Motif ID: NR5A1,2.p2

Z-value: 2.605


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2



Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_27113018 4.595 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr8_-_37576515 3.624 LOC157860
hypothetical protein LOC157860
chr5_+_176449156 3.414 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr3_+_50281582 3.349 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr16_-_28515868 3.076 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr12_-_120781002 3.065 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr3_-_49435114 2.946 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr20_-_44713466 2.700 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr14_-_60185659 2.289 NM_005982
SIX1
SIX homeobox 1
chr22_+_19458378 2.283 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr6_-_2785682 2.180 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr3_-_188492163 2.169 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr2_+_219354948 2.052 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr1_-_224143389 2.024 NM_020997
LEFTY1
left-right determination factor 1
chr5_+_80564894 2.023 NM_001099735
NM_001099736
NM_001825
CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr2_-_88208650 2.004 NM_001443
FABP1
fatty acid binding protein 1, liver
chr17_-_6557375 2.003 NM_001143838
NM_177550
SLC13A5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr16_+_30903963 2.001 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr10_+_60607232 1.990 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr20_+_34937928 1.948 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr11_-_8788765 1.932 NM_213618
ST5
suppression of tumorigenicity 5
chr1_-_42978320 1.788 NM_001123395
NM_001185117
NM_148960
CLDN19


claudin 19


chr19_+_11211282 1.783 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr1_-_2129031 1.767 NM_001146310
C1orf86
chromosome 1 open reading frame 86
chr8_-_145090045 1.734 NM_201382
PLEC
plectin
chr12_+_6768966 1.723 CD4
CD4 molecule
chr3_+_50281309 1.695 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr10_+_102722275 1.689 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr1_-_159459814 1.669 APOA2
apolipoprotein A-II
chr2_-_238164042 1.656 RAB17
RAB17, member RAS oncogene family
chr5_-_42847716 1.604 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr22_+_29848923 1.582 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr22_+_43451600 1.568 PRR5
proline rich 5 (renal)
chr11_+_7463175 1.566 NM_198474
OLFML1
olfactomedin-like 1
chr7_-_100077072 1.556 NM_003227
TFR2
transferrin receptor 2
chr17_+_1595012 1.552 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr10_-_21826211 1.552 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chr10_-_21826192 1.539 C10orf114
chromosome 10 open reading frame 114
chr7_+_100037817 1.521 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr3_-_124821868 1.516 MYLK
myosin light chain kinase
chr5_-_148738980 1.500 NM_014443
IL17B
interleukin 17B
chr6_+_131190237 1.481 NM_001195597
LOC285733
hypothetical LOC285733
chr11_+_67534364 1.478 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr17_-_7023378 1.477 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr14_-_93829347 1.472 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr3_-_185578621 1.460 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr2_+_70981223 1.453 NM_012476
VAX2
ventral anterior homeobox 2
chr10_+_685887 1.448 C10orf108
chromosome 10 open reading frame 108
chrX_+_152608159 1.446 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr11_+_67534371 1.423 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr3_-_127719283 1.420 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr12_-_49878216 1.417 NM_002702
POU6F1
POU class 6 homeobox 1
chr3_-_124822113 1.404 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr3_+_120983556 1.404 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr2_-_32344192 1.389 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr16_+_70646008 1.389 NM_001126102
NM_005143
HP

haptoglobin

chr19_-_5789740 1.385 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr2_+_70981233 1.379 VAX2
ventral anterior homeobox 2
chr12_+_7038240 1.377 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr19_-_4486202 1.372 NM_001013706
PLIN5
perilipin 5
chr7_+_94374862 1.371 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr3_+_186529376 1.369 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr11_-_16380967 1.323 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr16_-_65510230 1.319 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr4_+_86968069 1.317 ARHGAP24
Rho GTPase activating protein 24
chr6_+_20510019 1.316 NM_001949
E2F3
E2F transcription factor 3
chr22_+_43451351 1.314 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr20_-_42249146 1.310 JPH2
junctophilin 2
chr12_+_54910767 1.310 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr10_+_111755715 1.299 NM_019903
ADD3
adducin 3 (gamma)
chr16_-_16224791 1.296 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr8_-_17812151 1.293


chr20_+_43468617 1.293 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr1_+_221168388 1.288 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr12_+_6768866 1.288 NM_000616
CD4
CD4 molecule
chr18_-_28606839 1.287 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr9_+_33230165 1.282 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr1_+_46413335 1.252 NM_005727
TSPAN1
tetraspanin 1
chr11_-_64459910 1.250 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr3_-_24511180 1.247 NM_001128176
NM_000461
NM_001128177
THRB


thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)


chr3_-_52839727 1.242 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr12_-_23993830 1.230 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr11_+_116205830 1.225 NM_000040
APOC3
apolipoprotein C-III
chr12_-_51585004 1.217 NM_002273
KRT8
keratin 8
chr1_+_54132447 1.212 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr20_-_43889339 1.207 NM_003279
TNNC2
troponin C type 2 (fast)
chr7_+_116238309 1.206 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr3_+_50279993 1.204 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chrX_-_24600661 1.200 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr13_+_112825113 1.172 NM_000504
F10
coagulation factor X
chr20_+_48241334 1.172 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr17_+_77110011 1.169 NM_001077182
NM_012418
FSCN2

fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)

chr13_+_92677012 1.168 NM_005708
GPC6
glypican 6
chr9_-_129752687 1.166 NM_203305
FAM102A
family with sequence similarity 102, member A
chr16_-_73708118 1.163 LDHD
lactate dehydrogenase D
chr3_+_52803823 1.163 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr19_-_47723183 1.158 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr12_-_9159707 1.157 A2M
alpha-2-macroglobulin
chr3_-_49434874 1.152 AMT
aminomethyltransferase
chr20_-_22514092 1.151 NM_153675
FOXA2
forkhead box A2
chr8_-_17811750 1.150 FGL1
fibrinogen-like 1
chr5_+_154072654 1.149 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr12_-_9159780 1.139 A2M
alpha-2-macroglobulin
chr17_-_35774467 1.136 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr16_-_65781499 1.135 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr20_-_3097070 1.124 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr3_+_120983620 1.123 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr20_+_54420574 1.122 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr12_-_9159742 1.118 A2M
alpha-2-macroglobulin
chr2_+_172658453 1.114 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr3_+_134947940 1.108 TF
transferrin
chr17_-_17426416 1.108 PEMT
phosphatidylethanolamine N-methyltransferase
chr12_+_107797985 1.107 NM_001917
DAO
D-amino-acid oxidase
chr19_+_11510578 1.107 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr22_-_37569962 1.102 NM_014293
NPTXR
neuronal pentraxin receptor
chr20_-_42249631 1.100 NM_020433
NM_175913
JPH2

junctophilin 2

chr12_-_9159789 1.088 NM_000014
A2M
alpha-2-macroglobulin
chr16_-_86082818 1.083 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr17_-_7023283 1.083 ASGR1
asialoglycoprotein receptor 1
chr17_-_34014390 1.083 SRCIN1
SRC kinase signaling inhibitor 1
chr2_-_192419896 1.082 SDPR
serum deprivation response
chr2_-_238164452 1.079 NM_022449
RAB17
RAB17, member RAS oncogene family
chr11_+_73037382 1.075 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr3_-_49701085 1.072 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr1_+_16203317 1.071 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr22_-_36836620 1.069 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr3_+_134947894 1.066 TF
transferrin
chr12_+_54361685 1.066 METTL7B
methyltransferase like 7B
chr19_+_46640902 1.064 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr17_+_38306339 1.063 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr3_+_134947788 1.054 TF
transferrin
chr17_+_56832492 1.046 TBX2
T-box 2
chr22_-_36836478 1.046 BAIAP2L2
BAI1-associated protein 2-like 2
chr1_-_24342158 1.039 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr2_-_200033445 1.039 SATB2
SATB homeobox 2
chr3_-_10522221 1.036 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr16_+_52877009 1.030


chr2_+_138438277 1.025 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr12_-_113328271 1.024 NM_181486
TBX5
T-box 5
chr7_+_30758269 1.022 NM_006774
INMT-FAM188B
INMT
INMT-FAM188B read-through transcript
indolethylamine N-methyltransferase
chr17_-_19231049 1.018 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr2_+_27358800 1.011 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr12_+_54361596 1.009 NM_152637
METTL7B
methyltransferase like 7B
chr6_+_17390910 1.008 NM_153020
RBM24
RNA binding motif protein 24
chr1_+_18680010 1.008 NM_152375
KLHDC7A
kelch domain containing 7A
chr8_-_13178327 1.005


