Motif ID: FOXL1.p2

Z-value: 1.323


Transcription factors associated with FOXL1.p2:

Gene SymbolEntrez IDGene Name
FOXL1 2300 forkhead box L1



Activity profile for motif FOXL1.p2.

activity profile for motif FOXL1.p2


Sorted Z-values histogram for motif FOXL1.p2

Sorted Z-values for motif FOXL1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXL1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_190811479 1.974 NM_002922
RGS1
regulator of G-protein signaling 1
chrX_-_33139349 1.871 NM_004006
DMD
dystrophin
chrX_-_117003310 1.698 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr5_-_88155360 1.624 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_+_24660849 1.347 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr3_-_87408301 1.237 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr12_-_101115677 1.157 NM_002674
PMCH
pro-melanin-concentrating hormone
chr10_-_98021144 1.115 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_+_143603368 1.103 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr8_-_102005697 1.055 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr11_-_17147863 1.034 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr12_+_9713472 1.012 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr13_+_49487390 1.004 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr14_+_20319049 0.997 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr1_+_165565006 0.957 POU2F1
POU class 2 homeobox 1
chr7_+_110518297 0.943 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr4_+_169654742 0.941 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr8_+_107807415 0.926 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr5_+_76470829 0.924


chr1_+_194887630 0.914 NM_000186
NM_001014975
CFH

complement factor H

chr10_+_5976354 0.904 NM_032807
FBXO18
F-box protein, helicase, 18
chr5_+_180726874 0.899 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr10_-_14090459 0.873 FRMD4A
FERM domain containing 4A
chr4_+_88748704 0.870 NM_014208
DSPP
dentin sialophosphoprotein
chr20_-_42561725 0.864


chr1_+_74473672 0.856 NM_015978
TNNI3K
TNNI3 interacting kinase
chr15_-_78050515 0.849 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr10_+_89257569 0.832 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr3_+_190831909 0.809 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chrX_+_35974973 0.803 NM_173695
CXorf59
chromosome X open reading frame 59
chr19_+_39402167 0.803 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr7_+_116447527 0.802 ST7
suppression of tumorigenicity 7
chr1_-_181540631 0.802 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr17_-_26648375 0.800 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr9_-_99740243 0.798 NM_197978
HEMGN
hemogen
chr10_+_35524835 0.797 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr2_+_143603439 0.796 ARHGAP15
Rho GTPase activating protein 15
chr2_+_227900471 0.793 NM_020194
MFF
mitochondrial fission factor
chr5_-_169657192 0.777 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_169657395 0.777 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_+_158603480 0.775 NM_005598
NHLH1
nescient helix loop helix 1
chr14_+_87541220 0.769 NM_003608
GPR65
G protein-coupled receptor 65
chr10_+_94584449 0.766 NM_001013848
EXOC6
exocyst complex component 6
chr5_+_139485703 0.765 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr7_+_18502342 0.757 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr5_-_169657312 0.755 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr4_-_74307637 0.753 ANKRD17
ankyrin repeat domain 17
chr10_-_75080784 0.744 NM_024875
SYNPO2L
synaptopodin 2-like
chr12_-_101036407 0.740 NM_024057
NUP37
nucleoporin 37kDa
chr3_-_42818221 0.737


chr8_-_66863841 0.736 NM_002603
PDE7A
phosphodiesterase 7A
chr11_-_47356479 0.729 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr10_-_11614279 0.724 NM_001080491
USP6NL
USP6 N-terminal like
chr1_+_114295289 0.720 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr1_+_160868932 0.714 DDR2
discoidin domain receptor tyrosine kinase 2
chr19_+_55614006 0.705 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr9_+_263025 0.695 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr1_+_149395728 0.694 NM_024575
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr5_-_94442941 0.694 MCTP1
multiple C2 domains, transmembrane 1
chr19_-_43608641 0.682 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chr7_-_113346284 0.682 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr3_-_143230124 0.681 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr14_-_30927931 0.671 NM_015473
HEATR5A
HEAT repeat containing 5A
chr17_+_32807040 0.648 NM_173625
C17orf78
chromosome 17 open reading frame 78
chr11_-_47356650 0.640 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr3_-_186752952 0.637 NM_139248
LIPH
lipase, member H
chr12_-_69317441 0.630 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr5_-_169657360 0.629 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_-_122400937 0.627 NM_001167856
NM_018183
SBNO1

strawberry notch homolog 1 (Drosophila)

chr13_-_98757634 0.616 NM_004951
GPR183
G protein-coupled receptor 183
chr10_+_63331018 0.615 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr4_+_53975597 0.611 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr1_-_181889070 0.610 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr1_+_181380837 0.603 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr11_-_47356642 0.603 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr1_+_160868822 0.599 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr11_-_57883117 0.599 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr12_+_63510481 0.590


