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Motif ID: SREBF1,2.p2

Z-value: 1.128

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr22_+_34107087	3.966		HMOX1	heme oxygenase (decycling) 1
chr10_-_14090459	3.086		FRMD4A	FERM domain containing 4A
chr22_+_34107051	3.040	NM_002133	HMOX1	heme oxygenase (decycling) 1
chr17_+_75851984	2.726
chr17_+_73638430	2.681	NM_152468	TMC8	transmembrane channel-like 8
chr14_-_93512818	2.577		ASB2	ankyrin repeat and SOCS box containing 2
chr19_+_55614006	2.491	NM_003121	SPIB	Spi-B transcription factor (Spi-1/PU.1 related)
chr12_-_47604930	2.424	NM_001143781	FKBP11	FK506 binding protein 11, 19 kDa
chr13_+_48582389	2.278	NM_014923	FNDC3A	fibronectin type III domain containing 3A
chr2_+_143603439	2.216		ARHGAP15	Rho GTPase activating protein 15
chr9_-_37566248	2.213	NM_012166	FBXO10	F-box protein 10
chr13_-_31900218	2.166	NM_001079691 NM_052818	N4BP2L1	NEDD4 binding protein 2-like 1
chr12_+_56284867	2.138	NM_178502	DTX3	deltex homolog 3 (Drosophila)
chr19_-_15436333	2.083	NM_022904	RASAL3	RAS protein activator like 3
chr10_-_98021144	1.895	NM_001114094 NM_013314	BLNK	B-cell linker
chr22_+_40724674	1.822	NM_152613	WBP2NL	WBP2 N-terminal like
chr11_-_60475558	1.818	NM_016582	SLC15A3	solute carrier family 15, member 3
chr1_-_152797707	1.727	NM_017582	UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr8_+_75066117	1.704	NM_001195797 NM_015364	LY96	lymphocyte antigen 96
chr17_-_7078446	1.697	NM_004422	DVL2	dishevelled, dsh homolog 2 (Drosophila)
chrX_+_128741578	1.651		SASH3	SAM and SH3 domain containing 3
chrX_+_128741562	1.631	NM_018990	SASH3	SAM and SH3 domain containing 3
chr11_+_59979857	1.568	NM_021950 NM_152866	MS4A1	membrane-spanning 4-domains, subfamily A, member 1
chr17_-_7078304	1.543		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr1_-_152797820	1.521		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr12_+_52733927	1.482	NM_153633	HOXC4 HOXC6	homeobox C4 homeobox C6
chr4_+_177223978	1.474	NM_170710 NM_181265	WDR17	WD repeat domain 17
chr7_+_101861007	1.469		ORAI2	ORAI calcium release-activated calcium modulator 2
chr1_-_152797767	1.463		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr1_+_181871830	1.427	NM_015149	RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr3_-_126414252	1.409	NM_024628	SLC12A8	solute carrier family 12 (potassium/chloride transporters), member 8
chr3_+_44878380	1.402	NM_144638	TMEM42	transmembrane protein 42
chr2_+_219751230	1.375		FAM134A	family with sequence similarity 134, member A
chr9_-_133574928	1.364	NM_198679	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1
chr1_-_152797760	1.351		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr20_-_4743768	1.335	NM_170774	RASSF2	Ras association (RalGDS/AF-6) domain family member 2
chr17_-_7078399	1.333		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr11_+_120828275	1.323		SORL1	sortilin-related receptor, L(DLR class) A repeats containing
chr19_+_54149843	1.314	NM_004324 NM_138761 NM_138763 NM_138764	BAX	BCL2-associated X protein
chr11_+_120828058	1.309	NM_003105	SORL1	sortilin-related receptor, L(DLR class) A repeats containing
chr19_+_54149941	1.297		BAX	BCL2-associated X protein
chr14_-_93512647	1.282		ASB2	ankyrin repeat and SOCS box containing 2
chr1_+_111544469	1.269
chr14_-_19999475	1.269	NM_001100814 NM_144568	TMEM55B	transmembrane protein 55B