chr16_+_82544327 1.004 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr16_-_51138306 1.001 NM_001080430
TOX3
TOX high mobility group box family member 3
chr22_+_36531246 0.984 H1F0
H1 histone family, member 0
chr7_-_100262971 0.976 NM_004444
EPHB4
EPH receptor B4
chr2_-_165259334 0.972 COBLL1
COBL-like 1
chr22_-_37044034 0.969 NM_001894
CSNK1E
casein kinase 1, epsilon
chr14_-_22658078 0.968 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr12_+_6768960 0.968 CD4
CD4 molecule
chr3_-_73756668 0.966 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr15_+_41597097 0.964 NM_002373
MAP1A
microtubule-associated protein 1A
chr1_+_17817397 0.964 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr12_-_56418295 0.963 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr3_-_195553297 0.962 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr16_+_55963899 0.955 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_+_6768934 0.955 NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4



CD4 molecule



chr17_-_64108529 0.954 NM_017565
FAM20A
family with sequence similarity 20, member A
chr19_-_1464187 0.953 NM_213604
ADAMTSL5
ADAMTS-like 5
chr9_+_116131889 0.945 NM_000608
ORM2
orosomucoid 2
chr22_-_35835548 0.942 TMPRSS6
transmembrane protease, serine 6
chr11_+_60858611 0.927 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr11_-_8789457 0.925 NM_139157
ST5
suppression of tumorigenicity 5
chr19_-_54350457 0.921 NM_002152
HRC
histidine rich calcium binding protein
chr16_-_65984836 0.918 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr6_-_135312899 0.918 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr16_+_55963883 0.916 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr16_-_73708165 0.915 NM_153486
NM_194436
LDHD

lactate dehydrogenase D

chr11_+_20001130 0.915 NM_001111019
NAV2
neuron navigator 2
chr16_-_52877467 0.915 IRX3
iroquois homeobox 3
chr6_+_35812836 0.911 NM_145028
C6orf81
chromosome 6 open reading frame 81
chrX_+_49718954 0.910 NM_000084
CLCN5
chloride channel 5
chr20_-_22513050 0.908 NM_021784
FOXA2
forkhead box A2
chr16_+_620932 0.906 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr6_+_43846735 0.906 VEGFA
vascular endothelial growth factor A
chr11_+_22652957 0.904 GAS2
growth arrest-specific 2
chr2_-_105421661 0.902 NM_201557
FHL2
four and a half LIM domains 2
chr2_+_220200530 0.901 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr6_+_43136159 0.890 NM_201522
KLC4
kinesin light chain 4
chr19_-_40711034 0.889 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr16_+_82540172 0.880 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr6_+_31731647 0.876 NM_019101
APOM
apolipoprotein M
chr6_+_35881048 0.874 NM_182548
LHFPL5
lipoma HMGIC fusion partner-like 5
chr20_-_22512893 0.871 FOXA2
forkhead box A2
chr3_+_9933763 0.868 NM_032732
NM_153460
NM_153461
IL17RC


interleukin 17 receptor C


chr6_+_31731667 0.862 APOM
apolipoprotein M
chr12_-_52975777 0.862 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr7_+_101704145 0.858 CUX1
cut-like homeobox 1
chr7_-_75876830 0.855 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr17_-_17426469 0.851 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr6_+_27883877 0.848 NM_003509
HIST1H2AI
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H3f
chr17_-_74361620 0.846 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_+_32021899 0.845 CFB
complement factor B
chr3_-_24511456 0.841 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr14_+_23937766 0.840 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr7_+_142692165 0.838 NM_153345
TMEM139
transmembrane protein 139

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 8.48e-06 GO:0032501 multicellular organismal process
1.25 8.37e-03 GO:0065008 regulation of biological quality
1.18 1.59e-02 GO:0007275 multicellular organismal development
1.06 3.53e-02 GO:0009987 cellular process
1.19 4.58e-02 GO:0048731 system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.76 5.91e-03 GO:0016323 basolateral plasma membrane
2.55 7.82e-03 GO:0000786 nucleosome
4.79 2.02e-02 GO:0005833 hemoglobin complex
2.03 2.23e-02 GO:0044449 contractile fiber part
1.99 2.25e-02 GO:0043292 contractile fiber
1.41 3.09e-02 GO:0030054 cell junction
1.98 3.89e-02 GO:0030016 myofibril
1.50 3.95e-02 GO:0045202 synapse

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.23 1.76e-02 GO:0016775 phosphotransferase activity, nitrogenous group as acceptor
7.18 4.55e-02 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity