_39461054 4.767 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr9_+_90339835 4.757 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr6_+_41712907 4.724 MDFI
MyoD family inhibitor
chr10_-_123346148 4.677 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr12_-_45506001 4.667 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr8_-_42184350 4.654 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chrX_-_83644054 4.576 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr1_+_114323552 4.528 NM_020190
OLFML3
olfactomedin-like 3
chr8_+_70541412 4.521 NM_001128204
NM_015170
SULF1

sulfatase 1

chr14_-_22516271 4.503 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr14_-_22515725 4.477 JUB
jub, ajuba homolog (Xenopus laevis)
chr3_-_113841941 4.464 CCDC80
coiled-coil domain containing 80
chr3_+_50281582 4.417 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr3_-_113841967 4.207 CCDC80
coiled-coil domain containing 80
chr3_+_9919295 4.132 NM_153483
IL17RE
interleukin 17 receptor E
chr5_+_38882017 4.048 OSMR
oncostatin M receptor
chr17_-_37828643 3.992 NM_012232
PTRF
polymerase I and transcript release factor
chr6_-_75972473 3.978 COL12A1
collagen, type XII, alpha 1
chrX_-_114703273 3.973


chr12_-_78608873 3.940 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr11_-_47427263 3.927 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr12_+_51728999 3.892 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr6_+_134251940 3.847 NM_198392
NM_003206
TCF21

transcription factor 21

chr18_+_30427279 3.840 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr3_-_113842133 3.839 CCDC80
coiled-coil domain containing 80
chr3_+_50281309 3.810 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr10_+_102782151 3.788 SFXN3
sideroflexin 3
chr6_+_134251957 3.756 TCF21
transcription factor 21
chr15_-_93671314 3.746 LOC400456
hypothetical LOC400456
chr1_-_199704773 3.730 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr11_+_7463175 3.697 NM_198474
OLFML1
olfactomedin-like 1
chr10_-_125843092 3.673 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr11_+_66580884 3.624 RHOD
ras homolog gene family, member D
chrX_-_10548458 3.623 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr2_-_160972606 3.608 RBMS1
RNA binding motif, single stranded interacting protein 1
chr3_-_113842350 3.598 CCDC80
coiled-coil domain containing 80
chr5_-_20024050 3.594 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr11_-_85107569 3.590 NM_206929
SYTL2
synaptotagmin-like 2
chr11_+_66580861 3.483 NM_014578
RHOD
ras homolog gene family, member D
chr11_-_6298284 3.482 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr4_+_158361185 3.448 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr2_-_238164452 3.427 NM_022449
RAB17
RAB17, member RAS oncogene family
chr2_+_102169864 3.415 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chr4_-_152368492 3.390 SH3D19
SH3 domain containing 19
chr3_-_113842255 3.353 CCDC80
coiled-coil domain containing 80
chr10_-_116382089 3.332 ABLIM1
actin binding LIM protein 1
chr3_-_113842237 3.281 CCDC80
coiled-coil domain containing 80
chr4_+_15089931 3.209 CC2D2A
coiled-coil and C2 domain containing 2A
chr1_+_85819004 3.162 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr19_-_13910167 3.128 NM_024825
PODNL1
podocan-like 1
chr11_-_85108030 3.072 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr1_-_207892296 3.066 NM_001127641
LAMB3
laminin, beta 3
chr2_+_95303947 3.014 PROM2
prominin 2
chr2_-_158439868 2.926 NM_001105
ACVR1
activin A receptor, type I
chr4_+_19864332 2.919 NM_004787
SLIT2
slit homolog 2 (Drosophila)
chr1_-_151848039 2.870 S100A16
S100 calcium binding protein A16
chrX_-_53327473 2.864 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr5_-_38881636 2.854


chr18_+_50646616 2.795 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr10_+_102782156 2.789 SFXN3
sideroflexin 3
chr9_-_72673753 2.786 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr1_+_78126787 2.784 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chrX_-_106129854 2.782 MORC4
MORC family CW-type zinc finger 4
chr9_-_16717887 2.779 BNC2
basonuclin 2
chr12_-_13044314 2.756 HEBP1
heme binding protein 1
chr5_+_152850276 2.733 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr7_-_155297576 2.717 NM_000193
SHH
sonic hedgehog
chr14_-_22974707 2.654 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr3_-_113842553 2.625 CCDC80
coiled-coil domain containing 80
chr2_-_238164042 2.602 RAB17
RAB17, member RAS oncogene family
chr11_+_93394025 2.591 NM_001098672
HEPHL1
hephaestin-like 1
chr3_+_25444753 2.590 NM_016152
RARB
retinoic acid receptor, beta
chr3_-_150533948 2.548 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chrX_-_6156655 2.537 NM_181332
NLGN4X
neuroligin 4, X-linked
chr5_+_38881719 2.537 NM_003999
OSMR
oncostatin M receptor
chr2_+_95303922 2.522 NM_001165977
NM_001165978
NM_144707
PROM2