chr11_-_47356672 0.590 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr11_-_47356562 0.582 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr5_-_137502975 0.579 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr7_+_106897737 0.574 NM_005295
GPR22
G protein-coupled receptor 22
chr1_-_158815895 0.574 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr6_-_49712483 0.565 NM_000324
RHAG
Rh-associated glycoprotein
chr2_+_33592445 0.564 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_-_8004671 0.562 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr1_+_103898844 0.561 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr13_+_110653407 0.556 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr21_+_37713076 0.551 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr13_-_74799898 0.549 TBC1D4
TBC1 domain family, member 4
chr13_-_45640679 0.548 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_+_147568795 0.546 STXBP5
syntaxin binding protein 5 (tomosyn)
chr3_-_25658829 0.545 TOP2B
topoisomerase (DNA) II beta 180kDa
chr3_+_35658852 0.545 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_-_108311872 0.544 NM_001024607
C7orf66
chromosome 7 open reading frame 66
chr17_-_26665220 0.543 NM_006495
EVI2B
ecotropic viral integration site 2B
chr11_-_83071084 0.542 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr7_+_142723340 0.541 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr3_+_44665220 0.540 NM_003420
ZNF35
zinc finger protein 35
chr17_-_26665213 0.539 EVI2B
ecotropic viral integration site 2B
chr4_-_38710376 0.538 NM_024943
TMEM156
transmembrane protein 156
chr5_+_139869819 0.536


chr1_-_180822686 0.534 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr6_-_133120587 0.529 NM_004665
VNN2
vanin 2
chr15_+_38296920 0.527 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr15_-_23204887 0.523 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr1_+_84540921 0.523 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr5_+_67622242 0.522 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr21_-_14840506 0.520 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr8_+_67568044 0.517 NM_152765
C8orf46
chromosome 8 open reading frame 46
chr13_-_40454360 0.516 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_-_152585226 0.515 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr1_-_178100204 0.510


chr2_+_151922350 0.508 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_+_62835759 0.508 NM_014495
ANGPTL3
angiopoietin-like 3
chr12_+_21417068 0.507 NM_000415
IAPP
islet amyloid polypeptide
chr2_-_55053398 0.507


chrX_-_131989963 0.505 NM_031907
USP26
ubiquitin specific peptidase 26
chr1_+_242281199 0.505 ZNF238
zinc finger protein 238
chr14_-_94669547 0.498 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_+_40635058 0.494 NM_001198980
SMAP2
small ArfGAP2
chrX_-_138742050 0.492 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr12_+_25096472 0.490 NM_006152
LRMP
lymphoid-restricted membrane protein
chr7_+_129634935 0.490 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr13_-_98708549 0.489 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr2_-_207291364 0.487 NM_001093730
DYTN
dystrotelin
chr17_-_26665194 0.480 EVI2B
ecotropic viral integration site 2B
chr1_+_151015471 0.479 NM_178354
LCE1F
late cornified envelope 1F
chr7_+_113853790 0.478 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr9_-_21472311 0.478 NM_176891
IFNE
interferon, epsilon
chr11_-_5321329 0.476 NM_001005567
OR51B5
olfactory receptor, family 51, subfamily B, member 5
chr10_-_61570665 0.475 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr14_-_80475636 0.474 NM_152446
C14orf145
chromosome 14 open reading frame 145
chr11_-_72057755 0.473 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr3_+_44667504 0.473 ZNF35
zinc finger protein 35
chr1_+_196874759 0.471 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr8_-_102872372 0.471 NCALD
neurocalcin delta
chr14_-_101617680 0.470 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr1_-_239865724 0.465 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr5_-_43326922 0.463 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr2_+_161701711 0.463 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr3_-_195670256 0.463 NM_024524
ATP13A3
ATPase type 13A3
chr17_-_36209672 0.461 NM_181535
KRT28
keratin 28
chr4_+_73123712 0.459 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr10_-_97190885 0.458 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr2_-_55090759 0.458 NM_007008
RTN4
reticulon 4
chr1_+_78243181 0.455 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr17_-_26665144 0.455 EVI2B
ecotropic viral integration site 2B
chr17_-_1195096 0.455 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr10_+_50177192 0.455 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr4_+_71492581 0.448 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr1_-_246869181 0.447 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr2_+_211129567 0.445 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr6_-_32892705 0.442 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr8_-_102872614 0.441 NM_032041
NCALD
neurocalcin delta
chr21_-_30836051 0.437 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr3_-_17757402 0.437 NM_014744
TBC1D5
TBC1 domain family, member 5
chr9_+_19280748 0.437 NM_017925
DENND4C
DENN/MADD domain containing 4C
chr2_-_55413253 0.436 CCDC88A
coiled-coil domain containing 88A
chr6_+_135558744 0.434 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr8_-_102872354 0.432 NCALD
neurocalcin delta
chr4_+_77214886 0.430 NM_001130016
NM_001179
ART3

