Motif ID: HES1.p2

Z-value: 1.011


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)



Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_225615556 2.659 NM_014689
DOCK10
dedicator of cytokinesis 10
chr17_-_10042579 1.921 NM_201433
GAS7
growth arrest-specific 7
chr7_+_154720547 1.309 INSIG1
insulin induced gene 1
chr7_+_154720416 1.035 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr2_-_96174502 1.010 DUSP2
dual specificity phosphatase 2
chr2_-_96174865 0.836 NM_004418
DUSP2
dual specificity phosphatase 2
chr3_-_185025989 0.812 NM_024871
MAP6D1
MAP6 domain containing 1
chr2_+_29191711 0.734 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr9_+_123501186 0.709 DAB2IP
DAB2 interacting protein
chr17_+_45940911 0.705 MYCBPAP
MYCBP associated protein
chr12_+_120840829 0.702 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr4_-_10068055 0.691 NM_053042
ZNF518B
zinc finger protein 518B
chr1_+_234372454 0.686 NM_003272
GPR137B
G protein-coupled receptor 137B
chr1_-_35957030 0.668 C1orf216
chromosome 1 open reading frame 216
chr13_+_42046182 0.662 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr11_+_131285747 0.640 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chrX_+_21302317 0.635 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr22_-_42539399 0.625 NM_022785
NM_198856
EFCAB6

EF-hand calcium binding domain 6

chr2_+_149895274 0.611 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr3_-_109292444 0.592 NM_001777
NM_198793
CD47

CD47 molecule

chr4_-_83938920 0.591 NM_001037582
NM_024906
SCD5

stearoyl-CoA desaturase 5

chr6_+_72949092 0.582 RIMS1
regulating synaptic membrane exocytosis 1
chr7_-_100068612 0.576 TFR2
transferrin receptor 2
chr17_+_26322081 0.572 NM_001184992
NM_032322
NM_197939
RNF135


ring finger protein 135


chr17_+_45940743 0.570 NM_032133
MYCBPAP
MYCBP associated protein
chr3_-_129024665 0.565 NM_001003794
MGLL
monoglyceride lipase
chr17_+_26322168 0.556 RNF135
ring finger protein 135
chr11_+_19691397 0.527 NM_145117
NM_182964
NAV2

neuron navigator 2

chr3_-_181237210 0.522 NM_016559
PEX5L
peroxisomal biogenesis factor 5-like
chr11_+_65357972 0.522 NM_152760
SNX32
sorting nexin 32
chr1_+_199108705 0.517 NM_005298
GPR25
G protein-coupled receptor 25
chr18_+_18969724 0.515 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr19_-_19599973 0.511 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr11_-_133332089 0.511 NM_014987
IGSF9B
immunoglobulin superfamily, member 9B
chr19_-_61680510 0.511 NM_022103
ZNF667
zinc finger protein 667
chr10_+_11824361 0.511 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr4_+_91267706 0.499 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr4_+_2789686 0.494 NM_001145856
SH3BP2
SH3-domain binding protein 2
chr2_-_175255717 0.488 NM_001077269
WIPF1
WAS/WASL interacting protein family, member 1
chr13_-_27967215 0.485 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr16_-_87535106 0.483 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr7_-_525336 0.479 PDGFA
platelet-derived growth factor alpha polypeptide
chr3_-_129023850 0.475 NM_007283
MGLL
monoglyceride lipase
chr2_-_73350103 0.474 NM_001080410
FBXO41
F-box protein 41
chr1_-_35957314 0.464 NM_152374
C1orf216
chromosome 1 open reading frame 216
chr13_-_76358370 0.464 KCTD12
potassium channel tetramerisation domain containing 12
chr9_-_21549696 0.462 LOC554202
hypothetical LOC554202
chr20_+_56701224 0.458 NM_024663
NPEPL1
aminopeptidase-like 1
chr18_-_42590989 0.453 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr10_+_105334704 0.452 NEURL
neuralized homolog (Drosophila)
chr10_-_88720908 0.451 LOC100133190
hypothetical LOC100133190
chr13_-_105985313 0.450 NM_004093
EFNB2
ephrin-B2
chr1_+_156229934 0.450 KIRREL
kin of IRRE like (Drosophila)
chr2_-_222145240 0.449 NM_004438
EPHA4
EPH receptor A4
chr7_-_87687276 0.447 SRI
sorcin
chr7_+_98084531 0.446 NM_002523
NPTX2
neuronal pentraxin II
chr13_-_43259032 0.444 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr16_+_65754788 0.442 NM_001040667
NM_001538
HSF4

