Motif ID: RXRG_dimer.p3

Z-value: 0.748


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma



Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_50004458 1.444 MBD2
methyl-CpG binding domain protein 2
chr12_-_6535481 1.195 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr2_+_206732575 1.194 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr5_+_92944680 1.163 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr4_+_30330963 1.152 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr2_+_206732562 1.128 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr7_+_142790047 1.121 ZYX
zyxin
chr3_-_49424322 1.119 RHOA
ras homolog gene family, member A
chr2_-_206732348 1.091 NM_005006
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr4_+_30331289 1.026 PCDH7
protocadherin 7
chr3_-_49424361 1.021 RHOA
ras homolog gene family, member A
chr3_-_49424380 1.007 RHOA
ras homolog gene family, member A
chr2_+_206732859 0.959 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr6_+_142510094 0.957 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr6_+_144040751 0.953 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr3_-_49424397 0.950 RHOA
ras homolog gene family, member A
chr18_-_50004770 0.922 MBD2
methyl-CpG binding domain protein 2
chr3_-_49424404 0.916 RHOA
ras homolog gene family, member A
chr5_+_80292313 0.916 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr6_+_142510075 0.903 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr3_-_49424427 0.880 RHOA
ras homolog gene family, member A
chr2_+_219141761 0.866 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr6_+_142510108 0.859 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr3_-_49424413 0.844 RHOA
ras homolog gene family, member A
chr7_+_142789476 0.822 ZYX
zyxin
chr2_-_219141199 0.766 NM_020935
USP37
ubiquitin specific peptidase 37
chr19_+_41980248 0.762 LOC284408
hypothetical LOC284408
chr6_+_142510034 0.749 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr3_-_114947330 0.744 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr14_-_94693359 0.696 DICER1
dicer 1, ribonuclease type III
chr3_-_49424506 0.691 RHOA
ras homolog gene family, member A
chr3_-_49424529 0.680 NM_001664
RHOA
ras homolog gene family, member A
chr16_+_79829794 0.673 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr12_+_65949631 0.655 CAND1
cullin-associated and neddylation-dissociated 1
chr3_-_49289285 0.622 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr1_-_154147787 0.602 NM_006912
RIT1
Ras-like without CAAX 1
chr2_+_198073358 0.579 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr12_+_67489063 0.577 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr4_+_109761170 0.566 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr20_+_19981157 0.563 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr1_-_101263867 0.555 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr2_-_27966715 0.555 NM_022128
RBKS
ribokinase
chr20_-_19981005 0.551 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr2_+_138438277 0.532 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr1_+_101263989 0.528


chr3_+_151747266 0.525 EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr1_-_154147687 0.522 RIT1
Ras-like without CAAX 1
chr17_+_7474128 0.507 SHBG
sex hormone-binding globulin
chr3_+_151747204 0.506 NM_032025
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr3_-_151746821 0.503 SERP1
stress-associated endoplasmic reticulum protein 1
chr16_-_86527608 0.489 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr2_+_198073257 0.486 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr18_-_44730706 0.484 SMAD7
SMAD family member 7
chr2_+_161725172 0.481 TANK
TRAF family member-associated NFKB activator
chr2_+_119841611 0.478 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr1_-_120285753 0.475 NOTCH2
notch 2
chr2_+_219141546 0.466 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr9_+_88086932 0.459


chr11_+_117735558 0.448 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr12_+_94776901 0.446 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr22_+_28493351 0.435 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr4_-_4594620 0.434 STX18
syntaxin 18
chr12_+_48422220 0.432 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr20_+_43943254 0.431 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr3_-_114947681 0.424 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr3_-_49178762 0.418 CCDC71
coiled-coil domain containing 71
chr3_-_49178773 0.412 NM_022903
CCDC71
coiled-coil domain containing 71
chr11_+_85690900 0.408 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr2_+_219354692 0.405 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr14_-_74713086 0.398 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr19_+_50086482 0.398 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr14_-_74713062 0.393 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr3_-_49178738 0.388 CCDC71
coiled-coil domain containing 71
chr14_-_74713088 0.386 NM_006827
TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr3_-_151746924 0.383 SERP1
stress-associated endoplasmic reticulum protein 1
chr3_-_151746970 0.382 NM_014445
SERP1
stress-associated endoplasmic reticulum protein 1
chr6_+_30702586 0.377 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr5_-_42847716 0.374 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chrX_+_100241453 0.370 NM_006733
CENPI
centromere protein I
chr14_-_74713039 0.370 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr3_-_151746954 0.368 SERP1
stress-associated endoplasmic reticulum protein 1
chr12_+_94776836 0.366 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr2_+_198072965 0.362 NM_002157
HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr9_+_103335983 0.361 RNF20
ring finger protein 20
chr9_+_114182216 0.361 HSDL2
hydroxysteroid dehydrogenase like 2
chr6_+_143813472 0.339 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr4_-_4594591 0.337 STX18
syntaxin 18
chr17_+_7474177 0.334 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr1_-_149404954 0.334 NM_212551
NM_001136543
LYSMD1

