Motif ID: SRF.p3

Z-value: 3.308


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)



Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_34603311 12.501 MYL9
myosin, light chain 9, regulatory
chr20_+_34603290 12.484 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr15_-_32875040 8.704 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr11_+_116575249 6.594 NM_001001522
NM_003186
TAGLN

transgelin

chr2_+_73973640 5.585 ACTG2
actin, gamma 2, smooth muscle, enteric
chr9_-_78710698 5.425 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr2_+_73973600 5.363 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr10_-_90702490 4.701 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_-_33928049 4.685 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr5_-_33927724 4.433 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr9_+_91409746 4.276 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr2_-_128149112 3.375 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr17_-_44026042 3.288 NM_002147
HOXB5
homeobox B5
chr3_+_189413414 3.250 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr6_-_109882116 3.241 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr1_+_221955876 3.194 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr6_+_116939500 3.103 NM_153711
FAM26E
family with sequence similarity 26, member E
chr9_+_36126710 3.080 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr22_+_29810981 2.904 SMTN
smoothelin
chr9_+_36126667 2.834 GLIPR2
GLI pathogenesis-related 2
chr2_+_88148413 2.799 NM_198274
SMYD1
SET and MYND domain containing 1
chr12_+_74160779 2.725 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr17_+_3326045 2.634 NM_000049
ASPA
aspartoacylase
chr10_-_131652364 2.530 EBF3
early B-cell factor 3
chr5_-_141981083 2.526 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr11_-_118799058 2.424 THY1
Thy-1 cell surface antigen
chr17_-_44026321 2.366 HOXB5
homeobox B5
chr3_-_124821868 2.230 MYLK
myosin light chain kinase
chr10_+_88418147 2.055 NM_001171610
LDB3
LIM domain binding 3
chr3_-_124822113 2.055 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr10_+_112247614 2.020 NM_004419
DUSP5
dual specificity phosphatase 5
chr10_+_88418243 1.976 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr20_-_42249146 1.964 JPH2
junctophilin 2
chr6_+_151603201 1.880 AKAP12
A kinase (PRKA) anchor protein 12
chr12_-_48902692 1.788 NM_001113547
LIMA1
LIM domain and actin binding 1
chr15_-_63147350 1.787 NM_016563
RASL12
RAS-like, family 12
chr17_+_30498948 1.755 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr11_-_65424434 1.728 FOSL1
FOS-like antigen 1
chr6_-_105691675 1.656 BVES
blood vessel epicardial substance
chr11_-_65424385 1.645 FOSL1
FOS-like antigen 1
chr15_+_72006015 1.605 LOXL1
lysyl oxidase-like 1
chr5_+_60663842 1.598 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr10_+_31650069 1.581 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr9_+_18464090 1.540 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr19_+_59064471 1.525 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr5_+_88220846 1.515


chr4_+_156899575 1.496 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr11_-_65424436 1.494 NM_005438
FOSL1
FOS-like antigen 1
chr6_+_151602787 1.481 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr20_+_32610161 1.468 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr1_-_89303478 1.391 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr2_+_42128521 1.347 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr1_-_152431175 1.334 NM_152263
TPM3
tropomyosin 3
chr4_+_14985272 1.320 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr14_-_52487558 1.305 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr7_-_107430566 1.297 NM_002291
LAMB1
laminin, beta 1
chr10_+_75427853 1.278 NM_003373
NM_014000
VCL