heat shock transcription factor 4

chr16_-_53520208 0.436 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr15_-_43457916 0.431 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr13_-_77390907 0.430 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr14_-_87859284 0.430 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr4_+_2790338 0.428 NM_003023
SH3BP2
SH3-domain binding protein 2
chr1_-_35956979 0.424 C1orf216
chromosome 1 open reading frame 216
chr5_+_110587546 0.419 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr1_-_85235210 0.418 NM_153259
MCOLN2
mucolipin 2
chr7_-_87687302 0.416 NM_003130
SRI
sorcin
chr8_-_29262240 0.415 NM_057158
DUSP4
dual specificity phosphatase 4
chr17_-_53920699 0.408 NM_001080439
HSF5
heat shock transcription factor family member 5
chr12_-_105165805 0.404 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr3_+_154035425 0.402 NM_002563
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr17_-_40695216 0.401 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr1_+_22909916 0.395 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr7_+_129919134 0.395 MEST
mesoderm specific transcript homolog (mouse)
chr7_+_44110527 0.394 AEBP1
AE binding protein 1
chr6_-_80713589 0.394 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr5_+_175725050 0.392 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr13_-_26232777 0.389 NM_005288
GPR12
G protein-coupled receptor 12
chr3_-_159932899 0.389 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr3_+_106568334 0.384 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr4_+_19864332 0.384 NM_004787
SLIT2
slit homolog 2 (Drosophila)
chr7_+_129918408 0.383 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr5_+_118719591 0.382 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr20_+_41978195 0.380 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr7_+_129919157 0.379 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr5_+_118719448 0.378 NM_014350
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr11_+_2355099 0.376 CD81
CD81 molecule
chr11_+_65311104 0.372 NM_004561
OVOL1
ovo-like 1(Drosophila)
chr6_-_72187168 0.370 C6orf155
chromosome 6 open reading frame 155
chr2_-_62586979 0.369 NM_198276
TMEM17
transmembrane protein 17
chr5_-_1547872 0.367 LPCAT1
lysophosphatidylcholine acyltransferase 1
chr3_+_51403760 0.367 NM_013286
RBM15B
RNA binding motif protein 15B
chr18_-_72336133 0.363 NM_014643
ZNF516
zinc finger protein 516
chr13_-_76358433 0.361 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr19_+_61770701 0.360 NM_001001668
ZNF470
zinc finger protein 470
chr3_-_159932965 0.358 NM_002888
NM_206963
RARRES1

retinoic acid receptor responder (tazarotene induced) 1

chr8_+_59069522 0.358 NM_147189
FAM110B
family with sequence similarity 110, member B
chr15_-_43458247 0.357 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr13_-_109236897 0.356 NM_003749
IRS2
insulin receptor substrate 2
chr9_-_112381593 0.356 NM_153366
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr8_-_72919241 0.354 NM_005098
MSC
musculin
chr20_-_55718351 0.350 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr8_+_72918772 0.344 LOC100132891
hypothetical LOC100132891
chr22_+_34107051 0.342 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr9_-_112840064 0.341 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr13_+_26896614 0.340 NM_002097
GTF3A
general transcription factor IIIA
chr15_+_38485310 0.338 IVD
isovaleryl-CoA dehydrogenase
chr3_+_9826643 0.338 NM_001025930
TTLL3
tubulin tyrosine ligase-like family, member 3
chr22_+_34107087 0.335 HMOX1
heme oxygenase (decycling) 1
chr2_-_175060001 0.334 NM_001033045
NM_152529
GPR155