chr10_-_105427898	1.256		SH3PXD2A	SH3 and PX domains 2A
chr3_-_113763049	1.251	NM_022488	ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)
chr15_-_70455153	1.241		HEXA	hexosaminidase A (alpha polypeptide)
chr19_+_1018293	1.239		HMHA1	histocompatibility (minor) HA-1
chr4_+_177224142	1.237		WDR17	WD repeat domain 17
chr19_+_54149963	1.236		BAX	BCL2-associated X protein
chr5_-_150517499	1.234		ANXA6	annexin A6
chr22_+_23153529	1.225	NM_000675	ADORA2A	adenosine A2a receptor
chr15_+_86983038	1.197	NM_002201	ISG20	interferon stimulated exonuclease gene 20kDa
chr5_+_244625	1.187	NM_001080478	LRRC14B	leucine rich repeat containing 14B
chr22_-_35232979	1.182		FOXRED2	FAD-dependent oxidoreductase domain containing 2
chr5_-_150517454	1.182		ANXA6	annexin A6
chr7_+_101860958	1.175	NM_001126340 NM_032831	ORAI2	ORAI calcium release-activated calcium modulator 2
chr13_-_32757835	1.170	NM_178006	STARD13	StAR-related lipid transfer (START) domain containing 13
chr19_+_1018536	1.165		HMHA1	histocompatibility (minor) HA-1
chr15_-_70455355	1.145	NM_000520	HEXA	hexosaminidase A (alpha polypeptide)
chr22_-_36907638	1.131	NM_001004426 NM_003560	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)
chr12_+_64869181	1.096	NM_001142523 NM_007199	IRAK3	interleukin-1 receptor-associated kinase 3
chr19_+_14405100	1.080	NM_002741	PKN1	protein kinase N1
chr2_-_55090759	1.079	NM_007008	RTN4	reticulon 4
chr11_-_16992524	1.071	NM_175058	PLEKHA7	pleckstrin homology domain containing, family A member 7
chr1_-_153477673	1.068	NM_001171812 NM_000157	GBA	glucosidase, beta, acid
chr3_-_49370755	1.058	NM_000581 NM_201397	GPX1	glutathione peroxidase 1
chr22_-_35233032	1.041	NM_024955 NM_001102371	FOXRED2	FAD-dependent oxidoreductase domain containing 2
chr16_+_639278	1.039	NM_145294	WDR90	WD repeat domain 90
chr7_-_29995809	1.034	NM_001145515 NM_014766 NM_001145513	SCRN1	secernin 1
chr2_+_227898163	1.032		MFF	mitochondrial fission factor
chr2_-_25328452	1.027	NM_153759	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha
chr2_+_208284610	1.022		CCNYL1	cyclin Y-like 1
chr3_-_49370682	1.021		GPX1	glutathione peroxidase 1
chr12_+_64869271	1.020		IRAK3	interleukin-1 receptor-associated kinase 3
chr12_-_107551783	1.002	NM_003006	SELPLG	selectin P ligand
chr8_+_109525050	0.981		TTC35	tetratricopeptide repeat domain 35
chr11_+_9642226	0.978		SWAP70	SWAP switching B-cell complex 70kDa subunit
chr12_-_107551744	0.970		SELPLG	selectin P ligand
chr2_+_208284691	0.965		CCNYL1	cyclin Y-like 1
chr2_+_208284484	0.963	NM_001142300 NM_152523	CCNYL1	cyclin Y-like 1
chr16_-_66072477	0.959	NM_004691	ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chrX_+_55760774	0.953	NM_006064 NM_016656	RRAGB	Ras-related GTP binding B
chr16_-_87570716	0.947	NM_005187	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr1_-_153477511	0.946		GBA	glucosidase, beta, acid
chr12_-_107551694	0.944		SELPLG	selectin P ligand
chr2_+_219751207	0.941		FAM134A	family with sequence similarity 134, member A
chr11_-_71491916	0.937		LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr11_+_9642182	0.935		SWAP70	SWAP switching B-cell complex 70kDa subunit
chr11_+_9642229	0.934		SWAP70	SWAP switching B-cell complex 70kDa subunit
chr11_+_9642200	0.929	NM_015055	SWAP70	SWAP switching B-cell complex 70kDa subunit
chr17_-_44043361	0.926	NM_004502	HOXB7	homeobox B7