ADP-ribosyltransferase 3

chr4_+_71713324 0.429 NM_031889
ENAM
enamelin
chr4_+_71283383 0.425 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr7_-_135263737 0.425 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr11_+_33319680 0.424 HIPK3
homeodomain interacting protein kinase 3
chr5_+_156540425 0.424 NM_005546
ITK
IL2-inducible T-cell kinase
chrX_+_65300803 0.421 NM_001130860
NM_014799
HEPH

hephaestin

chr13_+_45174446 0.420 NM_152719
SPERT
spermatid associated
chr1_+_84539876 0.418 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr15_-_75135496 0.417 TSPAN3
tetraspanin 3
chr1_+_207926172 0.416 NM_181755
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr17_+_58440629 0.416 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr4_-_146315341 0.415 NM_017493
OTUD4
OTU domain containing 4
chr17_+_23824784 0.415 NM_001145975
NM_001145976
NM_003984
SLC13A2


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2


chr2_-_162717159 0.414 NM_002054
GCG
glucagon
chr2_+_33514896 0.412 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_-_32665409 0.411 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr18_-_65766068 0.411 CD226
CD226 molecule
chrX_-_135691168 0.409 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_+_157167965 0.408 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr17_-_36276987 0.403 NM_000223
KRT12
keratin 12
chr1_-_150398327 0.402 NM_001122965
RPTN
repetin
chr15_-_42756377 0.401 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr5_-_58918031 0.401 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_52281050 0.400 NM_001130059
ATF7
activating transcription factor 7
chr3_+_113534604 0.400 NM_001004196
NM_005944
CD200

CD200 molecule

chr10_-_21226536 0.400 NM_006393
NEBL
nebulette
chr16_-_54466709 0.399 NM_001143685
NM_145024
CES5A

carboxylesterase 5A

chr21_+_37714470 0.394 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr10_+_98054074 0.393 NM_001017520
NM_004088
DNTT

deoxynucleotidyltransferase, terminal

chr3_-_147696411 0.393 NM_020359
PLSCR2
phospholipid scramblase 2
chr2_-_37150876 0.393 HEATR5B
HEAT repeat containing 5B
chr21_-_31995972 0.392 SCAF4
SR-related CTD-associated factor 4
chr6_-_117853710 0.392 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chrX_+_41468351 0.389 NM_080817
GPR82
G protein-coupled receptor 82
chr21_-_36870736 0.386 NM_001146077
CLDN14
claudin 14
chr22_+_27779877 0.383 ZNRF3
zinc and ring finger 3
chr10_-_31328426 0.382 NM_001143769
ZNF438
zinc finger protein 438
chr12_+_130004404 0.377 NM_198827
GPR133
G protein-coupled receptor 133

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.84 3.86e-16 GO:0007606 sensory perception of chemical stimulus
2.93 1.89e-15 GO:0007608 sensory perception of smell
2.23 6.94e-14 GO:0007600 sensory perception
1.75 5.59e-12 GO:0003008 system process
1.34 1.36e-10 GO:0032501 multicellular organismal process
1.77 2.30e-09 GO:0050877 neurological system process
1.22 1.34e-04 GO:0050896 response to stimulus
2.53 1.54e-03 GO:0007517 muscle organ development
1.62 3.26e-02 GO:0006955 immune response
1.47 3.44e-02 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 2.41e-07 GO:0071944 cell periphery
1.32 4.74e-07 GO:0005886 plasma membrane
1.41 9.63e-05 GO:0005576 extracellular region
3.04 1.50e-04 GO:0030016 myofibril
3.00 3.37e-04 GO:0044449 contractile fiber part
2.87 4.78e-04 GO:0043292 contractile fiber
3.03 1.36e-03 GO:0030017 sarcomere
2.45 2.03e-03 GO:0005882 intermediate filament
2.27 5.07e-03 GO:0045111 intermediate filament cytoskeleton
1.93 2.11e-02 GO:0015629 actin cytoskeleton
1.46 2.32e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.03 8.10e-17 GO:0004984 olfactory receptor activity
2.21 1.59e-14 GO:0004930 G-protein coupled receptor activity
1.77 1.59e-09 GO:0004888 transmembrane receptor activity
1.53 2.95e-06 GO:0004872 receptor activity
1.42 8.46e-05 GO:0004871 signal transducer activity
1.42 8.46e-05 GO:0060089 molecular transducer activity
1.92 1.53e-02 GO:0003779 actin binding
3.94 1.62e-02 GO:0008307 structural constituent of muscle
1.67 3.19e-02 GO:0008092 cytoskeletal protein binding