G protein-coupled receptor 155

chr14_+_51850754 0.333 NM_000956
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr8_+_104582151 0.332 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr15_+_82113813 0.330 NM_207517
ADAMTSL3
ADAMTS-like 3
chr3_+_120496180 0.329 ARHGAP31
Rho GTPase activating protein 31
chrX_-_106846684 0.329 TSC22D3
TSC22 domain family, member 3
chr2_+_88250949 0.329 NM_018271
THNSL2
threonine synthase-like 2 (S. cerevisiae)
chr8_+_72918889 0.329


chr6_-_137407504 0.328 IL20RA
interleukin 20 receptor, alpha
chr2_-_233501069 0.327 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr10_-_90740935 0.327 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr17_-_24068759 0.325 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr6_+_73388529 0.320 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr3_+_198214173 0.320 LOC100507057
MFI2
hypothetical LOC100507057
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr1_+_13899272 0.319 NM_001135610
PRDM2
PR domain containing 2, with ZNF domain
chr14_+_73128162 0.319 NM_152331
ACOT4
acyl-CoA thioesterase 4
chrX_+_7075820 0.318 STS
steroid sulfatase (microsomal), isozyme S
chr20_+_6696744 0.317 NM_001200
BMP2
bone morphogenetic protein 2
chr20_-_4752067 0.315 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr11_-_2907169 0.313 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr6_+_86216457 0.311 NT5E
5'-nucleotidase, ecto (CD73)
chr6_-_150431864 0.310 NM_024518
ULBP3
UL16 binding protein 3
chr3_+_54131731 0.309 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr2_-_127580975 0.308 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr16_-_85099941 0.307 LOC400550
hypothetical LOC400550
chr8_-_70908130 0.307 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr8_-_72919161 0.306 MSC
musculin
chr10_-_14686243 0.304 FAM107B
family with sequence similarity 107, member B
chr6_+_137185441 0.302 PEX7
peroxisomal biogenesis factor 7
chr10_+_80672842 0.301 ZMIZ1
zinc finger, MIZ-type containing 1
chr4_+_109072120 0.300 NM_183075
CYP2U1
cytochrome P450, family 2, subfamily U, polypeptide 1
chr18_+_32131628 0.297 NM_025135
FHOD3
formin homology 2 domain containing 3
chr11_-_605649 0.296 NM_004031
IRF7
interferon regulatory factor 7
chr1_-_58815753 0.296 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr17_-_3814334 0.294 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr3_+_54131613 0.292 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr12_-_41269679 0.292 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr22_-_39964001 0.292 CHADL
chondroadherin-like
chr10_+_90741024 0.292 FAS
Fas (TNF receptor superfamily, member 6)
chr11_-_62233600 0.292 NM_001130702
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr4_+_82171142 0.291 NM_001201
BMP3
bone morphogenetic protein 3
chr8_+_69405510 0.291 NM_001195639
NM_052958
C8orf34

chromosome 8 open reading frame 34

chr11_-_62233552 0.291 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr13_-_39075200 0.290 LHFP
lipoma HMGIC fusion partner
chr18_+_54681657 0.289 ZNF532
zinc finger protein 532
chr1_-_92721633 0.289 GFI1
growth factor independent 1 transcription repressor
chr12_-_67613213 0.287 NM_001005502
NM_198320
CPM

carboxypeptidase M

chr4_-_35922288 0.286 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_5750229 0.285 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr2_-_45090025 0.285 NM_016932
SIX2
SIX homeobox 2
chr14_+_73105618 0.284 ACOT2
acyl-CoA thioesterase 2
chr19_+_1022208 0.284 HMHA1
histocompatibility (minor) HA-1
chrX_-_7076146 0.284 NM_001135565
NM_001178135
NM_001178136
NM_012080
HDHD1



haloacid dehalogenase-like hydrolase domain containing 1



chr12_-_37585602 0.280 NM_153634
CPNE8
copine VIII
chrX_-_13866565 0.279 NM_001001994
GPM6B
glycoprotein M6B
chr18_-_75894902 0.278