LysM, putative peptidoglycan-binding, domain containing 1

chr11_+_117948350 0.330 ARCN1
archain 1
chr3_-_152173475 0.330 NM_001195794
NM_174878
CLRN1

clarin 1

chr19_+_54708312 0.328 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr15_-_98091143 0.326 NM_152449
LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr10_-_52315390 0.323 A1CF
APOBEC1 complementation factor
chr17_+_3324096 0.323 NM_001128085
ASPA
aspartoacylase
chr6_-_146326918 0.319 NM_001042683
NM_173082
SHPRH

SNF2 histone linker PHD RING helicase

chr1_-_158579653 0.317 COPA
coatomer protein complex, subunit alpha
chr2_-_198073242 0.316 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr19_+_54708302 0.314 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_+_117735502 0.299 NM_004788
UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr3_-_52287297 0.299 WDR82
WD repeat domain 82
chr10_-_52315436 0.293 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr2_+_119841298 0.291 NM_001178017
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr12_-_52407470 0.287 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr11_+_117735529 0.286 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr11_+_117735530 0.283 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr1_-_158579680 0.274 COPA
coatomer protein complex, subunit alpha
chr20_-_7869068 0.271 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr1_-_158579583 0.271


chr1_-_39815048 0.267 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr1_+_158579685 0.262 NM_015331
NCSTN
nicastrin
chr13_+_20612709 0.262 SAP18
Sin3A-associated protein, 18kDa
chr6_-_146327238 0.258 SHPRH
SNF2 histone linker PHD RING helicase
chr9_+_103335964 0.254 RNF20
ring finger protein 20
chr1_+_78126787 0.252 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr18_+_52469559 0.249 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr10_-_21854616 0.249 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr1_-_79244948 0.243 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr3_-_195874202 0.234 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr1_+_43628186 0.234 C1orf84
chromosome 1 open reading frame 84
chr14_-_74713012 0.233 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr1_-_111771877 0.232 NM_002557
OVGP1
oviductal glycoprotein 1, 120kDa
chr2_+_27966985 0.230 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr1_+_61320213 0.229 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr11_+_117948301 0.229 NM_001142281
NM_001655
ARCN1

archain 1

chr1_-_95311031 0.227 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr12_+_67291016 0.226 RAP1B
RAP1B, member of RAS oncogene family
chr18_+_45594326 0.224


chr3_-_195874227 0.224 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr19_+_50086362 0.222 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr2_+_26422495 0.219 EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr6_-_146326863 0.219 SHPRH
SNF2 histone linker PHD RING helicase
chr15_-_98091063 0.218 LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr15_-_98091118 0.205 LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr6_-_146327155 0.205 SHPRH
SNF2 histone linker PHD RING helicase
chr18_-_44731078 0.205 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr19_+_44082458 0.202 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr17_+_35532994 0.202 MSL1
male-specific lethal 1 homolog (Drosophila)
chr19_+_50086357 0.199 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr2_+_73294852 0.195 NM_006062
SMYD5
SMYD family member 5
chr10_+_103995297 0.190 NM_004193
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr12_-_117295095 0.186 NM_016281
TAOK3
TAO kinase 3
chr19_-_41514437 0.186 LOC100506930
hypothetical LOC100506930
chr2_-_219742950 0.184 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr19_-_40317829 0.182 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chr19_+_44082410 0.181 NM_001001716
NM_002503
NFKBIB