chr1_-_24386324	0.923	NM_170743 NM_173064 NM_173065	IL28RA	interleukin 28 receptor, alpha (interferon, lambda receptor)
chr17_+_45527507	0.922	NM_002611	PDK2	pyruvate dehydrogenase kinase, isozyme 2
chr7_+_17304707	0.910	NM_001621	AHR	aryl hydrocarbon receptor
chr12_+_120840829	0.907	NM_001178003 NM_144668	WDR66	WD repeat domain 66
chr16_+_55580910	0.903	NM_032206	NLRC5	NLR family, CARD domain containing 5
chr14_-_19999324	0.903		TMEM55B	transmembrane protein 55B
chr8_+_109525010	0.901	NM_014673	TTC35	tetratricopeptide repeat domain 35
chr1_-_197173159	0.899		LOC100131234	familial acute myelogenous leukemia related factor
chrX_-_114703273	0.886
chr12_+_64869296	0.886		IRAK3	interleukin-1 receptor-associated kinase 3
chr8_+_67507271	0.881	NM_144650	ADHFE1	alcohol dehydrogenase, iron containing, 1
chr8_+_21937533	0.875		NPM2	nucleophosmin/nucleoplasmin 2
chr12_-_56432292	0.869		CDK4	cyclin-dependent kinase 4
chr17_-_3407780	0.867		TRPV3	transient receptor potential cation channel, subfamily V, member 3
chr19_+_14405216	0.862		PKN1	protein kinase N1
chr14_-_23752507	0.860		CHMP4A	chromatin modifying protein 4A
chr11_-_71491942	0.850		LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr14_+_23711044	0.847	NM_001048205 NM_005132	REC8	REC8 homolog (yeast)
chr9_-_21984379	0.841		CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr3_-_113763449	0.834		ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)
chr5_-_150517528	0.831	NM_001155	ANXA6	annexin A6
chr17_+_1574782	0.830	NM_001163809	WDR81	WD repeat domain 81
chr2_+_219751192	0.823		FAM134A	family with sequence similarity 134, member A
chr20_-_2769120	0.821		FAM113A	family with sequence similarity 113, member A
chr11_-_36267510	0.817		COMMD9	COMM domain containing 9
chr12_+_52713098	0.816	NM_018953	HOXC5	homeobox C5
chr10_+_106018915	0.811		GSTO2	glutathione S-transferase omega 2
chr9_-_21984329	0.809		CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr14_-_34661156	0.808		PPP2R3C	protein phosphatase 2, regulatory subunit B'', gamma
chr14_-_23752498	0.808		CHMP4A	chromatin modifying protein 4A
chr8_+_11599119	0.805	NM_002052	GATA4	GATA binding protein 4
chr3_-_113763217	0.804		ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)
chr17_-_41018291	0.797
chr12_-_57600564	0.796		LRIG3	leucine-rich repeats and immunoglobulin-like domains 3
chr3_-_113763454	0.796		ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)
chr17_-_53764867	0.784
chr10_-_100196624	0.782		HPS1	Hermansky-Pudlak syndrome 1
chr3_+_51403760	0.780	NM_013286	RBM15B	RNA binding motif protein 15B
chr2_+_215885063	0.772		ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr3_-_51950919	0.772	NM_004704	RRP9	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
chr14_-_34661190	0.768	NM_017917	PPP2R3C	protein phosphatase 2, regulatory subunit B'', gamma
chr14_-_63830830	0.766	NM_001040275 NM_001437	ESR2	estrogen receptor 2 (ER beta)
chr4_+_54660954	0.766	NM_133267	GSX2	GS homeobox 2
chr12_+_115660468	0.764	NM_001109903 NM_032814	RNFT2	ring finger protein, transmembrane 2
chr8_-_54918389	0.763	NM_015941 NM_213619	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr11_+_7491789	0.756		PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr3_-_113763425	0.752		ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)
chr15_-_32398220	0.748	NM_005135	SLC12A6	solute carrier family 12 (potassium/chloride transporters), member 6