chr1_+_40193424 0.276 MFSD2A
major facilitator superfamily domain containing 2A
chr15_+_90738108 0.276 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr3_-_49370755 0.275 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr7_-_525556 0.273 PDGFA
platelet-derived growth factor alpha polypeptide
chr2_+_207016525 0.272 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr9_-_129656581 0.272 ENG
endoglin
chr22_-_16020153 0.271 CECR5
cat eye syndrome chromosome region, candidate 5
chr11_-_60475558 0.269 NM_016582
SLC15A3
solute carrier family 15, member 3
chr18_-_55091596 0.269 NM_013435
RAX
retina and anterior neural fold homeobox
chr13_-_39075304 0.268 LHFP
lipoma HMGIC fusion partner
chr11_+_124438407 0.266 SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr15_+_38485292 0.266 IVD
isovaleryl-CoA dehydrogenase
chr3_-_55490401 0.266 WNT5A
wingless-type MMTV integration site family, member 5A
chr15_+_38485269 0.266 IVD
isovaleryl-CoA dehydrogenase
chr10_-_113933457 0.264 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr20_+_19903778 0.264 RIN2
Ras and Rab interactor 2
chr3_-_55490442 0.264 WNT5A
wingless-type MMTV integration site family, member 5A
chr15_-_27650218 0.260 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr22_-_16020076 0.260 CECR5
cat eye syndrome chromosome region, candidate 5
chr1_-_111018798 0.259 KCNA3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr17_-_25112393 0.259 SSH2
slingshot homolog 2 (Drosophila)
chr7_+_142205266 0.259


chr11_-_122571046 0.259 CLMP
CXADR-like membrane protein
chr12_+_50686990 0.257 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr1_+_40193389 0.257 MFSD2A
major facilitator superfamily domain containing 2A
chr6_+_133604181 0.257 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr3_-_88190737 0.256 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr19_+_2240996 0.255


chr16_-_21739231 0.255 RRN3P1
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
chrX_-_140098959 0.255 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr12_+_52806103 0.254 LOC400043
hypothetical LOC400043
chrX_-_11593741 0.254 NM_006125
NM_013427
ARHGAP6

Rho GTPase activating protein 6

chr18_+_54682261 0.254 ZNF532
zinc finger protein 532
chr11_+_66381451 0.253 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr14_+_76297885 0.252 NM_014909
VASH1
vasohibin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 1.93e-11 GO:0044260 cellular macromolecule metabolic process
1.20 2.04e-11 GO:0044237 cellular metabolic process
1.11 8.32e-11 GO:0009987 cellular process
1.43 1.95e-10 GO:0006464 protein modification process
1.41 8.85e-10 GO:0043412 macromolecule modification
1.34 1.74e-09 GO:0044267 cellular protein metabolic process
1.18 2.65e-09 GO:0044238 primary metabolic process
1.21 1.30e-08 GO:0043170 macromolecule metabolic process
1.16 3.69e-08 GO:0008152 metabolic process
1.16 1.53e-07 GO:0050794 regulation of cellular process
1.51 6.82e-07 GO:0006793 phosphorus metabolic process
1.51 6.82e-07 GO:0006796 phosphate metabolic process
1.14 1.15e-06 GO:0050789 regulation of biological process
1.38 1.22e-06 GO:0023051 regulation of signaling
1.26 1.70e-06 GO:0019538 protein metabolic process
1.13 6.06e-06 GO:0065007 biological regulation
1.39 6.82e-06 GO:0009966 regulation of signal transduction
1.29 7.59e-05 GO:0048523 negative regulation of cellular process
1.22 7.88e-05 GO:0016043 cellular component organization
1.52 7.89e-05 GO:0006468 protein phosphorylation
1.22 1.06e-04 GO:0006807 nitrogen compound metabolic process
1.21 1.28e-04 GO:0071840 cellular component organization or biogenesis
1.22 1.65e-04 GO:0034641 cellular nitrogen compound metabolic process
1.35 1.81e-04 GO:0007399 nervous system development
1.24 2.14e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 2.86e-04 GO:0071842 cellular component organization at cellular level
1.24 3.55e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.46 3.72e-04 GO:0016310 phosphorylation
1.26 4.51e-04 GO:0048519 negative regulation of biological process
1.33 7.70e-04 GO:0009653 anatomical structure morphogenesis
1.52 7.92e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.22 1.02e-03 GO:0048731 system development
1.41 1.06e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.21 1.68e-03 GO:0048856 anatomical structure development
1.19 2.15e-03 GO:0007275 multicellular organismal development
1.27 2.42e-03 GO:0048583 regulation of response to stimulus
1.30 2.65e-03 GO:0006996 organelle organization
1.41 2.72e-03 GO:0022008 neurogenesis
1.57 3.03e-03 GO:0031175 neuron projection development
1.18 3.20e-03 GO:0032502 developmental process
1.37 4.94e-03 GO:0007049 cell cycle
1.23 4.95e-03 GO:0048522 positive regulation of cellular process
1.50 5.19e-03 GO:0009887 organ morphogenesis
1.41 5.21e-03 GO:0048699 generation of neurons
1.18 7.10e-03 GO:0031323 regulation of cellular metabolic process
1.19 7.29e-03 GO:0060255 regulation of macromolecule metabolic process
1.47 7.73e-03 GO:0030030 cell projection organization
1.23 8.00e-03 GO:0044249 cellular biosynthetic process
1.22 8.71e-03 GO:0009058 biosynthetic process
3.08 1.28e-02 GO:0060349 bone morphogenesis
1.20 1.63e-02 GO:0048518 positive regulation of biological process
1.52 1.64e-02 GO:0000904 cell morphogenesis involved in differentiation
1.80 1.70e-02 GO:0045786 negative regulation of cell cycle
1.17 1.82e-02 GO:0080090 regulation of primary metabolic process
1.16 1.86e-02 GO:0019222 regulation of metabolic process
1.36 2.67e-02 GO:0042127 regulation of cell proliferation
1.43 2.88e-02 GO:0045595 regulation of cell differentiation
1.42 3.75e-02 GO:0030182 neuron differentiation
1.53 4.19e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.49 4.36e-02 GO:0007010 cytoskeleton organization
1.56 4.48e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.71 4.67e-02 GO:0000165 MAPKKK cascade