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

chr2_-_198072767 0.179 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr1_-_43691932 0.178 HYI
hydroxypyruvate isomerase (putative)
chr2_+_27967102 0.175 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_+_27967116 0.172 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr12_-_6995988 0.172 NM_005768
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr7_-_106991941 0.170 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr2_-_198072868 0.170 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr1_-_153213454 0.169 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr2_-_198072805 0.169 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr7_+_288195 0.168 FAM20C
family with sequence similarity 20, member C
chr12_+_67290951 0.168 RAP1B
RAP1BL
RAP1B, member of RAS oncogene family
RAP1B, member of RAS oncogene family pseudogene
chr1_-_120112989 0.167 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr2_-_218843109 0.163 NM_001087
AAMP
angio-associated, migratory cell protein
chr4_+_4594619 0.158 LOC100507266
hypothetical LOC100507266
chr1_+_43628136 0.156 NM_001012961
C1orf84
chromosome 1 open reading frame 84
chr10_-_119795663 0.155 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr9_+_114182009 0.154 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr4_-_4594648 0.153 NM_016930
STX18
syntaxin 18
chr4_-_68249442 0.152 NM_018227
UBA6
ubiquitin-like modifier activating enzyme 6
chr6_+_127006298 0.152 LOC728666
PRELI domain containing 1 pseudogene
chr1_-_39815106 0.151 NM_001135653
NM_001135654
NM_003819
PABPC4


poly(A) binding protein, cytoplasmic 4 (inducible form)


chr11_+_118374071 0.151 CCDC84
coiled-coil domain containing 84
chr9_+_139633272 0.150 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr9_+_103335941 0.149 NM_019592
RNF20
ring finger protein 20
chr10_+_102722275 0.147 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr19_+_60487345 0.147 NM_032430
BRSK1
BR serine/threonine kinase 1
chr2_-_19421852 0.144 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr12_+_67290881 0.140 NM_001010942
NM_015646
RAP1B

RAP1B, member of RAS oncogene family

chr19_+_50086350 0.139 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr4_+_91035025 0.138 NM_007351
MMRN1
multimerin 1
chr14_-_94693418 0.138 NM_177438
DICER1
dicer 1, ribonuclease type III
chr17_+_7063970 0.138 ACADVL
acyl-CoA dehydrogenase, very long chain
chr8_-_82769761 0.136 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr1_+_149405128 0.136 NM_024041
SCNM1
sodium channel modifier 1
chr4_+_156900053 0.132 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr19_+_54708247 0.131 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr14_-_20636337 0.130 ZNF219
zinc finger protein 219
chr10_+_119796324 0.130 CASC2
cancer susceptibility candidate 2
chr19_+_54708389 0.129 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_-_84150885 0.129 LIN54
lin-54 homolog (C. elegans)
chr12_+_67290975 0.127 RAP1B
RAP1B, member of RAS oncogene family
chr22_-_28114568 0.126 NM_001127
NM_001166019
NM_145730
AP1B1


adaptor-related protein complex 1, beta 1 subunit


chr14_+_94693744 0.126 FLJ45244
hypothetical locus FLJ45244
chr11_-_123261549 0.125 NM_001013743
TMEM225
transmembrane protein 225
chr2_+_201691664 0.125 CFLAR
CASP8 and FADD-like apoptosis regulator
chr12_+_67290977 0.122 RAP1B
RAP1BL
RAP1B, member of RAS oncogene family
RAP1B, member of RAS oncogene family pseudogene
chr2_+_201691513 0.122 NM_001127183
CFLAR
CASP8 and FADD-like apoptosis regulator
chr1_-_201411533 0.119 NM_004997
MYBPH
myosin binding protein H
chr3_+_185538998 0.118 FAM131A
family with sequence similarity 131, member A
chr8_+_22492586 0.118 PDLIM2
PDZ and LIM domain 2 (mystique)
chr19_+_44308224 0.116 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr7_-_25131427 0.116 NM_018947
CYCS
cytochrome c, somatic
chr12_-_117294933 0.114 TAOK3
TAO kinase 3
chr4_-_84150997 0.114 NM_001115008
NM_194282
LIN54

lin-54 homolog (C. elegans)


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.96 1.04e-02 GO:0005759 mitochondrial matrix
1.40 1.20e-02 GO:0044444 cytoplasmic part
2.56 2.14e-02 GO:0044429 mitochondrial part
1.72 3.17e-02 GO:0031974 membrane-enclosed lumen
1.19 4.32e-02 GO:0044424 intracellular part

Nothing significant found in function category.