vinculin

chr1_-_166373434 1.272 GPR161
G protein-coupled receptor 161
chr15_-_57452361 1.255 NM_004998
MYO1E
myosin IE
chr16_+_55523526 1.189 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr5_+_92944680 1.181 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr2_-_231697999 1.174 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr15_-_57452357 1.173 MYO1E
myosin IE
chr12_-_90029672 1.161 NM_002345
LUM
lumican
chr1_-_16217025 1.153 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr2_-_151052391 1.098 NM_005168
RND3
Rho family GTPase 3
chr1_-_227636462 1.048 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr19_+_59064795 1.036 MYADM
myeloid-associated differentiation marker
chr2_-_96174502 1.025 DUSP2
dual specificity phosphatase 2
chr19_-_40939756 1.012 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr18_-_42804531 0.965 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr2_-_40593074 0.934 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_+_100545827 0.921 NM_024065
PDCL3
phosducin-like 3
chr2_-_105381855 0.920 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr19_-_50975603 0.914 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr2_-_96174865 0.910 NM_004418
DUSP2
dual specificity phosphatase 2
chr18_-_42804291 0.900 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr7_-_5536783 0.888 ACTB
actin, beta
chr19_+_2427122 0.887 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr15_-_63147228 0.877 RASL12
RAS-like, family 12
chrX_-_99873728 0.858 NM_001129896
SYTL4
synaptotagmin-like 4
chr18_-_42810446 0.852 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr5_-_178983241 0.847 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr1_-_148080888 0.820 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr17_+_29707583 0.811 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr17_+_16259636 0.796 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr17_-_4831644 0.782 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr10_+_123912930 0.756 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_-_240228987 0.744 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr12_+_60940404 0.741 NM_006313
USP15
ubiquitin specific peptidase 15
chr1_-_89261021 0.736 NM_018284
GBP3
guanylate binding protein 3
chr1_-_31618405 0.730 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr17_+_16259573 0.718 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr7_-_94123308 0.718 SGCE
sarcoglycan, epsilon
chr4_+_81337663 0.709 NM_001099403
PRDM8
PR domain containing 8
chr21_-_27139143 0.705 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr1_-_166373159 0.698 GPR161
G protein-coupled receptor 161
chr15_-_57452345 0.697 MYO1E
myosin IE
chr1_-_166373351 0.669 GPR161
G protein-coupled receptor 161
chr1_-_11830328 0.658 NM_006172
NPPA
natriuretic peptide A
chr7_-_94123413 0.648 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr5_-_178983281 0.638 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr3_+_145173329 0.631 NM_173552
C3orf58
chromosome 3 open reading frame 58
chr7_-_5536704 0.631 NM_001101
ACTB
actin, beta
chr7_-_94123362 0.618 SGCE
sarcoglycan, epsilon
chr9_+_115396020 0.612 NM_144489
RGS3
regulator of G-protein signaling 3
chr18_-_63333487 0.609 DSEL
dermatan sulfate epimerase-like
chr3_+_150675117 0.608 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr3_-_158704056 0.605 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr14_+_74815233 0.604 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr4_+_24406182 0.598 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr8_+_24827173 0.575 NM_005382
NEFM
neurofilament, medium polypeptide
chr5_+_140730014 0.564 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr11_-_75599433 0.562 WNT11
wingless-type MMTV integration site family, member 11
chr1_-_150599105 0.558 NM_001014342
FLG2
filaggrin family member 2
chr3_+_62279707 0.554 C3orf14
chromosome 3 open reading frame 14
chr4_-_88669267 0.551 SPARCL1
SPARC-like 1 (hevin)
chr17_+_39990124 0.551 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr17_-_4831388 0.541 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr6_-_16869579 0.539 NM_000332
NM_001128164
ATXN1

ataxin 1

chr22_+_24468110 0.536 NM_032608
MYO18B
myosin XVIIIB
chr22_+_36412277 0.534 NM_024313
NOL12
nucleolar protein 12
chr11_+_46339691 0.528 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr17_-_1336073 0.527 MYO1C
myosin IC
chr2_-_105421661 0.520 NM_201557
FHL2
four and a half LIM domains 2
chr14_-_73296643 0.513 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr16_+_31390567 0.512 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr4_-_88669625 0.504 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr17_+_16259812 0.497 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr20_+_60558104 0.489 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr3_+_25445071 0.487 RARB
retinoic acid receptor, beta
chr5_-_56283672 0.472 NM_152622
MIER3
mesoderm induction early response 1, family member 3
chr14_-_104507862 0.462 AHNAK2
AHNAK nucleoprotein 2
chr19_-_63550712 0.462 A1BG
alpha-1-B glycoprotein
chr7_+_94123612 0.457 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr9_+_139892049 0.453 NM_000718
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr1_+_15957832 0.448 NM_017556
FBLIM1
filamin binding LIM protein 1
chr4_+_86918882 0.443 ARHGAP24
Rho GTPase activating protein 24
chr20_-_61728866 0.442 GMEB2
glucocorticoid modulatory element binding protein 2
chr1_+_179324458 0.429 IER5
immediate early response 5
chr9_-_4290028 0.422 NM_001042413
GLIS3
GLIS family zinc finger 3
chr22_+_28206180 0.418 NM_021076
NEFH
neurofilament, heavy polypeptide
chr11_-_2118743 0.418 IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_-_160972606 0.417 RBMS1
RNA binding motif, single stranded interacting protein 1
chr17_-_36456949 0.404 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr7_+_111908143 0.404 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr7_-_5535726 0.403 ACTB
actin, beta
chr14_-_73296387 0.389 C14orf43
chromosome 14 open reading frame 43
chr6_-_132314004 0.386 NM_001901
CTGF
connective tissue growth factor
chr3_+_189354167 0.382 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr7_-_44147436 0.381 NM_021223
MYL7
myosin, light chain 7, regulatory
chr22_+_24468168 0.377 MYO18B
myosin XVIIIB
chr22_-_29694186 0.364 NM_014941
MORC2
MORC family CW-type zinc finger 2
chr12_-_46405477 0.362 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr10_+_6226884 0.361 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr4_-_158111995 0.358 NM_016205
PDGFC
platelet derived growth factor C
chr6_+_144654565 0.339 NM_007124
UTRN
utrophin
chr10_+_6226909 0.328 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr11_-_57038891 0.328 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr18_-_42798364 0.324 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr18_+_9698299 0.319 RAB31
RAB31, member RAS oncogene family
chr4_+_120276386 0.318 NM_016599
MYOZ2
myozenin 2
chr19_+_12996368 0.317 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_-_3129017 0.315 NM_002551
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr19_+_54068300 0.294 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr15_+_79276273 0.293 NM_001172128
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr13_-_98757634 0.292 NM_004951
GPR183
G protein-coupled receptor 183
chr19_+_977608 0.285 CNN2
calponin 2
chr14_+_73775927 0.282 NM_182894
VSX2
visual system homeobox 2
chr2_+_46560207 0.277 NM_001145051
LOC388946
transmembrane protein ENSP00000343375
chr8_+_24827181 0.276 NEFM
neurofilament, medium polypeptide
chr17_+_29621352 0.272 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr1_-_89364273 0.267 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr14_-_93512647 0.265 ASB2
ankyrin repeat and SOCS box containing 2
chr11_-_64402629 0.261 NM_006795
EHD1
EH-domain containing 1
chr20_-_21442663 0.261 NM_002509
NKX2-2
NK2 homeobox 2
chr10_+_63950212 0.261 NM_199452
ZNF365
zinc finger protein 365
chr10_+_6226764 0.252 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr8_+_1937711 0.250 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr5_+_6799100 0.242 NM_001171806
PAPD7
PAP associated domain containing 7
chr11_+_62189354 0.237 NM_001043229
METTL12
methyltransferase like 12
chr17_+_38256710 0.235 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr3_+_150675169 0.234 TM4SF4
transmembrane 4 L six family member 4
chr19_+_977627 0.232 CNN2
calponin 2
chr19_+_40541327 0.231 NM_005304
FFAR3
free fatty acid receptor 3
chr5_+_137829077 0.229 NM_001964
EGR1
early growth response 1
chr22_+_38246509 0.227 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr11_-_30562324 0.227 MPPED2
metallophosphoesterase domain containing 2
chr11_+_74950893 0.225 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr17_-_1335763 0.217 NM_001080950
MYO1C
myosin IC
chr15_+_38430517 0.215 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr7_+_94123556 0.213 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr2_+_87536106 0.212 NCRNA00152
non-protein coding RNA 152
chr10_+_114033403 0.211 NM_058222
TECTB
tectorin beta
chr19_+_977555 0.210 CNN2
calponin 2
chr20_+_60558369 0.210 C20orf166
chromosome 20 open reading frame 166
chr20_-_61728774 0.207 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chr7_+_134114701 0.206 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr7_-_80386258 0.204 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr7_-_5535432 0.200 ACTB
actin, beta