prominin 2


chr3_+_148609841 2.474 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr3_+_25444837 2.449 NM_000965
RARB
retinoic acid receptor, beta
chr1_-_207892420 2.448 NM_000228
LAMB3
laminin, beta 3
chr11_-_126375895 2.444 NM_001161707
NM_032531
KIRREL3

kin of IRRE like 3 (Drosophila)

chr12_+_13044604 2.428 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chr19_+_50041424 2.412 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_-_148175345 2.411 MTMR11
myotubularin related protein 11
chr12_-_13044448 2.394 HEBP1
heme binding protein 1
chr5_-_151046680 2.384 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr14_-_88090641 2.373 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr1_-_199613406 2.360 TNNT2
troponin T type 2 (cardiac)
chr12_-_13044467 2.345 NM_015987
HEBP1
heme binding protein 1
chr16_-_31054321 2.344 PRSS8
protease, serine, 8
chr2_-_75641535 2.322 FAM176A
family with sequence similarity 176, member A
chr11_+_1812115 2.312 NM_138567
SYT8
synaptotagmin VIII
chr19_-_56147971 2.310 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr1_+_181422016 2.303 LAMC2
laminin, gamma 2
chr10_-_17699309 2.295 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr8_-_38444398 2.292 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr2_-_75641587 2.282 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr1_-_199613427 2.278 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr1_+_183970093 2.276 NM_031935
HMCN1
hemicentin 1
chr5_-_151046638 2.263 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chrX_+_114701665 2.247 PLS3
plastin 3
chr5_-_58607673 2.241 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr9_+_112470871 2.230 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr5_+_38881716 2.196 NM_001168355
OSMR
oncostatin M receptor
chr19_+_41980248 2.193 LOC284408
hypothetical LOC284408
chr16_+_15435825 2.192 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr11_+_57123927 2.179 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr11_+_113671744 2.160 NM_006169
NNMT
nicotinamide N-methyltransferase
chr3_-_12561962 2.151 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr11_-_2127368 2.123 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr7_+_72883128 2.108 NM_001305
CLDN4
claudin 4
chr3_-_162572441 2.078 NM_001040100
C3orf57
chromosome 3 open reading frame 57
chr17_+_35109802 2.066 ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr3_-_52844274 2.064 NM_205853
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chrX_-_13307425 2.064


chr5_-_127901376 2.059 FBN2
fibrillin 2
chr17_-_15463742 2.041 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr6_+_83130220 2.023 TPBG
trophoblast glycoprotein
chr5_-_138822475 2.020 NM_001077693
ECSCR
endothelial cell-specific chemotaxis regulator
chr20_+_34603290 2.016 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr16_-_31054563 2.009 NM_002773
PRSS8
protease, serine, 8
chr17_+_71229191 1.993 ITGB4
integrin, beta 4
chrX_+_107569671 1.992 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr19_-_56163815 1.984 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr19_-_41514390 1.982


chr10_+_24538094 1.976 KIAA1217
KIAA1217
chr1_-_148175383 1.974 NM_001145862
MTMR11
myotubularin related protein 11
chr6_+_144040751 1.962 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr8_-_38505331 1.948 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr6_+_123152044 1.936 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr4_+_8322358 1.909 NM_053044
HTRA3
HtrA serine peptidase 3
chr3_-_113842652 1.907 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr4_-_171247757 1.905 NM_016228
AADAT
aminoadipate aminotransferase
chr19_+_55918405 1.882 NM_002975
CLEC11A
C-type lectin domain family 11, member A
chr17_+_71229151 1.873 ITGB4
integrin, beta 4
chr1_-_1283770 1.861 NM_032348
MXRA8
matrix-remodelling associated 8
chr11_-_126375864 1.857 KIRREL3
kin of IRRE like 3 (Drosophila)
chr1_+_181421984 1.851 LAMC2
laminin, gamma 2
chr2_+_151922350 1.845 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_+_61320213 1.825 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr5_-_83052606 1.824 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr4_+_159311353 1.810 LOC285505
hypothetical protein LOC285505
chr12_+_2938703 1.805 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr20_+_34603311 1.796 MYL9
myosin, light chain 9, regulatory
chr2_+_112612511 1.794 FBLN7
fibulin 7
chr5_-_16989371 1.779 NM_012334
MYO10
myosin X
chr19_+_55918450 1.776 CLEC11A
C-type lectin domain family 11, member A
chr12_-_53099277 1.767 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr10_+_24537725 1.759 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr12_-_53099203 1.752 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_-_54522881 1.751 NM_002429
MMP19
matrix metallopeptidase 19
chr12_-_53099269 1.743 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr5_-_59100091 1.714 PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_-_97366313 1.714 NM_001102612
PGPEP1L
pyroglutamyl-peptidase I-like
chr17_-_6958282 1.711 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr1_-_27604656 1.710 WASF2
WAS protein family, member 2
chr17_-_36347197 1.693 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr3_+_148610516 1.689 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr2_+_112612429 1.683 NM_001128165
NM_153214
FBLN7