chr1_-_210939929	0.737	NM_018664	BATF3	basic leucine zipper transcription factor, ATF-like 3
chr6_-_90178685	0.735	NM_021244	RRAGD	Ras-related GTP binding D
chr6_+_151815114	0.734	NM_024573	C6orf211	chromosome 6 open reading frame 211
chr1_-_210939727	0.734
chr13_-_45654327	0.726	NM_002298	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_224253678	0.721	NM_152608	C1orf55	chromosome 1 open reading frame 55
chr17_-_44022595	0.718		HOXB3	homeobox B3
chr19_-_9908014	0.716	NM_058164	OLFM2	olfactomedin 2
chr11_+_7491576	0.715	NM_003621	PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_-_150118747	0.714	NM_001135643 NM_016221	DCTN4	dynactin 4 (p62)
chr2_-_182253457	0.714	NM_002500	NEUROD1	neurogenic differentiation 1
chr14_+_23710924	0.712		REC8	REC8 homolog (yeast)
chr14_-_23752476	0.709		CHMP4A	chromatin modifying protein 4A
chr2_-_158008763	0.703	NM_004288	CYTIP	cytohesin 1 interacting protein
chr4_+_91267706	0.702	NM_001145065	FAM190A	family with sequence similarity 190, member A
chr20_+_56861430	0.701	NM_001077490 NM_080425	GNAS	GNAS complex locus
chr3_+_134775946	0.700	NM_001134423	CDV3	CDV3 homolog (mouse)
chr8_+_133856738	0.694	NM_016018 NM_032205 NM_198513	PHF20L1	PHD finger protein 20-like 1
chr2_-_219791638	0.693		ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr18_+_54958095	0.689	NM_033280	SEC11C	SEC11 homolog C (S. cerevisiae)
chr9_-_21984414	0.688	NM_058195	CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr17_-_60346042	0.684		LRRC37A3	leucine rich repeat containing 37, member A3
chr17_+_1574583	0.684	NM_001163811	WDR81	WD repeat domain 81
chr11_-_71491983	0.684		LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr4_-_647424	0.681
chr10_+_69314714	0.679		SIRT1	sirtuin 1
chr20_+_33823318	0.679	NM_016436	PHF20	PHD finger protein 20
chr2_-_219791902	0.677	NM_005689	ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr17_-_44043278	0.671		HOXB7	homeobox B7
chr1_-_165211128	0.668	NM_199351	ILDR2	immunoglobulin-like domain containing receptor 2
chr17_+_52410466	0.662	NM_021626	SCPEP1	serine carboxypeptidase 1
chr13_-_45654296	0.649		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr14_+_75114692	0.649	NM_017791	FLVCR2	feline leukemia virus subgroup C cellular receptor family, member 2
chr12_-_57600336	0.648	NM_153377	LRIG3	leucine-rich repeats and immunoglobulin-like domains 3
chr1_-_210939820	0.648		BATF3	basic leucine zipper transcription factor, ATF-like 3
chr7_-_50103335	0.636	NM_001159878 NM_007009	ZPBP	zona pellucida binding protein
chr14_+_34661497	0.635	NM_014672	KIAA0391	KIAA0391
chr1_-_224253610	0.635		C1orf55	chromosome 1 open reading frame 55
chr10_-_100196647	0.633		HPS1	Hermansky-Pudlak syndrome 1
chr17_-_33043514	0.631	NM_001163544 NM_001163545 NM_001163546 NM_001163547 NM_007247 NM_080550 NM_198882	SYNRG	synergin, gamma
chr2_+_241903395	0.630	NM_001008491 NM_006155	SEPT2	septin 2
chr20_+_37024383	0.627	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr9_-_19117462	0.626		PLIN2	perilipin 2
chr13_-_49057707	0.626	NM_018191	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr4_-_23500706	0.624	NM_013261	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr9_+_115151632	0.624	NM_017688	BSPRY	B-box and SPRY domain containing
chr17_-_73636386	0.624	NM_001127198	TMC6	transmembrane channel-like 6
chr8_+_98725505	0.623	NM_178812	MTDH	metadherin