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 7.57e-26 GO:0005622 intracellular
1.15 3.60e-25 GO:0044424 intracellular part
1.17 2.29e-17 GO:0043231 intracellular membrane-bounded organelle
1.15 2.77e-17 GO:0043226 organelle
1.15 3.50e-17 GO:0043229 intracellular organelle
1.17 3.95e-17 GO:0043227 membrane-bounded organelle
1.17 7.20e-16 GO:0005737 cytoplasm
1.21 3.33e-11 GO:0005634 nucleus
1.17 2.50e-08 GO:0044444 cytoplasmic part
1.27 5.67e-05 GO:0005829 cytosol
1.04 1.00e-04 GO:0044464 cell part
1.04 1.05e-04 GO:0005623 cell
1.14 1.53e-04 GO:0044446 intracellular organelle part
1.23 5.32e-04 GO:0031974 membrane-enclosed lumen
1.13 6.01e-04 GO:0044422 organelle part
1.22 1.78e-03 GO:0043233 organelle lumen
1.22 2.33e-03 GO:0070013 intracellular organelle lumen
1.21 7.70e-03 GO:0044428 nuclear part
1.71 1.18e-02 GO:0005813 centrosome
1.38 2.36e-02 GO:0015630 microtubule cytoskeleton
1.22 3.11e-02 GO:0031981 nuclear lumen
1.17 4.00e-02 GO:0043228 non-membrane-bounded organelle
1.17 4.00e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 1.84e-09 GO:0005488 binding
1.15 3.78e-08 GO:0005515 protein binding
1.47 1.99e-04 GO:0019899 enzyme binding
1.24 5.92e-04 GO:0000166 nucleotide binding
1.38 1.63e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.27 1.72e-03 GO:0016740 transferase activity
1.25 2.82e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.13 5.00e-03 GO:0003824 catalytic activity
1.24 6.34e-03 GO:0017076 purine nucleotide binding
1.41 6.60e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.24 6.95e-03 GO:0032553 ribonucleotide binding
1.24 6.95e-03 GO:0032555 purine ribonucleotide binding
1.39 8.02e-03 GO:0016301 kinase activity
1.27 8.69e-03 GO:0005524 ATP binding
2.03 1.37e-02 GO:0051020 GTPase binding
1.25 1.72e-02 GO:0030554 adenyl nucleotide binding
1.42 2.09e-02 GO:0004672 protein kinase activity
1.25 2.10e-02 GO:0032559 adenyl ribonucleotide binding
2.14 2.29e-02 GO:0017016 Ras GTPase binding
1.84 2.31e-02 GO:0004721 phosphoprotein phosphatase activity
2.06 3.07e-02 GO:0031267 small GTPase binding
1.55 3.29e-02 GO:0042578 phosphoric ester hydrolase activity
1.59 3.80e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
2.66 4.02e-02 GO:0004722 protein serine/threonine phosphatase activity
1.64 4.16e-02 GO:0016791 phosphatase activity
1.61 4.61e-02 GO:0016881 acid-amino acid ligase activity