fibulin 7

chr18_-_51219880 1.670 TCF4
transcription factor 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.42 4.19e-04 GO:0048731 system development
1.80 7.36e-04 GO:0048468 cell development
1.37 1.28e-03 GO:0048856 anatomical structure development
2.51 1.66e-03 GO:0061061 muscle structure development
1.49 3.68e-03 GO:0048513 organ development
1.91 4.53e-03 GO:0032989 cellular component morphogenesis
3.93 5.08e-03 GO:0051146 striated muscle cell differentiation
2.35 5.47e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.25 6.26e-03 GO:0032501 multicellular organismal process
2.00 6.70e-03 GO:0006935 chemotaxis
2.00 6.70e-03 GO:0042330 taxis
3.24 6.81e-03 GO:0014706 striated muscle tissue development
2.07 8.81e-03 GO:0048812 neuron projection morphogenesis
1.79 1.06e-02 GO:0007155 cell adhesion
1.79 1.06e-02 GO:0022610 biological adhesion
1.32 1.09e-02 GO:0007275 multicellular organismal development
1.99 1.36e-02 GO:0000904 cell morphogenesis involved in differentiation
1.53 1.41e-02 GO:0009653 anatomical structure morphogenesis
1.95 2.17e-02 GO:0032990 cell part morphogenesis
1.97 2.24e-02 GO:0031175 neuron projection development
2.60 2.61e-02 GO:0007517 muscle organ development
2.97 2.74e-02 GO:0060537 muscle tissue development
1.70 2.76e-02 GO:0040011 locomotion
2.04 2.86e-02 GO:0007409 axonogenesis
2.18 2.88e-02 GO:0007411 axon guidance
2.01 2.98e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.93 3.74e-02 GO:0048858 cell projection morphogenesis
1.68 4.71e-02 GO:0009888 tissue development
4.17 4.84e-02 GO:0055001 muscle cell development
3.67 4.88e-02 GO:0045785 positive regulation of cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.67 3.21e-09 GO:0005576 extracellular region
1.86 8.72e-07 GO:0044421 extracellular region part
2.44 7.02e-06 GO:0031012 extracellular matrix
1.31 7.50e-05 GO:0071944 cell periphery
2.45 7.63e-05 GO:0005578 proteinaceous extracellular matrix
3.56 1.19e-04 GO:0044420 extracellular matrix part
1.31 1.53e-04 GO:0005886 plasma membrane
15.94 7.48e-04 GO:0001527 microfibril
1.75 1.30e-03 GO:0005615 extracellular space
1.40 4.19e-03 GO:0044459 plasma membrane part
3.72 6.12e-03 GO:0042383 sarcolemma
3.55 2.01e-02 GO:0005604 basement membrane
9.57 2.63e-02 GO:0043205 fibril
2.07 3.41e-02 GO:0015629 actin cytoskeleton
3.59 3.48e-02 GO:0016459 myosin complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.42 1.02e-04 GO:0003779 actin binding
3.10 3.55e-04 GO:0005539 glycosaminoglycan binding
2.99 4.29e-04 GO:0001871 pattern binding
2.99 4.29e-04 GO:0030247 polysaccharide binding
3.40 1.26e-03 GO:0019838 growth factor binding
6.89 1.31e-03 GO:0050840 extracellular matrix binding
8.93 2.27e-03 GO:0043236 laminin binding
1.93 2.32e-03 GO:0008092 cytoskeletal protein binding
3.25 2.53e-03 GO:0008201 heparin binding
4.89 4.53e-03 GO:0008307 structural constituent of muscle
8.83 1.23e-02 GO:0001968 fibronectin binding
3.35 3.03e-02 GO:0005201 extracellular matrix structural constituent
12.75 4.98e-02 GO:0043237 laminin-1 binding