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.46 3.70e-08 GO:0003012 muscle system process
7.67 8.47e-08 GO:0006936 muscle contraction
4.47 2.94e-04 GO:0030029 actin filament-based process
1.66 1.18e-03 GO:0032502 developmental process
1.51 1.82e-03 GO:0032501 multicellular organismal process
1.66 4.27e-03 GO:0007275 multicellular organismal development
2.81 5.44e-03 GO:0010628 positive regulation of gene expression
9.78 6.77e-03 GO:0030048 actin filament-based movement
2.63 7.09e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.66 1.28e-02 GO:0048856 anatomical structure development
1.40 1.47e-02 GO:0050896 response to stimulus
8.31 2.03e-02 GO:0008360 regulation of cell shape
1.68 2.49e-02 GO:0048731 system development
3.96 2.76e-02 GO:0030036 actin cytoskeleton organization
1.83 3.00e-02 GO:0030154 cell differentiation
2.41 3.19e-02 GO:0009891 positive regulation of biosynthetic process
2.50 3.65e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30 4.26e-02 GO:0065007 biological regulation
2.13 4.27e-02 GO:0031325 positive regulation of cellular metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.48 1.83e-08 GO:0015629 actin cytoskeleton
8.69 3.30e-08 GO:0043292 contractile fiber
8.83 1.09e-07 GO:0044449 contractile fiber part
8.60 1.56e-07 GO:0030016 myofibril
8.73 2.16e-06 GO:0030017 sarcomere
17.27 2.41e-06 GO:0042641 actomyosin
2.36 2.66e-06 GO:0005856 cytoskeleton
17.81 1.59e-05 GO:0001725 stress fiber
7.92 2.46e-05 GO:0005925 focal adhesion
16.63 2.67e-05 GO:0032432 actin filament bundle
7.54 4.09e-05 GO:0005924 cell-substrate adherens junction
7.26 6.02e-05 GO:0030055 cell-substrate junction
5.74 2.25e-04 GO:0005912 adherens junction
5.18 6.58e-04 GO:0070161 anchoring junction
8.91 9.45e-03 GO:0031674 I band
6.68 4.79e-02 GO:0016459 myosin complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.06 1.03e-04 GO:0003779 actin binding
3.04 7.55e-04 GO:0008092 cytoskeletal protein binding
17.81 1.16e-02 GO:0000146 microfilament motor activity
1.17 1.17e-02 GO:0005488 binding
2.10 3.31e-02 GO:0030528 transcription regulator activity