Motif ID: NR3C1.p2

Z-value: 1.607


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)



Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_9804682 2.275 NM_001781
CD69
CD69 molecule
chr2_+_143603368 2.068 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr5_+_143171918 1.983 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr17_+_42641426 1.686 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr1_-_202726068 1.678 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr10_+_70517823 1.672 NM_002727
SRGN
serglycin
chr1_-_158759606 1.657 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr9_-_70780574 1.654


chr16_-_66075216 1.433 NM_001138
AGRP
agouti related protein homolog (mouse)
chr17_+_42641712 1.374 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr20_-_10360569 1.327 NM_018848
MKKS
McKusick-Kaufman syndrome
chr1_-_205161821 1.283 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr17_+_35078032 1.192 NM_002686
PNMT
phenylethanolamine N-methyltransferase
chr8_-_110724594 1.173 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chrX_-_70243362 1.158 NM_001025265
CXorf65
chromosome X open reading frame 65
chr6_-_32299757 1.153 NM_004557
NOTCH4
notch 4
chr14_-_105804211 1.131 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_+_87541220 1.128 NM_003608
GPR65
G protein-coupled receptor 65
chr11_+_59804634 1.089 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr20_-_44612619 1.061 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr3_+_52254782 1.049 PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr5_+_169749068 1.032


chr11_-_64906683 1.032 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr12_+_6925997 1.029 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr22_-_40666168 1.017 NM_001110215
CENPM
centromere protein M
chr21_+_37713076 1.004 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr22_+_36008465 1.000 CYTH4
cytohesin 4
chr11_+_73036241 0.999 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_-_181889070 0.992 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr17_-_31441390 0.990 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr3_+_99733432 0.989 NM_005290
GPR15
G protein-coupled receptor 15
chr22_-_37480898 0.963 SUN2
Sad1 and UNC84 domain containing 2
chr2_+_37282516 0.930 LOC100505876
hypothetical LOC100505876
chr2_-_31293882 0.927 NM_001145122
CAPN14
calpain 14
chr6_-_6265874 0.913 F13A1
coagulation factor XIII, A1 polypeptide
chr14_-_64416307 0.888 SPTB
spectrin, beta, erythrocytic
chr15_+_40481879 0.883 NM_173088
CAPN3
calpain 3, (p94)
chr12_+_6926014 0.882 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr6_+_64289585 0.875 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr17_-_40843530 0.851 ARHGAP27
Rho GTPase activating protein 27
chr6_+_36752244 0.844 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr22_+_36008511 0.844 CYTH4
cytohesin 4
chr4_+_91035025 0.844 NM_007351
MMRN1
multimerin 1
chr17_-_59363352 0.840 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr1_+_32417909 0.832 NM_175852
TXLNA
taxilin alpha
chr7_-_20223467 0.830 NM_182762
MACC1
metastasis associated in colon cancer 1
chr20_+_61838389 0.822 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr21_+_29322100 0.820 USP16
ubiquitin specific peptidase 16
chr1_+_111544469 0.813


chr11_-_33678861 0.802 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr8_-_101384633 0.798 NM_015435
RNF19A
ring finger protein 19A
chr11_-_58099884 0.792 NM_004811
LPXN
leupaxin
chr1_-_111544784 0.784 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr4_-_146315341 0.780 NM_017493
OTUD4
OTU domain containing 4
chr1_-_144426918 0.778 NM_007053
CD160
CD160 molecule
chr17_-_23928041 0.773 ALDOC
aldolase C, fructose-bisphosphate
chrX_+_65299157 0.773 NM_138737
HEPH
hephaestin
chr17_-_24491521 0.770 MYO18A
myosin XVIIIA
chr1_-_219977424 0.767 NM_144728
DUSP10
dual specificity phosphatase 10
chr17_-_23928048 0.766 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr19_-_47724365 0.764 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr13_+_45174446 0.727 NM_152719
SPERT
spermatid associated
chr11_+_10439253 0.711 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr6_-_6265896 0.703 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr19_-_1989937 0.699 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr1_-_111544603 0.693


chr17_-_23927973 0.690 ALDOC
aldolase C, fructose-bisphosphate
chr6_+_37511383 0.684