chr14_-_38971370	0.621	NM_203301	FBXO33	F-box protein 33
chr12_-_101835183	0.620		PAH	phenylalanine hydroxylase
chr12_+_6703686	0.616	NM_001164093	COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chrX_+_10084984	0.610	NM_001830	CLCN4	chloride channel 4
chr19_+_18069596	0.607	NM_015016	MAST3	microtubule associated serine/threonine kinase 3
chr17_+_6856521	0.603	NM_001004333	RNASEK-C17ORF49 RNASEK	RNASEK-C17orf49 read-through transcript ribonuclease, RNase K
chr3_+_49002774	0.603		P4HTM	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr5_+_41940216	0.600	NM_175921	C5orf51	chromosome 5 open reading frame 51
chr19_+_7493436	0.599	NM_020533	MCOLN1	mucolipin 1
chr17_-_44026042	0.598	NM_002147	HOXB5	homeobox B5
chr8_-_54918325	0.597		ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr11_+_107304344	0.596	NM_017516	RAB39	RAB39, member RAS oncogene family

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.23	8.94e-06	GO:0044237	cellular metabolic process
1.20	3.26e-04	GO:0044238	primary metabolic process
1.32	3.55e-04	GO:0006807	nitrogen compound metabolic process
1.33	4.81e-04	GO:0034641	cellular nitrogen compound metabolic process
1.18	5.78e-04	GO:0008152	metabolic process
1.35	7.29e-04	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.10	6.58e-03	GO:0009987	cellular process
2.94	1.05e-02	GO:0000041	transition metal ion transport
4.95	1.44e-02	GO:0015682	ferric iron transport
4.95	1.44e-02	GO:0033572	transferrin transport
1.23	1.66e-02	GO:0044260	cellular macromolecule metabolic process
1.31	4.89e-02	GO:0044249	cellular biosynthetic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.16	3.04e-13	GO:0044424	intracellular part
1.15	1.53e-12	GO:0005622	intracellular
1.21	2.08e-11	GO:0043227	membrane-bounded organelle
1.21	3.78e-11	GO:0043231	intracellular membrane-bounded organelle
1.22	1.62e-10	GO:0005737	cytoplasm
1.18	2.98e-10	GO:0043226	organelle
1.30	4.29e-10	GO:0044446	intracellular organelle part
1.29	6.51e-10	GO:0044422	organelle part
1.18	6.58e-10	GO:0043229	intracellular organelle
1.28	1.30e-09	GO:0044444	cytoplasmic part
1.50	1.25e-08	GO:0043233	organelle lumen
1.50	1.32e-08	GO:0031974	membrane-enclosed lumen
2.49	5.21e-08	GO:0005773	vacuole
1.49	7.03e-08	GO:0070013	intracellular organelle lumen
1.50	8.11e-08	GO:0044428	nuclear part
1.64	2.71e-07	GO:0005654	nucleoplasm
1.51	1.42e-06	GO:0031981	nuclear lumen
2.42	5.48e-06	GO:0000323	lytic vacuole
2.42	5.48e-06	GO:0005764	lysosome
1.23	1.05e-05	GO:0005634	nucleus
1.43	2.67e-05	GO:0005829	cytosol
2.75	5.66e-05	GO:0044437	vacuolar part
2.79	6.37e-05	GO:0005774	vacuolar membrane
1.72	1.92e-04	GO:0044451	nucleoplasm part
1.28	3.30e-04	GO:0032991	macromolecular complex
3.86	7.80e-04	GO:0016605	PML body
2.27	9.44e-04	GO:0016604	nuclear body
2.82	1.30e-03	GO:0005765	lysosomal membrane
2.54	1.83e-02	GO:0005770	late endosome
5.40	2.07e-02	GO:0033176	proton-transporting V-type ATPase complex
1.73	2.21e-02	GO:0005768	endosome
1.25	2.65e-02	GO:0043234	protein complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.12	1.08e-07	GO:0005488	binding
1.20	2.19e-06	GO:0005515	protein binding
1.81	2.68e-02	GO:0003712	transcription cofactor activity
1.80	2.88e-02	GO:0000988	protein binding transcription factor activity
1.80	2.88e-02	GO:0000989	transcription factor binding transcription factor activity
2.04	4.49e-02	GO:0003713	transcription coactivator activity