chr2_-_233586145 0.679 NGEF
neuronal guanine nucleotide exchange factor
chr7_+_128795280 0.678 AHCYL2
adenosylhomocysteinase-like 2
chr16_-_67039874 0.676 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr1_+_67404756 0.662 NM_144701
IL23R
interleukin 23 receptor
chr4_-_10295412 0.658 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr1_+_173111306 0.658 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr17_-_9870292 0.658 NM_001130831
GAS7
growth arrest-specific 7
chr15_-_72288362 0.656 NM_001142617
NM_001142619
NM_001142620
STRA6


stimulated by retinoic acid gene 6 homolog (mouse)


chr11_+_66927976 0.650 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr5_-_169749215 0.644 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr12_+_52126131 0.622 PRR13
proline rich 13
chr4_-_95482994 0.610 NM_014485
HPGDS
hematopoietic prostaglandin D synthase
chr3_-_184316553 0.602 MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr3_+_16949585 0.601 NM_015184
PLCL2
phospholipase C-like 2
chrX_+_128741578 0.599 SASH3
SAM and SH3 domain containing 3
chr2_-_233586164 0.596 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr16_-_70591377 0.584 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr1_-_111544820 0.580 DENND2D
DENN/MADD domain containing 2D
chr3_+_188197029 0.578


chr19_-_56841819 0.578 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr4_+_2783743 0.575 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr6_-_36412562 0.564 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chr16_+_8722068 0.560 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr10_+_70517863 0.559 SRGN
serglycin
chr20_+_61838479 0.557 LIME1
Lck interacting transmembrane adaptor 1
chr19_-_2233174 0.554 NM_198532
C19orf35
chromosome 19 open reading frame 35
chr2_-_45648608 0.550 SRBD1
S1 RNA binding domain 1
chr3_-_120761092 0.549 NM_005191
CD80
CD80 molecule
chrX_+_118598325 0.545 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr2_-_121964373 0.543 CLASP1
cytoplasmic linker associated protein 1
chr17_-_60439764 0.537 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chrX_+_128741562 0.531 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_+_32417846 0.530 TXLNA
taxilin alpha
chr1_+_117345894 0.529 NM_004258
CD101
CD101 molecule
chr13_-_40454188 0.525 ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_+_40511909 0.523 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr6_+_38798529 0.491 NM_001371
DNAH8
dynein, axonemal, heavy chain 8
chr8_+_103633023 0.485 NM_024410
ODF1
outer dense fiber of sperm tails 1
chrX_-_48212683 0.477 SLC38A5
solute carrier family 38, member 5
chr3_+_46423682 0.475 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr17_-_53849929 0.461 NM_017763
RNF43
ring finger protein 43
chr17_-_36570508 0.453 NM_032524
KRTAP4-4
keratin associated protein 4-4
chrX_+_65299352 0.448 HEPH
hephaestin
chr18_-_53438854 0.441


chr21_+_45396903 0.440 ADARB1
adenosine deaminase, RNA-specific, B1
chr14_-_91403609 0.436 NM_001128596
TC2N
tandem C2 domains, nuclear
chr2_-_175170674 0.429 WIPF1
WAS/WASL interacting protein family, member 1
chr5_+_67622242 0.428 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_74231266 0.426 CYTH1
cytohesin 1
chr2_+_43919606 0.425 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr19_+_15644885 0.425 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr17_+_7900926 0.423


chr6_+_150731720 0.423 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr6_-_33016561 0.421 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chrX_+_78087484 0.418 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chrX_-_100434700 0.417 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr1_-_239865724 0.416 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr1_+_158975662 0.415 NM_021181
SLAMF7
SLAM family member 7
chr10_+_106003941 0.408 NM_001191003
GSTO1
glutathione S-transferase omega 1
chr14_-_20128721 0.408 NM_001024822
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr10_-_75352540 0.403 NM_001001791
C10orf55
chromosome 10 open reading frame 55
chr6_+_26264531 0.400 HIST1H1E
histone cluster 1, H1e
chr11_-_36576352 0.394 NM_000536
RAG2
recombination activating gene 2
chrX_+_65300803 0.389 NM_001130860
NM_014799
HEPH

hephaestin

chr17_+_19917420 0.382 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr17_-_71352182 0.375 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr2_-_158008763 0.370 NM_004288
CYTIP
cytohesin 1 interacting protein
chr4_+_71713324 0.368 NM_031889
ENAM
enamelin
chr20_-_4743768 0.361 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr2_-_37727472 0.357 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr3_-_147696411 0.357 NM_020359
PLSCR2
phospholipid scramblase 2
chr10_+_97505398 0.352 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chrX_+_153423652 0.349 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr17_-_53849888 0.348 RNF43
ring finger protein 43
chr3_-_19950675 0.347 NM_144715
EFHB
EF-hand domain family, member B
chr6_+_26264537 0.344 NM_005321
HIST1H1E
histone cluster 1, H1e
chr3_+_99350859 0.343 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr11_-_117589283 0.341 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr5_+_140690387 0.340 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr11_-_3759886 0.340 NUP98
nucleoporin 98kDa
chr7_-_112545847 0.339 LOC401397
hypothetical LOC401397
chr19_+_7608010 0.336 STXBP2
syntaxin binding protein 2
chr12_+_53241365 0.326 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr4_+_2783764 0.326 SH3BP2
SH3-domain binding protein 2
chr6_+_32713160 0.326 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr5_+_171553780 0.324 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr3_+_179759181 0.323 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_-_94359266 0.322 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr11_-_123918759 0.322 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr3_+_173043832 0.319 NM_001164436
TMEM212
transmembrane protein 212
chr20_+_55569542 0.317 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr19_-_4131778 0.314 SIRT6
sirtuin 6
chr19_+_59865935 0.313 NM_001081438
NM_006847
LILRB4

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4

chr7_-_112545840 0.310 LOC401397
hypothetical LOC401397
chr6_-_130585650 0.309 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr12_+_102859354 0.307 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr20_-_45418818 0.307 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr8_-_92122219 0.306 NM_018710
TMEM55A
transmembrane protein 55A
chr1_+_208067974 0.306 DIEXF
digestive organ expansion factor homolog (zebrafish)
chr7_+_20008870 0.305 RPL21
ribosomal protein L21
chr16_+_56134037 0.303 GPR114
G protein-coupled receptor 114
chr1_-_184684478 0.300 NM_022576
PDC
phosducin
chr21_-_36836767 0.300 NM_001146078
CLDN14
claudin 14
chr1_+_156490550 0.299 NM_001763
CD1A
CD1a molecule
chr7_+_117651947 0.299 NM_019644
ANKRD7
ankyrin repeat domain 7
chrX_+_22200950 0.297 NM_152577
ZNF645
zinc finger protein 645
chrX_+_123062143 0.297 STAG2
stromal antigen 2
chr7_-_107930170 0.294 PNPLA8
patatin-like phospholipase domain containing 8
chr1_-_54256390 0.294 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr7_-_97339616 0.291 ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr11_+_72658586 0.286 NM_176798
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr22_-_15453440 0.286 NM_014406
CCT8L2
chaperonin containing TCP1, subunit 8 (theta)-like 2
chr1_+_208067986 0.282 DIEXF
digestive organ expansion factor homolog (zebrafish)
chrX_-_154146930 0.282 NM_171998
RAB39B
RAB39B, member RAS oncogene family
chr7_-_88262966 0.281 NM_152706
C7orf62
chromosome 7 open reading frame 62
chr8_-_81246215 0.278 NM_001025253
NM_005079
TPD52

tumor protein D52

chr12_+_56114724 0.278 NM_005538
INHBC
inhibin, beta C
chr6_-_31756119 0.278 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr3_-_52712639 0.277 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr5_-_71838875 0.275 NM_152625
ZNF366
zinc finger protein 366
chrX_-_47374187 0.274 NM_001145252
CFP
complement factor properdin
chr1_-_159099090 0.272 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr6_+_53991672 0.270 NM_138569
C6orf142
chromosome 6 open reading frame 142
chr22_+_21053972 0.269


chr6_-_26343139 0.268 NM_005320
HIST1H1D
histone cluster 1, H1d
chr7_+_55947824 0.268 NM_182633
ZNF713
zinc finger protein 713
chr4_+_35962038 0.268 NM_001170700
DTHD1
death domain containing 1
chr6_-_53321545 0.267 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr6_+_31651319 0.267 NM_000594
TNF
tumor necrosis factor
chr8_-_95289945 0.266 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr21_+_44597911 0.264 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr8_-_53484753 0.264 NM_014682
ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.27 2.96e-03 GO:0001775 cell activation
3.17 2.97e-03 GO:0006887 exocytosis

Nothing significant found in compartment category.

Nothing significant found in function category.